Strengthening the Role of the Unified Agricultural Tax in Economic Incentives of the Agro-Industrial Complex by M. E. Kosov, A. O. Zvereva, R. G. Akhmadeev, E. V. Golubtsova

“…In the context of countering sanctions from unfriendly countries within the framework of the implementation of the state import substitution program and the food security doctrine, improving measures aimed at developing subjects of the agro-industrial complex is of particular relevance. …”
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Stem Cell-Derived Exosomes with High Expression of PD-L1 as Nanotherapeutics in Rheumatoid Arthritis Model Mice by Wang S, Zhang K, Wang L, Guo Y

“…To explore a novel therapeutic strategy targeting these cells, we aimed to develop mesenchymal stem cell-derived exosomes with enhanced PD-L1 expression (Exo-PD-L1) and evaluate their therapeutic potential in RA.Methods: Mouse bone marrow mesenchymal stem cells (MSCs) were stimulated with interferon γ (IFN-γ) to upregulate programmed death ligand 1 (PD-L1) expression. …”
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Identification of a pyroptosis-related prognostic model for colorectal cancer and validation of the core gene SPTBN5 by Guangyao Li, Pingyu Wang, Xiangnan Feng, Yongxiang Li

“…SPTBN5 may present a potential therapeutic target for CRC.…”
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Insights into the evolution and regulation of miRNAs from the view of their DNA replication temporal domains by Xudong Wu, Tingting Liu

“…Furthermore, we performed the simulation of miRNA-target regulatory networks to elucidate the co-regulation patterns among late-miRNAs. …”
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Determinants of nosocomial infections and emerging antibiotic resistance in the Intensive Care Unit: A prospective evidence-based study by Pranali Patil, Amol Muthal, Jignesh Shah, Asavari Raut

“…Conclusions: This study highlights the high incidence rate of ventilator-associated pneumonia, with extensive drug resistance in ICU patients, highlighting the need for an optimized antimicrobial stewardship program to develop effective strategies for the management of nosocomial infections. …”
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Multidimensional Evaluation Framework and Classification Strategy for Low-Carbon Technologies in Office Buildings by Hongjiang Liu, Yuan Song, Yawei Du, Tao Feng, Zhihou Yang

“…To address this gap, this study develops a multidimensional decision-making system to quantify and rank low-carbon technologies for office buildings in Beijing. …”
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Auto-segmentation of cerebral cavernous malformations using a convolutional neural network by Chi-Jen Chou, Huai-Che Yang, Cheng-Chia Lee, Zhi-Huan Jiang, Ching-Jen Chen, Hsiu-Mei Wu, Chun-Fu Lin, I-Chun Lai, Syu-Jyun Peng

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Unraveling the significance of cuproptosis in hepatocellular carcinoma heterogeneity and tumor microenvironment through integrated single-cell sequencing and machine learning appro... by Wang Liu, Liangjing Xia, Yuan peng, Qiang Cao, Ke Xu, Huiyan Luo, Yongjun Peng, Yanping Zhang

“…Finally, a prognostic nomogram was developed to support clinical decision-making. Results 12 programmed cell death pathways were enriched in tumors, with cuproptosis defining HCC, particularly in the C2 subpopulation. …”
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InterTransViewer: a comparative description of differential gene expression profiles from different experiments by А. V. Tyapkin, V. V. Lavrekha, E. V. Ubogoeva, D. Yu. Oshchepkov, N. A. Omelyanchuk, E. V. Zemlyanskaya

“…For automatic calculation and visualization of these indicators, we have developed the program InterTransViewer. We have used InterTransViewer to comparatively describe 23 auxin- and 16 ethylene- or 1-aminocyclopropane-1-carboxylic acid (ACC)-induced transcriptomes in Arabidopsis thaliana L. …”
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Evaluation and prioritization of food safety risks in the Nigerian red meat industry by Ismail Ayoade Odetokun, Damilola Christiana Olawoye, Akeem Adebola Bakare, Tajudeen Opeyemi Isola, Nma Bida Alhaji, Oluwadamilola Olawumi Abiodun-Adewusi, Taiwo Adeniyi Adewoye, Hama Cisse, Ibraheem Ghali-Mohammed

“…Abstract Food safety is a global concern, particularly in developing countries like Nigeria. Hence, this study aims to identify and rank food safety priorities in the red meat industry in Ilorin, Northcentral Nigeria, as a first step towards targeting interventions and resource allocation. …”
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Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols by Deborah Collyar, Christian M Capitini, Gary Kohanbash, Yana G Najjar, Carlo B Bifulco, Barbara Seliger, Holden T Maecker, Elizabeth Garrett-Mayer, Joe Yeong, Leslie Cope, Sacha Gnjatic, Sumit K Subudhi, Michael T Lotze, Saman Maleki Vareki, Alaa Ali, Laura Q M Chow, Tricia R Cottrell, Tullia C Bruno, Denise Goh, Codruta Chiuzan, Janis Taube, Ryan J Sullivan, Kristin G Anderson, Isabella C Glitza Oliva, Wim Vos, Paola Grandi, Susan Halabi, Julie Stein Deutsch, Ivan Diaz-Padilla, Anthony R Cillo, Genia Dubrovsky, Sarah Mullin, Elizabeth G Hill, Brian P Hobbs, Phyllis Pettit Nassi, Virgil H Simons, Chris H Takimoto

“…Immunotherapy of cancer is now an essential pillar of treatment for patients with many individual tumor types. Novel immune targets and technical advances are driving a rapid exploration of new treatment strategies incorporating immune agents in cancer clinical practice. …”
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Dichotomous intronic polyadenylation profiles reveal multifaceted gene functions in the pan-cancer transcriptome by Jiao Sun, Jin-Young Kim, Semo Jun, Meeyeon Park, Ebbing de Jong, Jae-Woong Chang, Sze Cheng, Deliang Fan, Yue Chen, Timothy J. Griffin, Jung-Hee Lee, Ho Jin You, Wei Zhang, Jeongsik Yong

“…Abstract Alternative cleavage and polyadenylation within introns (intronic APA) generate shorter mRNA isoforms; however, their physiological significance remains elusive. In this study, we developed a comprehensive workflow to analyze intronic APA profiles using the mammalian target of rapamycin (mTOR)-regulated transcriptome as a model system. …”
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Bibliometric analysis of global research on PD-L1/PD-1 pathway and neurodegenerative diseases over the last two decades (2004–2023) by Jialin Wu, Jialin Wu, Chaojin Zhang, Chaojin Zhang, Qiang Cao, Wei Xuan, Xiaorong Huai, Jie Zhou, Jie Tian, Jie Tian

“…BackgroundProgrammed death receptor 1 (PD-1), encoded by the PDCD1 gene, functions as a pivotal immunosuppressive molecule. …”
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Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…Our findings may serve as a foundation for elucidating the mechanism underlying the molecular metabolism of programmed cell death and should be useful for marker-assisted selection breeding in watermelon.…”
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Trends in mortality rate and years of life lost due to premature deaths from colorectal cancer in Danyang City， Jiangsu Province， 2013‒2023 by HU Jiahui, WANG Jiaye, CHEN Lili, JIANG Tao

“…Continued efforts to strengthen CRC prevention and control are needed, particularly targeting males and the elderly population.…”
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Synthesis, Radiolabeling, and Biological Evaluation of 68Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer by Samiah Alhabardi, Hesham Radwan, Basim Alotaibi, Yousif Almalki, Ehab Elzayat, Zakia Shinwari, Subhani M. Okarvi, Ibrahim Aljammaz

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Designing of a Novel Aerolysin-based Multiepitope Vaccine against Aeromonas hydrophila Isolated from Osphronemus goramy Using Reverse Vaccinology: an in Silico Approaches by Rozi, Wiwiek Tyasningsih, Jola Rahmahani, Eduardus Bimo Aksono, Muchammad Yunus, Mohammad Anam Al-Arif, Suryo Kuncorojati, Rahayu Kusdarwati, Putri Desi Wulan Sari, Mohammad Noor Azmai Amal, Annas Salleh, Nadeem Khanand, Suwarno

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Sprayable hydrogel sponge for neurovascular microenvironment reconstruction and inflammation modulation in diabetic wound healing by Xiaozhen Zhou, Pengchao Ma, Yihao Liu, Zhaojian Wang, Shida Chen, Zekun Cheng, Songlu Tseng, Hui Wu, Mengdi Zhang, Fengzhou Du, Nanze Yu, Xiao Long, Jiuzuo Huang, Xiumei Wang

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Antimicrobial Stewardship and Infection Prevention and Control in the Veneto Region, Northeastern Italy: Governance Models, Resources, and Key Challenges Across Hospital and Commun... by Paola Anello, Stefano Vianello, Vincenzo Baldo, Enrica Frasson, Umberto Gallo, Roberta Rampazzo, Milvia Marchiori, Mara Carraro, Sara Marchiori, Marta Pigozzo, Vinicio Manfrin, Annarita Mazzariol, Paola De Ambrosis, Davide Gentili, Michele Tonon, Romina Cazzaro, Giovanna Scroccaro, Francesca Russo, Daniele Mengato

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White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities by Jessica Alber, Suvarna Alladi, Hee‐Joon Bae, David A. Barton, Laurel A. Beckett, Joanne M. Bell, Sara E. Berman, Geert Jan Biessels, Sandra E. Black, Isabelle Bos, Gene L. Bowman, Emanuele Brai, Adam M. Brickman, Brandy L. Callahan, Roderick A. Corriveau, Silvia Fossati, Rebecca F. Gottesman, Deborah R. Gustafson, Vladimir Hachinski, Kathleen M. Hayden, Alex M. Helman, Timothy M. Hughes, Jeremy D. Isaacs, Angela L. Jefferson, Sterling C. Johnson, Alifiya Kapasi, Silke Kern, Jay C. Kwon, Juraj Kukolja, Athene Lee, Samuel N. Lockhart, Anne Murray, Katie E. Osborn, Melinda C. Power, Brittani R. Price, Hanneke F.M. Rhodius‐Meester, Jacqueline A. Rondeau, Allyson C. Rosen, Douglas L. Rosene, Julie A. Schneider, Henrieta Scholtzova, C. Elizabeth Shaaban, Narlon C.B.S. Silva, Heather M. Snyder, Walter Swardfager, Aron M. Troen, Susanne J. vanVeluw, Prashanthi Vemuri, Anders Wallin, Cheryl Wellington, Donna M. Wilcock, Sharon Xiangwen Xie, Atticus H. Hainsworth

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