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  1. 4021

    Study of the Elemental Composition of Gadolinium–Aluminum Garnets—Obtaining Predictable Optical Properties by Natalia A. Korotkova, Kseniya V. Petrova, Vasilisa B. Baranovskaya, Marina S. Doronina, Alexandra A. Arkhipenko

    Published 2024-12-01
    “…For the first time, inductively coupled plasma mass spectrometry (ICP-MS) was developed for determining the target elemental composition of gadolinium–aluminum garnets with the varying composition Gd<sub>3–x</sub>Ce<sub>x</sub>Sc<sub>y</sub>Al<sub>5–y</sub>O<sub>12</sub>, where x = 0.01–0.16 and y = 0.25–1.75. …”
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  2. 4022
  3. 4023

    Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer by Jing Zhang, Ming Yi, Zhijun Dai, Pengfei Zhou, Yuze Wu, Mengke Niu, Shuangli Zhu, Yongxiang Yan, Kongming Wu

    Published 2022-12-01
    “…In this work, we constructed a bispecific antibody targeting TGF-β and human PD-L1 (termed BiTP) and explored the antitumor effect of BiTP in TNBC.Methods BiTP was developed using Check-BODYTM bispecific platform. …”
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  4. 4024

    Efficacy and safety of immunotherapy in cervical cancer: a review of advances in immune-related therapy for cervical cancer by Jing Liu, Yaxin Kang, Li Li, Lele Zang, Lan Luo, Fei Zhu, Mingxuan Zhu, Huiqi Zhang, Qin Xu

    Published 2025-03-01
    “…Abstract Purpose Immunotherapy is emerging as a promising approach for cervical cancer treatment, with new targets and drugs continuously being developed. In response to the wide range of immunotherapies currently available, this article aims to review and sort the immunotherapy for cervical cancer and the advancements in assessing effectiveness and prognosis. …”
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  5. 4025
  6. 4026
  7. 4027

    Optimized lentiviral backbone induces robust and diverse T cell immunity against neoantigens to counteract tumor heterogeneity by Benjamin Vesin, Ingrid Fert, Amandine Noirat, Pierre Authié, Sylvain Ciret, Catherine Blanc, Yakov Vitrenko, Pierre Charneau, Laleh Majlessi, François Anna

    Published 2025-07-01
    “…Incorporating proteasome-targeting sequences and 4-alanine spacers between neoepitopes enhanced responses to both dominant and subdominant neoepitopes. …”
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  8. 4028
  9. 4029

    Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma by Yu Chen, Yang Chen, Yu Zhou, Yongsheng Li, Ran Ren, Juan Lei

    Published 2024-07-01
    “…Furthermore, the lipid metabolism score (LMS) system was constructed, and based on the LMS system, we further performed screening for potential agents targeting lipid metabolism. The mechanism of MK1775 was further validated using RNA sequencing, co-culture technology, and in vivo experiments.Results We developed an LSM system and identified a potential sensitizing agent, MK1775, which targets lipid metabolism and enhances the effects of anti-PD-1 treatment. …”
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  10. 4030
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  12. 4032
  13. 4033

    A Protozoology and Parasitological Techniques Brochure by Josefina Isabel Vázquez Martínez, Miladys Caridad Cedeño Borges, Mabel Collazo Díaz, Martina Sabina Jiménez Suárez, Luis Quintero Hernández, Jorge Barleta Del Castillo

    Published 2012-06-01
    “…The theoretical contents listed in this brochure were developed in response to the contents included in the program for biological agents incorporated to the new curriculum of Bachelors in Health Technology, Bachelors in Clinical Bio-analysis and the rest of the studies in the field of Medical Sciences.…”
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  14. 4034
  15. 4035

    Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. by Giampiero Porcu, Eliseo Serone, Velia De Nardis, Daniele Di Giandomenico, Giuseppe Lucisano, Marco Scardapane, Anna Poma, Antonella Ragnini-Wilson

    Published 2015-01-01
    “…One of the causes of permanent disability in chronic multiple sclerosis patients is the inability of oligodendrocyte progenitor cells (OPCs) to terminate their maturation program at lesions. To identify key regulators of myelin gene expression acting at the last stages of OPC maturation we developed a drug repositioning strategy based on the mouse immortalized oligodendrocyte (OL) cell line Oli-neu brought to the premyelination stage by stably expressing a key factor regulating the last stages of OL maturation. …”
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  16. 4036

    Expanding the Role of FurA as Essential Global Regulator in Cyanobacteria. by Andrés González, M Teresa Bes, M Luisa Peleato, María F Fillat

    Published 2016-01-01
    “…The results of such approaches led us to identify 15 novel direct iron-dependent transcriptional targets belonging to different functional categories including detoxification and defences against oxidative stress, phycobilisome degradation, chlorophyll catabolism and programmed cell death, light sensing and response, heterocyst differentiation, exopolysaccharide biosynthesis, among others. …”
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  17. 4037

    Prognostic value of disulfidptosis-associated genes in gastric cancer: a comprehensive analysis by Jin Tang, Jing Yang, Long-Kuan Yin

    Published 2025-03-01
    “…FRMD6-AS emerged as a potential target for gastric cancer treatment.ConclusionsThis study developed a novel prognostic model for gastric cancer using DRLs, identifying two key signaling axes related to prognosis. …”
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  18. 4038
  19. 4039

    In Silico Analysis of miRNA-mRNA Binding Sites in <i>Arabidopsis thaliana</i> as a Model for Drought-Tolerant Plants by Yryszhan Zhakypbek, Aizhan Rakhmetullina, Zhigerbek Kamarkhan, Serik Tursbekov, Qingdong Shi, Fei Xing, Anna Pyrkova, Anatoliy Ivashchenko, Bekzhan D. Kossalbayev, Ayaz M. Belkozhayev

    Published 2025-06-01
    “…Using the MirTarget program, 274 miRNAs and 48,143 gene transcripts were analyzed to predict high-confidence miRNA–mRNA interactions based on binding free energies (−79 to −129 kJ/mole). …”
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  20. 4040

    Improving company communication activity amidst the СOVID-19 restrictions by Volodymyr Kyslyy, Tetyana Bondar, Yevhen Kabluchko, Hlib Lieonov

    Published 2021-06-01
    “…The findings allowed developing the suggestions for forming a communication program of Like Center LLC under quarantine the COVID-19 restrictions. …”
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