Targeting PD-1 post-translational modifications for improving cancer immunotherapy by Jie Shi, Chuan He, Li Chen, Xixin Xing, Wenyi Wei, Jinfang Zhang

“…Programmed cell death protein 1 (PD-1) is a critical immune checkpoint receptor that suppresses immune responses largely through its interaction with PD-L1. …”
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Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit apoptosis by Hejie Wang, Wafa Yousaf, Abdul Haseeb, Ziyang Wang, Jiangang Zheng

“…Next, the Schrodinger Maestro 13.5 software was utilized for molecular docking to ascertain the binding free energy and binding mode between SAL and target proteins. Molecular dynamics simulations were performed using the Desmond program. …”
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Oncology Clinical Trials Targeting Members of the Cadherin Superfamily: A Review by Jacob Keeling, Gerald Falchook

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Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges by Febri Gunawan Sugiokto, Renfeng Li

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Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications by Chih Hung Lo, Lenny Yi Tong Cheong, Jialiu Zeng

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Pathways to nurse development and retention: development of an academic/community-engaged partnership by Lakeshia Cousin, Courtney Bowen, Linda Behar-Horenstein, Debra Lyon, Kimberly Martinez

“…Addressing this crisis requires innovative strategies that prioritize diversity and address health inequities. This study aimed to develop and assess the pilot implementation of a community-engaged program targeting underrepresented high school students in a southeastern state. …”
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Five ways to get a grip by incorporating trust into the design and implementation of peer coaching programs by Adriane E Bell, Holly S Meyer, Lauren A Maggio, Lakesha N Anderson

“…Nevertheless, faculty developers face challenges in creating sustainable, effective peer coaching programs as faculty fear scrutiny of their teaching practices. …”
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Implementation of educational programs with digital distance education technologies complying with the requirements for ship crew members by Sergey S. Sokolov, Marina N. Saveleva, Anastasiya V. Mitrofanova

“…According to the Decree of the Government of the Russian Federation on May 23, 2015 No. 497 «On the Federal Targeted Program for the Development of Education for 2016-2020», within the framework of Target 5 «Formation of a high-demand system for assessing the quality of education and educational outcomes», the following activities are planned: Typical models of constant evaluation of students’ learning achievements, allowing to form trajectories of individual development of students in secondary professional educational organizations and organizations of higher education». …”
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Functional annotation and identification of novel drug targets from uncharacterized proteome of Trichuris trichiura by Kanchan Rauthan, Saranya Joshi, Lokesh Kumar, Sudhir Kumar

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Features of a Systematic Approach to the Prevention of Healthcare-Associated Infections in the Russian Federation and abroad by M. A. Davydova, G. D. Bryukhanova, V. N. Gorodin

“…Measures are proposed to increase the commitment of medical personnel and collectives in general, other employees of medical organizations to epidemiologically safe skills in their professional activities, to develop patient education programs for personal prevention of HCAI.…”
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GSK3 acts as a switch for transcriptional programs in a model of low-grade gliomagenesis by Marilin S Koch, Minh Deo, Lena-Marie Schmitt, Michael S Hoetker, Şevin Turcan

“…Through the use of chemical compounds, we targeted WNT/GSK3, TGF-β and NOTCH-signaling, assessing their functional, transcriptional, and translational impacts. …”
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Oral inferential comprehension intervention program for children with Autism: A randomized controlled trial by Ramandeep Kaur

“…Inferential comprehension, involving the understanding of hidden meanings and contextual cues, is a critical component of language, social, and cognitive development. While existing interventions focus heavily on literal language, the lack of specialized programs for inferential comprehension leaves a significant gap in treatment options for CWA.To address this, the study introduces a treatment model that Speech-Language Pathologists (SLPs) can utilize to deliver targeted interventions. …”
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Experience in implementing workplace wellbeing programs in Russia: results of a survey of employers on the ATRIA platform by A. A. Antsiferova, A. V. Kontsevaya, M. B. Khudyakov, P. V. Ipatov, O. M. Drapkina

“…The majority of employers (73%; n=73) consider it necessary to develop and implement WWPs, while the majority of them (66,9%, n=121) were not familiar with such programs. …”
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The Effectiveness of Self-Esteem Enhancement Program Among Adolescence in Selected Nursing College, Wayanad by Lida Antony, Treety George, Mansheena K, Darshana ., Aimy Hynse

“…The data collection tools included demographic questionnaires and the Rosenberg Self-Esteem Scale. The program consisted of a five-day intervention involving presentations relaxation techniques role-plays quizzes group discussions and dance sessions.Results Statistical analysis revealed a significant improvement in self-esteem post-intervention mean pre-test score 17.39 mean post-test score 20.42 t 4.670 P lt 0.001 indicating the programrsquos effectiveness in enhancing self-esteem among participants.Conclusion This study underscores the importance of addressing low self-esteem in adolescents and highlights the value of targeted interventions such as the self-esteem enhancement program implemented in this study to promote positive self-concept and psychosocial development among nursing students and potentially other adolescent populations.…”
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The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of... by Antje Pommereau, Francesca Sassone, Alessandro Poli, Marcella De Silvestris, Lia Scarabottolo, Yasmin Zuschlag, Thomas Licher, Felix Bärenz

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Fidelity of virtual self-management programs in pediatric autoimmune diseases: A scoping review protocol by Babatope O. Adebiyi, Kathryn A. Birnie, Jessica Booth, Lily S. Lim, Dax Rumsey, Maria Santana, Jennifer N. Stinson, Heinrike Schmeling

“…These findings aim to inform program development, enhance implementation fidelity, and improve therapeutic outcomes in pediatric autoimmune care. • Program Fidelity Assessment: This review aims to systematically document methodologies used to assess fidelity in virtual self-management programs, evaluating their impact on program execution and patient outcomes. • Implementation Strategies: It will analyze existing literature on implementation strategies for virtual programs, identifying factors that influence their delivery and effectiveness. • Future Directions: The review seeks to identify research gaps and propose directions for future studies, informing the development of more effective virtual self-management programs for children with autoimmune diseases.…”
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A targeted vaccination strategy: Integrating vaccines into biosafety, biosecurity, and one health initiatives by Laith N. AL-Eitan, Rabi A. Abu Khiarah, Diana L. Almahdawi

“…When developing a vaccination program, it is essential to identify the target groups, including travelers, infants, high-risk workers, and those in critical roles such as farming and agriculture. …”
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Cardiovascular Disease Management and Prevention in Saudi Arabia: Strategies, Risk Factors, and Targeted Interventions by Aseel Awad Alsaidan

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Bladder cancer biomarker analysis and drugtarget prediction based on pyroptosis-related genes by Ping Li, Xuexi Yang, Qin Liu, Hanchao Zhang, Zhumei Luo

“…Pyroptosis is a type of programmed cell death distinguished by inflammatory reactions associated with innate immunity. …”
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Exploring pre-service mathematics teachers’ thinking for solving linear programming word problems by Al Jupri, Dian Usdiyana, Sumanang Muhtar Gozali

“…These insights can be leveraged to provide targeted support for pre-service teachers facing challenges in problem-solving and to develop pedagogical interventions aimed at enhancing their problem-solving skills.…”
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