Non‐targeted hepatitis C virus screening in acute care healthcare settings in the Southern Appalachian region by Cody A. Chastain, Cathy A. Jenkins, Michelle Rose, Daniel Moore, Diana Parker, Barbra Cave, Jane Crowe, Sarah Adams, Marrieth G. Rubio, Rachel Potter, Kimberly Quedado, Ian D. Jones, Jin H. Han, Wesley H. Self

“…Methods In the Southern Appalachian region of the United States, we developed non‐targeted HCV screening and linkage‐to‐care programs in 10 institutions at different healthcare settings, including EDs, outpatient clinics, and inpatient units. …”
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Reducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites by Brian J. Parrett, Satoko Yamaoka, Michael A. Barry

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Application of Genomic Selection in Beef Cattle Disease Prevention by Ramanathan Kasimanickam, Joao Carlos Pinheiro Ferreira, John Kastelic, Vanmathy Kasimanickam

“…Moreover, precision medicine, powered by genomic data, supports development of tailored health management strategies, including targeted vaccination plans and antimicrobial stewardship. …”
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HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis by Manman Xie, Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Xiaoying Liu, Qi Chen

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The Nonlinear Contact Simulation for Manufacturing Process by Using ANSYS Program as Case study with Cylindrical rolling contact by Ammar Dawood Ghali

“…        Numerical simulation plays an indispensable role in the modern manufacturing process, especially in production operation and metal forming by using different of forming Dies Because it give perfect product design to improving quality and performance and reduce the time and cost .Because of the most of forming operation include contact option between the product surface (contact surface) and Die surface (Target surface) then the determination of the contact surface nature and material behavior ( uniform linear ) or ( not uniform nonlinear) that very effect on the carryout of forming process with required product .To improving simulation accuracy, approximations of linear behavior have become less  acceptable, while it is possible to perform nonlinear analysis and design more often  while minimizing approximations, the nonlinear analysis capabilities in general-purpose   programs such as ANSYS Mechanical.The significance of the research is into linear simulation analysis and its limitation and development to nonlinear simulation  where interest with the development manufacturing processes that including change in the geometry , properties and material behavior  through forming ,the search give an example of Case study with Cylindrical rolling contact that very important for wide application to manufacturing processes such as drawing ,Rolling ,Forging , Extrusion, Bending and other .The structural nonlinearities can be classified as geometric nonlinearity, material nonlinearity, and contact or boundary nonlinearity Numerical results indicate the success of ANSYS contact technologies in solving very large scale engineering problems especially large deformation frictional contact problems with the  new surface based contact elements have many advantages over the node based contact  elements . …”
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Scaling up access to antiretroviral treatment for HIV: lessons from a key populations program in Nigeria by Abdulsamad Salihu, Ibrahim Jahun, David Olusegun Oyedeji, Wole Fajemisin, Omokhudu Idogho, Samira Shehu, Aminu Yakubu, Jennifer Anyanti

“…The KPIF initiative was implemented through partner organizations such as the Society for Family Health (SFH), a KP-friendly and indigenous non-governmental organization. Earlier, the program implemented by SFH was largely an HIV prevention program. …”
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A gene signature related to programmed cell death to predict immunotherapy response and prognosis in colon adenocarcinoma by Lei Zheng, Jia Lu, Dalu Kong, Yang Zhan

“…Background Tumor development involves the critical role of programmed cell death (PCD), but the correlation between colon adenocarcinoma (COAD) and PCD-related genes is not clear. …”
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MESI INITIATIVES IN TRAINING IN ICT IN EDUCATION AND EDUCATIONAL TECHNOLOGY by Maria A. Tatarinova

“…The paper outlines the process of setting the educational program goals, building the trained specialists professional portrait, target audience, learning content selection and structuring, used educational technologies for training and future educational program development perspectives.…”
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The Socioeconomic Benefit to Individuals of Achieving the 2020 Targets for Five Preventive Chemotherapy Neglected Tropical Diseases. by William K Redekop, Edeltraud J Lenk, Marianne Luyendijk, Christopher Fitzpatrick, Louis Niessen, Wilma A Stolk, Fabrizio Tediosi, Adriana J Rijnsburger, Roel Bakker, Jan A C Hontelez, Jan H Richardus, Julie Jacobson, Sake J de Vlas, Johan L Severens

“…We estimated the potential economic benefit of achieving these targets, focusing specifically on productivity and out-of-pocket payments.…”
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Unraveling the immunomodulatory role of TIM-3 in head and neck squamous cell carcinoma: implications for targeted therapy by Shuang Xu, Yang Luo, Yuzhu He, Yuxiang Chen, Fengfeng Qin, Wenjian Hu

“…Inhibiting TIM-3 can restore T cell function and enhance the immune response against HNSCC, making it a promising immunotherapeutic target for this disease. This article reviews the expression of TIM-3 in HNSCC and its immunomodulatory mechanism and briefly introduces the combined application and development prospects of TIM-3 as a potential immunotherapeutic target.…”
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Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation by Zhixin Xu, Jingdi Zhang, Zhan Li, Hongzheng Wu, Honglin Xu, Ye Guo, Yongzhe Li

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MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma by Zhihui Liu, Jason J. Hong, Xiyuan Zhang, Carly M. Sayers, Wendy Fang, Man Xu, Sydney Loria, Sakereh Maskal, Haiyan Lei, Haitao Wu, Rolf Swenson, Jordan L. Meier, Jack F. Shern, Carol J. Thiele

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Computational complexity when constructing rational plans for program execution in a given field of parallel computers by V. M. Bakanov

“…The target consumers of the developed methods for generating schedules for parallel execution of programs are, first of all, developers of translators and virtual machines, and researchers of the properties of algorithms (for identifying and exploiting the potential of their hidden parallelism). …”
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rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids. by Sergio Ruiz-Carmona, Daniel Alvarez-Garcia, Nicolas Foloppe, A Beatriz Garmendia-Doval, Szilveszter Juhos, Peter Schmidtke, Xavier Barril, Roderick E Hubbard, S David Morley

“…When the structure of the intended target is available, one approach is to use molecular docking programs to assess the chemical complementarity of small molecules with the target; such calculations provide a qualitative measure of affinity that can be used in virtual screening (VS) to rank order a list of compounds according to their potential to be active. rDock is a molecular docking program developed at Vernalis for high-throughput VS (HTVS) applications. …”
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Geospatial analysis and scale-up modelling of the impact of mobile programming on access to essential childhood vaccinations in Yemen by Kent Garber, Priyanka Kanth, Kebir Hassen, Sherin Varkey, Kyandindi Sumaili

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YAP‐TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape by Roberto Alva‐Ruiz, Ryan D. Watkins, Jennifer L. Tomlinson, Jennifer A. Yonkus, Amro M. Abdelrahman, Caitlin B. Conboy, Erik Jessen, Nathan W. Werneburg, Hendrien Kuipers, Jack W. Sample, Gregory J. Gores, Sumera I. Ilyas, Mark J. Truty, Rory L. Smoot

“…CA3 was associated with on‐target decreases in YAP‐TEAD target gene expression, TEAD reporter activity, and overall TEAD levels. …”
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Episodic memory improvement in community-dwelling women following a remote language-based stimulation program by Vanessa Bisol, Bárbara Luzia Covatti Malcorra, Bárbara Rusch da Rocha, Ana Luiza Licodiedoff Peruzzo, Luciana Zanatta, Letícia Priscila Pacheco, Erica dos Santos Rodrigues, Maria Teresa Carthery-Goulart, Lilian Cristine Hübner

“…The increasing aging of the world's population has motivated studies leading to initiatives like developing online and face-to-face cognitive stimulation programs targeting typical and atypical aging populations. …”
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Effectiveness of second step program in fostering social-emotional skills in young children: a study in Japan by Rikuya Hosokawa, Riho Tomozawa, Megumi Fujimoto

“…The intervention group participated in the Second Step program, while the control group did not participate in any program. …”
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A qualitative RE-AIM evaluation of an embedded community paramedicine program in an Ontario Family Health Team by Sarisha Philip, Lauren Konikoff, Samuel Tiukuvaara, Tracey Izzard, Kyle Sitka, Ghislain Bercier, Kimberley Hewton, Barry Bruce, Mark Fraser, Karen Ferguson, Chris LeBouthillier, Courtney Maskerine, Krystal Kehoe MacLeod

“…Results Reach: The community paramedicine program is primarily used by physicians to target older patients with multiple chronic conditions, frequent health care use, and limited social support. …”
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Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma by Zhenfa Zhang, Lianmin Zhang, Yanan Cui, Guangyao Zhou, Pengpeng Zhang

“…Mitochondria play a central role in the energy metabolism of eukaryotic cells and can influence programmed cell death (PCD) mechanisms, which are critical in tumorigenesis and cancer progression. …”
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