Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance by Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. vanLiere, Bart Westendorp

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PD-L1 as a Potential Target in Cancer Therapy (Review) by N. N. Andrusova, M. A. Kolganova, A. V. Aleshina, I. E. Shohin

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Single-cell insights into HNSCC tumor heterogeneity and programmed cell death pathways by Yuanhao Chai, Jianlin Zhang, Wenwen Shao, Ziwei Zhang

“…The study examined programmed death and metabolic pathways in each subpopulation and developed a novel prognostic model using LASSO regression. …”
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Approval of a comprehensive psychosocial rehabilitation program for patients with negative symptoms in schizophrenia by Yu. A. Kushnir

“…The aim of the work is to develop and evaluate the effectiveness of a comprehensive program of psychosocial rehabilitation of patients with negative symptoms in schizophrenia. …”
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Injection well site optimization of carbon geological sequestration based on dynamic programming by Bin LIU, Chunsheng SHI

“…Building upon this model, the optimization problem of well placement was transformed into a dynamic programming framework. Dynamic programming, a mathematical optimization approach, is well-suited for solving problems that can be broken down into smaller subproblems with overlapping solutions. …”
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Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects... by Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

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StackNAFLD: An Accurate Stacking Ensemble Learning Targeting NAFLD Treatment by Andi Endang Kusuma Intan, Kanokwan Jarukamjorn, Tarapong Srisongkram

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Ferroptosis determinants – potential predictors and therapeutic targets for acute myeloid leukemia by V. E. Shevchenko, T. I. Kushnir, M. V. Gudkova, N. E. Arnotskaya

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Ferroptosis as a potential therapeutic target for obesity-related metabolic diseases by Chao-Dong Huang, Tao Luo, Hua Zhang, Hua Zhang, Lin-Hui Cheng, Shu-Hong Peng, Xiao-Wei Zhou, Lan Cao, Fang-You Chen, Jun-Wei He, Chen Chen, Chang-Hua Zhang, Chang-Hua Zhang, Yu-Ai Zhang, Ling-Yun Zhong

“…Clarifying the molecular mechanism of ferroptosis may discover potential therapeutic targets for the treatment of these diseases. This article comprehensively reviews the role, pathogenesis, prevention, treatment strategies, current research gaps and future development directions of ferroptosis in obesity-related chronic metabolic diseases have been thoroughly discussed, and novel perspectives for the future treatment and research of ferroptosis in these diseases carefully provided. …”
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Targeting cuproptosis for cancer therapy: Focus on the anti-tumor immune system by Xuan Zhang, Xiaohong Han

“…The combination of these two approaches may help researchers develop more therapies targeting cuproptosis-related pathways. …”
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Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets by Xiang Y, Huang G, Luo C, Jiang J, Zhang T, Zeng Q, Zhou F, Du D

“…PANoptosis, a unique inflammatory programmed cell death, it manifests as the simultaneous activation of signaling markers for pyroptosis, apoptosis, and necroptosis. …”
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Regional Variation in Residential Aged Care Provision in Australia: Targets and Trajectories by Mark Cooper-Stanbury

“… Background and objectives: Population-based planning targets have been a feature of the Australian aged care policy landscape for decades. …”
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Pyroptosis as a therapeutic target in preeclampsia: current research and future directions by Yongchun Zhu, Yuting Xiang, Yuting Xiang, Sathiskumar Swamiappan, Zhongjun Li, Zhongjun Li, Zhongjun Li, Xinsheng Peng

“…It explores the regulatory roles of NLRP3 Inflammasome,oxidative stress, T helper type 1 (Th1)/T helper type 2 (Th2) cell imbalance, microRNAs and other factors in trophoblast pyroptosis, providing potential targets for the development of early diagnostic biomarkers and therapeutic strategies for PE.…”
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Targeting caspase-8: a new strategy for combating hepatocellular carcinoma by Haoran Chen, Yumeng Lin, Jie Chen, Xuemei Luo, Yubo Kan, Yuqi He, Renhe Zhu, Jiahui Jin, Dongxuan Li, Yi Wang, Zhongyu Han

“…Furthermore, we emphasize how caspase-8 plays pivotal roles in the development, progression, and drug resistance observed in HCC, and explore the potential of targeting caspase-8 as a promising strategy for HCC treatment.…”
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The Antiglioma Potential of Plant Lectins: Molecular Targets, Mechanisms, and Future Directions by Rodrigo Bainy Leal, Vanir Reis Pinto-Junior, Messias Vital Oliveira, Vinicius Jose Silva Osterne, Nicole Sartori, Ana Carolina dos Santos, Ricardo Castilho Garcez, Kyria Santiago Nascimento, Benildo Sousa Cavada

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Enhancing Health Research with Machine Learning: Practical Case Studies Using the All of Us Researcher Workbench by Jonathan R. Holt, Stefanee Tillman, Javan Carter, Edward Preble, Sheryl C. Cates, Daniel Brannock, Michael Long, John McCarthy, Leslie Zapata Leiva, Jamboor K. Vishwanatha, Toufeeq Syed, Legand Burge, Robert T. Mallet, Shelly Kowalczyk, Jennifer D. Uhrig, Megan A. Lewis

“…Our case studies cover critical topics, such as dataset selection, data cleaning, machine learning applications, and visualization in Python, which together provide the foundation of a targeted training program. Evaluated through pre- and post-program surveys, the program significantly boosted participants’ machine learning competencies. …”
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Targeted protein editing technique in living mammalian cells by peptide-fused PNGase by Min Wu, Guijie Bai, Ziyi Zhang, Haixia Xiao, Wenliang Sun, Chaoguang Tian

“…Selective protein deglycosylation editors were developed by fusing high-affinity protein-targeting peptides with active peptide:N-glycanases (PNGases). …”
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Glutathione Peroxidases: An Emerging and Promising Therapeutic Target for Pancreatic Cancer Treatment by Paula Iglesias-Matesanz, Carlos Lacalle-Gonzalez, Carlos Lopez-Blazquez, Michael Ochieng’ Otieno, Jesus Garcia-Foncillas, Javier Martinez-Useros

“…Current research is focusing on the development of small-molecule inhibitors of GPx4 as potential candidates for pancreatic cancer treatment.…”
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Caution when using network partners for target identification in drug discovery by Dandan Tan, Yiheng Chen, Yann Ilboudo, Kevin Y.H. Liang, Guillaume Butler-Laporte, J. Brent Richards

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Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer by Nayara Gusmão Tessarollo, Isabella dos Santos Guimarães, Diandra Zipinotti dos Santos, Taciane Barbosa Henriques, Paulo Cilas Morais Lyra-Junior, Josiany Carlos de Souza, Tatiana Massariol Pimenta, Bárbara da Silva Martins, Solenny Maria Silva Butzene, José Matheus Simões Padilha, Leide Laura Figueiredo Maciel, João Carlos de Aquino Almeida, Ian Victor Silva, Leticia Batista Azevedo Rangel, Leticia Batista Azevedo Rangel, Leticia Batista Azevedo Rangel

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