Trend analysis of rainfall and temperature extremes in the Ginbora watershed, Northern Ethiopia by Semaigzer Ayalew, Alemu Ale, Mandefro Sisay

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Next-generation immunotherapy: igniting new hope for lung cancer by Molly S. C. Li, Andrew L. S. Chan, Kevin K. S. Mok, Landon L. Chan, Tony S. K. Mok

“…However, the vast majority of patients with advanced NSCLC treated with anti-PD-(L)1 still develop therapeutic resistance, and the prognosis after anti-PD-(L)1 resistance is poor. …”
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Collagen-based micro/nanogel delivery systems: Manufacturing, release mechanisms, and biomedical applications by Bowei Du, Shuhan Feng, Jiajun Wang, Keyi Cao, Zhiheng Shi, Cuicui Men, Tengfei Yu, Shiqi Wang, Yaqin Huang, Yuanyuan Ji

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TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models by Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens

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Exploring Ethical, Cultural, and Transnational Competence Among International Healthcare Management Students: An Australian Perspective by Howard M, Tan KL, Jayasekara R

“…This study suggests that international healthcare students need targeted support and training in cultural and ethical competence to prepare for leadership roles in countries like Australia. …”
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Biomethane as a Fuel for Energy Transition in South America: Review, Challenges, Opportunities, and Perspectives by Luís Pedro Vieira Vidigal, Túlio Augusto Zucareli de Souza, Roberto Berlini Rodrigues da Costa, Luís Filipe de Almeida Roque, Gustavo Vieira Frez, Nelly Vanessa Pérez-Rangel, Gabriel Marques Pinto, Davi José Souza Ferreira, Vítor Brumano Andrade Cardinali, Felipe Solferini de Carvalho, João Andrade de Carvalho, Ana Paula Mattos, Juan José Hernández, Christian Jeremi Rodriguez Coronado

“…The findings indicate that biomethane remains largely underdeveloped in most South American countries, primarily due to fragmented data, inadequate infrastructure, and a lack of targeted public policies. Brazil emerges as a regional leader, backed by robust legal frameworks such as the RenovaBio program, the Future Fuel Law, and specific regulations governing landfill waste treatment and biomethane quality standards. …”
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Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

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Territorial obstacles causing early school dropout in Morocco: Multivariate spatial analysis by Aomar Ibourk, Soukaina Raoui

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Highly Curated and Reliable E-Probes for Detection of Viral Pathogens in Unassembled High-Throughput Sequencing Datasets from Hops by Ali Pasha, Andres S. Espindola, Heiko Ziebell, Francisco M. Ochoa‐Corona

“…The e-probes developed in this study allow the direct detection of targeted hop viruses and viroids in unassembled HTS datasets. …”
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model and explaining the obstacles to the popularization of women's sports, from the perspective of sports science professors and female employees in Mashhad by Fahimeh Rivadeh, Muhammad Ali Qara, Elham Karimi Torghabeh, Raheleh Kardovani, Shabnam Olomi, Farideh Hashemiyan

“…Objective: To provide a model and explain the obstacles to the universalization of women's sports from the point of view of sports science professors and working women in Mashhad and to provide a model that leads to expansion and development.Method: mixed (qualitative-quantitative). …”
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Clinical and economic implications of using daratumubab with lenalidomide in the 1st and 2nd lines of therapy for multiple myeloma patients by О. I. Ivakhnenko, V. V. Ryazhenov, N. A. Falaleeva

“…Partitioned survival model was developed to compare overall survival in the treatment programs of MM patients in the 1st to 3rd lines of therapy. …”
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Single-cell RNA sequencing reveals important role of monocytes and macrophages during mucopolysaccharidosis treatment by Gaohui Zhu, Yue Xie, Li Li, Rong Li, Yihong Sun, Ting Zhou, Yupeng Cun

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OICR-41103 as a chemical probe for the DCAF1 WD40 domain by Serah W. Kimani, Mahmoud Noureldin, Brian Wilson, Laurent Hoffer, Stuart R. Green, Magdalena M. Szewczyk, Héctor González-Álvarez, Mohammed Mohammed, Manuel Chan, Chiara Krausser, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Dhananjay Joshi, Punit Saraon, Brigitte Thériault, Ji Sup Kim, Vijayaratnam Santhakumar, Peter Loppnau, Yanjun Li, Almagul Seitova, Aiping Dong, Taira Kiyota, Tobias Hammann, Paul Gehrtz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Paras Jagodra, Peter J. Brown, Ahmed Aman, Jailall Ramnauth, Gennady Poda, David Uehling, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Richard Marcellus, Suzanne Ackloo, Ahmed Mamai, Rima Al-awar, Levon Halabelian

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New Fuzzy Implication Model Consisting Only of Basic Logical Fuzzy Connectives by Stefanos Makariadis, Eleftherios Makariadis, Avrilia Konguetsof, Basil Papadopoulos

“…Moreover, a computer program has been developed to display various interpretations of the proposed model and allow the readers to form a deeper understanding of the paper’s research. …”
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Differences of Maternal Sociodemographic Characteristics with Term and Preterm Birth Among 17 Hospitals In South Sulawesi by Sriyana Herman, Syamsuriati, Rika Handayani, Julia Fitrianingsih, Alanti, Andriani, Mariani Marzila, Eka Lestari, Rusli

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Relationship between early neurological function and motor skills in Brazilian preterm infants: a cross-sectional study by Wendy Gabrielle Franca de Sousa, Ana Luiza Righetto Greco, Maja de Medeiros, Alicia Jane Spittle, Cibelle Kayenne Roberto Formiga

“…Thus, monitoring their development is needed for early detection and targeted intervention. …”
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Seroprevalence and Molecular Analysis of Bovine Leukemia Virus in Kazakhstan by Saltanat Mamanova, Ainur Nurpeisova, Elvira Bashenova, Saira Kaimoldina, Vladimir Kirpichenko, Perizat Akshalova, Aiken Karabassova, Malik Yussupov, Akzhigit Mashzhan, Dauriya Tazhbayeva, Zhandos Abay, Marzena Rola-Luszczak, Jacek Kuzmak, Raikhan Nissanova, Markhabat Kassenov

“…Validation of a domestically developed AGID diagnostic kit showed full concordance with commercial assays (IDEXX, IDvet), supporting its use in national surveillance programs. …”
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Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo. by Mohamed Abdel-Mohsen, Xutao Deng, Ali Danesh, Teri Liegler, Evan S Jacobs, Andri Rauch, Bruno Ledergerber, Philip J Norris, Huldrych F Günthard, Joseph K Wong, Satish K Pillai

“…<h4>Conclusions</h4>The specific reduction of miR-422a is associated with exogenous IFN-α treatment, and likely contributes to the IFN-α suppression of HIV-1 through the enhancement of anti-HIV-1 restriction factor expression and regulation of genes involved in programmed cell death. Moreover, our regulatory network analysis presents additional candidate miRNAs that may be targeted to enhance anti-HIV-1 restriction factor expression in vivo.…”
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Parent–child shared book reading challenges and facilitators: a systematic review and meta synthesis by Jiaopeng Nan, Yin Tian

“…BackgroundParent–child shared book reading is a foundational activity that supports children’s literacy development, including language skills, cognitive growth, and social–emotional competencies. …”
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A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells. by Johnny R Ramroop, Mary Ellen Heavner, Zubaidul H Razzak, Shubha Govind

“…These results help explain why the lymph gland is specifically and precisely targeted for destruction. The parasite's simultaneous and multipronged approach to block cellular immunity not only eliminates blood cells, but also tactically blocks the genetic programming needed for supplementary hematopoietic differentiation necessary for host success. …”
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