Advancement of a diagnostic prediction model for spatiotemporal calibration of earth observation data: a case study on projecting forest net primary production in the mid-latitude... by Eunbeen Park, Hyun-Woo Jo, Gregory Scott Biging, Jong Ahn Chun, Seong Woo Jeon, Yowhan Son, Florian Kraxner, Woo-Kyun Lee

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An effective hybrid decomposition approach to solve the network-constrained stochastic unit commitment problem in large-scale power systems by Ricardo M. Lima, Gonzalo E. Constante-Flores, Antonio J. Conejo, Omar M. Knio

“…This scheduling problem is formulated as a two-stage stochastic programming problem with continuous and binary variables in the first stage and only continuous variables in the second stage. …”
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Pan-cancer analysis uncovered the prognostic and therapeutic value of disulfidptosis by Yiwei Zhang, Zihua Li, Hengli Lu, Zongrui Jiang, Yixian Song, Zhanhui Ye, Chenzheng Gu, Kequan Chen, Anquan Shang

“…PF-562271, EHT-1864, and IPA-3 are potential therapeutic agents targeting disulfidptosis. Collectively, this study deciphered for the first time the importance of disulfidptosis for pan-cancer and developed the DRGs Score model that can assist clinicians in accurately predicting the prognosis and guiding individualized treatment of pan-cancer patients.…”
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Analytical Inverse Kinematics-Based Method for a 6-DOF Hexa Parallel Robot by Hendriko Hendriko, Nur Khamdi, Jajang Jaenudin, Roni Novison, Muhammad Ikhsan

“…The results indicate that the developed algorithm can determine the rotation motion of all the motors, which are used to place the end of the arm tool to the target position and orientation. …”
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Promising New Anti‐TIGIT Agents: Stealthy Allies in Cancer Immunotherapy by Gatadi Srikanth, Durga Prasad Beda, Ashish Ranjan Dwivedi, Nandan Kumar Duddukuri, Srinivas Nanduri, Jitendra Patel

“…CD155, the principal ligand of TIGIT in humans, has been recognized as a pivotal target for immunotherapy owing to its interaction with TIGIT. …”
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SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides by Andrea Loreto, Kaitlyn M.L. Cramb, Lucy A. McDermott, Christina Antoniou, Ilenia Cirilli, Maria Claudia Caiazza, Elisa Merlini, Peter Arthur-Farraj, W. Daniel du Preez, Elliot D. Mock, Hien T. Zhao, David L. Bennett, Giuseppe Orsomando, Michael P. Coleman, Richard Wade-Martins

“…Pathological SARM1 activation causes rapid NAD consumption, disrupting cellular homeostasis and leading to axon degeneration. In this study, we develop antisense oligonucleotides (ASOs) targeting human SARM1, demonstrating robust neuroprotection against morphological, metabolic, and mitochondrial impairment in human iPSC-derived dopamine neurons induced by the lethal neurotoxin vacor, a potent SARM1 activator. …”
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Models for the Design and Operation of Digital Educational Environments by A. V. Solovov, A. A. Menshikova

“…The main functions of these subsystems and their various components have been identified.A didactic model of a typical complex of digital educational resources has been developed. Within this model, the diversity of digital educational resources across each academic discipline is integrated into complexes that provide a complete study at different target levels of assimilation, from initial acquaintance to solving uncharacteristic professionally oriented tasks.From the point of view of pedagogical psychology and cybernetics, the high importance of feedback in EIEE EI is shown. …”
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Process simulation for revamping of a dehydration gas plant by H.A. El Mawgoud, T.M. Elshiekh, S.A. Khalil

“…The plant was almost depreciated, and the company administration decided to revamp it and at the same time perform the necessary modifications in order to cut down the equipment cost and reduce energy consumption. To achieve this target the existing plant configuration was simulated using Aspen HYSIS program. …”
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Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In... by Muhammad Iqbal, Nur Hasanah, Aimee Detria Arianto, Widya Dwi Aryati, Meidi Utami Puteri, Fadlina Chany Saputri

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Genetics and Epigenetics of Chemoinduced Oral Mucositis in Paediatric Patients with Haematological Malignancies—A Review by Juliana Ramalho Guimarães, José Maria Chagas Viana Filho, Naila Francis Paulo de Oliveira

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Enabling Power Systems With SQKD in Presence of Remote Nodes by Mariam Gado, Muhammad Ismail

“…The optimization problem is formulated as a binary program that upgrades a pre-existing classical cyber layer of power system to support SQKD. …”
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Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies by Reshmi Nair, Veena Somasundaram, Anshu Kuriakose, Shiv Ram Krishn, David Raben, Rachel Salazar, Pradip Nair

“…We believe that gaining insight into the mechanisms of T-cell exhaustion within the TME of human solid tumors will pave the way for developing therapeutic strategies to target and potentially re-invigorate exhausted T-cells in cancer.…”
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Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor by Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai, Hongkui Deng

“…Simultaneous targeting of these two inhibitory molecules could be an efficient checkpoint modulation strategy. …”
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Assessment of country implementation of the WHO global health sector strategy on sexually transmitted infections (2016-2021). by Melanie M Taylor, Teodora Wi, Antonio Gerbase, Soe Soe Thwin, Sami Gottlieb, Maria Theresa Babovic, Daniel Low-Beer, Monica Alonso, Maeve B Mello, Naoko Ishikawa, Anne Brink, Joumana Hermez, Ahmed Sabry, Saliyou Sanni, Leopold Ouedraogo, Bharat Rewari, Mukta Sharma, Nicole Seguy, Elena Vovc, Ian Askew, Meg Doherty, Nathalie Broutet

“…<h4>Conclusions</h4>Mechanisms to support improvements to STI service delivery through national-level policy, commitment, programming and surveillance are needed to operationalize, accelerate and monitor progress towards achievement of the 2030 global STI strategy targets.…”
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Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity. by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan

“…Mice expressing Notch dimerization-deficient alleles (NDD) of Notch1 and Notch2 are sensitized to environmental insults but otherwise develop and age normally. Transcriptomic analysis of colonic spheroids uncovered no evidence of dimer-dependent target gene miss-regulation, confirmed impaired stem cell maintenance in-vitro, and discovered an elevated signature of epithelial innate immune response to symbionts, a likely underlying cause for heightened sensitivity in NDD mice. …”
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Effects of Physical Health Status, Social Support, and Depression on Quality of Life in the Korean Community-Dwelling Elderly by Koung-Oh Chang

“…Therefore, it is necessary to develop a program and intervention strategies for individual and customized health care suitable for the characteristics of the elderly in the local community.…”
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Improving Equatorial Upper Ocean Vertical Mixing in the NOAA/GFDL OM4 Model by Brandon G. Reichl, Andrew T. Wittenberg, Stephen M. Griffies, Alistair Adcroft

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Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence by Lexin Qin, Tingting Liang, Hailong Zhang, Xian Gong, Meidan Wei, Xiangrong Song, Yaoyu Hu, Xinyu Zhu, Wentao Hu, Jianxiang Li, Jin Wang

“…IntroductionCancer’s inherent heterogeneity, marked by diverse genetic and molecular alterations, presents significant challenges for developing effective treatments. One such alteration is the regulation of disulfidoptosis, a recently discovered programmed cell death pathway. …”
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Understanding Patterns of the Gut Microbiome May Contribute to the Early Detection and Prevention of Type 2 Diabetes Mellitus: A Systematic Review by Natalia G. Bednarska, Asta Kristine Håberg

“…This review shows how metagenomic studies have and will continue to identify novel therapeutic targets (probiotics, prebiotics or targets for elimination from flora). …”
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Empiric: A Card Game for Guideline-Based Antibiotic Prescribing Used for Continuing Medical Education by Michael Cosimini, Diego Molina Ochoa, Diana Yu, Alison Chiang

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