Neuronal substrates underlying stress resilience and susceptibility in rats. by Fabia Febbraro, Katrine Svenningsen, Thao Phuong Tran, Ove Wiborg

“…Six areas, all of which represents limbic structures, were found to be sensitive to stress exposure. …”
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Emerging per- and polyfluoroalkyl substance perfluoro-(3,5,7,9-tetraoxadecanoic) acid (PFO4DA) impairs steroidogenesis and spermatogenesis by suppressing StAR and CYP11A1 expressio... by Lutefei Mutalifu, Wei Xie, Danyang Wang, Mengxue Zhi, Yong Guo, Jianshe Wang

“…Mechanistic analysis revealed that PFO4DA significantly repressed the expression levels of steroidogenic genes StAR and CYP11A1 both in testes and in cultured Leydig cells (TM3). …”
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Divergent Mechanisms of H2AZ.1 and H2AZ.2 in PRC1-Mediated H2A Ubiquitination by Xiangyu Shen, Chunxu Chen, Amanda E. Jones, Xiaokun Jian, Gengsheng Cao, Hengbin Wang

“…In contrast, H2AZ.2 does not significantly affect Ring1B recruitment but instead functions as a structural component that stabilizes H2AK119ub-modified nucleosomes. …”
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Genome-wide identification of TCP transcription factors and functional role of UrTCP4 in regulating terpenoid indole alkaloids biosynthesis in Uncaria rhynchophylla by Xinghui Liu, Yingying Shao, Detian Mu, Yu Zhou, Jialong He, Huan Zhao, Iain W. Wilson, Yao Zhang, Lina Zhu, Deyou Qiu, Qi Tang

“…Dual luciferase assays revealed the UrTCP4 protein could activate or repress the transcription of UrLAMT and Ur7-DLH in the TIAs synthesis pathway. …”
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Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…Under dual stress, protein synthesis and lipid metabolism were further repressed, and immune-related gene expression was markedly up-regulated. …”
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14-3-3 proteins inhibit autophagy by regulating SINAT-mediated proteolysis of ATG6 in Arabidopsis by Ting Liu, Yuping Zheng, Shunkang Zhou, Yao Wang, Xue Lei, Lijuan Xie, Qingqi Lin, Changqing Chang, Shi Xiao, Rongliang Qiu, Hua Qi

“…Furthermore, our investigation unveiled the involvement of 14-3-3λ and 14-3-3κ in the RING finger E3 ligase SINAT1-mediated ubiquitination and destabilization of ATG6 in vivo. We also observed repressed turnover of ATG6 and translocation of GFP-ATG6 to mCherry-ATG8a-labelled punctate structures in the autophagy-defective mutant, which suggesting that ATG6 is probably a target of autophagy. …”
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HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis by Jie Yu, Bing Guo, Fan Zhang, Miao Liu, Ying Xie, Hui-mei Zou, Yuan-yuan Ruan, Xiao-min An, Pei-lei Chen, Ying-qin Luo, Ming-jun Shi, Li-fen Xu

“…In contrast, HNF1-β inhibition exacerbated renal dysfunction and structural damage in MRL/lpr mice. Interestingly, HNF1-β inhibition transcriptionally repressed ERP44, leading to calcium ions (Ca²+) release-mediated disruption and inactivation of the Derlin-1/VCP/VIMP complex. …”
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