A phase I, open-label, multicentre, first-in-human study to evaluate safety, pharmacokinetics and efficacy of AMG 404, a PD-1 inhibitor, in patients with advanced solid tumours by Yasutoshi Kuboki, Hendrik-Tobias Arkenau, Vivek Subbiah, Timothy Price, Gerald Falchook, Hans Prenen, Rafal Dziadziuszko, Hansen Wong, Iwona Lugowska, Daniel Tan, Weibing Shi, Ryota Shibaki, Min Hee Hong, Sant P Chawla, Jose G Monzon, Mun Hui, Caio Max Rocha Lima, Kejia Wang, Antreas Hindoyan, Mira Kistler

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Stressful life events in childhood and adulthood and risk of physical, psychological and cognitive multimorbidities: a multicohort studyResearch in context by Yaguan Zhou, Mika Kivimäki, Julianne Holt-Lunstad, Lijing L. Yan, Yue Zhang, Hui Wang, Sunyi Wang, Xiaolin Xu

“…During a follow-up of 8–9 years, 10,913 (43.7%) participants developed physical, psychological and cognitive multimorbidities. …”
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ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

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Dual inhibition of HERs and PD-1 counteract resistance in KRASG12C-mutant head and neck cancer by Ofra Novoplansky, Sankar Jagadeeshan, Manu Prasad, Ksenia M. Yegodayev, Divyasree Marripati, Raghda Abu Shareb, Yariv Greenshpan, Sooraj Mathukkada, Talal Ben-Lulu, Baisali Bhattacharya, Angel Porgador, Dexin Kong, Johannes Brägelmann, J. Silvio Gutkind, Moshe Elkabets

“…However, development of resistance to KRASG12C-mutant-specific inhibitors (KRASG12Ci) remains a major obstacle. …”
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Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases by Antonio Cuadrado, Eduardo Cazalla, Anders Bach, Boushra Bathish, Sharadha Dayalan Naidu, Gina M. DeNicola, Albena T. Dinkova-Kostova, Raquel Fernández-Ginés, Anna Grochot-Przeczek, John D. Hayes, Thomas W. Kensler, Rafael León, Karen T. Liby, Manuela G. López, Gina Manda, Akshatha Kalavathi Shivakumar, Henriikka Hakomäki, Jessica A. Moerland, Hozumi Motohashi, Ana I. Rojo, Gerasimos P. Sykiotis, Keiko Taguchi, Ángela M. Valverde, Masayuki Yamamoto, Anna-Liisa Levonen

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Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV by Cara W. Chao, Kaitlin R. Sprouse, Marcos C. Miranda, Nicholas J. Catanzaro, Miranda L. Hubbard, Amin Addetia, Cameron Stewart, Jack T. Brown, Annie Dosey, Adian Valdez, Rashmi Ravichandran, Grace G. Hendricks, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Jackson McGowan, Boston Simmons, Catherine Treichel, Isabelle Willoughby, Alexandra C. Walls, Andrew T. McGuire, Elizabeth M. Leaf, Ralph S. Baric, Alexandra Schäfer, David Veesler, Neil P. King

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Decarbonizing the Maritime Industry: A Collaborative Path Forward by Yudan Whulanza, Eny Kusrini, Muhamad Arif Budiyanto, Arnas, Yanuar

“…A cargo operator highlighted the success of their biofuel program, which has supplied 100,000 tons of biofuels in hubs like Rotterdam and Singapore. …”
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A noncanonical role of roX RNAs in autosomal epigenetic repression by Jianjian Li, Shuyang Xu, Zicong Liu, Liuyi Yang, Zhe Ming, Rui Zhang, Wenjuan Zhao, Huipai Peng, Jeffrey J. Quinn, Manyin Wu, Yushan Geng, Yuying Zhang, Jiazhi He, Minghai Chen, Nan Li, Ning-Yi Shao, Qing Ma

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Designing a Business Model in the Tourism Industry of Iran by Amirhossein Samadian, Saeid Ehdaie, kamyar Raissifar

“…The most key activities among tourism companies are: obtaining insurance, concluding contracts, training employees, obtaining permits, hiring, programming, advertising, research and development, content production, maintenance of tools and equipment, and knowledge management. …”
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Circulating PIWI-interacting RNAs in Acute Ischemic Stroke patients by Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Abdelilah Arredouani, Ghulam Jeelani Pir, Sajitha V. Pananchikkal, Omar El-Agnaf, Ashfaq Shuaib, Nehad M. Alajez, Omar M.E. Albagha

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Mixed-methods, descriptive and observational cohort study examining feeding and growth patterns among low birthweight infants in India, Malawi and Tanzania: the LIFE study protocol by Christopher R Sudfeld, Karim Manji, Rodrick Kisenge, Tisungane Mvalo, Melda Phiri, Christopher Duggan, Lauren Spigel, Anne CC Lee, Bethany A Caruso, Laura Subramanian, Megan Marx Delaney, Shivaprasad S Goudar, Linda Vesel, Katherine EA Semrau, Irving F Hoffman, Melissa Young, Friday Saidi, Jnanindra Nath Behera, Roopa M Bellad, Leena Das, Sangappa Dhaded, Gowdar Guruprasad, Sujata Misra, Sanghamitra Panda, Latha G Shamanur, Sunil S Vernekar, Sarah Somji, Linda Adair, Kiersten Israel-Ballard, Stephanie L Martin, Kimberly L Mansen, Krysten North, Emily Benotti, Eliza Fishman, Katelyn Fleming, Natalie Henrich, Kate Miller, Danielle E Tuller

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Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis by Mouyuan Sun, Ning Zhan, Zhan Yang, Xiaoting Zhang, Jingyu Zhang, Lianjie Peng, Yaxian Luo, Lining Lin, Yiting Lou, Dongqi You, Tao Qiu, Zhichao Liu, Qianting Wang, Yu Liu, Ping Sun, Mengfei Yu, Huiming Wang

“…Abstract The development, progression, and curative efficacy of head and neck squamous cell carcinoma (HNSCC) are influenced by complex interactions between epithelial and immune cells. …”
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Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice by Mayara Mattos, Carolina Q. Sacramento, André C. Ferreira, Natalia Fintelman-Rodrigues, Filipe S. Pereira-Dutra, Caroline Souza de Freitas, João S. M. Gesto, Jairo R. Temerozo, Aline de Paula Dias Da Silva, Mariana T. G. Moreira, Rafael S. C. Silva, Gabriel P. E. Silveira, Douglas P. Pinto, Heliana M. Pereira, Laís B. Fonseca, Marcelo Alves Ferreira, Camilla Blanco, João P. B. Viola, Dumith Chequer Bou-Habib, Patrícia T. Bozza, Thiago Moreno L. Souza

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SARS-CoV-2 Receptor Binding Domain (RBD) Protein–Protein Conjugate Induces Similar or Better Antibody Responses as Spike mRNA in Rhesus Macaques by Puthupparampil V. Scaria, Christopher G. Rowe, Ivan Kosik, Zhe Hu, Jonathan P. Renn, Nada Alani, Pinar Kemanli, Sachy Orr-Gonzalez, Lynn E. Lambert, Kayode Adeyemi, Justin Y. A. Doritchamou, Emma K. Barnafo, Kelly M. Rausch, Liya Muslinkina, Robert D. Morrison, John-Paul Todd, Dominic Esposito, Andrew Lees, Jonathan Yewdell, Patrick E. Duffy

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Comparing NASA Discovery and New Frontiers Class Mission Concepts for the Io Volcano Observer by Christopher W. Hamilton, Alfred S. McEwen, Laszlo Keszthelyi, Lynn M. Carter, Ashley G. Davies, Katherine de Kleer, Kandis Lea Jessup, Xianzhe Jia, James T. Keane, Kathleen Mandt, Francis Nimmo, Chris Paranicas, Ryan S. Park, Jason E. Perry, Anne Pommier, Jani Radebaugh, Sarah S. Sutton, Audrey Vorburger, Peter Wurz, Cauê Borlina, Amanda F. Haapala, Daniella N. DellaGiustina, Brett W. Denevi, Sarah M. Hörst, Sascha Kempf, Krishan K. Khurana, Justin J. Likar, Adam Masters, Olivier Mousis, Anjani T. Polit, Aditya Bhushan, Michael Bland, Isamu Matsuyama, John Spencer

“…Io is important for understanding the development of volcanogenic atmospheres and mass exchange within the Jupiter system. …”
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Enhancing Network Slicing Architectures With Machine Learning, Security, Sustainability and Experimental Networks Integration by Joberto S. B. Martins, Tereza C. Carvalho, Rodrigo Moreira, Cristiano Bonato Both, Adnei Donatti, Joao H. Correa, Jose A. Suruagy, Sand L. Correa, Antonio J. G. Abelem, Moises R. N. Ribeiro, Jose-Marcos S. Nogueira, Luiz C. S. Magalhaes, Juliano Wickboldt, Tiago C. Ferreto, Ricardo Mello, Rafael Pasquini, Marcos Schwarz, Leobino N. Sampaio, Daniel F. Macedo, Jose F. De Rezende, Kleber V. Cardoso, Flavio De Oliveira Silva

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Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…A consensus procedure (n = 172) developed an anatomical protocol and minimum targets for diagnosis. …”
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Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

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Estimation of Genetic Parameters for Growth and Acute Hepatopancreatic Necrosis Resistance in Different Strains of Penaeus vannamei by Guixian HUANG, Xupeng LI, Jiteng TIAN, Sheng LUAN, Jie KONG, Baoxiang CAO, Ning LIU, Kun LUO, Jian TAN, Jiawang CAO, Ping DAI, Baolong CHEN, Guangfeng QIANG, Mianyu LIU, Yang LIU, Hongjie WANG, Xuehui LIU, Juan SUI, Xianhong MENG

“…Among them, acute hepatopancreatic necrosis disease (AHPND) hinders the development of the global shrimp farming industry and causes catastrophic economic losses. …”
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Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses... by Xiaoxi Zhang, Xinwen Ren, Yongxin Zhang, Yongwei Zhang, Lei Zhang, Hongjian Shen, Zifu Li, Pengfei Xing, Ping Zhang, Weilong Hua, Fang Shen, Bing Tian, Wenhuo Chen, Hongxing Han, Liyong Zhang, Chenghua Xu, Tong Li, Yu Gao, Yu Zhou, Qiao Zuo, Dongwei Dai, Rui Zhao, Qiang Li, Qinghai Huang, Yi Xu, Xiaoying Chen, Qiang Li, Lili Song, Craig S. Anderson, Pengfei Yang, Jianmin Liu

“…Interpretation: Our study indicates that collateral status may help identify patients at risk from intensive blood pressure lowering treatment to a systolic target of 120 mm Hg or lower, in patients undergoing endovascular therapy for acute ischaemic stroke from large-vessel occlusion. …”
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