Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xiii] Only 7 percent of renal transplant programs use formal criteria for subjective psychosocial assessments, while no pediatric solid organ transplant programs use formal, explicit, or uniform review to assess developmental delays and psychosocial support.…”
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The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study protocol by Lana M. Chahine, Naomi Louie, J Solle, Fulya Akçimen, Andrew Ameri, Samantha Augenbraun, Sabrina Avripas, Sarah Breaux, Christopher Causey, Shivika Chandra, Marissa Dean, Elizabeth A. Disbrow, Lauren Fanty, Jessica Fernandez, Erin R. Foster, Erin Furr Stimming, Deborah Hall, Vanessa Hinson, Ashani Johnson-Turbes, Cabell Jonas, Camilla Kilbane, Scott A. Norris, Bao-Tran Nguyen, Mahesh Padmanaban, Kimberly Paquette, Carly Parry, Natalia Pessoa Rocha, Ashley Rawls, Ejaz A. Shamim, Lisa M. Shulman, Rebeka Sipma, Julia Staisch, Rami Traurig, Rainer von Coelln, Peter Wild Crea, Tao Xie, Zih-Hua Fang, Alyssa O’Grady, Catherine M. Kopil, Maggie McGuire Kuhl, Andrew Singleton, Cornelis Blauwendraat, Sara Bandres-Ciga, the BLAAC PD Study and the Global Parkinson’s Genetics Program (GP2)

“…The Black and African American Connections to Parkinson’s Disease (BLAAC PD) study is part of the Global Parkinson’s Genetics Program, supported by the Aligning Science Across Parkinson’s initiative. …”
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Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses by Shailender Bhatia, Paul Nghiem, Rima Kulikauskas, Candice Church, David M Koelle, Lisa Tachiki, Kimberly Smythe, Thomas Pulliam, Shira Tabachnick-Cherny, Saumya Jani, Peter H Goff, Rashmi Bhakuni, Brandon W Seaton

“…The stimulator of interferon genes (STING) protein, an innate sensor of cytoplasmic DNA, is a promising target with several agonists in development. However, response rates in most recent clinical trials have been low and mechanisms of response remain unclear. …”
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A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Diogo Crispim Nascimento Portella, Erik Aranha Rossi, Bruno Diaz Paredes, Tanira Matutino Bastos, Cássio Santana Meira, Carolina Vasques Kymie Nonaka, Daniela Nascimento Silva, Alex Improta-Caria, Diogo Rodrigo Magalhaes Moreira, Ana Cristina Lima Leite, Gevanio Bezerra de Oliveira Filho, José Maria Barbosa Filho, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Bruno Solano de Freita Souza

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Chronical kidney disease in clinical practice: non progredi est regredi (lat. not to go forward is to go back) by A. L. Vertkin, N. A. Burakova, Yu. V. Sedyakina, S. S. Kurdzhieva, M. M. Shamuilova, E. M. Ledeneva

“…Upon stabilization of the patient’s condition, she was discharged from the hospital with recommendations to continue the program hemodialysis. However, even upon admission to the hospital, the patient’s creatinine level was 260 μmol/L, which may indicate that chronic kidney disease had been developing for a long time before myocardial infarction and before the administration of X-ray contrast medium during coronary angiography.Conclusion. …”
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Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies by Marta Pineda, Sabela Carballal, María Pellisé, Liseth Rivero, Francesc Balaguer, Fátima Marín, Leticia Moreira, Teresa Ocaña, Manel Juan, Daniel Benitez-Ribas, Georgina Flórez-Grau, Joaquín Castillo-Iturra, Cristina Bayó, Giancarlo Castellano, Hardeep Kumari, Maria Daca-Alvarez, Oswaldo Ortiz, Rebeca Moreira, Julia Canet-Hermida, Capella Gabriel

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A novel key virulence factor, FoSSP71, inhibits plant immunity and promotes pathogenesis in Fusarium oxysporum f. sp. cubense by Shuang Liu, Junyu Wu, Yinhui Sun, Yun Xu, Siyu Zhou, Peiping Luo, Zhibiao Wang, Daipeng Chen, Xiaofei Liang, Zhensheng Kang, Li Zheng

“…The Foc4 mutant lacking FoSSP71 showed significantly reduced pathogenicity toward bananas, demonstrating that FoSSP71 is a potential target for controlling banana wilt disease. These findings provide a scientific basis for breeding banana varieties resistant to wilt disease and for developing new disease control strategies, which are crucial for the sustainable development of the global banana industry.…”
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The COVID-19 Vaccination Rollout in Tanzania: The Role of Coordination in Its Success by Fredrick Rwegerera, Mwendwa Mwenesi, Belinda J. Njiro, Florian Tinuga, Pricilla Kinyunyi, Mary Rose Giattas, Alice Christensen, Ntuli Kapologwe, Adam Meshack, Joseline Ishengoma, Sophia A. Kagoye, Mwinyi I. Msellem, Mwanahamisi Hassan Magwangwala, Fatma Mohammed Kabole, Daniel Ali, Chizoba Wonodi

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Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients by Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Jesús Alonso Gándara-Mireles, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Rodrigo José Vargas Rosales, Oscar Kevin Sánchez García, Andrea Mariela Ruano Toledo, Amy Kateleen Aldana de la Cruz, Ismael Lares-Asseff, Ismael Lares-Asseff, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda

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Gene polymorphism of aldosterone synthetase (CYP11B2) variants and main cardiovascular risk factors by L. Ye. Lobach, V. Ye. Dosenko, M. M. Dolzhenko

“…Statistical analysis of the results was performed using Microsoft Excel, the statistical program SPSS (version 13US). Results. When analyzing the average levels of low density lipoprotein (LDL) cholesterol statistically significant difference between the group of patients with postinfarction cardiosclerosis and the group of high-risk patients (2.93±1.2 mmol/L vs 3.4±1.2 mmol/L, p=0.0075) was demonstrated, indicating a better cholesterol control in the group of patients with postinfarction cardiosclerosis, despite the fact that the average cholesterol level did not reach the target. …”
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Cuproptosis: a novel therapeutic mechanism in lung cancer by Cheng Luo, Xinhui Wu, Shipeng Zhang, Junwen Tan, Yuzhi Huo, Xinyue Zhang, Bo Ning, Yuanhang Ye, Fei Wang

“…Unlike pyroptosis and necroptosis, cuproptosis is a non-apoptotic programmed cell death process. Studies have demonstrated that cuproptosis is involved in the incidence, development, and metastasis of lung cancer. …”
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Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models by Jian Ye, Brian A Belt, Shuyang S Qin, Rachel Jewell, Laura M Calvi, Bradley N Mills, Tara G Vrooman, Carl J Johnston, Scott A Gerber, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles, Nadia Luheshi, Noah A Salama, Sidney Lesser, Sarah L Eckl, Lauren Benoodt, Edith Lord, David Linehan

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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem by Cecilia Hes, Lu Ting Gui, Alexandre Bay, Fernando Alvarez, Pierce Katz, Tanushree Paul, Nadejda Bozadjieva-Kramer, Randy J. Seeley, Ciriaco A. Piccirillo, Paul V. Sabatini

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A new approach in prevention and correction of intradialysis hypotension in patients on maintenance hemodialysis by I. Yu. Drachev, V. Yu. Shilo, G. S. Dzhulay

“…However, when automatic pressure monitoring system was used in patients, the target phosphate levels were achieved: the inorganic phosphorus value was 1.5 mmol/L when using the UF control algorithm vs. 1.8 mmol/L with a standard dialysis program. …”
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Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context by Yan Zhang, Siyuan Yang, Zhaoju Deng, Huangwei Song, Ning Xie, Yunrui Tian, Shangshang Qin, Jifeng Liu, Yong Guo, Dongli Wang, Junfeng Liu, Congming Wu, Jianzhong Shen, Shizhen Ma, Yang Wang, Dejun Liu

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The gut microbiota mediates protective immunity against tuberculosis via modulation of lncRNA by Fang Yang, Yi Yang, Lingming Chen, Zhiyi Zhang, Linna Liu, Chunmin Zhang, Qiongdan Mai, Yiwei Chen, Zixu Chen, Tao Lin, Liang Chen, Huixin Guo, Lin Zhou, Hongbo Shen, Xinchun Chen, Lei Liu, Guoliang Zhang, Hongying Liao, Lingchan Zeng, Gucheng Zeng

“…The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays a critical role in regulating host immunity and contributing to tuberculosis (TB) development and progression, the underlying mechanisms whereby gut microbiota may impact TB outcomes are not fully understood. …”
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Integrated land systems for sustainable food production and biodiversity conservation in the semi-arid to moist tropics: stakeholder perspectives from Andhra Pradesh, India by Iris Berger, Iris Berger, Manan Bhan, Rekha Bhangaonkar, Abhishek Chaudhary, Gopinath R. Mallapu, Tanaya Nair, Eswarayya Ramireddy, Rengalakshmi Raj, Vijay Ramprasad, Vishnupriya Sankararaman, Vartika Singh, A. S. Hareesha, Parthiba Basu, Boraiah Bheemappa, Chandrashekhar Biradar, Archana Chatterjee, Ramdas Dagam, Israel Oliver King Edwin Devarathna, Reuben Gergan, Vinuthna Patibandla, Benjamin Paul, Vamshi Krishna Pulluri, Nandini Rajamani, Mounika Ramireddy, Imran Siddiqui, Sowmithri Vadaganambi Ramachari, Farida Tampal, Swati Udayraj, Tata Venkateswarlu, Tata Venkateswarlu, Lynn V. Dicks, Lynn V. Dicks

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Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer by Bo Yin, Wei Wang, Ang Li, Mengjie Li, Huijuan Zhou, Haoran Hu, Jianyi Ding, Yashi Zhu, Xinxin Xu, Meiqin Yang, Tiefeng Huang, Yifan Kou, Zilale Rahim, Baoyou Huang, Lingfei Han

“…Mechanistically, CMTM4 interacts and stabilizes PHB2 (prohibitin 2) through post-translational modification, which further induces activation of the STING (stimulator of interferon genes)/TBK1 (TANK-binding kinase 1)/STAT6 (signal transducer and activator of transcription 6) pathway, facilitating the nuclear translocation of STAT6 which binds to the CCL2/IL-6 promoter, leading to the upregulation of CCL2/IL-6 transcription expression. Importantly, targeting CMTM4 with CMTM4-small interfering RNA enhanced the effectiveness of anti-programmed cell death protein 1 (anti-PD-1) therapy. …”
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Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma by Akshay Patel, Yin Wu, Sophie Papa, Sean Whittaker, Ashley Di Meo, Ioannis Prassas, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis, Thomas J Tull, Sophia Tsoka, Dhruva Biswas, Jitesh Chauhan, Katie Stoker, Zena N Willsmore, Lucy Booth, Amanda Fitzpartick, Matthaios Kapiris, Esperanza Perucha, Gary W Middleton

“…Background The majority of patients with melanoma develop immune-related adverse events (irAEs), and over half do not respond to anti-PD-1 (Programmed cell death protein 1) checkpoint inhibitor (CPI) immunotherapy. …”
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