Functional annotation of the Hippo pathway somatic mutations in human cancers by Han Han, Zhen Huang, Congsheng Xu, Gayoung Seo, Jeongmin An, Bing Yang, Yuhan Liu, Tian Lan, Jiachen Yan, Shanshan Ren, Yue Xu, Di Xiao, Jonathan K. Yan, Claire Ahn, Dmitry A. Fishman, Zhipeng Meng, Kun-Liang Guan, Ruxi Qi, Ray Luo, Wenqi Wang

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Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights by Sathiyamoorthy Padmanaban, Ji-Won Baek, Sai Sahithya Chamarthy, Saipriya Chandrasekaran, Antony V Samrot, Vijayakumar Gosu, In-Kyu Park, Kamalakannan Radhakrishnan, Don-Kyu Kim

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Examining and comparing the clinical characteristics of adults with persisting post-concussion symptoms presenting for outpatient rehabilitation following a mild traumatic brain in... by Linda Fordal, Grant L. Iverson, Julia E. Maietta, Alexander Olsen, Cathrine Einarsen, Simen B. Saksvik, Toril Skandsen

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Combination therapy with expanded natural killer cells and atezolizumab exerts potent antitumor immunity in small cell lung cancer by Manh-Cuong Vo, Van-Tan Nguyen, Van-Dinh-Huan Tran, Hyung-Joo Oh, Sung-Hoon Jung, Woo Kyun Bae, Je-Jung Lee, In-Jae Oh

“…Here, we investigated whether the combination of NK cells plus atezolizumab, a fully humanized monoclonal antibody that specifically targets the protein programmed death-ligand 1 (PD-L1), has a synergistic effect against SCLC. …”
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Assessment of Metabolic Alterations Induced by Halogenated Additives and Antifungal Activity of Extracts from the Endophytic Fungus <i>Fusarium</i> sp. Associated with <i>Dizygoste... by Hilzimar de Jesus Freitas Sá, Anne Karoline Maiorana Santos, Adriano Souza Fonseca, Lourivaldo da Silva Santos, Josivan Regis Farias, Rosane Nassar Meireles Guerra, Edson Rodrigues-Filho, Gilmar Silverio da Silva, Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Antônio José Cantanhede Filho

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Lymphedema pathogenesis involves antigen-driven expansion of CD4+ T cells in skin by Adana-Christine Campbell, Annica R. Stull-Lane, Jung Eun Baik, Ananta Sarker, Jinyeon Shin, Gopika Ashokan, Hyeung Ju Park, Bracha L. Pollack, Pradhi Pakkerakari, Yollanda Franco Parisotto, Arielle Roberts, Chrysothemis C. Brown, Babak J. Mehrara, Raghu P. Kataru

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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…Outstanding clinical trials and animal-model study designs, innovative technology, and analytical approaches in bioinformatics are essential tools to successfully uncover novel glaucoma biomarkers with a high potential for translation into clinical practice.MethodsTo better understand the clinical and biochemical-molecular-genetic glaucoma pathogenesis, we conducted an analytical, observational, and case-comparative/control study in 358 primary open-angle glaucoma (POAG) patients and 226 comparative-control individuals (CG) to collect tears, aqueous humor, and blood samples to be processed for identifying POAG biomarkers by exploring several biological pathways, such as inflammation, neurotransmitter/neurotrophin alteration, oxidative stress, gene expression, miRNAs fingerprint and its biological targets, and vascular endothelial dysfunction, Statistics were done by using the IBM SPSS 25.0 program. …”
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A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes by Jessica Bomyea, Morgan M. Caudle, Nathalie Dugas, Raeanne C. Moore, Alan N. Simmons, Michael L. Thomas

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Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia by Nadine A. Kerr, James Choi, Simone Y. Mohite, Praveen Kumar Singh, Helen M. Bramlett, Jae K. Lee, W. Dalton Dietrich

“…These complex responses lead to patterns of programmed cell death, diffuse axonal injury, increased blood-brain barrier disruption, neuroinflammation, and reactive gliosis, each a potential target for therapeutic interventions. …”
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Guidance on sexual, reproductive, maternal, newborn, child and adolescent health in humanitarian and fragile settings: a scoping review by Per Ashorn, Etienne V Langlois, Neha S Singh, Samira Aboubaker, Egmond Samir Evers, Teesta Dey, Mehr Gul Shah, Mariana Rodo, Sophie Marie Kostelecky, Maria El Bizri

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Identification of novel anti-tumor peptides from enzymatic hydrolysis of soy-based tempeh and their mechanism in pancreatic and colorectal cancer cells by Kiki Lukman, Prapanca Nugraha, Nurpudji Astuti Taslim, Nuril Farid Abshori, Elvan Wiyarta, Timothy Sahala Gerardo, Krisanto Tanjaya, Juan Leonardo, Raymond Rubianto Tjandrawinata, Happy Kurnia Permatasari, Fahrul Nurkolis

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Effect of individual quick freezing treatment and cold storage on the host egg (Lepidoptera: Saturniidae) quality for the production of the parasitoid Anastatus japonicus Ashmead (... by Yi-Hui Wu, Shih-Yang Lee, Yi-Yuan Chuang, Hsy-Yu Tzeng, Jui-Sheng Lai, Ming-Yi Chou

“…Abstract Background The augmentative release of the parasitoid species Anastatus japonicus Ashmead (Hymenoptera: Eupelmidae) is essential for managing the recent invasion of litchi stink bugs (Tessaratoma papillosa (Drury)) (Hemiptera: Tessaratomidae) in Taiwan. The mass release program in the spring targets this univoltine pest’s reproduction cycle. …”
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Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort studyResearch in context by Tingting Wang, Matthias Arnold, Kevin Huynh, Patrick Weinisch, Corey Giles, Natalie A. Mellett, Thy Duong, Bharadwaj Marella, Kwangsik Nho, Alysha De Livera, Xianlin Han, Colette Blach, Chenglong Yu, John J. McNeil, Paul Lacaze, Andrew J. Saykin, Gabi Kastenmüller, Peter J. Meikle, Rima Kaddurah-Daouk

“…Interpretation: These findings highlight lipidomic profiling as a potential blood-based biomarker for identifying individuals at high risk of AD progression, offering a scalable, non-invasive approach for early detection, risk stratification, and targeted interventions in AD. Funding: The National Health and Medical Research Council of Australia (#1101320 and #1157607); NHMRC Investigator grant (#GNT1197190); Victorian Government’s Operational Infrastructure Support Program; National Heart Foundation of Australia, Future Leader Fellowship (#102604), and National Health and Medical Research Council Investigator Grant (#2026325); Investigator grant (#2009965) from the National Health and Medical Research Council of Australia; a National Health and Medical Research Council of Australia Senior Research Fellowship (#1042095); National Institutes of Health grants: P30AG010133, P30AG072976, R01AG019771, R01AG057739, U19AG024904, R01LM013463, R01AG068193, T32AG071444, U01AG068057, U01AG072177, U19AG074879, R01AG069901, R01AG046171, RF1AG051550, RF1AG057452; National Institutes of Health/National Institute on Aging grants RF1AG058942, RF1AG059093, U01AG061359, U19AG063744, and R01AG081322, NIH/NLM R01LM012535; FNIH: DAOU16AMPA.…”
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Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts by Ka Wai Wong, Yingying Zeng, Edison Tay, Jia Hao Jackie Teo, Nadia Omega Cipta, Kiyofumi Hamashima, Yao Yi, Haijun Liu, Tushar Warrier, Minh T. N. Le, Soon Chye Ng, Qi-Jing Li, Hu Li, Yuin-Han Loh

“…The Nr1h2-centred intrinsic program governs and drives the development of both blastoids and early embryos.…”
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Gene Expression Sets and Renal Profiling from the Renal AL Amyloid Involvement and NEOD00 (RAIN) Trial by Cindy Varga, Felix Eichinger, Viji Nair, Abhijit S. Naik, Samih H. Nasr, Agnes B. Fogo, Denis Toskic, Matthias Kretzler, Raymond L. Comenzo

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Shock reaction model for impact energy release behavior of Al/PTFE reactive material by Bao-yue Guo, Ke-rong Ren, Xia-yin Ma, Gan Li, Cai-min Huang, Zhi-bin Li, Rong Chen

“…When reactive materials are used to make warhead fragments, they can deliver a significant amount of chemical energy to the target in addition to the kinetic energy damage. When used as the core of a PELE (Penetrator with Enhanced Lateral Efficiency) projectile, reactive materials can enhance the fragmentation of the projectile shell after penetrating the target, causing both physical and chemical damage. …”
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Integrating bioinformatics and machine learning to uncover lncRNA LINC00269 as a key regulator in Parkinson's disease via pyroptosis pathways by LiLi Ma, Yue Liu, Yajing Ren, Na Mi, Jing Fang, Rui Bao, Xiuzhi Xu, Hongjia Zhang, Ying Tang

“…Abstract Background Pyroptosis, a specific type of programmed cell death, which has become a significant factor to Parkinson's disease (PD). …”
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Bertolotti Syndrome: Does it really exist? systematic review by Acevedo-Gonzalez Juan Carlos, Delgado-Caicedo Mónica Gabriela, Lacouture-Silgado Isabella

“…The search covered the last 21 years (2013 to 2024). The “Rayyan” program was used to gather information and facilitate the analysis process. …”
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AKAP12 positive fibroblast determines immunosuppressive contexture and immunotherapy response in patients with TNBC by promoting macrophage M2 polarization by Wenxin Xu, Jialei Weng, Siyuan Hu, Zhenkun Liu, Xinlei Zhao, Feng Ju, Meiying Gu, Yabing Du

“…Our goal is to identify specific CAFs subpopulations contributing to TNBC development.Methods Multiomics analyses were applied to identify the CAFs-specific genes related to immunotherapy response. …”
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Generation Healthy Kids: Protocol for a cluster-randomized controlled trial of a multi-component and multi-setting intervention to promote healthy weight and wellbeing in 6-11-year... by Louise T Thomsen, Jesper Schmidt-Persson, Camilla Trab Damsgaard, Peter Krustrup, Anders Grøntved, Rikke Fredenslund Krølner, Glen Nielsen, Jesper Lundbye-Jensen, Thomas Skovgaard, Christian Mølgaard, Anders Blædel Gottlieb Hansen, Didde Hoeeg, Malte Nejst Larsen, Line Lund, Paulina Sander Melby, Natascha Holbæk Pedersen, Jens Troelsen, Nikolai Baastrup Nordsborg, Ulla Toft

“…"Generation Healthy Kids" (GHK) is a multi-setting, multi-component intervention to promote healthy weight development, health and wellbeing in Danish children aged 6-11 years. …”
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