Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis by Yunqing Sun, Ming Zhu, Lianmei Qiu

“…This meta-analysis aims to evaluate the efficacy of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP), and their combination in enhancing wound healing. …”
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Bone Mineral Turnover after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Single Center Cohort Study by Yuliya V. Skvortsova, Dmitriy N. Balashov, Elena V. Skorobogatova, Zhanna B. Shekhovtsova, Kirill A. Voronin, Alexei A. Maschan

“…We analyzed the data of medical charts of 294 children aged 0–17 y.o. who were hospitalized in 1994–2011, received  allogeneic HSCT, and survived for at least a year after intervention.  …”
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Rb substantially compensates for the double loss of p130 and p107 in adult but not embryonic neural stem cell lineages by Reem Swaidan, Ahmad Daher, Anthony T. Bejjani, Yara E. El Atie, Yasmina Chehab, Razan Bou Hamdan, Renaud Vandenbosch, Ruth S. Slack, Saad Omais, Noël Ghanem

“…Abstract The Retinoblastoma (Rb) family of pocket proteins (p107, Rb, and p130) controls all aspects of neurogenesis from stem cell activation to long-term neuronal survival in the brain. …”
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Therapeutic potential of hyaluronic acid hydrogel combined with bone marrow stem cells-conditioned medium on arthritic rats’ TMJs by Mai M. Assi, Mohammed E. Grawish, Heba Mahmoud Elsabaa, Mohamad E. Helal, Samah K. Ezzat

“…Abstract Conditioned media (CM) is derived from mesenchymal stem cells (MSC) culture and contains biologically active components. …”
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SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma by Xin Tang, Junji Tao, Yuanyuan Liu, Deao Gong, Xuefeng Shan, Kai Wang, Ni Tang

“…Immunoprecipitation-mass spectrometry analysis showed that SLC27A5-interacting proteins were significantly enriched in alternative polyadenylation (APA). RNA-sequencing data provided evidence that SLC27A5 plays a global role in regulating APA events in HCC. …”
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Place of Allogeneic Hematopoietic Stem Cell Transplantation in the First Complete Remission in Ph-positive Acute Lymphoblastic Leukemia in Adults by K. S. Afanaseva, A. G. Smirnova, Yu. Yu. Vlasova, I. S. Moiseev, S. N. Bondarenko

“…Since tyrosine kinase inhibitors (TKIs) were introduced, controversial data have been obtained on the efficacy of allogeneic hematopoietic stem cell (allo-HSCT) in the first complete remission.The objective was to evaluate the efficacy of allo-HSCT in the first complete remission of Ph-positive ALL in adult patients after remission induction with continuous chemotherapeutic exposure in combination with TKIs.Methods and materials. …”
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Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier by Jin-ze Li, Shan-shan Meng, Xiu-Ping Xu, Yong-bo Huang, Pu Mao, Yi-min Li, Yi Yang, Hai-bo Qiu, Chun Pan

“…Mesenchymal stem cells (MSCs) may improve the treatment of acute respiratory distress syndrome (ARDS). …”
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Characteristics of local and system immunity, and features of cancer stem cells in patients with different stage, dynamics and prognosis of colorectal carcinoma by E. Yu. Zlatnik, I. A. Novikova, E. S. Bondarenko, E. P. Uljanova, A. O. Sitkovskaya

“…Malignant cells expressing stem cell markers CSC), MHC and PDL-1 molecules were also counted in the tumor tissue. …”
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Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis by Seyed Danial Alizadeh, Shima Jahani, Mohammad Rezaei Zadeh Rukerd, Reza Tabrizi, Rasoul Masoomi, Seyedeh Zahra Banihashemian, Mahgol Sadat Hassan Zadeh Tabatabaei, Zahra Ghodsi, Ahmad Pour-Rashidi, James Harrop, Vafa Rahimi-Movaghar

“…Abstract Objective To assess the efficacy and safety of stem cell therapy in human studies for diabetic peripheral neuropathy (DPN). …”
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Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape by Xingzhao Lu, Wei Du, Jianping Zhou, Weiyang Li, Zhimin Fu, Zhibin Ye, Guobiao Chen, Xian Huang, Yuliang Guo, Jingsheng Liao

“…mRNA expression-based stemness index (mRNAsi) has been used for prognostic assessment in various cancers, but its application in lung adenocarcinoma (LUAD) is limited, which is the focus of this study. …”
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PROGNOSTIC IMPLICATIONS OF HIGH-RISK GENETIC MUTATIONS IN MULTIPLE MYELOMA PATIENTS UNDERGOING SECOND AUTOLOGOUS STEM CELL TRANSPLANT by Taner Tan, Ahmet Umur Topcu, Ümit Barbaros Üre, Emre Osmanbasoglu, Sinem Civriz Bozdağ, Olga Meltem Akay

“…Detailed analysis was conducted on 19 patients with available pre-transplant Fluorescence In Situ Hybridization (FISH) data. Among these, 9 patients underwent tandem transplantation, and 10 underwent a non-tandem second auto-HSCT. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…Additionally, protein structure extraction, protein-protein docking analysis, and data visualization were conducted.Results: Histomorphometry and flow cytometry showed that most seminiferous tubules in the therapy groups exhibit­ed normal morphology and restored spermatogenesis, unlike the azoospermia group. …”
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Successful treatment with refractory myasthenia gravis that developed after allogeneic hematopoietic stem cell transplantation: two case reports by Huili Zhang, Yi Wen, Yaotong Ou, Xi Chen, Yu Peng, Mingjun Lai, Wenjian Mo, Honghao Wang

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Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment by Jialong Yu, Wei Luo, Guangwei Xu, Mei Tao, Yuqi Wang, Qiman Dong, Linfei Hu, Xiukun Hou, Jingzhu Zhao, Dapeng Li, Songfeng Wei, Xianhui Ruan, Xiangqian Zheng

“…Methods Utilizing transcriptomic data from thyroid carcinoma (THCA) patients in The Cancer Genome Atlas (TCGA) database, we calculated the stemness index (mRNAsi) using the one-class logistic regression (OCLR) method. …”
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TREOSULFAN-BASED CONDITIONING REGIMEN IN SIBLING AND ALTERNATIVE DONOR HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CHILDREN WITH SICKLE CELL DISEASE by Antonio Marzollo, Elisabetta Calore, Manuela Tumino, Marta Pillon, Maria Vittoria Gazzola, Roberta Destro, Raffaella Colombatti, Piero Marson, Tiziana Tison, Anna Colpo, Chiara Mainardi, Maria Gabelli, Maria Paola Boaro, Sara Rossin, Aurora Strano, Nadia Quaglia, Federica Menzato, Giuseppe Basso, Laura Sainati, Chiara Messina

“…Background and objectives  Lack of suitable donors and regimen related toxicity are major barriers for hematopoietic stem cell transplantation (HSCT) in patients with sickle cell disease (SCD) when employing the most frequently used Busulfan-based conditioning regimen. …”
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Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis by Martina Lepore Signorile, Elisabetta Di Nicola, Giovanna Forte, Paola Sanese, Candida Fasano, Vittoria Disciglio, Katia De Marco, Marialaura Latrofa, Loris De Cecco, Marica Ficorilli, Marta Lucchetta, Erica Torchia, Chiara Dossena, Giusy Bianco, Vito Spilotro, Claudia Ferroni, Nicoletta Labarile, Raffaele Armentano, Francesco Albano, Anna Mestice, Gianluigi Gigante, Valerio Lantone, Giuliano Lantone, Leonardo Vincenti, Alberto Del Rio, Greta Varchi, Valentina Grossi, Cristiano Simone

“…Abstract Cancer stem cells (CSCs) are responsible for colorectal cancer (CRC) chemoresistance, recurrence, and metastasis. …”
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Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses by Xiaokang Ruan, Xiaokang Ruan, Linwei Wu, Zijian Tang, Yao Li, Jin Wang, Haolin Jiang, Li Zhang, Shengjia Wang, Shengjia Wang, Shengjia Wang, Shengjia Wang, Zhaoqiang Chen, Chenlei Yuan, Yujian Xia, Yan Pan, Jianling Gao, Xin Zhao, Xin Zhao, Xin Zhao, Xin Zhao

“…There are reports that chemotherapeutic drugs can promote the antitumor immune responses of patients by increasing the number of CD8+ T cells; however, whether chemotherapeutic drugs increase these two stem-like CD8+ T cells remain further exploration.MethodsTpex cell-associated subpopulations in human colorectal tumors were analyzed by using single-cell sequencing data. …”
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Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages by Xiaohong Zheng, Siyuan Tian, Ting Li, Si Zhang, Xia Zhou, Yansheng Liu, Rui Su, Miao Zhang, Bo Li, Chao Qi, Guanya Guo, Shuoyi Ma, Keshuai Sun, Fangfang Yang, Yinan Hu, Chunmei Yang, Lina Cui, Yulong Shang, Changcun Guo, Boquan Jin, Lei Guan, Jingbo Wang, Wen Ning, Ying Han

“…Taken together, our findings revealed that FSTL1 is a critical regulator of the fibrotic immune microenvironment and facilitates subsequent stem cell therapy. These data suggest that FSTL1 could serve as a predictive biomarker of stem cell therapy response in patients with liver cirrhosis.…”
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Newly established stem cell transplant program: 100 days follow-up of patients and its comparison with published Indian literature by Aseem Kumar Tiwari, Dinesh Arora, Ravi C Dara, Pranav Dorwal, Nitin Sood, Ruchira Misra, Sunil Kumar Gupta, Vimarsh Raina, Ashok Kumar Vaid

“…Materials and Methods: Patient demographics, indications, stem cell harvest by apheresis, dose collected, infusion, engraftment, and follow-up data were collected from hospital information system from 2010 to 2013 in a tertiary care hospital. …”
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Intranasal Administration of Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Has Therapeutic Effect in Experimental Autoimmune Encephalomyelitis by Barbara Rossi, Federica Virla, Gabriele Angelini, Ilaria Scambi, Alessandro Bani, Giulia Marostica, Mauro Caprioli, Daniela Anni, Roberto Furlan, Pasquina Marzola, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti, Ermanna Turano

“…Adipose stem cells (ASCs) are a subset of mesenchymal stem cells with validated immunomodulatory and regenerative capabilities that make them attractive tools for treating neurodegenerative disorders, such as multiple sclerosis (MS). …”
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