Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…Conclusion This study developed a single-cell atlas of pyroptosis in LUAD and identified prognostic biomarkers with potential translational value. …”
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Prerequisites for Cost-Effective Home Blood Pressure Telemonitoring: Early Health Economic Analysis by Job van Steenkiste, Pim van Dorst, Daan Dohmen, Cornelis Boersma

“…The HBPT intervention was based on an existing HBPT program applied by the Maasstad Hospital, Rotterdam, the Netherlands. …”
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A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories by Guanghao Zhang, Xiaolong Xu, Luojiang Zhu, Sisi Li, Rundong Chen, Nan Lv, Zifu Li, Jing Wang, Qiang Li, Wang Zhou, Pengfei Yang, Jianmin Liu

“…In summary, we identified five classifications of GBM and found that they exhibited distinct drug sensitivities and different prognoses, suggesting that the new grouping system may be able to provide important prognostic information and have certain guiding significance for the treatment of GBM, and identified the GSCL cluster in GBM tissues and described its characteristic program, which may help develop new potential therapeutic targets for GSCs in GBM.…”
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The effects of 12 weeks of high-intensity interval rope skipping training on speed and power indexes in male soccer players by Bo Wei, Bo Wei, Wenhu Cheng, Jiangang Qiu

“…This study integrates HIIT principles with rope skipping’s biomechanical SSC action to target neuromuscular adaptations.Research ConclusionThis finding enriches the functionality of the sport of jumping rope and provides an optional training tool for soccer players to develop their speed qualities.…”
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MAPPING OF EVACUATION PATHS AND SOCIALIZATION OF DISASTER MITIGATION IN TOURISM AREAS: EDU WISATA LONTAR SEWU, GRESIK REGENCY by Ratnaningtyas Wahyu Kusuma Wardani, Tofan Agung Eka Prasetya, Neffrety Nilamsari

“…Methods: The method of activities carried out is divided into 3 main stages, namely 1) the planning stage starting from exploring partner problems, reviewing the program target areas, preparing proposals, mapping evacuation route points at tourist sites; 2) the implementation stage consists of the location mapping stage, Focus Group Discussion (FGD), visualization stage, installation stage and socialization activities; 3) The last stage is the evaluation stage consisting of a question and answer session at the end of the socialization session, and 2) disaster simulation by participants. …”
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E2 Ubiquitin-Conjugating Enzymes Regulates Dengue Virus-2 Replication in <i>Aedes albopictus</i> by Jiaqi Wang, Xueli Zheng, Xuexue Wang, Daibin Zhong, Guofa Zhou

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The prevalence of metabolic syndrome in patients with non-alcoholic fatty liver disease in primary care clinics at King Saud University Medical City, Riyadh, Saudi Arabia by Alanoud Maan Alyousef, Alanoud Maan Alyousef, Doaa Zeinhom Mekawy, Doaa Zeinhom Mekawy, Yaser Yousef Bashumeel, Saleh Magdy Mohamed, Turky H. Almigbal, Turky H. Almigbal, Mohammed A. Batais, Mohammed A. Batais, Abdullah A. Alrasheed, Abdullah A. Alrasheed

“…Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria, which require at least three of five metabolic risk factors to be present. …”
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eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma by Jianxun Song, Xiang Chen, Ying Wen, Mingzhu Yin, Yan Cheng, Wenjun Yi, Xingcong Ren, Xisha Chen, Kuansong Wang, Shilong Jiang, Hongyin Sun, Xuanling Che, Minghui Zhang, Jiaying He, Mengting Liao, Xiangling Li, Xiaoming Zhou, Jinming Yang

“…Background Immune checkpoint blockade (ICB) targeting programmed death ligand-1 (PD-L1)/programmed cell death protein-1 (PD-1) pathway has become an attractive strategy for cancer treatment; however, unsatisfactory efficacy has limited its clinical benefits. …”
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Machine learning identification of key genes in cardioembolic stroke and atherosclerosis: their association with pan-cancer and immune cells by Tianxiang Zhang, Chunhui Yuan, Mo Chen, Jinjiang Liu, Wei Shao, Ning Cheng

“…Ferroptosis, a novel form of programmed cell death, may play a key role in CS and AS. …”
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Anoikis in prostate cancer bone metastasis gene signatures and therapeutic implications by Wei Xia, Miao Ye, Bo Jiang, Gang Xu, Guancheng Xiao, Qingming Zeng, Ruohui Huang

“…Anoikis, a form of programmed cell death triggered by the loss of cell-matrix interactions, plays a critical role in cancer progression. …”
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Employing Quantum Entanglement for Real-Time Coordination of Distributed Electric Vehicle Charging Stations: Advancing Grid Efficiency and Stability by Dawei Wang, Hanqi Dai, Yuan Jin, Zhuoqun Li, Shanna Luo, Xuebin Li

“…A rigorous mathematical formulation is developed, integrating over 40 system-level constraints, including power balance, transmission limits, renewable curtailment, carbon targets, voltage regulation, demand-side flexibility, social participation, and cyber-resilience. …”
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Design and Optimization of a Compliant Morphing Trailing Edge for High-Lift Generation by Salvatore Ameduri, Bernardino Galasso, Maria Chiara Noviello, Ignazio Dimino, Antonio Concilio, Pietro Catalano, Francesco Antonio D’Aniello, Giovanni Marco Carossa, Laurent Pinazo, John Derry, Britney Biju, Shruthi Shreedharan

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Investigating the adherence factors of Escherichia coli at the bovine recto-anal junction by Erin M. Nawrocki, Indira T. Kudva, Edward G. Dudley

“…Further analysis of adherence-associated gene clusters may lead to an improved understanding of the molecular mechanisms of RSE adherence and may help develop probiotics targeting STEC in cattle.IMPORTANCEE. coli strains that produce Shiga toxin cause foodborne illness in humans but colonize cattle asymptomatically. …”
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Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review by Liu Y, Zhang M, Wang T, Zhang J

“…ROS activate MAPK, NF-κB and NLRP3 cascades, boosting IL-1β, IL-6 and IL-27 release by M1 cells, while low NOX2 flux or mitochondrial H2O2 supports STAT6-dependent ARG1 expression and drives an M2 program. Additionally, we discuss the impact of different macrophage polarization states on asthma pathophysiology and the potential applications of macrophage-modulating agents in asthma treatment, particularly those targeting ROS-mediated polarization pathways. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Regarding the treatment of drug-resistant lactotroph PitNET, proliferative lymphocytes, CD8+ T, and NK cells could represent potentially valuable targets for developing new cancer immunotherapies.…”
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Unlocking the in vivo therapeutic potential of radiation-activated photodynamic therapy for locally advanced rectal cancer with lymph node involvementResearch in context by Rui Sang, Sheri Nixdorf, Tzongtyng Hung, Carl Power, Fei Deng, Thuy Anh Bui, Alexander Engel, Ewa M. Goldys, Wei Deng

“…In this study, a therapeutic strategy, radiation-activated photodynamic therapy (RA-PDT), for the treatment of LARC with lymph node-positive tumours was developed and evaluated. Methods: RA-PDT was achieved by using a lipid-polymer hybrid nanoplatform loaded with verteporfin (VP) and functionalised with folic acid (FA) as a targeting molecule. …”
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An automated pheochromocytoma and paraganglioma lesion segmentation AI-model at whole-body 68Ga- DOTATATE PET/CT by Fahmida Haque, Jorge A. Carrasquillo, Evrim B. Turkbey, Esther Mena, Liza Lindenberg, Philip C. Eclarinal, Naris Nilubol, Peter L. Choyke, Charalampos S. Floudas, Frank I. Lin, Baris Turkbey, Stephanie A. Harmon

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Proceedings of the 14th International Conference on Local Mechanical Properties - LMP 2019 by Editorial, Foreword

“…</p><p>The conference program consisted of research results and developments in the field of characterization of mechanical properties of various materials at nano- and micro-scales. …”
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Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer by Al B Benson, Anirban Maitra, Milind Javle, Michael Overman, Richard E Davis, Pankaj Vats, Chandan Kumar-Sinha, Lianchun Xiao, Niharika B Mettu, Edwin R Parra, Charles D Lopez, Veerendra Munugalavadla, Priti Patel, Lin Tao, Sattva Neelapu

“…Background The immunosuppressive desmoplastic stroma of pancreatic cancer represents a major hurdle to developing an effective immune response. Preclinical studies in pancreatic cancer have demonstrated promising anti-tumor activity with Bruton tyrosine kinase (BTK) inhibition combined with programmed cell death receptor-1 (PD-1) blockade.Methods This was a phase II, multicenter, open-label, randomized (1:1) clinical trial evaluating the BTK inhibitor acalabrutinib, alone (monotherapy) or in combination with the anti-PD-1 antibody pembrolizumab (combination therapy). …”
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The socioeconomic burden of meningococcal infection in the Russian Federation by Yu. V. Lobzin, A. S. Kolbin, A. A. Vilnits, A. A. Kurylev, Yu. E. Balykina, M. A. Proskurin

“…The total annual socioeconomic burden of GFMI in the target population of 611 patients (data 2023) of various ages was 1.395 billion RUR. …”
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