Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects by Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge, Navnath S. Gavande

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Transcriptome Profiling Unveils the Mechanisms of Inflammation, Apoptosis, and Fibrosis in the Liver of Juvenile Largemouth Bass <i>Micropterus salmoides</i> Fed High-Starch Diets by Xifeng Liu, Hongkang Liu, Kangwei Wang, Chuanjie Qin, Yuanfa He, Li Luo, Shimei Lin, Yongjun Chen

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Unlocking the potential of GLP-1 receptor agonists in ocular therapeutics: from molecular pathways to clinical impact by Zhixuan Xie, Zhixuan Xie, Zhixuan Xie, Zuyi Yang, Zuyi Yang, Zuyi Yang, Dianzhe Tian, Youxin Chen, Youxin Chen

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Unraveling anoikis in glioblastoma: insights from single-cell sequencing and prognostic modeling by Qikai Tang, Chenfeng Ma, Jiaheng Xie, Qixiang Zhang, Bingtao Zhang, Weiqi Bian, Qingyu Lu, Zeyu Wan, Wei Wu

“…Conclusion This study provides insights into the molecular mechanisms of anoikis resistance in GBM, underscoring its critical role in tumor progression and patient prognosis. The developed prognostic model offers a promising tool for personalized treatment strategies and warrants further exploration of targeted therapies to improve outcomes for GBM patients.…”
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In silico studies to understand the interactions of flavonoid inhibitor with nsp12-RNA dependent RNA polymerase of SARS-CoV-2 and its homologs by Shamiya Anwar Kizhakkiniyakath, Tejaswini Choudhury, Madhan Vishal Rajan, Sagar Rathee, Basant Meena, Gururao Hariprasad

“…RNA dependent RNA polymerase of SARS-CoV-2 which is crucial for replication is therefore a potential drug target. Methodology: Based on experimental structures of RdRp from SARS-CoV-2, computational models were generated of its homologs from SARS-CoV-1, MERS and Bat. …”
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FUNDING MECHANISMS FOR IMPLEMENTATION OF MARINE STRATEGY FRAMEWORK DIRECTIVE: EU EXPERIENCE by S. Kniaz, E. Pavlenko, O. Rubel, O. Zavnerchik

“…The main stages of the implementation of Directive 2008/56/EC include: 1) adoption of national legislation and designation the authority or authorities competent for the implementation of this Directive; 2) initial assessment of the current  environmental status of marine waters; determine good environmental status for marine waters and establishment environmental targets and associated indicators; establishment of monitoring program for the development of ongoing assessment and regular updating purposes; 3) development programme of measures to achieve good environmental status. …”
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Discovery and in vitro characterization of a human anti-CD36 scFv by Cecilia Mata-Cruz, Cecilia Mata-Cruz, Sandra L. Guerrero-Rodríguez, Keyla Gómez-Castellano, Gregorio Carballo-Uicab, Juan Carlos Almagro, Juan Carlos Almagro, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, S. Mayra Pérez-Tapia, Marco A. Velasco-Velázquez

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THE CONCEPT OF FORMING EVALUATION AND ANALYTICAL COMPETENCE OF FUTURE TEACHERS OF FOREIGN LANGUAGES by Nataliia V. Maiier

“…Such a concept should become the basis for the development of teaching methods in accordance with the conditions of the organization of the educational process in a higher education institution according to a specific educational program and within the limits of mandatory and/or optional components of the professional and methodological training of future teachers of foreign languages. …”
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Trends in HPV‐associated cancer incidence in Texas medically underserved regions by Thao N. Hoang, Abbey B. Berenson, Yong Shan, Fangjian Guo, Victor Adekanmbi, Christine Hsu, Xiaoying Yu, Yong‐Fang Kuo

“…This indicates that targeted prevention efforts towards these regions, especially in low socioeconomic status communities, may benefit future generations.…”
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Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade by Yu Chen, Yu Guo, Wen Cheng, Jiahao Fan, Jiacheng Li, Jiajia Song, Xiaohai Yang, Kemin Wang, Jin Huang

“…The multifunctional NS incorporate a targeting module for programming aptamers, a response module for programming i‐motif and DNA/RNA hybrid sequences, and a therapeutic module for packaging photosensitizers and PD‐L1 siRNA. …”
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Addressing knowledge, attitude and practice gaps for effective dengue management strategies in Indonesia by Ari Prayitno, Mei Neni Sitaresmi, Bachti Alisjahbana, Bachti Alisjahbana, Carolina Halim, Fauchil Wardati, Mentari Yudiansyach, Sri Rezeki Hadinegoro

“…The GEMKAP study was a cross-sectional electronic survey conducted in September and October 2022, targeting adults aged 21 to 60, recruited through email invitations from an existing web-based panel. …”
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Genome-wide identification, characterization and evolutionary analysis of the pyrroline-5-carboxylate synthetase (P5CS), succinic semialdehyde dehydrogenase (SSADH), and dehydrin (... by Amaal Maghraby, Mohamed Alzalaty

“…These findings offer valuable targets for tomato breeding programs aimed at developing stress-tolerant varieties under changing climate conditions.…”
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The role of education and ethnicity on amenable mortality due to five leading non-communicable diseases among Blacks and Whites in the United States, 1990-2015 by Alberto Barcelo, Fernando A B Colugnati, Maria Pastor-Valero

“… # Conclusions Our analysis showed a strong effect of attained education as a key factor for developing and directing health programs aiming to decrease NCD mortality among predominant US races. …”
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Implementasi Kebijakan Pengembangan Pariwisata Pada Objek Wisata Alam Goa Akbar Di Kabupaten Tuban by Irdina Iffata Qottrunnada, Ananta Prathama

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基于Pro/E弧面凸轮分度装置的3D参数化设计 by 刘韦华, 葛正浩, 黄薇, 蒋萌

“…Taking the globoidal cam indexing device’s center distance and the number of indexing roller as the known factor,parameter relations with all other size are defined.The following research work to the globoidal cam indexing device has been done which is based on Pro/Engineer Wildfire 4.0 as well as its re-development tool called Program.Taking the globoidal cam indexing device as the study object,its working principle,the design method,the type of movement and the structure style are systematically stated.Taking Pro/E as the three-dimensional modeling tool,and also based on re-development tool Program,parametric design of the globoidal cam indexing device and the automatic three-dimensional modeling are realized.To work up the digital prototype as the essential target,it has briefly narrated the basic method that establishes globoidal cam indexing device prototype,the globoidal cam indexing device’s components,assembly as well as the movement simulation’s effects are demonstrated,and its structure composition and the movement principle are really reappeared.…”
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Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases by Zhichao Li, Wenxiang Cheng, Kuanhui Gao, Songlin Liang, Liqing Ke, Mengjie Wang, Jilin Fan, Dandan Li, Peng Zhang, Zhanwang Xu, Nianhu Li

“…Consequently, pyroptosis has become a potential target for preventing and treating DBJDs. Aim of Review: This review explored the physiological and pathological roles of the pyroptosis pathway in bone and joint development and its relation to DBJDs. …”
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Functional analysis of StWRKY75 gene in response to heat stress in potato (Solanum tuberosum L.) by Xi Zhu, Xi Zhu, Xi Zhu, Xiaoqin Duan, Xiaoqin Duan, Yasir Majeed, Yasir Majeed, Junfu Luo, Junfu Luo, Junfu Luo, Nengkang Guan, Nengkang Guan, Nengkang Guan, Haifei Zheng, Haifei Zheng, Haifei Zheng, Huafen Zou, Huafen Zou, Hui Jin, Hui Jin, Zhuo Chen, Zhuo Chen, Yu Zhang, Yu Zhang, Yu Zhang

“…These findings demonstrate that StWRKY75 acts as a positive regulator of potato thermotolerance by enhancing growth, antioxidant capacity, proline metabolism, photosynthesis, and heat-responsive gene expression, providing a valuable target for improving crop heat resilience in breeding programs.…”
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Barriers to physical activity in women from ethnic minority groups: a systematic review by Ana Paula Delgado Bomtempo Batalha, Isabela Roque Marcal, Emilia Main, Gabriela Lima de Melo Ghisi

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Decadal trends and regional disparities in tuberculosis burden: a comprehensive analysis of global, African, and Southeast Asian data from the GBD 1990–2021 by Shiwei Xie, Heng Xiao, Lei Xu, Fan Zhang, Mingwei Luo

“…Statistical analyses were conducted using R software and Joinpoint Regression Program to identify trends in age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR). …”
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Localized policy design for clean heating transitions: a multi-city analysis of renter preferences for energy efficiency by Graeme Troxell, Steve Conrad, Reuven Sussman

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