Hierarchical progressive learning for zero-shot peptide-HLA binding prediction and automated antigenic peptide design by Xinyuan Zhu, Jiadong Lu, Xinting Hu, Tengchuan Jin, Shan Lu, Fuli Feng

“…HPL models improve the prediction performance for zero-shot HLA class-I alleles by 60.8% (1,414.0% for non-classical ones). We further developed an automated peptide mutation search program, which automatically identifies binding peptides for any target HLA class-I allele and mutates weak-binding or non-binding peptides to enhance binding affinity under the guidance of HPL models. …”
Get full text

Exploring experiences with an internet-delivered ACT intervention among individuals with a personal history of depression: A thematic analysis by Line Børtveit, Tine Nordgreen, Anders Nordahl-Hansen

“…These findings provide valuable insights for refining future internet-delivered intervention development targeting patients with depression or other mental health challenges.…”
Get full text

Analytical approach to digital channel performance optimization of mobile money transactions in emerging markets by Adeolu Dairo, Krisztián Szűcs

“…The research aims to develop a target selection and campaign optimization framework for mobile money customers along two channels of transactions. …”
Get full text

Enhancing the Potential of Smart Building for General Hospital: A Case Study in Malaysian Hospital. by Mohd Faisal Baharuddin, Chin Haw Lim, Ahmad Fazlizan

“…The targets are beneficial for the hospital itself to establish the Smart Building Program to improve its energy efficiency concurrent with the green policy of the Ministry of Health Malaysia and Sustainable Development Goals by the United Nations. …”
Get full text

Ethylene signals through an ethylene receptor to modulate biofilm formation and root colonization in a beneficial plant-associated bacterium. by T Scott Carlew, Eric Brenya, Mahbuba Ferdous, Ishita Banerjee, Lauren Donnelly, Eric Heinze, Josie King, Briana Sexton, Randy F Lacey, Arkadipta Bakshi, Gladys Alexandre, Brad M Binder

“…Our data suggests a model in which ethylene from host plants alters the density of colonization by A. brasilense and re-wires its metabolism, suggesting that the bacterium implements an adaptation program upon sensing ethylene. These data provide potential new targets to regulate beneficial plant-microbe interactions.…”
Get full text

Unraveling the Role of Microcystin-LR in Ferroptosis and Sepsis Pathogenesis: A Comprehensive Review by Honglian Ying, Hongli Zhao, Xiaqiu Zhang, Haoyuan Feng, Manjuan Zhou, Zunqiu Wu, Ning Wu

“…Ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation, is closely associated with the occurrence and development of various diseases. …”
Get full text

Prevalence and burden of no-toilet households in India: an analysis of 261,746 households in 36 states/Union Territories in 2022–2023 by Anoop Jain, Akhil Kumar, Rockli Kim, S. V. Subramanian

Get full text

PREVENTING CYBER ATTACKS ON CRIRICAL INFRASTRUCTURE: A NEW PRIORITY FOR THE RUSSIAN PUBLIC DIPLOMACY? by O. V. Demidov

“…As it was revealed in 2010, several Middle East States, first of all Iran in 2008, were the target for a series of systematic and sophisticated computer attacks, whose initiators remain unknown, which were aimed at the collection of information about the objects of critical information infrastructure of these states and its program intrusion. …”
Get full text

Ferroptosis and bone health: bridging the gap between mechanisms and therapy by Renyan Xiao, Zhongyu Han, Peng Jia, Pei Li, Meng Gong, Yijin Cai, Lina Pang, Xiangyin Ye, Song Jin

“…Numerous studies have shown that ferroptosis plays a critical role in the development and progression of bone and joint diseases, although the underlying mechanisms remain incompletely understood. …”
Get full text

Multi-Stage Evaluation of Demolition and Reclamation Carbon Storage from "System Design-Construction-Quality Effect" Perspectives by Deng Pingping, Ye Changdong, Ke Chunpeng, Hu Yueming, Fu Xiaoping, Zhou Long

“…Guangdong Province was selected as a representative case study for developing a comprehensive multi-stage evaluation framework for carbon storage, structured across three sequential stages: System Design (SD), Construction (CO), and Quality Effect (QE). …”
Get full text

A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System by Mario García-Domínguez

Get full text

Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases by Livia Alvarenga, Ludmila F. M. F. Cardozo, Márcia Ribeiro, Fernanda Kussi, Marta Esgalhado, Denise Mafra

Get full text

Structural basis of human VANGL-PRICKLE interaction by Yanyi Song, Shuyi Jian, Junlin Teng, Pengli Zheng, Zhe Zhang

Get full text

Using experience-based co-design approach to address mental health issues among healthcare workers and leaders in long-term care by Sheila A. Boamah, Mawukoenya Theresa Sedzro, Humayun Kabir, Brenda Vrkljan, Scott Mitchell, Laura De La Torre Pérez, Laura De La Torre Pérez, Marilina Santero

Get full text

Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease by CAI Xiaoyu, GAO Feng, HUANG Bin, QIN Huiping

“…Chronic obstructive pulmonary disease (COPD) has developed into a serious chronic respiratory disease threatening human health. …”
Get full text

Tiragolumab and TIGIT: pioneering the next era of cancer immunotherapy by Kosar Ghasemi, Kosar Ghasemi

“…By inhibiting TIGIT, Tiragolumab enhances T cell-mediated anti-tumor immunity, particularly when combined with programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors. …”
Get full text

Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications by Jinxin Tang, Yan Zhuang, Yibo Zhang, Hongkun Hu, Hua Wang, Haodong Xu, Yintao Li, Chao Tu

“…Abstract Necroptosis represents a distinct form of programmed cell death that exhibits characteristics of both necrosis and apoptosis. …”
Get full text

Experiences of undergoing internet-delivered cognitive behavioural therapy for climate change-related distress: a qualitative study by Nike Lindhe, Matilda Berg, Kali Andersson, Gerhard Andersson

“…The aim of the present study was to investigate participants’ experiences of undergoing a novel ICBT program targeting psychological symptoms associated with climate change. …”
Get full text

Operationalising an integrated mortality transition framework for programmatic priority setting across maternal and newborn health by Allisyn C Moran, Ties Boerma, Gloria Ikilezi, Ryan Fitzgerald, Uzma Syed

“…Data-driven decision making will be instrumental in reducing maternal mortality, newborn mortality, and stillbirth levels in the coming years as the Sustainable Development Goal targets draw near in 2030. Tailoring evidence to be context-specific is crucial to target relevant questions, priorities, and needs. …”
Get full text

Tensor‐structured decomposition improves systems serology analysis by Zhixin Cyrillus Tan, Madeleine C Murphy, Hakan S Alpay, Scott D Taylor, Aaron S Meyer

Get full text