A Spiritual Care Program for Patients With Cancer and Psychosomatic Disorders in Iran: A Protocol Study by Rahmatollah Marzband, Seyed Hamzeh Hosseini, Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Mohammad Eslamijouybari, Tahereh Yaghoubi, Marzieh Azizi, Fereshteh Araghian Mojarad, Ehsan Abedini

“…This study presents a protocol for developing a spiritual care program for patients with cancer and psychosomatic diseases in Iran.  …”
Get full text

Programmed cell death-driven remodeling of the melanoma microenvironment enables prognostic stratification and therapeutic prediction by Bo Hu, Shengnan Chai, Xuan Li, Qiang Zhang, Mei Jin, Long Zhang

“…These findings underscore the potential of targeting PCD dynamics as a novel approach in melanoma management.…”
Get full text

A Health Systems Approach to Nurse-Led Implementation of Diabetes Prevention and Management in Vulnerable Populations by Patricia C. Underwood, Brielle Ruscitti, Tam Nguyen, Cherlie Magny-Normilus, Katherine Wentzell, Sharon A. Watts, Diana Bowser

“…Case study results use examples to show large-scale implementation of DSME across the federal Veterans Health Administration (VHA) improves diabetes self-management and access for Veterans and smaller-scale DPP and DSME programs within community health centers targeting vulnerable populations impact health literacy and diabetes self-management. …”
Get full text

A hybrid simulation model of HIV program interventions: from transmission behavior to macroeconomic impacts by William Crown, Erin Britton, Moaven Razavi, Yiqun Luan, Senthil Veerunaidu, Jennifer Kates, Gary Gaumer, Monica Jordan, Clare L. Hurley, Allyala K. Nandakumar

“…Background: Considerable progress has been made in the estimation of drug safety treatment effects—particularly with observational medical claims and electronic medical record data. The use of the Target Trial framework, along with developments in statistical methodology such as doubly robust and G-estimation methods, has improved the ability to draw reliable causal inferences about drug and vaccine safety from observational data. …”
Get full text

Multiomics integration and machine learning reveal prognostic programmed cell death signatures in gastric cancer by Zihao Bai, Hao Wang, Jingru Han, Jia An, Zhaocong Yang, Xuming Mo

“…A machine learning model was developed to create the Gastric Cancer Multi-Omics Programmed Cell Death Signature (GMPS), targeting PCD-related genes. …”
Get full text

Programmed Cell Death-1 Expression in T-Cell Subsets in Chickens Infected with Marek’s Disease Virus by Jumpei Sato, Yoshinosuke Motai, Shunsuke Yamagami, Shwe Yee Win, Fumiya Horio, Hikaru Saeki, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi, Shiro Murata

“…The function of PD-1-expressing CD8⁺ and γδ T-cells in chickens may be impaired after developing MD, which may cause MDV-induced immunosuppression.…”
Get full text

Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program by Yuliya S. Nikolova, Yuliya S. Nikolova, Yuliya S. Nikolova, Anthony C. Ruocco, Anthony C. Ruocco, Anthony C. Ruocco, Anthony C. Ruocco, Daniel Felsky, Daniel Felsky, Daniel Felsky, Shannon Lange, Shannon Lange, Shannon Lange, Shannon Lange, Thomas D. Prevot, Thomas D. Prevot, Thomas D. Prevot, Erica Vieira, Erica Vieira, Daphne Voineskos, Daphne Voineskos, Jeffrey D. Wardell, Jeffrey D. Wardell, Jeffrey D. Wardell, Jeffrey D. Wardell, Daniel M. Blumberger, Daniel M. Blumberger, Kevan Clifford, Kevan Clifford, Ravinder Naik Dharavath, Philip Gerretsen, Philip Gerretsen, Ahmed N. Hassan, Ahmed N. Hassan, Ingrid M. Hope, Samantha H. Irwin, Sheila K. Jennings, Sheila K. Jennings, Bernard Le Foll, Bernard Le Foll, Osnat Melamed, Osnat Melamed, Josh Orson, Peter Pangarov, Leanne Quigley, Cayley Russell, Kevin Shield, Kevin Shield, Kevin Shield, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Matthew E. Sloan, Ashley Smoke, Ashley Smoke, Victor Tang, Victor Tang, Victor Tang, Diana Valdes Cabrera, Diana Valdes Cabrera, Wei Wang, Samantha Wells, Samantha Wells, Samantha Wells, Rajith Wickramatunga, Etienne Sibille, Etienne Sibille, Etienne Sibille, Lena C. Quilty, Lena C. Quilty

“…The CDiA Program comprises seven interdisciplinary projects that aim to evaluate the central thesis that EF has a crucial role in functional outcomes in SUDs. …”
Get full text

Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…We discussed the molecular basis of lipid uptake, synthesis, storage, lipolysis, and the tumor microenvironment, as well as their significance in OS development. Key enzymes such as adenosine triphosphate-citrate lyase (ACLY), acetyl-CoA synthetase 2 (ACSS2), fatty acid synthase (FASN) and stearoyl-CoA desaturase-1 (SCD1) are overexpressed in OS and associated with poor prognosis.Based on specific changes in metabolic processes, this review highlights potential therapeutic targets in the lipid metabolism and ferroptosis pathways, and in particular the HMG-CoA reductase inhibitor simvastatin has shown potential in inducing apoptosis and inhibiting OS metastasis. …”
Get full text

Evaluating the domains of generalism and equity, diversity and inclusion in preclinical simulated cases for targeted curricular improvements by Thomas Soroski, Kuda Hove, Lisa Steblecki, Jaime C. Yu

Get full text

Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions by Galih Januar Adytia, Henry Sutanto, Laras Pratiwi, Deasy Fetarayani

Get full text

Investigation of Underlying Biological Association and Targets between Rejection of Renal Transplant and Renal Cancer by Yinwei Chen, Zhanpeng Liu, Qian Yu, Xu Sun, Shuai Wang, Qingyi Zhu, Jian Yang, Rongjiang Jiang

Get full text

Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link by Alanoud Abdulla, Hana Q. Sadida, Jayakumar Jerobin, Imadeldin Elfaki, Rashid Mir, Sameer Mirza, Mayank Singh, Muzafar A. Macha, Shahab Uddin, Khalid Fakhro, Ajaz A. Bhat, Ammira S. Al-Shabeeb Akil

Get full text

NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy: Pathogenic Mechanisms and Therapeutic Targets by Chen Y, Chen R, Ji X, Zeng Z, Guan C

“…Pyroptosis, a newly defined form of programmed inflammatory necrosis, operates through the following molecular mechanism: inflammasome activation, gasdermin D (GSDMD)-mediated plasma membrane perforation and pro-inflammatory mediator release. …”
Get full text

Advances in cGAS-STING Signaling in Fibrosis Diseases: Therapeutic Target in Pathological Scars by Zhao W, Angspatt A, Kitkumthorn N, Meevassana J

Get full text

Differential expression of microRNAs and their target genes in cervical intraepithelial neoplasias of varying severity by T. A. Dimitriadi, D. V. Burtsev, E. A. Dzhenkova, D. S. Kutilin

“…Data analysis was carried out in the Python programming language using the SciPy library. Search for target genes was performed using the TarPmiR algorithm and the overrepresentation of microRNAs in signaling pathways (Over-Representation Analysis) was analyzed. …”
Get full text

A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets by Alexandra Vaiana, Jonathan Behr, Ryan Birol, Cornelis Blauwendraat, Bradford Casey, Kushan Chowdhury, Martin Citron, Joshua Crapser, Victoria Dardov, Fiona Ducotterd, Sonya Dumanis, John Dunlop, Michelle Durborow, Brian Fiske, Jessica Golden, Jonas Hannestad, Wendy Hung, Jennifer Kemp, Robin Kleiman, Adam Knight, Andrew Koemeter-Cox, Bruce Leuchter, Bejamin A. Logsdon, Rita Marreiros, Julie E. Miller, Amanda Mitchell, Pooja Mukherjee, Grace Navarro, Matthew R. Nelson, Karoly Nikolich, Tom Otis, Nicole Polinski, Shima Rastegar-Pouyani, Alastair D. Reith, Ekemini Riley, Lee Rubin, Mina Ryten, Jessica Sadick, Tina Schwabe, Todd Sherer, Sarah Silvergleid, Andrew Singleton, Lara St. Clair, Jan Stoehr, David J. Stone, Julianna Sullivan, Nicole Tanenbaum, Elisa Tinelli, Kate Trimble, Yifei Wang, Stacie Weninger, Nicolás Wiggenhauser, Stephen Wood, Darryle Schoepp, Virginie Buggia-Prevot, Shalini Padmanabhan, Gaia Skibinski

Get full text

The role of innovation and entrepreneurship employee training programs in enhancing organizational commitment from the perspective of industry–education integration by Zijing Wu, Qiang Li, Biao Zhang

“…This study aims to explore the role of employee training programs in enhancing organizational commitment. In the context where organizational commitment is crucial for enterprises’ stable development and employee training programs are an important part of human resources development, understanding their relationship is of great significance. …”
Get full text

Development of a workflow for in vitro on– and off-target cytotoxicity assessment of CAR T cell therapies to support first-in-human clinical trials: An orthogonal approach using hu... by Shari Price, Krista G. Zindel, Joshua K. Overcash, Elizabeth Glaze, Sandy Eldridge

“…Finally, an illustrative case of experimental CD33 CAR T cells co-cultured with a select panel of hiPSC-derived normal cells serves as a springboard for other CAR T cell developers to consider in their nonclinical safety programs.…”
Get full text

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment by Irene Scarfò, Marcela V. Maus

Get full text

Targeting iNAMPT and NAD Biosynthesis to Break the Obesity-Associated Liver Cancer Link by Kelly Thornton, Linda Torres, Elisa L. Pedone, Jessica S. Waltenbaugh, Cassandra M. Swanson, Emily Gonzalez, Ramona S. Price

Get full text