Optical Genome Mapping ( OGM) : Looking beyond karyotyping by Ruby Dhar, Arun Kumar, Subhradip Karmakar

“…In recent years, a surge in OGM analysis has been witnessed, primarily due to the higher resolution in detecting SVs. Further, with longer reads, OGM helps in the discovery of complex and rare genomic variations.8 OGM protocol employs a paramagnetic disk designed to capture DNA during wash steps, which helps to minimize the shearing forces. …”
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Identification and characterization of gene networks and key genes related to the high-yield production of milk in high-yield cows using meta-analysis of microarray data by Mahdi Rahmatzadeh, Reza Shokri-Gharelo, Morteza Derakhti-Dizaji, Asghar Bazzaz, Bizhan Mahmoudi

“…Milk yield is most important economic trait in dairy cows and understanding molecular basis and components involved in high-yield production is one of crucial steps to develop and select new breeds. In this study, we used combination of two statistical methods based on the p-value and effect sized to meta-analysis three datasets followed with construction of weighted gene co-expression network based on the expression matrix of differentially expressed genes identified in meta-analysis to detect major gene modules and hub genes. …”
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Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 by Heike Allgayer, Samikshya Mahapatra, Barnalee Mishra, Biswajit Swain, Suryendu Saha, Sinjan Khanra, Kavita Kumari, Venketesh K. Panda, Diksha Malhotra, Nitin S. Patil, Jörg H. Leupold, Gopal C. Kundu

“…We emphasize various methods to understand EMT function and the major steps of metastasis, including diverse migration, invasion and matrix degradation assays, microfluidics, 3D co-culture models, spheroids, organoids, or latest spatial and imaging methods to analyze complex compartments. …”
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Assessing the impact of a rare synonymous variant in the <i>KNG1</i> gene on the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. A. Totolian

“…Therefore, (1) the mutant high-molecular-weight kininogen is more easily activated by kallikrein and becomes a source of bradykinin formation through the kallikrein-kinin system; (2) the mechanism of bradykinin formation undergoes significant changes and results in the formation of functionally active but aberrant bradykinin, which alters its inactivation by enzymes with a consequent increase in its half-life, (3) the changes in positions 380-389 bring about modifications in Lys-bradykinin reproduction such that in subsequent steps it is “easily” cleaved to bradykinin by arginine aminopeptidase. …”
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Editorial by Teddy Surya Gunawan

“…Let us embrace these breakthroughs as stepping stones to a brighter, more sustainable future. …”
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Peroxisomal ether-glycerophospholipid synthesis is dysregulated after TBI by Amir A. Mehrabani-Tabari, Nivedita Hegdekar, Sabrina Bustos, Yulemni Morel, Yuanyuan Ji, Sazia Arefin Kachi, Olivia Pettyjohn-Robin, Sagarina Thapa, Maya Bhattiprolu, Marta M. Lipinski, Jace W. Jones, Chinmoy Sarkar

“…To restore the ether-GP level in the injured brain, we treated TBI mice with an ether-GP precursor, 1-O-octadecylglycerol (OAG), to bypass the peroxisomal ether-GPs synthesizing steps. OAG partially restored the levels of several ether-GPs, attenuated inflammatory cytokine expression, and improved their functional recovery after TBI. …”
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Design and Implementation of Active Antennas for IoT-Based Healthcare Monitoring System by Umar Musa, Shaharil Mohd Shah, Huda A. Majid, Ismail Ahmad Mahadi, Mohamad Kamal A. Rahim, Muhammad Sani Yahya, Zuhairiah Zainal Abidin

“…However, at 5.8 GHz, the <inline-formula> <tex-math notation="LaTeX">$\text{P}_{\mathrm {1-dB}}$ </tex-math></inline-formula> was observed at an RF input power level of 13.8 dBm, suggesting linear functionality up to this power level. The experimental data are obtained from ten participants with ages ranging between 18 and 40 years old for 10-minutes duration with a 1-minute step size which implies 10 samples. …”
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Opportunities for immunocorrection aiming for reduction of morbidity in the areas with adverse occupational and environmental conditions by S. V. Petlenko, E. G. Golovacheva, O. I. Afanasieva

“…The purpose of the study was determined by recent positive experience of using highly effective drugs based on thymic regulatory peptides affecting various steps of homeostasis, in order to correct immune disorders caused by exposure to radiation and other toxic substances. …”
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PhenoVision: A framework for automating and delivering research‐ready plant phenology data from field images by Russell Dinnage, Erin Grady, Nevyn Neal, Jonn Deck, Ellen Denny, Ramona Walls, Carrie Seltzer, Robert Guralnick, Daijiang Li

“…Abstract Plant phenology plays a fundamental role in shaping ecosystems, and global change‐induced shifts in phenology have cascading impacts on species interactions and ecosystem structure and function. Detailed, high‐quality observations of when plants undergo seasonal transitions such as leaf‐out, flowering and fruiting are critical for tracking causes and consequences of phenology shifts, but these data are often sparse and biased globally. …”
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Feasibility of estimating the percentage of desert pavement using Tasseled Cap Transformation indices extracted from Landsat 8 images by farzaneh Fotouhi Firoozabad, Atefeh jebali

“…Creating a detailed surface map is the initial step towards quantitative analysis of this role. …”
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Two-dimensional analysis of plasma-derived extracellular vesicles to determine the HER2 status in breast cancer patients by Alexis Wilhelm, Charlotte Flynn, Evelyn Hammer, Johannes Roessler, Bernhard Haller, Rudolf Napieralski, Moritz Leuthner, Sanja Tosheska, Kèvin Knoops, Anjusha Mathew, Giuliano Ciarimboli, Jan Kranich, Lavinia Flaskamp, Siobhan King, Heidrun Gevensleben, Quirin Emslander, Anna Pastucha, Mathias Reisbeck, Lukas Rief, Holger Bronger, Tobias Dreyer, Andreas R. Bausch, Andreas Pichlmair, Thomas Brocker, Reinhard Zeidler, Wolfgang Hammerschmidt, Melanie Piedavent-Salomom, Carmen López-Iglesias, Gabrielle Schricker, Oliver Haydn, Marion Kiechle, Sabine Grill, Ron Heeren, Percy A. Knolle, Olaf Wilhelm, Bastian Höchst

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Принципи ергодизайнерського забезпечення проектування авіаційних систем та заходи з їх реалізації... by Anatoly Rubtsov, Vladimir Svirko, Ivan Otroumov

“…Basic principles of ergodesign support of modern aviation systems and steps for their realization are defined and proved in paper based on analysis of unmanned aviation systems development. …”
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Applying bioinformatic analysis for prognostic assessment of the <i>HS3ST6</i> missense mutations clinical significance in the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. R. Denisova, N. S. Podchernyaeva, A. A. Totolian

“…Currently, mutations in the HS3ST6 gene remain poorly understood; only one missense mutation (p.Thr144Ser, rs746467957) associated with the development of HAE has been described.The aim of our work was to study new mutations in the HS3ST6 gene and analyze in silico their prognostic nature and clinical significance for the development of hereditary angioedema.The material was whole blood samples obtained from 13 patients with symptoms of hereditary angioedema without reduced levels and function of C1-INH.Whole exome sequencing of patients, bioinformatic analysis of HS3ST6 gene mutations using a number of databases and Web resources to predict the effect of mutations on the protein and assess the conservatism of the positions of the mutations detected was involved in study methods.Mutations in the HS3ST6 gene were identified in four patients, including two cases with two mutations simultaneously. …”
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Evaluation of Morphometric Factors on the Distribution of Debris: A Case Study on the Attica Ripples on the South of Paveh- Kermanshah Province, Iran by Mohammad Ahmadi

“…Non-destructive place data were detected at a confidence level of -0.15 p-value> normal. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…The search covered evidence from 1 January 2001 up to 21 July 2021 and yielded 16,775 hits, which were then reduced to 14,383, after using EndNote X9’s (2013) inbuilt duplication detection function and manual de-duplication. Results were imported to Covidence. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Treatment with insulin is aimed at replicating the function of the pancreas to manage hyperglycaemia and avoid hypoglycaemia. …”
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Kink Wave Phenomena in the Nonlinear Partial Differential Equation Representing the Transmission Line Model of Microtubules for Nanoionic Currents by Safyan Mukhtar, Weaam Alhejaili, Mohammad Alqudah, Ali M. Mahnashi, Rasool Shah, Samir A. El-Tantawy

“…The equation introduced here in this form is suitable for critical nanoscience concerns like cell signaling and might continue to explain some of the basic cognitive functions in neurons. We employ advanced procedures to replicate the previously detected solitary waves. …”
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Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices by Andrew M. Hughes, Alisha Lindsey, Jeffrey Annis, Kelly Burke, Hiral Master, Luke G. Silverman‐Lloyd, Jonah D. Garry, Michael J. Blaha, Erika S. Berman Rosenzweig, Robert P. Frantz, Paul M. Hassoun, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Brett Larive, Nicholas S. Hill, Serpil C. Erzurum, Gerald J. Beck, Anna R. Hemnes, Evan L. Brittain

“…Future studies should investigate if monitoring these health behaviors detects early functional decline and whether targeted interventions may improve outcomes.…”
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Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo by Xiuqi Chen, Vincent J. Hilser, Christian M. Kaiser

“…These early co-translational steps are crucial for overall folding and are guided by an intricate network of interactions with molecular chaperones. …”
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The integral visit to the family. Methodological guide for its execution by Anabel Geroy Fernández, Ana Teresa Fernández Vidal, Anais de la Caridad Núñez Herrera, Tania López Otero

“…<br /><strong>Results:</strong> the guide provides the steps to follow in the comprehensive visit to the family, among which stand out: characteristics, state of health, material, hygienic-sanitary and epidemiological conditions, family scheme, family functioning, etc., including a joint action doctor-family plan, to solve the problems detected.…”
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