Interferon regulatory factor 5: a potential target for therapeutic intervention in inflammatory diseases by Xinyuan Yu, Ata Ur Rehman, Lihong Dang, Xu Zhang, Jia Liu, Xiaoxing Xiong, Gang Chen, Zhihong Jian

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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain by Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang

“…However, developing a highly efficient and minimally toxic approach requires further exploration. …”
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A Hybrid Discrete Grey Wolf Optimizer to Solve Weapon Target Assignment Problems by Jun Wang, Pengcheng Luo, Xinwu Hu, Xiaonan Zhang

“…We propose a hybrid discrete grey wolf optimizer (HDGWO) in this paper to solve the weapon target assignment (WTA) problem, a kind of nonlinear integer programming problems. …”
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A biochemical screening platform to target chromatin states using condensates as a tool by Laura J. Hsieh, Tracy Lou, Muryam A. Gourdet, Emily Wong, Geeta J. Narlikar

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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…KRASG12C, ATM, ALK2), and neurodegeneration (e.g. amyloid beta plaques, MAPK p38), while exploring the intricacies associated with developing novel radiotracers for CNS targets. Examples highlight the preclinical and clinical uses of PET for studying biomarker function, drug candidate PK/PD, target occupancy/engagement, dosing regimen determination, clinical trial patient selection, and quantifying biomarker changes in response to treatments.…”
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Methods of Developing Strategies for Municipalities by Yu. N. Lapygin, D. V. Tulinova

“…The article is devoted to the procedures for constructing a strategy for the development of municipalities in the Russian Federation, both in terms of considering the formation of approaches to shaping the prospects for possible changes, and with respect to methods that allow us to determine the future on the basis of a set of strategically significant goals that are formed based on the results of constructing the target configurator.The goal is to compare different points of view on the organization of methodological support for the process of formulating the strategy itself and determining its main content and, as a result, to show the author’s version of the algorithm for constructing the strategy slogan and filling it with the content of strategic projects and programs.Methods for constructing mental maps were used, including the tools for analyzing the situation, forming a hierarchy of strategic goals, and determining the main content of the strategy for the development of the municipal formation.It is shown that in the scientific literature the controversy continues about the algorithms, methods, models and tools for the development of the strategy for the development of municipalities, and universal methods for developing strategies have not been worked out.The structure of strategic goals is determined as a result of the analysis of the factors of the external and internal environment, as a result of the analysis of the existing strategy of the municipal entity (legal or illegal), as the concretization of the Vision and the Mission. and also as an orientation to the reference variants of goal-setting in the municipality. …”
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Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs by Shuai Zhang, Xue Feng, Chong-Hui Li, Yuan-Ming Zheng, Meng-Ya Wang, Jun-Jie Li, Yun-Peng Dai, Naihe Jing, Jia-Wei Zhou, Gang Wang

“…Abstract Gaining the molecular understanding for myelination development and regeneration has been a long-standing goal in neurological research. …”
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Saving Angels Program: An Intervention for Students at Risk of Dropping Out (A Community of Practice Action Research) by Joanna Marie Yocampo

“…The program continues and grows to sustain the development of the Bagacañeno learners.…”
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VET leaders’ collaborative problem-solving skills: insights from a professionals’ master’s degree program by Anna Trikoili, Despoina Georgiou, Daniel Pittich

“…This study can be used as a roadmap for targeted professional development programs aiming to improve CPS skills and for informed decisionmaking in choosing professionals for pivotal leadership positions.…”
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Impact of a Structured Social Skills Training Program on Adolescents and Young Adults with Level 1 Autism by Leonardo Zoccante, Sara Sabaini, Erika Rigotti, Sophia Marlene Bonatti, Camilla Lintas, Marco Zaffanello

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Formation of a comprehensive program of marketing strategy measures for an industrial company in a changing competitive environment by O.A. Temchenko, V.M. Radko, D.Ya. Madzharova

“…A proposed model includes three main stages: analysis of the market environment, development of targeted measures (pricing, communication and product strategies) and their implementation with subsequent monitoring of effectiveness. …”
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Nurses' experiences of participating in employee assistance program and factors influencing its effectiveness: a qualitative study by Xuanhao Fan, Xuanhao Fan, Jiehao Zhuang, Jiehao Zhuang, Zhongqing Chen, Ziyi Xiong, Niu Yang, Jiangfeng Pu, Jiangfeng Pu, Peng Xu, Lifang Chen, Huigen Huang, Huigen Huang

“…To understand the experiences of clinical nurses participating in the EAP, to explore the relevant factors influencing its implementing effect, to provide reference for developing a more effective and reasonable EAP in healthcare organizations, to implement targeted assistance for nurses, and to promote the physical and mental health development of nurses.MethodsA descriptive research method was used to conduct semi-structured interviews with 14 clinical nurses. …”
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The importance of genotyping within the climate-smart plant breeding value chain – integrative tools for genetic enhancement programs by Ana Luísa Garcia-Oliveira, Rodomiro Ortiz, Fatma Sarsu, Søren K. Rasmussen, Paterne Agre, Asrat Asfaw, Moctar Kante, Subhash Chander

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Identification of clusters related to programmed cell death and potential prognostic biomarkers for immunotherapy response in endometrial cancer by Shan Lu, Yiyun Wei, Liuyan Chen, Jinlian Cheng, Liuyan Qin, Xuemei Lu, Lihong Pang

“…However, the current methods and biomarkers for predicting immunotherapy responses and prognosis are remain limited. Programmed cell death (PCD) pathways play a crucial role in cancer development and progression and may serve as prognostic markers and indicators of drug sensitivity in EC. …”
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Vaccine Development for Human Pneumoviruses by Elhadji Birane Mboup, Marie-Ève Hamelin, Julia Dubois, Manuel Rosa-Calatrava, Guy Boivin

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THE ROLE AND IMPACT OF INTERNATIONAL FUND FOR AGRICULTURAL DEVELOPMENT (IFAD) ON THE RURAL AREAS DEVELOPMENT OF THE REPUBLIC OF MOLDOVA by Aurelia LITVIN, Svetlana PETRASCU

“…These people could potentially be employed only in Agriculture as other economic activities are less developed in the rural areas. The Rural Financial Services and Agribusiness Development Project (RFSADP) is the fifth International Fund for Agricultural Development (IFAD) program in Moldova and became effective on July 4, 2011. …”
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The impact of a targeted Arab Board of Emergency Medicine examination preparation course on resident success rates by Shahzad Anjum, Khalid Bashir, Haris Iftikhar, Biju Gafoor, Aftab Mohammad Umar

“…Furthermore, the course’s development and the incorporation of ongoing feedback played key roles in further enhancing the quality and effectiveness of the training program.…”
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Health education interventions for individuals with visual or hearing impairment: a scoping review by Sohyun Jin, Geumbo Ko, Youngshin Song

“…These findings emphasize the need for innovation and targeted strategies to improve the effectiveness and inclusivity of health education programs.…”
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In Situ Pixel-Scale Magnetic Programming 3-Dimensional Printing for Multimode Soft Miniature Robots with Multifunctions by Song Zhao, Liwen Zhang, Kuntao Tan, Shengbin Zhang, Botao Ma, Xueshan Jing, Xinzhao Zhou, Yan Wang, Huawei Chen

“…In this study, a photocuring 3-dimensional (3D) printing technique with in situ pixel-scale magnetic programming was developed, enabled by a 3D large-scale uniform magnetic field generator with a high strength of approximately 50 mT. …”
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Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors by Xiong Zhang, Yatian Yang, Hongye Zou, Yang Yang, Xingling Zheng, Eva Corey, Amina Zoubeidi, Nicolas Mitsiades, Ai-Ming Yu, Yuanpei Li, Hong-Wu Chen

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