Frizzled-7-targeting antibody-derived bifunctional protein retargets NK cells against triple-negative breast cancer cells via MICA-NKG2D axis by Lin Yang, Tong Wang, Wei Xie, Jin Wang, Jing Xu, Hao Yang, Gang Huang, Haiyan Xie, Xiaofei Zhang, Danfang Li, Xingxing Li, Qingqing Huang, Chenyue Wang, Lisha Wu, Shuyang Mao, Zitong Wang, Yuxia Liu

“…To reestablish MICA/NKG2D-mediated immunosurveillance, we proposed the design of a fusion protein (SHH002-hu1-MICA) which consists of Frizzled-7 (Fzd7)-targeting antibody and MICA, serving as an engager retargeting NK cells against TNBCs, especially TNBCSCs.Methods Opal multicolor immunohistochemistry staining was used to validate the expression of membrane MICA (mMICA) and existence of NK cells in TNBC tumors; flow cytometry (FCM) assay was used to detect the expression of Fzd7/mMICA on TNBCs. Biolayer interferometry (BLI) and surface plasmon resonance (SPR) assays were executed to assess the affinity of SHH002-hu1-MICA towards rhFzd7/rhNKG2D; near-infrared imaging assay was used to evaluate the targeting capability. …”
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Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease by Romain Castelot, Aline Zarea, David Wallon, Anne Rovelet-Lecrux, Catherine Schramm, Muriel Quillard-Muraine, Anne Beaume, Frédéric Blanc, Olivier Bousiges, Julien Dumurgier, Maïté Formaglio, Gwenael Leguyader, Sylvain Lehmann, Cecilia Marelli, Matthieu Martinet, Leonor Nogueira, Jérémie Pariente, Isabelle Quadrio, Adeline Rollin-Sillaire, Susanna Schraen, Gaël Nicolas, Magalie Lecourtois

“…SorLA can be subject to proteolytic shedding at the cell surface, leading to the release of the soluble ectodomain of the protein (sSorLA) in the extracellular space. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Objectives: G protein-coupled receptors (GPCRs) are the most druggable targets in biology due to their cell-type specificity, ligand binding, and cell surface accessibility. Underscoring this, agonists for GPCRs have recently revolutionized the treatment of diabetes and obesity. …”
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Effects of direct moxibustion on antigen-presenting cells in gastric tissue of rat models with gastric cancer: Understanding the immunological mechanisms by Tian-yu GAO, Fei-cheng ZHANG, Ru-fang PAN, Shu-ya MA, Xiao-qi ZHANG, Li-jia PAN, Chun-sheng JIA

“…Immunohistochemistry (IHC) and a western blotting were used to detect the expression levels of CD80 and CD86 in gastric tissues. …”
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Study on Impact Excitation and System Dynamic Characteristics of Shield Machine Planetary Gear Train by Zeyin HE, Hongjian WU, Zhen YANG, Feng YI, ShiFeng PEI

“…The contact force between a single pair of tooth surfaces was extracted, and the rationality of the analysis model was verified through comparison. …”
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A study on toxicity, local irritative effect of and allergic response to a novel intranasal medication containing N-phenylacetyl-L-prolylglycine ethyl ester by B. S. Burlaka, I. F. Bielenichev

“…No visible reactions were detected in the experimental animals after 20 more skin applications of the intranasal gel containing N-phenylacetyl-L-prolylglycine ethyl ester during 4 weeks (5 times per week). …”
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Effects of moxibustion at different temperature on wound healing and apoptosis in rats with pressure ulcer based on PI3K/AKT/mTOR signal pathway by Hong PAN, Ying-Bo XI, Jin DING, Qin YIN, Hui-Qin XUE, Hai-Yu YUE

“…The paperless temperature recorder probe was placed on the wound surface where moxibustion was delivered, and the real-time temperature was monitored and adjusted, kept at (42 ± 1) °C. …”
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The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…Carbon disequilibrium chemistry strongly shapes the mid-infrared spectra of these sources, as a complex function of the metallicity and surface gravity. While a larger library of JWST/NIRSpec spectra is needed to conclusively examine the peculiarities of blended-light sources, this spectral binary is a crucial pathfinder to both understand the spectral features of planetary-mass atmospheres and detect binarity in unresolved, moderate-resolution spectra of the coldest brown dwarfs.…”
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Ground-based Characterization of (98943) Torifune 2001 CC21, the Target of the Hayabusa2# Space Mission by Marcel M. Popescu, Eri Tatsumi, Javier Licandro, Miguel R. Alarcon, Javier Rodríguez Rodríguez, Miquel Serra-Ricart, Julia de León, Joaquín Fernandez Martin, David Morate, Gabriel N. Simion, Bogdan Alexandru Dumitru, Daniel Nicolae Berteşteanu, George Pantelimon Prodan, Masatoshi Hirabayashi

“…The spectral data indicate a surface affected by moderate space weathering effects.…”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…The nanoLC-Obitrap-MS technology was utilized to detect the content of selected small molecules with differential metabolic activity in the hippocampus and mitochondria of mice to evaluate their permeability through the blood-brain barrier (BBB) and outer mitochondrial membrane. …”
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Biocrust recovery improves soil fertility after 10-year sand-fixation using reed checkerboard barriers on reshaped dunes in an arid sandy desert in central Asia by Yue Zhang, Qi-Wei Li, Wei-Wei Zhuang, Ye Tao, Xiao-Bing Zhou, Yuan-Ming Zhang

“…Consequently, in the early stage of sand-fixation (e.g., < = 10 years) by reed checkerboards on the damaged desert surface, BSC recovery can well promote and predict soil fertility in this area. …”
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Selective Dissolution of Clay Minerals in Tight Sandstone by Organic Acids by Fei YANG, Zhichao SHEN, Jiangmin DU, Fang WANG, Bo DONG

“…However, the heterogeneity of tight sandstone reservoirs is strong, and its complex mineral components and pore structure characteristics differ greatly; it has a higher content of clay minerals, and during the diagenesis process, clay minerals often precipitate on the rigid particle surface of the pore inner wall as authigenic minerals. …”
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Efficacy of Alginate-Antacid Medication in the Treatment of Patients with Gastroesophageal Reflux Disease by O. A. Storonova, A. S. Trukhmanov, V. T. Ivashkin

“…After a meal and before the administration of alginate-antacid medication, the layer of unbuffered acidic gastric juice (pH &lt; 2) was detected in the proximal stomach of 9 patients (90 %). …”
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Study on the theoretical and mechanism of CaF₂-catalyzed vacuum carbothermal reduction of MgO by Tingzhuang Ma, Bin Yang, Yang Tian, Neng Xiong, Baoqiang Xu, Guozheng Zha, Rong Yu, Dong Liang, Lipeng Wang, Dong Wang

“…Notably, while CaF₂ remained in the residue, it was not detected in the condensate, confirming its catalytic role. …”
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A Large Molecular Gas Reservoir in the Protocluster SPT2349−56 at z = 4.3 by Dazhi Zhou, Scott C. Chapman, Nikolaus Sulzenauer, Ryley Hill, Manuel Aravena, Pablo Araya-Araya, Jared Cathey, Daniel P. Marrone, Kedar A. Phadke, Cassie Reuter, Manuel Solimano, Justin S. Spilker, Joaquin D. Vieira, David Vizgan, George C. P. Wang, Axel Weiss

“…\limits^{\unicode{x02033}}$ 2) reveal a 75% excess CO(4–3) flux compared to the sum of individual sources detected in higher-resolution Atacama Large Millimeter/submillimeter Array (ALMA) data (1 $\mathop{.}…”
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A Detailed Single-pulse Study of Four-component Pulsar PSR J1239+0326 Discovered by FAST by R. Rejep, W. W. Zhu, N. Wang, W. M. Yan, J. P. Yuan, M. Kramer, L. Q. Meng, E. Gügercinoğlu, M. Yuan, W. Y. Wang, Z. W. Wu, Q. D. Wu, D. Zhao, S. Q. Wang, H. M. Tedila, S. J. Dang, M. Y. Xue, P. Wang, The FAST Collaboration

“…This two-mode modulation could result from the combination of sub-pulse drifts and the feedback between the voltage difference across the polar gap and surface thermal emission by backflowing charges.…”
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Microfacies, depositional environment and carbonate association of the Asmari Formation in Tang-e-Gojestan by Yadolah Ezampanah, Mohammad Goodarzi

“…The upper contact of the formation with the Gachsaran is covered and could not be detected. Whereas in the adjacent outcrops in the Eshgar Anticline, the Gachsaran Formation overlies the Asmari Formation (Zare et al. 2019). …”
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Effects of cinnamic acid treatment on aroma of Kyoho grape during low temperature storage by HU Yulong, TIAN Shufen, WANG Chaoxia, WANG Rong, MA Chuang, JIANG Jianfu

“…At 0, 7, and 14 of storage, the advanced headspace solid-phase microextraction technology combined with gas chromatography-mass spectrometry (HSSPME/GC-MS) was used to detect and analyze the volatile compounds released by the berries. …”
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Study on factors affecting fruit development of seedless ponkan cultivar Huagan No.4 by LIU Chenglang, LI Gangqiu, LI Shunxin, WEI Ranran, LU Yan, CHENG Chao, TANG Zheng, LIU Baoyan, YE Junli, CHAI Lijun, DENG Xiuxin, XIE Zongzhou

“…The paraffin section was used for observing the fruit development, sequencing transcriptome was performed to detect the difference of the gene expression between the two varieties. …”
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TOI-6324 b: An Earth-mass Ultra-short-period Planet Transiting a Nearby M Dwarf by Rena A. Lee, Fei Dai, Andrew W. Howard, Samuel Halverson, Jonathan Gomez Barrientos, Michael Greklek-McKeon, Heather A. Knutson, Benjamin J. Fulton, Guđmundur Stefánsson, Jack Lubin, Howard Isaacson, Casey L. Brinkman, Nicholas Saunders, Daniel Hey, Daniel Huber, Lauren M. Weiss, Leslie A. Rogers, Diana Valencia, Mykhaylo Plotnykov, Kimberly Paragas, Renyu Hu, Te Han, Erik A. Petigura, Ryan Rubenzahl, David R. Ciardi, Aaron Householder, Gregory J. Gilbert, J. M. Joel Ong, Jingwen Zhang, Jacob Luhn, Luke Handley, Corey Beard, Steven Giacalone, Rae Holcomb, Judah Van Zandt, Ashley D. Baker, Max Brodheim, Matt Brown, David Charbonneau, Karen A. Collins, Ian J. M. Crossfield, William Deich, Xavier Dumusque, Steven R. Gibson, Emily Gilbert, Grant M. Hill, Bradford Holden, Jon M. Jenkins, Stephen Kaye, Russ R. Laher, Kyle Lanclos, W. Garett Levine, Joel Payne, Alex S. Polanski, John O’Meara, George R. Ricker, Kodi Rider, Paul Robertson, Arpita Roy, Joshua E. Schlieder, Christian Schwab, Sara Seager, Abby P. Shaum, Martin M. Sirk, Stephanie Striegel, Johanna Teske, John Valliant, Roland Vanderspek, Gautam Vasisht, Josh Walawender, Sharon Xuesong Wang, Joshua N. Winn, Edward Wishnow, Sherry Yeh

“…From seven sectors of TESS data, we report a tentative detection of the optical phase-curve variation with an amplitude of 42 ± 28 ppm.…”
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