Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach by Hannes Hilberger, Bianca Buchgraber-Schnalzer, Simone Huber, Theresa Weitlaner, Markus Bödenler, Alara Abaci, Jeroen Bruinsma, Ana Diaz, Anna Giulia Guazzarini, Jenni Lehtisalo, Seungjune Lee, Vasileios Loukas, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Anna Rosenberg, Elisabeth Stögmann, Konsta Valkonen, Elena Uhlik, Helena Untersteiner, Laura Kneß, Helmut Ahammer, Sten Hanke

“…MethodsUsing a user-centered design approach, workshops and feedback rounds involved potential participants representing the target group and professionals. The LETHE app’s usability was assessed among 156 older adults enrolled in a 2-year multinational randomized controlled trial evaluating the feasibility of a digitally supported lifestyle program for dementia risk reduction. …”
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Circadian rhythm defects in Prader-Willi syndrome neurons by A. Kaitlyn Victor, Tayler Hedgecock, Chidambaram Ramanathan, Yang Shen, Andrew C. Liu, Lawrence T. Reiter

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A scoping review on U.S. undergraduate students with disabilities in STEM courses and STEM majors by Maura Borrego, Ariel Chasen, Hannah Chapman Tripp, Emily Landgren, Elisa Koolman

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Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer. by Federica Conte, Giulia Fiscon, Matteo Chiara, Teresa Colombo, Lorenzo Farina, Paola Paci

“…The ceRNAs are also called miRNA "decoys" or miRNA "sponges" and encompass different RNAs competing with each other to attract miRNAs for interactions: mRNA, long non-coding RNAs (lncRNAs), pseudogenes, or circular RNAs. Recently, we developed a computational method for identifying ceRNA-ceRNA interactions in breast invasive carcinoma. …”
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Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8. by Cinque Soto, Gilad Ofek, M Gordon Joyce, Baoshan Zhang, Krisha McKee, Nancy S Longo, Yongping Yang, Jinghe Huang, Robert Parks, Joshua Eudailey, Krissey E Lloyd, S Munir Alam, Barton F Haynes, NISC Comparative Sequencing Program, James C Mullikin, Mark Connors, John R Mascola, Lawrence Shapiro, Peter D Kwong

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TEACHERS’ PROFESSIONAL COMMITMENT AS AN INDICATOR OF PSYCHOLOGICAL READINESS TO THE PROFESSIONAL STANDARDS IMPLEMENTATION by S. A. Minyurova, A. I. Kalashnikov

“…The materials of the present article can be useful when developing the programmes for educators’ commitment to the profession.…”
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An Application-based programme to reinforce and maintain lower salt intake (AppSalt) in schoolchildren and their families in China by Yu Liu, Yuan Li, Wei Zhao, Feng J He, Graham A MacGregor, Puhong Zhang, Rong Luo, Fengge Chen, Yuhong Zhao, Daoxi Li, Hang Chen, Tianyong Wu, Jianyun Yao, Jinbao Li, Siyuan Zhou, Xian Li, Changqiong Wang

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Identification of hypoxene metabolites in urine samples using gas chromatography–tandem mass spectrometry for anti-doping control by P. V. Postnikov, A. V. Polosin, N. B. Savelieva, S. A. Kurbatkin, Yu. A. Efimova, E. S. Mochalova

“…They can act as markers for taking the target antihypoxant, and their possible structural formulas are given. …”
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The Associations of Anaemia Status and Body Mass Index with Asthma Severity in Saudi Arabia: A Comparative Study by Bugis AA, Bugis B, Alzahrani A, Alamri AH, Almalki HH, Alshehri JH, Alqarni AA, Turkestani FA

“…Health care professionals should be aware of these factors when assessing severity and developing treatment plans. Further research is needed to explore the underlying mechanisms and evaluate interventions targeting anaemia and BMI to improve outcomes.Keywords: asthma, exacerbation, airway hyperresponsiveness, anaemia, iron deficiency, body mass index, BMI…”
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Conceptual Design Study of a Coffee Stem Gasification Scheme in the Context of a Biorefinery by Camilo Andrés Guerrero-Martin, Leyder Alejandro Prieto-Moreno, Jaime Eduardo Arturo-Calvache, Stefanny Camacho-Galindo, Laura Estefanía Guerrero-Martin, William Alberto Guerrero, Oswaldo Hideo Ando Junior, John Carlos Arevalo, Elizabete Fernandes Lucas

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Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…In the last decade, immune checkpoint inhibitor (ICI)-based immunotherapy targeting programmed cell death-1 (PD-1) and its ligand 1 (PD-L1) has revolutionized cancer care. …”
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Mining for Protoclusters at z ∼ 4 from Photometric Data Sets with Deep Learning by Yoshihiro Takeda, Nobunari Kashikawa, Kei Ito, Jun Toshikawa, Rieko Momose, Kent Fujiwara, Yongming Liang, Rikako Ishimoto, Takehiro Yoshioka, Junya Arita, Mariko Kubo, Hisakazu Uchiyama

“…To tackle the issue, we develop a new deep-learning-based protocluster detection model, PCFNet, which considers a protocluster as a point cloud. …”
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Identification of anoikis-related subtypes and a risk score prognosis model, the association with TME landscapes and therapeutic responses in hepatocellular carcinoma by Xiangyu Zhai, Xiangyu Zhai, Kecheng Li, Hailing Ding, Yanmei Wu, Xinlu Zhang, Hao Zhang, Huaxin Zhou, Huaxin Zhou, Chongzhong Liu, Zili Zhang, Bin Jin, Bin Jin

“…TTC26 may serve as a novel biomarker and therapeutic target in HCC.…”
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Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation by Christopher Orr, Jeannette Stratton, Mohamed El-Shahawy, Elena Forouhar, Alice Peng, Gagandeep Singh, Keiko Omori, Meirigeng Qi, Fouad Kandeel

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Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer by Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Hankun Zhang, Mingyao Liu

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Natural history, immunological and genetic characteristics of preclinical inflammatory bowel disease (EARLY): study protocol for a prospective cohort study by Iago Rodríguez-Lago, Urko M. Marigorta, Beatriz Mateos, Míriam Mañosa, Lucía Márquez-Mosquera, Luis Menchén, Francisco Rodríguez-Moranta, Inmaculada Alonso, Mariam Aguas, Horacio Alonso-Galán, Pere Borràs, Beatriz Castro, Eugeni Domènech, Rocío Ferreiro-Iglesias, Ruth de Francisco, Francisco Javier García-Alonso, Natalia García, Orlando García-Bosch, Carla Gargallo, Javier P. Gisbert, Eva Iglesias, Francisco Mesonero, Jone Ortiz de Zárate, Laura Ramos, Empar Sáinz, Pablo Ladrón, Carles Suria, Cristina Suárez Ferrer, Coral Tejido, Pilar Varela, Raquel Vicente, Yamile Zabana, Gisela Castany, Eva Rodríguez, Ana Gutiérrez, Manuel Barreiro-de Acosta

“…Objectives: To determine the risk of developing symptoms after an incidental diagnosis of IBD and to describe the clinical, genetic, and immunological characteristics of IBD during its preclinical phase. …”
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Inhibition and co-condensation behaviour of 2-mercaptoethanol in top-of-line CO2 corrosion environments by Mariana C. Folena, Joshua Owen, Iain W. Manfield, Hanan Farhat, J.A.C. Ponciano, Richard Barker

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The solid state dispersion method for synthesizing eggshells ES/TiO2 composite to enhance photocatalytic degradation methylene blue by Rahmawati Munir, Dadan Hamdani, Darnah, Eva Marliana, Rahmiati Munir, Sahara Hamas Intifadhah, Ratna Kusuma

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Toward value-based care using cost mining: cost aggregation and visualization across the entire colorectal cancer patient pathway by Maura Leusder, Sven Relijveld, Derya Demirtas, Jon Emery, Michelle Tew, Peter Gibbs, Jeremy Millar, Victoria White, Michael Jefford, Fanny Franchini, Maarten IJzerman

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Adaptative Divergence of <i>Cryptococcus neoformans</i>: Phenetic and Metabolomic Profiles Reveal Distinct Pathways of Virulence and Resistance in Clinical vs. Environmental Isolat... by Camila Botelho Miguel, Geovana Pina Vilela, Lara Mamede Almeida, Mariane Andrade Moreira, Glicélia Pereira Silva, Jamil Miguel-Neto, Melissa Carvalho Martins-de-Abreu, Ferdinando Agostinho, Javier Emilio Lazo-Chica, Mariana Santos Cardoso, Siomar de Castro Soares, Aristóteles Góes-Neto, Wellington Francisco Rodrigues

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