The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. by Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos

“…Using the zebrafish pectoral fin bud as a model for early vertebrate fin/limb development, we found that K+ channels also scale this anatomical structure, and we determined how one K+-leak channel, Kcnk5b, integrates into its developmental program. …”
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Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis. by Mengmeng Niu, Yajun He, Jing Xu, Liangping Ding, Tao He, Yong Yi, Mengyuan Fu, Rongtian Guo, Fengtian Li, Hu Chen, Ye-Guang Chen, Zhi-Xiong Jim Xiao

“…Together, these results demonstrate that FBXO3 facilitates ΔNp63α degradation to empower TGF-β signaling in promoting tumor metastasis and that the TβRI-FBXO3-ΔNp63α axis is critically important in breast cancer development and clinical prognosis. This study suggests that FBXO3 may be a potential therapeutic target for advanced breast cancer treatment.…”
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Characterization of curcumin-loaded nano thermo-sensitive hydrogel by Ikhsanudin Azis, Saifullah S Teuku Nanda, Zai Khadijah, Ari S Bambang

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Metabolomics assays applied to schistosomiasis studies: a scoping review by Milena Lima Rodrigues, Antonia Regina dos Santos Gois, Ana Lúcia Coutinho Domingues, Ricardo Oliveira Silva, Edmundo Pessoa Lopes

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A bibliometric and visualization analysis of entosis research from 2007 to 2024 by Xinyu Yang, Jiatao Tu, Xinyi Zang, Xuan Huang, Ye Tao

“…It highlights critical areas of interest, including the development of inhibitors targeting entosis and their potential clinical applications. …”
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Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. by Candice C Clay, Kinjal Maniar-Hew, Joan E Gerriets, Theodore T Wang, Edward M Postlethwait, Michael J Evans, Justin H Fontaine, Lisa A Miller

“…We have previously reported that exposure to episodic ozone during postnatal development results in an attenuated peripheral blood cytokine response to lipopolysaccharide (LPS) that persists with maturity. …”
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Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy by Dirk Schadendorf, Celeste Lebbe, Teresa Amaral, Benjamin Weide, Mariaelena Capone, Gabriele Madonna, Lucia Festino, Reinhard Dummer, Domenico Mallardo, Paolo A Ascierto, Piotr Rutkowski, Jason John Luke, Kilian Wistuba-Hamprecht, Mitchell P Levesque, Roberta Turiello, Elva Morretta, Maria Chiara Monti, Rosa Azzaro, Laurence Imhof, Marc Chevrier, Antje Sucker, Aldo Pinto, Silvana Morello

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Prebiotic oligofructose protects against high-fat diet-induced obesity by changing the gut microbiota, intestinal mucus production, glycosylation and secretion by Paola Paone, Francesco Suriano, Ching Jian, Katri Korpela, Nathalie M. Delzenne, Matthias Van Hul, Anne Salonen, Patrice D. Cani

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Assessing the Agreement Between Diffusion Tension Imaging (DTI) and T2-Weighted MRI Sequence for Biometry of the Fetal Corpus Callosum by Liel N. Cohn, Shai Bookstein, Tamar Laytman Klein, Nadia Mordenfeld Kozlovsky, Tomer Ziv-Baran, Arnaldo Mayer, Eldad Katorza

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Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics by Jiaqian Si, Jie Wang, Hao Dai, Tuochen Lv, Songyun Zhao, Wanying Chen, Liqun Li, Siqi Ding, Yucang He

“…Ischemia-reperfusion injury (IRI) has become a significant challenge for clinical treatment due to the complex multi-mechanism pathological cascade response, including oxidative stress, inflammatory bursts, and programmed cell death. Adipose-derived stem cells (ADSCs) and their exosomes (ADSCs-exosomes) are emerging as a breakthrough therapeutic strategy to reverse IRI, owing to their multi-target synergistic effects. …”
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The cost of delivering COVID-19 vaccines in Mozambique: a bottom-up costing study by Tozé Namalela, Flavia Moi, Amélia Dipuve, Pedro Marizane Pota, José Guambe, Maria Tereza Couto, Laura Boonstoppel

“…Opportunity costs made up a considerable share of the economic cost per dose, 73% and 49% respectively during the initial rollout and when the program delivered at scale. The qualitative interviews found that political prioritization and workers’ commitment made the program possible despite little financial investment. …”
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Inter-city movement pattern of notifiable infectious diseases in China: a social network analysisResearch in context by Lin-Jie Yu, Peng-Sheng Ji, Xiang Ren, Yan-He Wang, Chen-Long Lv, Meng-Jie Geng, Jin-Jin Chen, Tian Tang, Chun-Xi Shan, Sheng-Hong Lin, Qiang Xu, Guo-Lin Wang, Li-Ping Wang, Simon I. Hay, Wei Liu, Yang Yang, Li-Qun Fang

“…Funding: National Key Research and Development Program of China.…”
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Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity by Mark F. Mabanglo, Brian Wilson, Mahmoud Noureldin, Serah W. Kimani, Ahmed Mamai, Chiara Krausser, Héctor González-Álvarez, Smriti Srivastava, Mohammed Mohammed, Laurent Hoffer, Manuel Chan, Jamie Avrumutsoae, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Stuart Green, Magdalena Szewczyk, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Suzanne Ackloo, Peter Loppnau, Yanjun Li, Almagul Seitova, Taira Kiyota, Jue George Wang, Gilbert G. Privé, Douglas A. Kuntz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Ahmed Aman, Gennady Poda, David Uehling, Jailall Ramnauth, Levon Halabelian, Richard Marcellus, Rima Al-awar, Masoud Vedadi

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Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke by He-Yan Tian, Yun-Xing Lei, Jing-Tao Zhou, Long-Jun Liu, Tong Yang, Yue Zhou, Jin-Wen Ge, Jin-Wen Ge, Chen Xu, Zhi-Gang Mei

“…In conclusion, the crosstalk between PANoptosis and autophagy in IS presents a promising target for the development of novel stroke therapies. …”
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Occupational health in the educational context: a descriptive and correlational study by Javier Rodríguez-Fragoso, Francisco José Moya-Faz, Francisco José Moya-Faz, Agata Horyza, Ana María Ruiz-Ruano García, Enrique Javier Garcés de los Fayos-Ruiz, Reyes López-López, Jorge López Puga, María Joao Vidal-Alves, María Joao Vidal-Alves

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Grape pomace as a natural source of antimicrobial agents for food preservation by Micaela Galante, María Emilia Brassesco, Carollyne Maragoni Santos, Carolina Beres, Ana Elizabeth Cavalcante Fai, Ana Elizabeth Cavalcante Fai, Ignacio Cabezudo

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Sun-Tanning Perceptions of a New Zealand Urban Population (1994–2005/6) by A. I. Reeder, G. F. H. McLeod, A. R. Gray, R. McGee

“…There was no statistically significant change in total ProTan scores from baseline. Conclusions. The development, pretesting, and evaluation of messages for those groups most likely to endorse ProTan statements should be considered for the New Zealand skin cancer prevention program. …”
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Reversible proliferative arrest induced by rapid depletion of RNase MRP by Yuan Liu, Shiyang He, Kawon Pyo, Reuben Franklin, Ibrahim B. Maaz, Chen Cai, Kriti Shah, Sihem Cheloufi, William F. Marzluff, Jernej Murn

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Spatiotemporal Evolution and Interactions of Vegetation and Water Balance Elements by Dongxu Qin, Zhonghua Li, Min Xu, Dong Wang, Xiaoshu Hou

“…Additionally, the main implementation areas of major ecological projects like the Three-North Shelterbelt Program and the Grain for Green Program (e.g., Northwest Rivers and the Yellow River basin) overlap significantly with the identified conflict-prone areas, raising concerns about the ecological water needs of vegetation in these areas. …”
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Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors by Irem Bayindir‐Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller‐Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig, Alexandros Vegiopoulos

“…Here, we identified the transcriptional cofactor Cited4 as a target and mediator of rosiglitazone in human and murine adipocyte progenitor cells, where it promoted specific sets of the rosiglitazone‐dependent transcriptional program. …”
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