Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo. by Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

“…Consistent with ING5 serving a tumor suppressive role, ING5 KO mice developed germinal centre diffuse large B-cell lymphomas at a rate 6-fold higher than control mice at 18 months of age. These data suggest that ING5 functions in vivo to maintain stem cell character in multiple organs, that reduction of stem cell populations is not limiting for murine lifespan and that like a subset of other ING family members, ING5 functions as a tumor suppressor in hematopoietic cells in vivo.…”
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D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion by Lijia Guo, Yanan Hou, Liang Song, Siying Zhu, Feiran Lin, Yuxing Bai

“…Periodontal ligament stem cell- (PDLSC-) mediated periodontal tissue regeneration has recently been proposed for the new therapeutic method to regenerate lost alveolar bone and periodontal ligament. …”
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Humeral Stem Designs in Reverse Total Shoulder Arthroplasty: A Focus on the Adjustability of Inclination, Torsion, and Version by Abdelkader Shekhbihi, Philipp Moroder

“…The analysis relied on technical specifications and data provided by manufacturers, supplemented by a critical review of design features. …”
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Terpenoids from quinoa reverse chemoresistance in breast cancer by suppressing the stemness‐related lncRNA 667012 by Xiaxia Fan, Mangmang Feng, Dan Guo, Songtao Li, Yuxuan An, Jinmiao Tian, Zhuoyu Li

“…More importantly, the findings revealed that lncRNA 667012 promoted stemness maintenance via the stemness‐related Wnt pathway. …”
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Delayed Mesoderm and Erythroid Differentiation of Murine Embryonic Stem Cells in the Absence of the Transcriptional Regulator FUBP1 by Josephine Wesely, Marlene Steiner, Frank Schnütgen, Manuel Kaulich, Michael A. Rieger, Martin Zörnig

“…The transcriptional regulator far upstream binding protein 1 (FUBP1) is essential for fetal and adult hematopoietic stem cell (HSC) self-renewal, and the constitutive absence of FUBP1 activity during early development leads to embryonic lethality in homozygous mutant mice. …”
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STEM-based flipped classroom: Improve students’ critical thinking skills and biological literacy in animalia material by Sekar Darmastuti, Hanum Isfaeni, Ratna Komala

“…This study investigates the impact of the STEM-based flipped classroom model on enhancing students' critical thinking skills and biological literacy. …”
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STEM-based e-module on excretory system to enhance high school students’ critical thinking and independence by Eko Sucipto, Kartika Ratna Pertiwi

“…This research aims to develop a STEM-based e-module for an enrichment program on excretory system material that is valid, practical, and effective to improve critical thinking skills and learning independence. …”
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IMMUNE STATE IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES AT LATE TERMS AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION by N. V. Minaeva, T. P. Zagoskina, E. P. Svedentsov, G. A. Zaitceva, N. V. Isaeva, N. А. Zorina

“…Autologous hematopoietic stem cell transplantation (auto-HSCT) is one of the most effective methods for treatment of patients with various forms of hemoblastoses, both in adults and children. …”
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Therapy efficacy in multiple myeloma patients received autologous stem cells transplantation as first line therapy by Ye. I. Darskaya, N. E. Marami-Zonuzi, Yu. S. Osipov, M. A. Estrina, Ye. V. Babenko, V. N. Vavilov, B. V. Afanasiev

“…Therapy results of 91 patients with newly diagnosed multiple myeloma who received autologous hematopoietic stem cells transplantation are presented. According to our data, survival depends on the preransplant response and the amount of transplantations. 5-years progressionfree survival in patients, achieved pre-transplant complete or almost complete remission and received one auto-HSCT was 40 % compared with 18 % in patients who achieved only a partial response (p = 0.07). 10-years overall survival in patients received tandem auto-HSCT was40 % compared with 20 % in patients after one auto-HSCT. …”
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Modified screening and management strategies for chronic rhinosinusitis in hematologic patients receiving hematopoietic stem cell transplantation by Yen-Hui Lee, Chih-Feng Lin, Te-Huei Yeh, Huai-Hsuan Huang, Yi-Tsen Lin

“…Methods: We conducted a nested case-control study in a retrospective cohort of hematologic patients receiving HSCT from April 2011 to April 2021 and collected data on demographics, smoking/atopic status, hematological diseases, and features of rhinosinusitis for analysis. …”
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DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability? by Angela Bentivegna, Mariarosaria Miloso, Gabriele Riva, Dana Foudah, Valentina Butta, Leda Dalprà, Giovanni Tredici

“…Mesenchymal stem cells (MSCs) hold great promise for the treatment of numerous diseases. …”
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Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties by Raghad Alghazali, Mouna Tabebi, Mouna Tabebi, Moustafa Elmasry, Moustafa Elmasry, Ahmed El-Serafi, Ahmed El-Serafi

“…The differentiation of stem cells into keratinocyte-like cells has been explored as a potential regenerative therapy. …”
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Suppressing MicroRNA-30b by Estrogen Promotes Osteogenesis in Bone Marrow Mesenchymal Stem Cells by Guanqi Liu, Yeming Lu, Zhihui Mai, Runheng Liu, Zhuli Peng, Lin Chen, Zheng Chen, Ruizhi Wang, Hong Ai

“…In the present study, the primary bone marrow mesenchymal stem cells from rats (rBMSCs) were isolated and incubated with E2, followed by miRNA profiling. …”
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Crosstalk between macrophages and mesenchymal stem cells shape patterns of osteogenesis and immunomodulation in mineralized collagen scaffolds by Vasiliki Kolliopoulos, Maxwell Polanek, Melisande Wong Yan Ling, Aleczandria Tiffany, Kara L. Spiller, Brendan A.C. Harley

“…Mesenchymal stem cells (MSCs) are highly plastic, with the capacity to differentiate into a spectrum of tissue-specific stromal cells. …”
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Novel Surface Marker for the Prospective Mesenchymal Stem Cell Characterization from Rabbit Visceral Adipose Tissue by Suryo Kuncorojakti, Ira Sari Yudaniayanti, Lina Susanti, Helen Susilawati, Ahmad Aswin, Diyantoro Diyantoro, Watchareewan Rodprasert

“…The exploration of rabbit mesenchymal stem cell (MSC) is still facing an obstacle regarding the standardization of characterization of MSC. …”
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Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells. by Beatriz Suárez-Alvarez, Ramón M Rodriguez, Vincenzo Calvanese, Miguel A Blanco-Gelaz, Steve T Suhr, Francisco Ortega, Jesus Otero, Jose B Cibelli, Harry Moore, Mario F Fraga, Carlos López-Larrea

“…<h4>Conclusions/significance</h4>Our data provide fundamental evidence for the epigenetic control of MHC in hESCs and iPSCs. …”
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Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes by Angela Maria Cozzolino, Valeria Noce, Cecilia Battistelli, Alessandra Marchetti, Germana Grassi, Carla Cicchini, Marco Tripodi, Laura Amicone

“…The rigidity of the substrate is an element no longer negligible for the cultivation of several cell types, so that many data so far obtained, where cells have been cultured on plastic, could be revised. …”
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Hierarchical segmentation framework with dynamic parameter optimization for accurate stem-leaf partitioning and phenotypic extraction in maize by Yingjie Zhao, Dongjie Liu, Jiangtan Yao, Zhen Wang, Xuanyu Mu, Zongwei Jia

“…The proposed method was systematically evaluated on maize plant point cloud data at multiple growth stages, and compared with manually annotated results. …”
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Maize breeding enhances lodging resistance through vertical allocation changes of stem dry matter and nitrogen by Alejo Ruiz, Agustin Listello, Slobodan Trifunovic, Sotirios V. Archontoulis

“…The maize stem provides structural support to other plant organs and stores carbohydrates and nitrogen (N) that can be remobilized to grain. …”
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Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis by Victoria Chapman, Hareklea Markides, Devi Rani Sagar, Luting Xu, James J. Burston, Paul Mapp, Alasdair Kay, Robert H. Morris, Oksana Kehoe, Alicia J. El Haj

“…Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. …”
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