Factors affecting hematological parameters in Creole goats on the Southern Coast of Peru by Jhony Soca, Emmanuel Alexander Sessarego, Pamela Sarmiento, María José Cevallos-Cardenas, Juan Canchino-Gutierrez, Jose Teran, Jose Antonio Ruiz, Juancarlos Cruz-Luis, Danny Julio Cruz

“…This study aimed to evaluate the effects of location, feeding regimen, age, and body condition score (BCS) on hematological parameters in Creole goats reared under extensive systems on the southern coast of Peru and to establish context-specific reference values. …”
Get full text

Dosimetric impact of different CT-to-RED curves on plans calculated using Eclipse TPS by Haydar Hamza Alabedi, Ibrahim H. Alnidawi, Islam Tarek Mahmoud Mustafa, Abdelrahman Mosallam, Belal Z. Hassan, Amr Shahin, Mohammed Sallah

“…Results A total of 45 volumetric modulated arc therapy plans for different clinical cases, including 15 brain, 15 breast, and 15 rectal patients, were recalculated using different CT-to-RED calibration curves for the two phantoms, in addition to the default curve implemented in the Eclipse Treatment Planning System. …”
Get full text

Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights by Yonglian Wang, Shuxia Jiang, Yaoxuan He, Ping Pang, Hongli Shan

“…Furthermore, recent advancements and innovative strategies in ALA-based derivatives and drug-delivery systems are summarized, emphasizing their potential to address complex diseases and the necessity for further translational studies. …”
Get full text

Multi-Target Mechanism of Compound Qingdai Capsule for Treatment of Psoriasis: Multi-Omics Analysis and Experimental Verification by Qiao Y, Li C, Chen C, Wu P, Yang Y, Xie M, Liu N, Gu J

“…Despite its efficacy, the molecular mechanisms underpinning its therapeutic action remain unclear.Purpose: This study aimed to unravel the molecular mechanism of Compound Qingdai Capsule for psoriasis based on the psoriasis pathogenic pathway network, integrating multi-omics analysis, systems pharmacology, machine learning modeling, and animal experimentation.Methods: Psoriasis pathogenic pathway network was constructed through employing bioinformatics analysis and psoriasis-related multi-omics data mining. …”
Get full text

Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE by Xiaodi Chu, Shuya Li, Yueying Wang, Dazhen Guo, Nana Zhao, Yuanyuan Han, Qian Xing

“…BackgroundIncreased intestinal permeability and altered intestinal microbiota may influence cytokine regulatory immunity in systemic lupus erythematosus (SLE). This study aimed to elucidate the relationship between intestinal flora alters and follicular helper T cells (Tfh), regulatory T cells (Treg) cells, and cytokines in SLE.MethodsIn total, 23 patients with active SLE (SLE-A group), 18 patients with stable SLE (SLE-nA group), and 24 healthy controls (HC group) were enrolled. …”
Get full text

Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers by Claudio Díaz-García, Elena Moreno, Alba Talavera-Rodríguez, Lucía Martín-Fernández, Sara González-Bodí, Laura Martín-Pedraza, José A. Pérez-Molina, Fernando Dronda, María José Gosalbes, Laura Luna, María Jesús Vivancos, Jaime Huerta-Cepas, Santiago Moreno, Sergio Serrano-Villar

“…Abstract Background Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity and mortality. …”
Get full text

Eudragit® EPO, modified with 4-phenylboronic acid groups, as a novel polymeric excipient with enhanced mucoadhesive properties by D. S. Gordeeva, S. F. Nasibullin, A. G. Karpov, V. V. Khutoryanskiy, R. I. Moustafine

“…The proposed chemical modification of Eudragit® EPO with a phenylboronic acid derivative, due to the presence of hydroxyl groups in their structure, leads to additional interaction with mucin oligosaccharides, providing enhanced mucoadhesive properties of this polymer.Aim. Synthesis and study of a chemically modified Eudragit® EPO using 4-bromophenylboronic acid in order to increase the mucoadhesive properties of the copolymer for use in transmucosal drug delivery systems.Materials and methods. …”
Get full text

Clinical and Economic Evaluation of a Real-Time Chest X-Ray Computer-Aided Detection System for Misplaced Endotracheal and Nasogastric Tubes and Pneumothorax in Emergency and Criti... by Chu-Lin Tsai, Teresa Cheng-Chieh Chu, Chih-Hung Wang, Wei-Tien Chang, Min-Shan Tsai, Shih-Chi Ku, Yen-Hung Lin, Hao-Chih Tai, Shuenn-Wen Kuo, Kuo-Chuan Wang, Anne Chao, Sung-Chun Tang, Wei-Lun Liu, Ming-Han Tsai, Ting-Ann Wang, Shu-Lin Chuang, Yi-Chia Lee, Lu-Cheng Kuo, Chiuan-Jung Chen, Jia-Horng Kao, Weichung Wang, Chien-Hua Huang

“…The National Taiwan University Hospital research team previously developed an AI-based emergency CXR system (Capstone project), which led to the creation of a CXR module. …”
Get full text

TEAD4 Transcriptionally Activates TRIB3 to Induce Ferroptosis Resistance through the MEK/ERK Signaling Pathway in Colorectal Cancer by Jianguo Wang, Xiangbo Wu

Get full text

Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery by Yang Li, Yang Li, Xiao-meng Li, Li-si Wei, Jun-feng Ye

“…This has propelled the development of nanomedicines aimed at precise mitochondrial targeting to modulate their function, marking a research hotspot. …”
Get full text

AI-Driven Adaptive Communications for Energy-Efficient Underwater Acoustic Sensor Networks by A. Ur Rehman, Laura Galluccio, Giacomo Morabito

Get full text

A Review of Emerging Neoadjuvant Intravesical Strategies to Enhance Systemic Immune Checkpoint Blockade in Patients With Cisplatin-Ineligible Muscle-Invasive Bladder Cancer Through... by Hye Won Lee, Hyun Hwan Sung

“…This review aims to summarize the mechanistic rationale and ongoing clinical trials involving novel neoadjuvant strategies combining intravesical TAR-200 or CG0070 with systemic ICIs for patients with cisplatin-ineligible MIBC, particularly focusing on the induction of immunogenic cell death and the development of tertiary lymphoid structures.…”
Get full text

Fatigue Mechanisms and their Implications in Hypertrophy: A Review by Benjamin Cleary

“…These fatigue mechanisms can be split into central and peripheral nervous system. Fatigue physiology plays a key role in potentially modulating muscle fiber hypertrophy however they are seldom discussed together. …”
Get full text

A Study on the Consistency and Efficiency of Student Performance Evaluation Methods: A Mathematical Framework and Comparative Simulation Results by Cecilia Leal-Ramírez, Héctor Alonso Echavarría-Heras, Enrique Villa-Diharce, Horacio Haro-Avalos

“…This paper addresses the critical need for consistent student evaluation methods, with a primary focus on ensuring mathematical consistency within grading systems. Methods: We propose a scheme aimed at identifying inconsistencies in student evaluation related to the mathematical framework of the used grading method. …”
Get full text

Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities by Xinyi Lv, Xinyi Lv, Shengguang Ding

“…This review provides a comprehensive overview of the molecular mechanisms by which STAT3 contributes to cancer cachexia and discusses emerging therapeutic strategies aimed at modulating STAT3 activity to mitigate the progression of this debilitating syndrome.…”
Get full text

Clostridium Butyricum 337279 shapes the gut microbiota to attenuate metabolic disorder in diet-induced obese mice by Xuejiao Zhang, Zhiyu Li, Junjun Cao, Haipeng Sun, Wenyan Niu

“…AimsObesity is one of the important challenges to public health worldwide. …”
Get full text

MNEMOSINE: A Modular Framework to Monitor Interaction in Multimodal Interactive Spaces by Fabio Barros, Bernardo Marques, Antonio Teixeira, Samuel Silva

“…This aims to enhance the understanding and supervision of interactions within multimodal systems and can, in turn, foster improved system development and refinement, subsequently supporting the integration of increasingly multimodal systems into daily life.…”
Get full text

A Compact Solar Thermic Cooking Solution: Design Validation and Performance Analysis by R. Jegadeeshwaran, K. Sudhan, G. Sakthivel, D. Saravana Kumar, S. Abirami, T. Nathezhtha, Y. S. Govardhan, P. Manickavasagam

“…The device utilizes a fluid-based heat transfer system, incorporating molten salt or mineral oil, and operates using four key modules: 1) a solar thermal concentrating system, 2) a thermal exchanger, 3) a heat dissipater, along 4) thermal Reservoir, utilizing a Fresnel lens-based Concentrated Solar Power (CSP) technique for energy conversion. …”
Get full text

Polycomplex Carrier for Buccal Mucoadhesion Delivery of Metronidazole by R. I. Moustafine, V. V. Budnikov, S. G. Abdullina, Sh. F. Nasibullin, R. A. Saleev

“…It should be noted that one of the advantages of buccal systems compared with oral ones is the absence of the «first pass effect» through the liver.Aim. …”
Get full text

An approach for 5G implementation in railways based on orthogonal time frequency space by Rouz Salih Almabrouk, Ibrahim M. M. Mohamed

“…We referred to this solution as the OTFS-based 5G-R system. In order to verify the effectiveness of the proposed solution, we compare its performance with that based on OFDM in different HSR environments using quadrature amplitude modulation (QAM) schemes. …”
Get full text