Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders by Hailin Wang, Ying Yang, Ziwei Ni, Xiaoting Qiao, Yaqian Guo, Xiaomin Wang, Duo Cao, Yayun Wang, Cailian Ruan

“…This review aims to elucidate the structure and molecular functions of the BCL11 gene family, discuss its impact on the development of the central nervous system, and explore its association with neurodevelopmental disorders.…”
Get full text

Epigenetic analysis of KSHV latent and lytic genomes. by Zsolt Toth, Dennis T Maglinte, Sun Hwa Lee, Hye-Ra Lee, Lai-Yee Wong, Kevin F Brulois, Stacy Lee, Jonathan D Buckley, Peter W Laird, Victor E Marquez, Jae U Jung

“…The genomic region encoding the IE genes ORF50 and ORF48 possesses the features of a bivalent chromatin structure characterized by the concomitant presence of the activating H3K4me3 and the repressive H3K27me3 marks during latency, which rapidly changes upon reactivation with increasing AcH3 and H3K4me3 marks and decreasing H3K27me3. …”
Get full text

sRNA Sequencing of Dahlia Bicolor Petals Revealed the Post-Transcriptional Regulation of Anthocyanin Biosynthetic Pathway by Jiuchun Zou, Xiaoshuang Wu, Shuyan Li, Mengqing Liu, Yuyu Chen, Haoran Wang, Xue Tao

“…Previous studies on the anthocyanin biosynthetic pathway (ABP) observed that the miR156-SPL9 module contributes to the formation of white tips on dahlia petals by repressing the MYB-bHLH-WDR complex. In this study, we further detected the potential post-transcriptional regulation involved in the bicolor petal formation by the small RNA sequencing of red bases and white tips. …”
Get full text

The Intersection of Religion, Public Policy, and Women's Online Activism in Sri Lanka and Afghanistan: A Comparative Analysis by Debasish Nandy, Ananta Kumar Besra

“…Research Implications and Contributions: The study highlights the necessity of addressing structural barriers to enhance women’s digital participation. …”
Get full text

The Toxic Masculinity Scale: Development and Initial Validation by Steven Michael Sanders, Claudia Garcia-Aguilera, Nicholas C. Borgogna, John Richmond T. Sy, Gianna Comoglio, Olivia A. M. Schultz, Jacqueline Goldman

“…Exploratory factor analysis indicated a five-factor structure (i.e., Masculine Superiority, Gender Rigidity, Emotional Restriction, Repressed Suffering, Domination and Desire). …”
Get full text

Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation. by J Carlos Villaescusa, Claudia Buratti, Dmitry Penkov, Lisa Mathiasen, Jesús Planagumà, Elisabetta Ferretti, Francesco Blasi

“…The homeodomain factor Bicoid (Bcd) has been shown to interact with 4EHP (eukaryotic translation initiation factor 4E homolog protein) to repress translation of Caudal mRNA and to drive Drosophila embryo development. …”
Get full text

Legal Protection for Female Victims of Electronic-based Sexual Violence (EBSV): A Legal System Theory Perspective by Nur Alfy Syahriana, Erfaniah Zuhriah, Ahmad Wahidi

“…Then the legal protection for victims is carried out through preventive and repressive efforts. In terms of legal structure, the facilities and infrastructure for handling KSBE cases at WCC Dian Mutiara and the police are not yet fully available. …”
Get full text

Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…Histone acetylation generally promotes a more open chromatin structure conducive to gene activation, while histone methylation can either activate or repress gene expression depending on the specific residue and its methylation state. …”
Get full text

Motives of Freud's essay Das Unheimliche in the collection of stories Žena koja zaustavlja satove by Kornelije Kvas by Lazić-Gavrilović Aleksandra M.

“…However, when Freudian psychoanalysis and the essay The Uncanny are incorporated into the interpretation, the hidden (repressed) meaning of Kvas's book becomes apparent, revealing it not merely as a collection of short stories but as a multi-layered, cohesive work with a novel-like structure.…”
Get full text

Isolation and expression analysis of CsWRKY6, CsWRKY31 and CsWRKY48 genes in tea plant by WANG Pengjie, YUE Chuan, CHEN Di, ZHENG Yucheng, ZHENG Zhilin, LIN Yi, YANG Jiangfan, YE Naixing

“…Phylogenetic tree and protein domain analysis indicated that all of them belong to class Ⅱ WRKY protein, and contained highly conserved DNA-binding domain of WRKYGQK and zinc finger structures. CsWRKY6 and CsWRKY31 shared the same zinc finger structure model of C-X₅-C-X₂₃-H-X-H, whereas CsWRKY48 belonged to C-X₄-C-X₂₃-H-X-H. …”
Get full text

Identification of the U-box gene family in peach (Prunus persica) and functional analysis of PpPUB20 in response to salt stress by Huiwen Zhang, Ruxuan Guo, Xiaoshuang Zhang, Chongyu Zhao, Junkai Wu, Xiao Xiao, Yanhong Shen, Chunsheng Liu, Gang Li, Kai Su, Kun Xiao, Chenguang Zhang, Libin Zhang

“…Multiple genes were induced or repressed by exogenous hormone treatments. Furthermore, Arabidopsis seedlings heterologously overexpressing PpPUB20 exhibited greater salt tolerance than wild-type seedlings under the same salt stress conditions. …”
Get full text

Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

“…Further studies revealed that PS-NPs and Cd synergistically repressed the SIRT3-SOD2/Gpx4 pathway, inducing mitochondrial oxidative stress and ferroptosis, resulting in damage to ovarian structure and function. …”
Get full text

Role of human herpesvirus homologs of infected cell protein 27 (ICP27) in the biogenesis, processing, and maturation of mRNAs by Abel A. Soto-Machuca, Gerardo E. Ortiz, Javier Carbone-Schellman, Ignacio A. Pastén-Ferrada, Angello Retamal-Díaz, Alexis M. Kalergis, Pablo A. González

“…Here, we review and discuss the roles of ICP27 and the corresponding homologs encoded in different human herpesviruses, focusing on their similarities and differences in structure and function. A more profound knowledge of the role of key viral factors required for effective herpesvirus replication could aid in the design and identification of novel antivirals to treat the diseases produced by these viruses.…”
Get full text

PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1 by Wenjing Dai, Qi Yu, Rui Ma, Zhu Zheng, Lingling Hong, Yuqing Qi, Fei He, Min Wang, Feng Ge, Xilan Yu, Shanshan Li

“…How cells transduce extracellular nutrient changes to SAGA structure and function changes remains unclear. Here, we found that SAGA is deacetylated by Rpd3L complex and uncover how its deacetylase activity is repressed by nutrient sensor protein kinase A (PKA). …”
Get full text

Genome-wide identification and characterization of BASIC PENTACYSTEINE transcription factors and their binding motifs in coconut palm by Zifen Lao, Jiali Mao, Runan Chen, Ran Xu, Zhuang Yang, Ying Wang, Junjie Zhou, Zhihua Mu, Hang Xu, Fengmei Li, Dongyi Huang, Yong Xiao, Jie Luo, Wei Xia

“…The dual-luciferase assay showed that CnBPCs could activate or repress the transcriptional activities of promoters containing either (GA)3 or (GA)11 motif but with a bias toward certain genes. …”
Get full text

Effects of ATF2/TSC1 on epilepsy by modulating the microphages polarization of microglia by Wenjiao Huang, Wenli Chen, Zhong Zhao, Lingchun Liu, Yuanyuan Zhao, Xinzhang Chen, Rong Li

“…ATF2 expression was increased in KA-induced HMC3 cells and hippocampal tissues of mouse, while TSC1 expression was repressed. ATF2 knockdown diminished the M1 polarization of KA-induced HMC3 cells, enhanced the M2 polarization, and relieved neuroinflammation in EP mouse. …”
Get full text

Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff by Jun Yang, Yaoyao Lu, Jingjing Yu, Xinhong Cai, Chengzhen Wang, Luchao Lv, Robert A. Moran, Xilin Zhao, Zhengyi Hu, Mingzhen Deng, Jian-Hua Liu

“…We solved the crystal structure of PrfaH and identified the residues that likely mediate interactions with its target. …”
Get full text

PI3K/AKT signaling mediates stress-inducible amyloid formation through c-Myc by Emma Lacroix, Evgenia A. Momchilova, Sahil Chandhok, Mythili Padavu, Richard Zapf, Timothy E. Audas

“…As a recently identified structure, the modulators of A-body biogenesis remain uncharacterized, with the seeding noncoding RNA being the only known regulatory factor. …”
Get full text

The effects of <i>Non3</i> mutations on chromatin organization in <i>Drosophila melanogaster</i> by A. A. Yushkova, A. A. Ogienko, E. N. Andreyeva, A. N. Pindyurin, A. E. Letiagina, E. S. Omelina

“…The nucleolus is a large membraneless subnuclear structure, the main function of which is ribosome biogenesis. …”
Get full text

KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers by Jieying Zhang, Suoyu Xiang, Dan Liu, Xiaomeng Pei, Meng Chen, Yiheng Zhao, Yongbin Wang, Qiong Wang, Lan Kang, Zuoren Yu, Jun Mi, Wujun Xiong

“…Additionally, integrated analysis of ATAC sequencing and RNA sequencing revealed altered chromatin structure during fibroblast activation. CUT-tag sequencing and co-IP assays demonstrate that KDM6A is bound to WDR5, facilitating its association with the COMPASS complex and the polycomb repressive complex at the expected target loci. …”
Get full text