Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling by Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Rui Manuel Reis, Renato Jose da Silva-Oliveira, Renato Jose da Silva-Oliveira

“…Proliferation was analyzed in real-time by xCELLigence; protein profiles were quantified by protein arrays; and mRNA expression profile was measured using the PanCancer Pathways panel by NanoString. …”
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Research on Outdoor Thermal Comfort Strategies for Residential Blocks in Hot-Summer and Cold-Winter Areas, Taking Wuhan as an Example by Yongkuan Li, Yuchen Zeng, Wenyu Tu, Guang Ao, Guiyuan Li

“…Sixteen morphological prototypes were developed by combining four building layout typologies (arrayed, staggered, enclosed, and hybrid) with three critical variables: the height-to-width ratio (HWR), building orientation deviation angle (θ), and sky visibility factor (SVF). …”
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Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover studyResearch in context by Ebenezer O. Chinedu-Eneh, Sharon Chiang, John P. Andrews, Ehsan Tadayon, Joline M. Fan, Paul A. Garcia, Ernesto Gonzalez-Giraldo, Manu Hegde, Patrick Hullett, Vikram R. Rao, Robert C. Knowlton, Edward F. Chang, Jonathan K. Kleen

“…Accurate delineation requires anatomical detail yet influences of intracranial electrode density on clinical variables have not been systematically studied. Methods: In this experimental study we compared SOZ localisation between spontaneously captured seizures on higher-density depth and grid electrode arrays (4–5 mm inter-electrode spacing) vs. lower-density resampled versions of those same seizures (8–10 mm spacing). …”
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Prediction efficiency and incremental processing strategy during spoken language comprehension in autistic children: an eye-tracking study by Zihui Hua, Tianbi Li, Ruoxi Shi, Ran Wei, Li Yi

“…Autism symptom severity and autistic traits varied systematically with prediction efficiency, with autism-related communication difficulties showing the strongest associations. …”
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CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation by He Fang, Ana R. Tronco, Giancarlo Bonora, Truong Nguyen, Jitendra Thakur, Joel B. Berletch, Galina N. Filippova, Steven Henikoff, Jay Shendure, William S. Noble, Zhijun Duan, Christine M. Disteche, Xinxian Deng

“…We found that six constitutive and two facultative escapees are located inside 30-800 kb domains marked by convergent arrays of CTCF binding sites, consistent with the formation of chromatin loops. …”
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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. …”
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