Exploration of virulence and immune evasion functions of the candidate vaccine antigen SpyAD in the globally disseminated M1T1 group A Streptococcus strain by Alexandra Stream, Samira Dahesh, Lamar Thomas, Nina J. Gao, Elisabet Bjånes, Kalisa Kang, Truman Koh, Neeraj Kapoor, Victor Nizet

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Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis by Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang

“…Subsequently, we evaluated the impact of ISG15 on pyroptosis, a form of programmed cell death, to understand its potential role in DKD pathology. …”
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Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study by Yuan Zhang, Dan Tang, Ning Zhang, Yi Xiang, Yifan Hu, Wen Qian, Yangji Baima, Xianbin Ding, Ziyun Wang, Jianzhong Yin, Xiong Xiao, Xing Zhao

“…The CMEC study was funded by the National Key Research and Development Program of China (Grant No. 2017YFC0907305, 2017YFC0907300). …”
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Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity by Rachel Duffié, Hani Shayya, Martín Escamilla del Arenal, Miao Wang, Jerome Kahiapo, Aileen Ugurbil, Abdurrahman Keskin, Fiona Clowney, Elizaveta V. Bashkirova, Ariel D. Pourmorady, Ira Schieren, Humberto Ibarra Avila, Luke E. Berchowitz, Francisco M. Barriga, Eduard Batlle, Marko Jovanovic, Stavros Lomvardas

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PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity by Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov

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Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity by Xingbin Hu, Wenhao Ouyang, Haizhu Chen, Zhihong Liu, Zijia Lai, Herui Yao

“…CLDN9 has the potential to serve as a novel prognostic marker and therapeutic target for GC.…”
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Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy by Tetsuichi Kansha, Tetsuichi Kansha, Tetsuichi Kansha, Xiaojuan Ma, Xiaojuan Ma, Xiaojuan Ma, Hao Wang, Hao Wang, Hao Wang, Xiaotong Yu, Xiaotong Yu, Xiaotong Yu, Ying Song, Ying Song, Ying Song, Zhengyang Guo, Zhengyang Guo, Zhengyang Guo, Jiagui Song, Jiagui Song, Jiagui Song, Lixiang Xue, Lixiang Xue, Lixiang Xue, Lixiang Xue, Jianling Yang, Jianling Yang, Jianling Yang

“…Future directions include the integration of exosomal PD-L1 profiling into immunotherapy decision-making and the development of therapeutic strategies targeting exosome secretion. …”
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Vegetarian dietary patterns and cardiovascular risk factors and disease prevention: An umbrella review of systematic reviews by Matthew J. Landry, Katelyn E. Senkus, A Reed Mangels, Nanci S. Guest, Roman Pawlak, Sudha Raj, Deepa Handu, Mary Rozga

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Modeling of project activities for UAV modernization to conduct swarm drone attack missions by Oleg Fedorovych, Leonid Malieiev, Oleksii Hubka, Andrei Popov

“…To address this, an optimization model based on integer (Boolean) programming was developed for selecting the most rational UAV component architecture. …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…It provides a novel molecular mechanistic perspective and offers potential targets for future therapeutic strategies.Keywords: Alzheimer’s disease, single-cell RNA sequencing, microglia, ferroptosis, SLC11A1…”
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Spontaneous and activation-induced apoptosis of peripheral blood mononuclear cells in the pathogenesis of type 1 diabetes mellitus by A. V. Lugovaya, N. M. Kalinina, V. Ph. Mitreikin, Yu. V. Emanuel, Yu. P. Kovalchuk, A. V. Artyomova

“…The data obtained are in accordance with the modern concept of T1DM immunopathogenesis, which includes a development of autoimmune diseases associated not only with enhanced apoptosis of target cells, but also with a defect in phagocytic clearance of apoptotic cells due to impaired efferocytosis, i.e., phagocytosis of apoptotic cells. …”
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Clinical Testing of a New Radiopharmaceutical [^99mТс]-Al₂O₃ for the Diagnosis of Sentinel Lymph Nodes by А. A. Medvedeva, V. I. Chernov, R. V. Zelchan, O. D. Bragina, A. A. Rybina, V. S. Skuridin, E. S. Stasyuk, S. Yu. Chizhevskaya, A. V. Goldberg, E. Yu. Garbukov

“…Within the framework of the grant from the Federal Target Program "Pharma-2020", an original radiopharmaceutical using gamma aluminum oxide – [99mТс]-Al2O3 was developed. …”
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The role of transcriptional ‘futile cycles’ in autophagy and microbial pathogenesis by Guowu Hu, Travis McQuiston, Amélie Bernard, Yoon-Dong Park, Jin Qiu, Ali Vural, Nannan Zhang, Scott R. Waterman, Nathan H. Blewett, Timothy G. Myers, John H. Kehrl, Gulbu Uzel, Daniel J. Klionsky, Peter R. Williamson

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Beyond the norm: high protein adherence impacts muscular force and size adaptations by Gabriella Gilbert, Kyle Travis, Antonella V. Schwarz

“…While many studies report average group outcomes, individual adherence to higher protein targets remains understudied, specifically in real-world training contexts. …”
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Identification of heat-induced proteomes in meiotic pollen mother cells of tomato 'Maxifort' using single-cell-type tandem mass tag (TMT) proteomics by Hui Li, Yaoguo Qin, Xingbo Wu, Joshua O'Hair, Jesse Potts, Suping Zhou, Yong Yang, Tara Fish, Theodore W. Thannhauser

“…Proteins affecting apoptotic programmed cell death and pollen mother cell meiotic activity were significantly changed under HS. …”
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease by William Kielbasa, Paul Goldsmith, Kevin B. Donnelly, Hugh N. Nuthall, Sergey Shcherbinin, Adam S. Fleisher, Jörg Hendle, Susan L. DuBois, Stephen L. Lowe, Feiyu Fred Zhang, Eric M. Woerly, Nicolas J.‐F. Dreyfus, David Evans, Jeremy Gilmore, Michele Mancini, Cristian C. Constantinescu, Roger N. Gunn, David S. Russell, Emily C. Collins, Miroslaw Brys, Michael L. Hutton, Dustin J. Mergott

“…Preclinical studies assessed the target engagement, inhibition of OGA enzyme activity, OGA enzyme occupancy, and changes in tau O‐GlcNAc. …”
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Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexusResearch in context by Xiaonan Guo, Yu Feng, Xiaolong Ji, Ningning Jia, Aierpati Maimaiti, Jianbo Lai, Zheng Wang, Sheng Yang, Shaohua Hu

“…Funding: The National Key Research and Development Program of China (2023YFC2506200, SHH). …”
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Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity by Liran Xu, Chao Yang, Kaidan Pang, Ying Zhang, Yu He, Siyu Liu, Huijing Tian, Zehua Shao, Siyu Wang, Xingqian Liu, Ting Li, Yapeng Cao, Luqin Yan, Jinjin Liu, Yanan Wang, Yongxin Li, Wei Zhao, Youhua Wang, Yang Yan, Shengpeng Wang

“…Objectives: The white adipose tissue (WAT) expansion plays a significant role in the development of obesity. Cytoskeletal remodeling directly impacts adipogenic program, however, the precise mechanism remains poorly understood. …”
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Contributory factors to partial implementation of prevention of mother to child transmission policy in South Africa by Hermina Manjekana Dyeshana, Sibusiso Memory Zuma

“…Abstract Background South Africa (SA) is amongst the countries that adopted the Global plan towards the elimination of new HIV infections amongst children and keeping their mothers alive, launched in June 2011 as well the global HIV strategies of the Sustainable Development Goal (SDG) 3.3 target of ending the HIV epidemic by 2030, including the strategy for measuring impact and progress made in the prevention of mother-to-child transmission (PMTCT), now called Vertical Transmission Prevention (VTP) of HIV and communicable infections. …”
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Network and systems biology approaches help investigate gene regulatory interactions between Salmonella disease and host in chickens: Model‐based in silico evidence combined with g... by Reza Tohidi, Hoda Javaheri Bargourooshi, Arash Javanmard

“…Conclusions In conclusion, the development of an appropriate selection program to improve resistance to salmonellosis can be facilitated by a comprehensive understanding of the immune responses of the chicken immune system after SE exposure.…”
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