Developing Laterality-Specific Computable Phenotypes from Electronic Health Record Data, Employing Treatment-Warranted Diabetic Macular Edema as a Use Case by Kaili Ding, MBBS, MS, Tracy Z. Lang, BS, Roberta McKean-Cowdin, PhD, Hossein Ameri, MD, PhD, Narsing A. Rao, MD, Brian C. Toy, MD

“…Laterality data completeness was evaluated for each category, independently and in a tiered hierarchical order. …”
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Complementary detection strategies for circulating tumor cells in breast cancer: clinical implications of combining immunofluorescence and cytopathological staining by Tanja Jesenko, Tanja Jesenko, Cvetka Grasic Kuhar, Cvetka Grasic Kuhar, Ziva Pisljar, Ziva Pisljar, Simona Miceska, Simona Miceska, Veronika Kloboves-Prevodnik, Veronika Kloboves-Prevodnik, Veronika Kloboves-Prevodnik, Maja Cemazar, Maja Cemazar, Maja Cemazar

“…The IF staining supported the identity of CTCs detected on Giemsa-stained slides by employing a three-color antibody panel-based approach and allowed detailed phenotypic discrimination and structural analysis of CTCs, including the identification of a distinctive CK polarization pattern suggestive of a transitional state during intravasation.ConclusionGiemsa and IF may thus be complementary rather than mutually exclusive and relying on a single detection approach could underestimate the true CTC burden. …”
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Synthesis of biosafe spirulina-derived carbon dots and their fluorescence imaging in zebrafish by Yue Wang, Zhizhi Gu, Jingyi Dong, Cunguang Liu, Jie Zhu, Zixu Wang, Jiaying Li, Meichen Lu, Jian Han, Shengnan Cao, Zhuang Xue, Yan Chen, Liyong Chen, Wei Wang

“…These CDs possess excellent tissue penetration capabilities and specific accumulation patterns, facilitating clear visualization of anatomical structures. …”
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Development and Assessment of a New Multichannel Electrocutaneous Device for Non-Invasive Somatosensory Stimulation for Magnetic Resonance Applications by Carolina Travassos, Alexandre Sayal, Paulo Fonte, Bruno Direito, Luis Lopes, Nuno Carolino, Sonia Afonso, Tania Lopes, Teresa Sousa, Miguel Castelo-Branco

“…Subsequently, safety and compatibility were evaluated in a 3 Tesla Magnetom Prisma fit scanner using a phantom. …”
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Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India by Thomas Alexander, Jagdish S. Hiremath, Jitendra P. S. Swahney, Subhash Chandra, Peeyush Jain, Praveen Chandra, Nakul Sinha, T. Sashikanth, Yugandhar Bachhu, Anil Balachandran, Pathiyil Balagopalan Jayagopal, T. Govindan Unni, Tiny Nair, Kumaresan Kannan, Dorairaj Prabhakar, M. Chenniappan, Ajay U. Mahajan, Rajiv D. Karnik, Chandrashekhar K. Ponde, Prashant Advani, Idris Ahmed Khan, Brij Mohan Goyal, P. R. Vaidyanathan, Hiren Prajapati, Willem J. Verberk

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Preparation and characterization of stearyl glycyrrhetinate/cyclodextrin complex using co-grinding by Momoko Ebisawa, Nao Kodama, Shun-ichi Mitomo, Junki Tomita, Mitsuaki Suzuki, Yutaka Inoue

“…The molecular interactions within the SG/CD complexes were also investigated using nuclear magnetic resonance (NMR) measurements to determine the mode of interaction. Methods: Here, we evaluated the physicochemical properties of SG complexes with CDs prepared by ground mixtures (GM SG/βCD or γCD = 1/1, 1/2). …”
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Examining the evolution and impact of OTC vending machines in Global Healthcare Systems by Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sahab Alkhoujah, Faris El-Dahiyat, Ammar Ali Saleh Jaber, Sa'ed H. Zyoud

“…Objectives: This study involves a bibliometric quantitative analysis of academic literature to evaluate OTC vending machines in terms of their evolution, current trends, and potential areas for future research. …”
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The study for asthma in older adults: a combined analysis of the effects of occupational asthmagens, high body-mass index and smoking by Jia-Qi Wang, Jia-Qi Wang, Yuan-Yu Liang, Yuan-Yu Liang, Zhong-Xue Zhao, Zhong-Xue Zhao, Wei Xie, Wan-Ning Sun, Wan-Ning Sun, Ji-Yu Zou, Ji-Yu Zou, Xiao-Dong Lv, Xiao-Dong Lv, Youfu He, Li-Jian Pang, Li-Jian Pang

“…Despite global advances in asthma control, little attention has been paid to the evolving composition and geographic disparity of modifiable risk factors in this age group.MethodsWe utilized data from the Global Burden of Disease Study 2021 to evaluate the long-term trends (1990–2021) in asthma burden attributable to high body-mass index (BMI), smoking, and occupational asthmagens among adults aged 60 years and older. …”
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Development characteristics and intelligent identification method of natural fractures: A case study of the Upper Triassic Xujiahe Formation in the western Sichuan Depression, Sich... by LI Wei, WANG Min, XIAO Dianshi, JIN Hui, SHAO Haoming, CUI Junfeng, JIA Yidong, ZHANG Zeyuan, LI Ming

“…The research suggests that structural fractures, diagenetic fractures, and overpressure fractures all develop in the study area. …”
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Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate by Maria Sofia Bertilacchi, Rebecca Piccarducci, Alessandro Celi, Lorenzo Germelli, Chiara Romei, Brian J Bartholmai, Greta Barbieri, Chiara Giacomelli, Claudia Martini

“…Conclusions: Overall, the data reveal a different pattern of activation of blood oxygenation compensatory mechanisms reflecting a different course of the COVID-19 disease specifically focusing on 2,3-BPG modulation.…”
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An Evolutionary Deep Reinforcement Learning-Based Framework for Efficient Anomaly Detection in Smart Power Distribution Grids by Mohammad Mehdi Sharifi Nevisi, Mehrdad Shoeibi, Francisco Hernando-Gallego, Diego Martín, Sarvenaz Sadat Khatami

“…To address these challenges, this study proposes a novel deep reinforcement learning (DRL)-based framework, integrating a convolutional neural network (CNN) for hierarchical feature extraction and a recurrent neural network (RNN) for sequential pattern recognition and time-series modeling. To enhance model performance, we introduce a novel non-dominated sorting artificial bee colony (NSABC) algorithm, which fine-tunes the hyper-parameters of the CNN-RNN structure, including weights, biases, the number of layers, and neuron configurations. …”
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Perspectives on the pH-Influenced Design of Chitosan–Genipin Nanogels for Cell-Targeted Delivery by Julieta D. Glasman, Agustina Alaimo, Cecilia Samaniego López, María Edith Farías, Romina B. Currá, Diego G. Lamas, Oscar E. Pérez

“…Rheological studies and SAXS analysis assessed structural properties. Biocompatibility was evaluated via MTT assay, and internalisation was monitored by fluorescence microscopy on mammalian cell lines. …”
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Pomacea canaliculata hemocyanin as a novel natural immunostimulant in mammals by Ignacio Rafael Chiumiento, Ignacio Rafael Chiumiento, María Alejandra Tricerri, María Alejandra Tricerri, María Fernanda Cortéz, Santiago Ituarte, Santiago Ituarte, Julia Tau, Karina Valeria Mariño, Paola Lorena Smaldini, Horacio Heras, Horacio Heras, Marcos Sebastián Dreon, Marcos Sebastián Dreon

“…This species, known for its high reproductive rate and easy rearing, represents a promising source of potential biomedical compounds, including hemocyanin.MethodsEmploying flow cytometry, fluorescence microscopy, immunoassays, and quantitative PCR, we analysed the effects of PcH on THP-1 monocytes and their derived macrophages, as well as its ability to induce humoral response on C57BL/6 mice. Additionally, we evaluated the structural stability of PcH across a wide range of temperature and pH values.Results and discussionOur findings demonstrate that PcH is a structurally stable protein that not only triggers a pro-inflammatory effect on THP-1 derived-macrophages by increasing IL1-β and TNF-α levels, but also promotes phenotypic changes associated with the monocyte-to-macrophage differentiation. …”
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Strengthening Family Bonds: A Systematic Review of Factors and Interventions That Enhance Family Cohesion by Nicolette V. Roman, Tolulope V. Balogun, Letitia Butler-Kruger, Solomon D. Danga, Janine Therese de Lange, Anja Human-Hendricks, Fundiswa Thelma Khaile, Kezia R. October, Olaniyi J. Olabiyi

“…This systematic review examines global evidence on factors influencing family cohesion and evaluates intervention strategies designed to strengthen familial relationships. …”
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Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach by Zihan Li, Jun Li, Jiahui Li, Mengying Wang, Andi Xu, Yushu Huang, Qi Yu, Lingzhi Zhang, Yingjun Li, Zilin Li, Xifeng Wu, Jiajun Bu, Wenyuan Li

“…Model performance was evaluated using mean absolute error (MAE) against benchmark models, while generalization capability was further validated on an external UK Biobank dataset. …”
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Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment by Rahul Kumar, Kiran Marla, Kyle Sporn, Phani Paladugu, Akshay Khanna, Chirag Gowda, Alex Ngo, Ethan Waisberg, Ram Jagadeesan, Alireza Tavakkoli

“…Technological developments in imaging, including photon-counting detector computed tomography, quantitative magnetic resonance imaging, and four-dimensional computed tomography, have enhanced the ability to visualize structural and dynamic musculoskeletal abnormalities with greater precision. …”
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Data-driven risk assessment of antibiotic mixtures against gram-negative and gram-positive bacteria: QSAR, joint toxic action, and component contribution by Haoyu Sun, Fangyu Xu, Ruijia Luo, Ying Liu, Jiajun Wang, Bo Lei, Liang Tang, Xianjuan Pu, Minghong Wu

“…Within the hormetic phenomena of antibiotic mixtures, the pattern of joint toxic action and component contribution generally changed with the transition from stimulatory to inhibitory actions. …”
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Intravoxel Incoherent Motion Improves the Accuracy of Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Hepatocellular Carcinoma by Li M, Zhang G, Li J, Ren Y, Jin X, Ke Q, Guo C, Lv J, Lu H, Xu Y, Liang W, Quan X, Li X

“…Min Li,1,2,* Ge Zhang,2,* Jing Li,2,* Yufan Ren,2 Xuan Jin,3 Qiying Ke,4 Congyue Guo,2 Jiaqi Lv,2 Haojun Lu,2 Yongzhou Xu,5 Wen Liang,2 Xianyue Quan,2,6 Xinming Li2 1Department of Radiology, Chengdu Sixth People’s Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Radiology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, People’s Republic of China; 4Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 5Philips Healthcare, Guangzhou, People’s Republic of China; 6Department of Radiology, Heyou Hospital, Foshan, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianyue Quan, Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email quanxianyue2014@163.com Xinming Li, Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China, Email lixinmingsmu@163.comPurpose: Hepatocellular carcinoma (HCC) with vessels encapsulating tumor clusters (VETC) pattern presents a higher risk of recurrence and metastasis, and the unique vascular structure of the VETC pattern may affect the perfusion and diffusion, and the effect that can be captured by intravoxel incoherent motion (IVIM). …”
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Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Abstract Background 3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes. Methods We collected data from three multicenter prospective studies to evaluate the ability to establish Patient-Derived Organoids (PDOs) from different biological samples and timepoints, correlating their characteristics and drug sensitivity with clinical outcomes. …”
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Case Report: A 55 kg retroperitoneal liposarcoma by Ren Yingzheng, An Junjie, Wang Guifei, Yang Yang, Dong Long, Jiang Linlin, Fang Zhiqiang, Bi Xiaogang, Dong Yonghong

“…Retroperitoneal liposarcoma (RPLS), particularly the well-differentiated subtype, often presents as large masses due to its deep anatomical location and indolent growth pattern. Moreover, its frequent adherence to vital structures poses significant challenges for complete surgical resection.Case presentationA 62-year-old male was admitted to the hospital due to the gradual enlargement of a mass in the abdomen and pelvis over the past 20 years. …”
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