DOK7 gene therapy enhances motor activity and life span in ALS model mice by Sadanori Miyoshi, Tohru Tezuka, Sumimasa Arimura, Taro Tomono, Takashi Okada, Yuji Yamanashi

“…Here, we show that therapeutic administration of an adeno‐associated virus vector encoding the human DOK7 gene suppressed motor nerve terminal degeneration at NMJs together with muscle atrophy in the SOD1‐G93A ALS mouse model. …”
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A CRISPR-Cas9 system protecting E. coli against acquisition of antibiotic resistance genes by Danna Lee, Petra Muir, Sara Lundberg, August Lundholm, Linus Sandegren, Sanna Koskiniemi

“…Engineered probiotics show strong potential in treating or preventing bacterial infections. …”
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DNA and protein-generated chimeric molecules for delivery of influenza viral epitopes in mouse and humanized NSG transfer models by Nikolina M. Mihaylova, Iliyan K. Manoylov, Maria H. Nikolova, Jozsef Prechl, Andrey I. Tchorbanov

“…Adjuvanted protein-based vaccine or DNA constructs encoding simultaneously T- and B-cell peptide epitopes from influenza viral hemagglutinin, and scFvs specific for costimulatory immune cell receptors may induce a significant increase of anti-influenza antibody levels and strong CTL activity against virus-infected cells in a manner that mimics the natural infection. …”
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Mycobacterial mutants with defective control of phagosomal acidification. by Graham R Stewart, Janisha Patel, Brian D Robertson, Aaron Rae, Douglas B Young

“…Early acidification of the phagosome is associated with reduced survival of BCG in macrophages. A strong correlation exists between genes required for intracellular survival of BCG and those required for growth of M. tuberculosis in mice. …”
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Structural Fingerprinting of Crystalline Materials from XRD Patterns Using Atomic Cluster Expansion Neural Network and Atomic Cluster Expansion by Xiao Zhang, Xitao Wang, Shunbo Hu

“…This study introduces a novel contrastive learning-based X-ray diffraction (XRD) analysis framework, an SE(3)-equivariant graph neural network (E3NN) based Atomic Cluster Expansion Neural Network (EACNN), which reduces the strong dependency on databases and initial models in traditional methods. …”
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Multi-USV Task Assignment Based on NSGA II-MC by Yonghao Zhang, Xueman Fan, Zhuo Cheng, Changyou Xue

“…The research results enrich the methods of multi-objective optimization algorithms and multi-USV task allocation, providing strong support for more efficient underwater target search.…”
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Genome-wide identification of key genes related to chloride ion (Cl−) channels and transporters in response to salt stress in birch by Xiuyan Bian, Tao Xie, Jiying Chen, Chunxu Li, Dandan Yin, Wenbo Zhang

“…In addition, the molecular docking simulations showed that sodium ion (Na+) and Cl−, respectively, had a strong binding affinity towards BpCLCa/b, BpDTX45, and BpDTX18/19. …”
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Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence by Ning Ma, Zhi-Wu Xia, Zhe-Gang Zhang, Xuan-Xuan Nian, Xue-Dan Li, Zheng Gong, Guo-Mei Zhang, Yang Le, Rong Zhou, Jia-You Zhang, Xiao-Ming Yang

“…This study developed a lipid nanoparticle-encapsulated nucleoside-modified mRNA vaccine (mRNA-LNPs) encoding a consensus full-length HA sequence (H1c) and evaluated its protective efficacy and immunogenicity through in vitro and in vivo assays. …”
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Biocontrol potential and comparative genomic analysis of two Bacillus velezensis strains against sclerotinosis in mulberry fruit by Fangfang Peng, Xunlan Li, Zhaoxin Wei, Guohui Han

“…Two strains of Bacillus velezensis (JT-3 and JD-3) were isolated, demonstrating strong inhibitory effects against the sclerotinia pathogen (56.06% for JT-3 and 75.42% for JD-3). …”
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Quadratic unconstrained binary optimization and constraint programming approaches for lattice-based cyclic peptide docking by J. Kyle Brubaker, Kyle E. C. Booth, Akihiko Arakawa, Fabian Furrer, Jayeeta Ghosh, Tsutomu Sato, Helmut G. Katzgraber

“…We propose a “resource efficient” QUBO encoding for this problem, and baseline its performance with a novel constraint programming (CP) approach. …”
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Characterizing privacy in quantum machine learning by Jamie Heredge, Niraj Kumar, Dylan Herman, Shouvanik Chakrabarti, Romina Yalovetzky, Shree Hari Sureshbabu, Changhao Li, Marco Pistoia

“…We further investigate conditions for a strong privacy breach, where original input data can be recovered from snapshots by classical or quantum-assisted methods. …”
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SALM: A Unified Model for 2D and 3D Region of Interest Segmentation in Lung CT Scans Using Vision Transformers by Hadrien T. Gayap, Moulay A. Akhloufi

“…Evaluation on the LUNA16 dataset demonstrated strong performance in both modalities. In 2D segmentation, SALM achieved a Dice score of 93% on 124,662 slices. …”
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Few-shot network intrusion detection method based on multi-domain fusion and cross-attention. by Congyuan Xu, Donghui Li, Zihao Liu, Jun Yang, Qinfeng Shen, Ningbing Tong

“…Moreover, the method exhibits strong cross-domain generalization, achieving over 95.13% accuracy in cross-domain scenarios, thereby proving its robustness and practical applicability in real-world, dynamic network environments.…”
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Harnessing hybrid perception on multi-scale features for hand-foot-mouth disease multi-region prediction based on Seq2Seq. by Bingbing Lei, Xuanjun Zhu, Tao Zhou, Yuxi Zhang

“…Secondly, a novel Spatio-Temporal Parallel Encoding(STPE) Cell is designed; multiple STPE Cells constitute an encoder capable of hybrid perception across multi-scale spatio-temporal features. …”
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Emergency task scheduling algorithm for space-based networks by LI Zheyuan, HE Lijun, JIA Ziye, LI Bokang, WANG Yanting, MIN Minghui

“…As an essential component of the space-air-ground integrated network, the space-based network has advantages such as wide coverage, high throughput, and strong disaster resilience, and is widely applied in emergency communication and other fields. …”
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LMGDoc: Light Multigranular GNN for Efficient Document Understanding by Abdellatif Sassioui, Yasser Elouargui, Mohamed El Kamili, Rachid Benouini, El Mehdi Benyoussef, Meriyem Chergui, Mohammed Ouzzif

“…While recent transformer-based models have achieved strong performance, they typically rely on large-scale pretraining and have high computational demands, limiting their usability in real-time or resource-constrained settings. …”
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QTL Mapping and Candidate Gene Analysis for Cotton Fiber Quality and Early Maturity Using F₂ and F₃ Generations by Xiaoyun Jia, Jijie Zhu, Hongxia Zhao, Linglei Kong, Shijie Wang, Miao Li, Guoyin Wang

“…<i>Ghir_A04G014830.1</i>, covered by qHNFFB-A4-1 and qFU-A4-1, encoded ACLA-1. <i>Ghir_D13G015010.1</i>, encoding VTC2, and <i>Ghir_D13G016670.1</i>, encoding GA2OX1, were in the stable QTL qFL-D13-1 region. …”
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Systematic regional variations in Purkinje cell spiking patterns. by Jianqiang Xiao, Nadia L Cerminara, Yuriy Kotsurovskyy, Hanako Aoki, Amelia Burroughs, Andrew K Wise, Yuanjun Luo, Sarah P Marshall, Izumi Sugihara, Richard Apps, Eric J Lang

“…Similar, though less strong trends were observed in the zonal recordings. …”
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SMM-POD: Panoramic 3D Object Detection via Spherical Multi-Stage Multi-Modal Fusion by Jinghan Zhang, Yusheng Yang, Zhiyuan Gao, Hang Shi, Yangmin Xie

“…A cross-attention-based feature extraction module and a transformer encoder–decoder with spherical positional encoding enable the accurate and efficient fusion of image and point cloud features. …”
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HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni. by Sutas Suttiprapa, Gabriel Rinaldi, Isheng J Tsai, Victoria H Mann, Larisa Dubrovsky, Hong-Bin Yan, Nancy Holroyd, Thomas Huckvale, Caroline Durrant, Anna V Protasio, Tatiana Pushkarsky, Sergey Iordanskiy, Matthew Berriman, Michael I Bukrinsky, Paul J Brindley

“…The rate of integrations in the genome exceeded five per 1,000 kb and HIV-1 integrated into protein-encoding loci and elsewhere with integration bias dissimilar to that of human T cells. …”
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