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Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics
Published 2025-05-01Get full text
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Comprehensive analysis and experimental validation of disulfidptosis-associated prognostic signature and immune microenvironment characterization of gastric cancer
Published 2025-02-01“…There is evidence that targeting disulfidptosis is a promising anticancer strategy. …”
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Socioeconomic disparities in Plasmodium falciparum infection risk in Southern Malawi: mediation analyses
Published 2024-11-01Get full text
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Pengembangan Perangkat Pembelajaran Konstruktivistik Model Teaching with Analogies (TWA) pada Mata Kuliah Database Management System (DBMS) untuk Meningkatkan Kemampuan Berpikir Kr...
Published 2020-10-01“…The target of this research was the production of learning tool which implemented in 15 students of the Information Technology Education Study Program of STKIP Yapis Dompu. …”
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PANoptosis: Cross-Talk Among Apoptosis, Necroptosis, and Pyroptosis in Neurological Disorders
Published 2025-06-01“…Pengpeng Li,1– 3,* Yangyang Gao,4,* Zhenxing Tao,2,5 Zhenqian Mu,1,2 Shiqing Du,2 Xudong Zhao3 1Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China; 2Department of Neurosurgery, Jiangnan University Medical Center, Wuxi, Jiangsu, People’s Republic of China; 3Department of Neurosurgery, The Affiliated Wuxi No. 2 People’s Hospital of Nantong Medical University, Wuxi, Jiangsu, People’s Republic of China; 4Ningxia Medical University, Yinchuan, People’s Republic of China; 5Wuxi Neurosurgical Institute, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Zhao, Email 9862022148@jiangnan.edu.cnAbstract: Cell death mechanisms play a critical role in organismal development and homeostasis, primarily categorized into energy-dependent programmed cell death (PCD) and energy-independent necrotic cell death. …”
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Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model
Published 2020-01-01“…B lymphocyte-induced maturation protein 1 (Blimp-1) and programmed cell death protein 1 (PD-1) have opposing roles in the development of T cells; however, the mechanism of autoimmune thyroiditis- (AIT-) associated abortion is unclear. …”
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Risk factors for preterm birth and its effect on neonatal mortality in India: evidence from the National Health Family Survey-5
Published 2025-08-01“…India urgently needs to accelerate investment in, and scale up primary interventions that prevent preterm births for achieving target 3.2 of the Sustainable Development Goals (SDGs) 2030.…”
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From Prompts to Motors: Man-in-the-Middle Attacks on LLM-Enabled Vacuum Robots
Published 2025-01-01“…In this study, we present a systematic analysis of man-in-the-middle (MITM) attacks targeting an LLM-enabled vacuum robot. Our research follows a three-phase development process: 1) command-line simulation of LLM–robot interactions, 2) tabletop setup, and 3) implementation of a physical robot using a commercial vacuum platform enhanced with a Raspberry Pi–hosted ChatGPT application programming interface (API) and you only look once (YOLO, v8) object detection. …”
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Anglers Perceptions About European Catfish <i>Silurus glanis</i> in a Newly Invaded Region
Published 2025-03-01“…The majority of surveyed anglers were males (>95%) who consider that catfish is not beneficial to the development of angling (>62%) and acknowledge its negative impact on other fish species (>84%), mainly by predation (>89%). …”
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Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
Published 2025-07-01Get full text
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Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.
Published 2019-12-01“…The critical role of Bcl-2 proteins in homeostasis and tumorigenesis, coupled with mounting insight in their structural properties, make them therapeutic targets of interest. A better understanding of gene expression, mutational profile, and molecular mechanisms of pro-survival Bcl-2 proteins in different cancer types, could help to clarify their role in cancer development and may guide advancement in drug discovery. …”
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Analysis of the relationship between the predicted biological activity and the chemical structure of S-derivatives of 5-(5-bromofuran-2-yl)-4R-1,2,4-triazole-3-thiols
Published 2021-07-01“…1,2,4-Triazole derivatives are actively used as components in the development of new drugs, plant protection products, polymeric materials, anti-corrosion agents and etc. …”
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APPROACH TO BUILDING A GLOBAL MOBILE AGENT WAY BASED ON Q-LEARNING
Published 2020-09-01“…The following tasks are solved in the article: development of an approach to training and support of a reinforcement learning algorithm for building a global path of a mobile agent; testing the agent's ability to find a path in environments that are not in the training set. …”
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Interventions to Address Clinical Incivility in Nursing: A Systematic Review
Published 2025-06-01“…Seventeen studies met the inclusion criteria and were analyzed for intervention types, target populations, delivery methods, and outcomes. …”
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