Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum. by Mehdi Ghorbal, Christine Scheidig-Benatar, Salma Bouizem, Christophe Thomas, Genevieve Paisley, Claire Faltermeier, Melanie Liu, Artur Scherf, Jose-Juan Lopez-Rubio, Deshmukh N Gopaul

“…Finally, Pf-Int knock-out parasite is viable showing no detectable impact on blood stage development, which is compatible with such function.…”
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Modeling the impact of using trastuzumab deruxtecan in patients with breast cancer on reducing cancer mortality in Russia by N. A. Avxentyev, Yu. V. Makarova, A. S. Makarov

“…Reducing malignant mortality to 185 cases per 100,000 by 2030 is one of goals of the state program “Healthcare development” in Russia.Aim. To assess potential impact of using trastuzumab deruxtecan in patients with breast cancer on reducing cancer mortality.Materials and methods. …”
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Elevation of hepatic de novo lipogenesis in mice with overnutrition is dependent on multiple substrates by Jordan W. Strober, Stephan Siebel, Susan F. Murray, Manuel González Rodríguez, Carlos Rodriguez-navas Gonzalez, Daniel F. Vatner

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Improving Control in the Digital Environment in the Field of Public Administration on the Example of the Republic of Mordovia by O.  V. Shibileva, V.  V. Parshutkina

“…The main stages of the development of control activities in the context of digital transformation are considered, indicating the implementation of some areas of improving the quality of control of the budget process and the effectiveness of public finance management in 2022, the formation of an integrated and coherent program for the introduction and implementation of electronic control, designed for the period up to 2027. …”
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Characteristics of online behavior and structure of consumed content in Abakan adolescents of different age, groups and ethnicity by L. S. Evert, T. V. Potupchik, Yu. R. Kostyuchenko

“…One of the reasons for the greater prevalence of maladaptive online behavior among Khakasses may be the association of maladaptive Internet use with the presence of emotional disorders and behavioral problems that reach the borderline level and are causally significant factors in the development of Internet addiction. Adolescents with maladaptive online behavior, who have not yet reached the level of formed Internet addiction, are the target group requiring medical and psychological assistance.…”
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Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. by Anthony R Dallosso, Anne L Hancock, Marianna Szemes, Kim Moorwood, Laxmi Chilukamarri, Hsin-Hao Tsai, Abby Sarkar, Jonathan Barasch, Raisa Vuononvirta, Chris Jones, Kathy Pritchard-Jones, Brigitte Royer-Pokora, Sean Bong Lee, Ceris Owen, Sally Malik, Yi Feng, Marcus Frank, Andrew Ward, Keith W Brown, Karim Malik

“…Wilms' tumour (WT) is a pediatric tumor of the kidney that arises via failure of the fetal developmental program. The absence of identifiable mutations in the majority of WTs suggests the frequent involvement of epigenetic aberrations in WT. …”
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Neuroglobin: A promising candidate to treat neurological diseases by Ivan Millan Yañez, Isabel Torres-Cuevas, Marisol Corral-Debrinski

“…Among the common features of neurological handicaps, we find protein aggregation, oxidative stress, neuroinflammation, and mitochondrial impairment in the target tissues, e.g., the brain, cerebellum, and spinal cord. …”
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Identification of Serum‐Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV‐HCC: A Cross‐Sectional Study by Yasmeen Ishaq, Bisma Rauff, Badr Alzahrani, Hassnain Javed, Aqsa Ikram

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Advancing the accuracy of clathrin protein prediction through multi-source protein language models by Watshara Shoombuatong, Nalini Schaduangrat, Pakpoom Mookdarsanit, Jaru Nikom, Lawankorn Mookdarsanit

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Sterile inflammation, cross-presentation, autophagy and adaptive immunity in immunoinflammatory rheumatic diseases by M. Z. Saidov

“…The most important place in the development of DAMP-mediated sterile inflammation is occupied by the phenomenon of cross-presentation and autophagy. …”
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Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth by Mario Guerrero, Elizabeth Proaño-Pérez, Eva Serrano-Candelas, Alfonso García-Valverde, Berenice Carrillo-Rodríguez, Jordi Rosell, César Serrano, Margarita Martin

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Silymarin as a potent polyphenol against metabolic disease pathways: A computational insight and ADMET/MM-PBSA analysis by Fatemeh Mahmoudi Lamooki, Fatemeh Alami, Farzad Mirab Toupchi, Parham Jalali, Armita Banimahdidehkordi, Payam Baziyar, Shamim Ghiabi, Ehsan Heidari-Soureshjani, Seyedeh Atefeh Mirahmadi

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Exploring ethnic fermented drink ‘Pakhoi’ for its therapeutic properties: An in-silico perspective by Shikha Tomar, Shalini Kotnala, Riya, Kuldeep Chauhan, Anmol Sharma, Manu Pant, Pallavi Singh, Sumit Sharma, Kumud Pant

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Nanoparticles induced cuproptosis to enhance antitumor immunotherapy by Wen Deng, Zichen Zhong, Haojie Shang, Yonghua Tong, Qiu Huang, Yu He, Jian Wu, Xiaozhuo Ba, Zhiqiang Chen, Yuan Chen, Kun Tang

“…Cuproptosis, a newly discovered form of programmed cell death, can effectively circumvent tumor cells' resistance to apoptosis. …”
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Astragaloside IV: a potential nemesis for gastric cancer by Chao Hu, Qiong Li, Song-Nan Gong, Xiao-Jie Zou, Jia-Yue Xu, Hai-Feng Ying, Lan Zheng

“…Many studies demonstrate that AS-IV can inhibit the development of GC through multi-target and multi-pathway mechanisms, making it a well-deserved nemesis of GC. …”
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A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions by Pritha Saha, Palaniyandi Ravanan, Priti Talwar

“…PPARG is reported to be a promising target for patients diagnosed with colorectal cancer (CRC). …”
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Methods for Applying Matrices when Creating Models of Group Pursuit by A. A. Dubanov

“…In some cases, the location of targets and pursuers was defined as points on the circle of Apollonius. …”
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Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses by Maryam Rezazadeh, Shahla Danaei-Mehrabad, Nahideh Afshar Zakariya, Fatemeh Kazemi, Marziyeh Sadat Moslehian, Amin Tamadon, Reza Shirazi, Mahdi Mahdipour, Parvin Hakimi

“…Conclusion: This study contributes to our understanding of the molecular processes driving EC metastasis, which may result in the development of new treatment targets and indicators for the early identification of EC metastasis. …”
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MIAT: A pivotal oncogenic long noncoding RNA tunning the hallmarks of solid malignancies by Monica M. Rostom, Alaa A. Rashwan, Christina D. Sotiropoulou, Sama Z. Hozayen, Abdelhamid M. Abdelhamid, Miriam Mokhtar Abdelhalim, Omar Eltahtawy, Hadir M. Emara, Noha M. Elemam, Christos K. Kontos, Rana A. Youness

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First Description of Loreto Virus in Three Culicidae Species from the Atlantic Forest, Bahia, Brazil by Thito Y. Bezerra da Paz, Leonardo H. Almeida Hernández, Fábio Silva da Silva, Ana C. Ribeiro Cruz, Sandro Patroca da Silva, Hellen Thais Fuzii, Janaina M. Vasconcelos Massafra, João L. S. G. Vianez Júnior, Sharon L. Deem, Leonardo de Carvalho Oliveira, Kristel Myriam De Vleeschouwer, Lilian Silva Catenacci

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