RANKL blockade inhibits cancer growth through reversing the tolerogenic profile of tumor-infiltrating (plasmacytoid) dendritic cells by Pascale Hubert, Patrick Roncarati, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs, Margaux Luyckx, Michael Renard, Florian Poulain, Rebekah Crake, Raphael Peiffer

“…Mechanistically, we highlighted that RANKL indirectly promotes regulatory T cell differentiation and suppressive function by inhibiting the mTOR signaling pathway on antigen-presenting cells.Conclusions Taken together, this study provides insight into the role of RANKL/RANK axis in immune tolerance, demonstrates the significant impact of RANKL-dependent impairment of T cell–DC/pDC crosstalk on tumor development and, ultimately, supports that this ligand could be an interesting actionable target for cancer immunotherapy.…”
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Interatrial block is an independent risk factor for new-onset atrial fibrillation after cardiac surgeryCentral MessagePerspective by Spela Leiler, MD, Andre Bauer, PhD, Wolfgang Hitzl, PhD, Rok Bernik, MD, Valentin Guenzler, MD, Matthias Angerer, MD, Theodor Fischlein, PhD, Jurij Matija Kalisnik, PhD

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Pragmatic clustered randomised control trial to evaluate a self-regulated learning intervention to be implemented in South Australian primary schools—study protocol by S.A Brinkman, B. Lam, S. Dawson, R. Marrone, D. Schunk, K. Winkel, H. Hermes, F. Gabriel, S. Fowler, D. Engelhardt

“…While SRL is recognised as a key lifelong competency, there remain questions regarding how educators can best develop and promote SRL in school settings. A scalable, low-cost intervention targeted at grade 1 students (6–7 years old) in Germany was found to have substantial effects on impulse control and self-regulated learning, with sustained impacts on long-term academic success Schunk (Nat Hum Behav 6(12):1680-90, 2022). …”
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Pentagon Fraud Analysis in Detecting Fraudulent Financial Reporting by Eny Kusumawati, Ika Putri Yuliantoro, Eskasari Putri

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Characterization and comparative profiling of piRNAs in serum biopsies of pediatric Wilms tumor patients by Fatma S. Mohamed, Deena Jalal, Youssef M. Fadel, Samir F. El-Mashtoly, Wael Z. Khaled, Ahmed A. Sayed, Mohamed A. Ghazy

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Comparative Proteomic Analysis of Popcorn Genotypes Identifies Differentially Accumulated Proteins Associated with Resistance Pathways to Southern Leaf Blight Disease by Caio Cézar Guedes Corrêa, Tatiana Santos Barroso, Lucas Rodrigues Xavier, Vitor Batista Pinto, Ricardo Souza Reis, Guilherme Ferreira Pena, Claudete Santa-Catarina, Marcelo Vivas, Antonio Teixeira do Amaral Júnior, Vanildo Silveira

“…These results offer valuable insights into breeding programs aimed at developing SLB-resistant popcorn varieties.…”
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Rapid emergence of resistance to broad-spectrum direct antimicrobial activity of avibactam by Michelle Nägeli, Shade Rodriguez, Aimee Iradukunda, Abigail L. Manson, Ashlee M. Earl, Thea Brennan-Krohn

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Elucidating divergent biology in uterine carcinosarcoma by Vikas Garg, Stephenie D. Prokopec, Simone C. Stone, Sara Pakbaz, Min Li Chen, Bernard Lam, Czin Czin Benito, Michelle Mcmullen, Ilinca Lungu, Samanta Del Rossi, Anthony Msan, Valerie Bowering, Valentin Sotov, Christine Tran, Marcus O. Butler, Amit M. Oza, Phedias Diamandis, Ben X. Wang, Stephanie Lheureux

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AWARENESS AND TREATMENT SPECIFICS OF STATIN THERAPY IN PERSONS WITH VARIOUS CARDIOVASULAR RISK: THE STUDY ESSE-RF by S. A. Shalnova, A. D. Deev, V. A. Metelskaya, S. E. Evstifeeva, O. P. Rotar, Yu. V. Zhernakova, S. А. Boytsov, Yu. A. Balanova, N. V. Gomyranova, A. E. Imaeva, A. V. Kapustina, A. V. Kontsevaya, O. A. Litinskaya, M. N. Mamedov, G. A. Muromtseva, R. G. Oganov, E. I. Suvorova, M. B. Khudyakov, E. I. Baranova, A. O. Konradi, E. V. Shlyakhto, V. A. Ilin, R. A. Kasimov, A. A. Shabunova, K. N. Kalashnikov, O. N. Kalachikova, O. A. Kondakova, A. V. Popov, N. A. Ustinova, O. G. Azarin, N. I. Babenko, L. V. Bondartsov, E. V. Minakov, A. E. Khvostikova, G. I. Furmenko, S. V. Nedogoda, A. A. Ledyaeva, E. V. Chumachek, N. V. Kulakova, M. V. Mokshina, V. A. Nevzorova, L. V. Rodionova, N. V. Shestakova, O. A. Belova, O. A. Nazarova, S. V. Romanchuk, O. A. Shutemova, V. S. Kaveshnikov, R. S. Karpov, V. N. Serebryakova, I. A. Trubacheva, A. I. Aristov, Yu. I. Grinshtein, L. K. Danilova, A. A. Evsyukov, D. S. Kaskaeva, A. A. Kosinova, M. M. Petrova, R. R. Ruf, N. V. Topolskaya, V. V. Shabalin, E. N. Shmatova, O. L. Barbarash, G. V. Artamonova, A. E. Skripchenko, E. V. Indukaeva, T. A. Mulerova, S. A. Maksimov, N. V. Cherkass, M. V. Tabakaev, Ya. V. Danilchenko, I. R. Basyrova, E. N. Isaeva, V. Yu. Kondratenko, R. A. Libis, E. A. Lopina, D. V. Safonova, S. K. Gutnova, T. M. Gatagonova, G. V. Tolparov, S. A. Gudkova, D. V. Duplyakov, N. A. Cherepanova, A. Yu. Efanov, I. V. Medvedeva, M. A. Storozhok, V. P. Shava, S. V. Shalaev

“…The data dictates necessity  of development  and implementation of specific educational programs for citizens, of physician improvement and availability of cheap but effective lipid-lowering medications.…”
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Metabolic Profiling Reveals Potential Prognostic Biomarkers for SFTS: Insights into Disease Severity and Clinical Outcomes by Zhuo-Min Zhu, Huan-Yu Liu, Na An, An-Ling Li, Jia Li, Sai-Jun Wang, Gui Yang, Yong-Wei Duan, Ying Yang, Mei Zhang, Quan-Fei Zhu, Song-Mei Liu, Yu-Qi Feng

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Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates by Zikun Tu, Zikun Tu, Haiyan Guo, Haiyan Guo, Yajing Gao, Yajing Gao, Wenfeng Xiao, Wenfeng Xiao, Xueru Xie, Xueru Xie, Hongmiao Yu, Hongmiao Yu, Qiuyan Liang, Qiuyan Liang, Yufeng Zhou, Yufeng Zhou, Yufeng Zhou

“…BackgroundHyperoxia plays a key role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of preterm infants. …”
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Illustrated capsules from the Advanced Course in Platelet Research by Christian Andrea Di Buduo, Vittorio Abbonante, Alessandro Malara, Alessandra Balduini, Amie K. Waller, Steve P. Watson, Eleyna M. Martin, Lloyd Bridge, Jonathan Gibbins, Ingeborg Hers, Claire Masson, Anita Eckly, Natalie S. Poulter, Beatriz Martínez-García, Sonia Aguila, Paolo Gresele, Stefania Momi, Paul Amstrong, Matthew Rondina, Sara Troitiño, Ángel García, José M. Bastida, Ana Marín Quilez, Ana Sánchez Fuentes, José Rivera, Raul Torres-Ruiz, Paula Ojeda-Walczuk, Neil V. Morgan, Belen de la Morena, Kato Ramaekers, My Tran, Koen De Wispelaere, Kathleen Freson, Wolfgang Bergmeier, Andreas Greinacher, Fan He, Stephen Oh, Jorge Di Paola, John W. Semple, María L. Lozano, Pilar Llamas, Chris Ward

“…This unique course focused on new methodologies applied in platelet research and how these are increasing our understanding of platelet formation, their multifunctionality in different physiological and pathological contexts, and contributing to the development of new platelet-targeted therapies to improve the management of hemostatic/thrombotic pathologies. …”
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Harnessing Artificial Intelligence for the Diagnosis, Treatment and Research of Multiple Sclerosis by Manisha S. Patil, Linda Y. Lin, Rachel K. Ford, Elizaveta J. James, Stella Morton, Felix Marsh-Wakefield, Simon Hawke, Georges E. Grau

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The gut-brain-metabolic axis: exploring the role of microbiota in insulin resistance and cognitive function by Gulshara Zh Abildinova, Gulshara Zh Abildinova, Valeriy V. Benberin, Valeriy V. Benberin, Tamara A. Vochshenkova, Tamara A. Vochshenkova, Alireza Afshar, Alireza Afshar, Nadiar M. Mussin, Asset A. Kaliyev, Zhanna Zhussupova, Amin Tamadon, Amin Tamadon, Amin Tamadon

“…Overall, this comprehensive review underscores the significance of the gut-brain-metabolic axis in the pathogenesis and treatment of metabolic and cognitive disorders, offering a promising avenue for the development of novel therapeutic strategies targeting this intricate system.…”
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Immunopathogenesis of Acute Pancreatitis by G. V. Bulava

“…This review will discuss the role of various populations of innate immune cells, including macrophages, neutrophils, dendritic and mast cells, and regulatory immune cells in the pathogenesis of gland tissue destruction and the relationship between immune responses and systemic inflammatory response syndrome. Targeting innate immune cell populations and metabolite signaling pathways in acute pancreatitis may lead to a broader and ultimately more effective redirection of the treatment program towards disease resolution and improved clinical outcomes.…”
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What influences Indian primary school children’s food behaviors? - Perceptions of children, mothers and teachers by Neha Rathi, Prarthana Tiwari, Manisha Kanwar, Anjali Patel, Mukta Singh, Kalpna Gupta, Anthony Worsley

“…Abstract Background Development of healthy food behaviors in childhood is significant for optimum growth and development of children as well as future health. …”
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HIV Preexposure Prophylaxis Practice among Urban Female Sex Workers in Northwest Ethiopia: Using Generalized Structural Equation Modeling by Lakew Asmare MPH, Atalay Goshu MPH, Tihtna Alemu MSc, Ejigu Gebeye MPH

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Pyroptosis in Pulpitis by Wei X, Ran S, Yan X, Huang J, Xue L, He TC, Zhang H, Wu S

“…This review aims to enrich the mechanism under the development of dental pulp inflammation, and to uncover potential therapeutic targets for early alleviation and treatment of pulp inflammation.Keywords: pulpitis, pyroptosis, dental pulp cells…”
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Towards a better protection of human rights through the use of AI and related technologies in budgeting and auditing of public expenditure by María Amparo Grau Ruiz

“… The full potential of many human rights cannot be reached due to the economic costs in their development. The use of artificial intelligence and related technologies in budgetary and audit processes could help in a better allocation of scarce public resources and deliver savings due to better targeting in programming and execution, avoiding irregularities and corruption. …”
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Review on atomistic and quantum mechanical simulation approaches in chemical mechanical planarization by Seokgyu Ryu, Murali Ramu, Patrick Joohyun Kim, Junghyun Choi, Kangchun Lee, Jihoon Seo

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