GVHD PROPHYLAXIS WITH METHOTREXATE IN HAPLOIDENTICAL HCT USING POSTTRANSPLANT CYCLOPHOSPHAMIDE: A PHASE IB/II CLINICAL TRIAL (NCT04622956) by G Fatobene, AM Ferreira, LJ Otuyama, LB Ribeiro, I Colturato, JGD Santos, B Moraes, V Colturato, A Vigorito, V Rocha

“…All patients received mobilized peripheral stem cells, except for two patients in the Level +1 group who received bone marrow grafts. …”
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Cellular effects of splenectomy on liver regeneration after 70% resection by Andrey Elchaninov, Andrey Elchaninov, Polina Vishnyakova, Polina Vishnyakova, Elena Gantsova, Elena Gantsova, Miroslava Chirkova, Victoria Karyagina, Larkin Anatoliy, Evgeniya Kananykhina, Maria Kuznetsova, Ibrahim Atabekov, Evgeny Karpulevich, Silachev Denis, Dmitry Trofimov, Dmitry Goldshtein, Timur Fatkhudinov, Timur Fatkhudinov, Gennady Sukhikh

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Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol‐Related Liver Disease by Nicole Welch, Pugazhendhi Kannan, Saurabh Mishra, Annette Bellar, Vandana Agrawal, Grahame Kidd, Emily Benson, Ryan Musich, Raya Tabbalat, Ling Li, J. Mark Brown, Belinda Willard, Karyn A. Esser, Laura E. Nagy, Srinivasan Dasarathy

“…Stabilization of HIF1α (C2C12, 6hEtOH 0.24 ± 0.09; p = 0.043; mALD 0.32 ± 0.074; p = 0.005; data shown as mean difference ± standard error mean) was accompanied by enrichment in the early transient and late change clusters, −log(p‐value) = 1.5–3.8, of the HIF1α signalling pathway. …”
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Cold hardiness evaluation and physiological mechanism elucidation in apricot-plum hybrid (Prunus salicina × P. armeniaca) germplasm by WANG Aning, QI Anguo, WANG Mengyao, ZHU Gaopu, LI Taishan, LI Fangdong, YANG Shaobin, HU Haifang, BAI Danfeng

“…The superior cold tolerance of Weiwang and XL9 primarily stems from enhanced antioxidant capacity and osmotic adjustment in dormant branches. …”
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VENETOCLAX-BASED VERSUS 7+3 INDUCTION THERAPY IN FIT YOUNGER ADULTS WITH NEWLY DIAGNOSED NON-CBF AML by Dmitrii Zhogolev, Nikita Pastukhov, Bella Aybova, Anna Smirnova, Ivan Moiseev, Sergey Bondarenko, Alexander Kulagin

“…Despite these findings, direct comparative data between venetoclax-based therapies and intensive induction chemotherapy in fit patients with non-CBF AML remains limited. …”
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Results of Molecular Monitoring in Posttransplant Period by Means of Series Investigation of WT1 Gene Expression in Patients with Acute Myeloid Leukemia by YaV Gudozhnikova, NN Mamaev, IM Barkhatov, VA Katerina, TL Gindina, AI Shakirova, SN Bondarenko, OA Slesarchuk, EI Darskaya, OV Paina, LS Zubarovskaya, BV Afanas’ev

“…To demonstrate diagnostic and prognostic significance of series measurement of WT1 expression in patients with acute myeloid leukemia (AML) after allogenic hematopoietic stem cell transplantation (allo-HSCT). Materials & Methods. …”
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The global spectrum of tree crown architecture by Tommaso Jucker, Fabian Jörg Fischer, Jérôme Chave, David A. Coomes, John Caspersen, Arshad Ali, Grace Jopaul Loubota Panzou, Ted R. Feldpausch, Daniel Falster, Vladimir A. Usoltsev, Toby D. Jackson, Stephen Adu-Bredu, Luciana F. Alves, Mohammad Aminpour, Bhely Angoboy Ilondea, Niels P. R. Anten, Cécile Antin, Yousef Askari, Narayanan Ayyappan, Lindsay F. Banin, Nicolas Barbier, John J. Battles, Hans Beeckman, Yannick E. Bocko, Ben Bond-Lamberty, Frans Bongers, Samuel Bowers, Michiel van Breugel, Arthur Chantrain, Rajeev Chaudhary, Jingyu Dai, Michele Dalponte, Kangbéni Dimobe, Jean-Christophe Domec, Jean-Louis Doucet, Juan Manuel Dupuy Rada, Remko A. Duursma, Moisés Enríquez, Karin Y. van Ewijk, William Farfán-Rios, Adeline Fayolle, Marco Ferretti, Eric Forni, David I. Forrester, Hammad Gilani, John L. Godlee, Matthias Haeni, Jefferson S. Hall, Jie-Kun He, Andreas Hemp, José L. Hernández-Stefanoni, Steven I. Higgins, Robert J. Holdaway, Kiramat Hussain, Lindsay B. Hutley, Tomoaki Ichie, Yoshiko Iida, Hai-Sheng Jiang, Puspa Raj Joshi, Hasan Kaboli, Maryam Kazempour Larsary, Tanaka Kenzo, Brian D. Kloeppel, Takashi S. Kohyama, Suwash Kunwar, Shem Kuyah, Jakub Kvasnica, Siliang Lin, Emily R. Lines, Hongyan Liu, Craig Lorimer, Jean-Joël Loumeto, Yadvinder Malhi, Peter L. Marshall, Eskil Mattsson, Radim Matula, Jorge A. Meave, Sylvanus Mensah, Xiangcheng Mi, Stéphane T. Momo, Glenn R. Moncrieff, Francisco Mora, Rodrigo Muñoz, Sarath P. Nissanka, Zamah Shari Nur Hajar, Kevin L. O’Hara, Steven Pearce, Raphaël Pelissier, Pablo L. Peri, Pierre Ploton, Lourens Poorter, Mohsen Javanmiri Pour, Hassan Pourbabaei, Sabina C. Ribeiro, Casey Ryan, Anvar Sanaei, Jennifer Sanger, Michael Schlund, Giacomo Sellan, Alexander Shenkin, Bonaventure Sonké, Frank J. Sterck, Martin Svátek, Kentaro Takagi, Anna T. Trugman, Matthew A. Vadeboncoeur, Ahmad Valipour, Mark C. Vanderwel, Alejandra G. Vovides, Peter Waldner, Weiwei Wang, Li-Qiu Wang, Christian Wirth, Murray Woods, Wenhua Xiang, Fabiano de Aquino Ximenes, Yaozhan Xu, Toshihiro Yamada, Miguel A. Zavala, Niklaus E. Zimmermann

“…Using data from 374,888 globally distributed trees, we explore how climate, disturbance, competition, functional traits, and evolutionary history constrain the height and crown width scaling relationships of 1914 tree species. …”
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Effectiveness of introducing pulse oximetry and clinical decision support algorithms for the management of sick children in primary care in Kenya and Senegal on referral and antibi... by Hélène Langet, Papa Moctar Faye, Francis Njiri, Silvia Cicconi, Gillian A. Levine, Tracy R. Glass, Rose J. Kosgei, Kevin Ngari, Fabian Schaer, Aliou Thiongane, Jean Augustin Diégane Tine, Maymouna Ba, Leah F. Bohle, Mira Emmanuel-Fabula, Mouhamadou Mansour Faye, Susan Horton, Andolo Miheso, Mercy Mugo, Mariah Ngutu, Michael Ruffo, Janet Shauri, Ndèye Marème Sougou, Valérie D’Acremont, Kaspar Wyss, Ousmane Ndiaye, Fenella Beynon

“…Trained research assistants collected data from caregivers and facility records on Day 0, with a follow-up phone call at Day 7. …”
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Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer by Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Da Li, Da Li, Da Li, Da Li, Chao Quan, Chao Quan, Zhu Yu, Zhu Yu, Zhu Yu, Yue Feng, Yue Feng, Yue Feng, Yue Feng, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Yong Li, Yong Li, Yong Li, Yong Li, Tongtong Qi, Tongtong Qi, Tongtong Qi, Tongtong Qi, Junqiang Chen, Junqiang Chen, Junqiang Chen, Junqiang Chen

“…This study investigates the correlation between FZD2 expression and clinical outcomes, as well as its underlying molecular mechanisms in pan-cancer.MethodsA comprehensive bioinformatic analysis was performed using pan-cancer data from The Cancer Genome Atlas (TCGA), which included 33 cancer types. …”
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DIREITO À EDUCAÇÃO INTEGRAL E(M) TEMPO INTEGRAL:normativas, princípios orientadores e indicadores para monitoramento by Bruno Adriano Rodrigues da Silva, Lígia Martha Coimbra da Costa Coelho, Sabrina Moehlecke

“…This approach stems from an epistemological requirement and also from the necessity to establish indicators for monitoring the suply of the right to full-time integral education in Brazil. …”
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DETERMINATION OF FREQUENCY AND RISK FACTORS OF SECONDARY MALIGNANCY DEVELOPMENT IN HEMATOLOGICAL MALIGNANCIES by Ennur Ramadan, Güven Çetin, Özge Pasin

“…Additionally, most studies on this topic conducted on data from the SEER (Surveillance, Epidemiology, and End Results) database. …”
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Research On Calculation of Longitudinal Deformation of The Underlying Shield Tunnel Caused By Excavation of The Foundation Pit Considering Consolidation Effects by LYU Linhai, DONG Cheng, ZHAO Zhe, JIANG Mingjie, JI Yongkai, QIU Shizheng, ZHANG Zhendong, MEI Guoxiong

“…The proposed theoretical methodology was employed to calculate the tunnel uplift displacement, with its predictive accuracy rigorously validated against field monitoring data. In this case study, the rebound modulus of each soil layer was determined as four times its compression modulus, following established engineering practice for cohesive soils. …”
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Results of asciminib therapy as part of managed access program in patients with chronic myeloid leukemia with T315I mutation by A. N. Petrova, E. G. Lomaia, E. V. Morozova, O. A. Shukhov, E. Yu. Chelysheva, Yu. Yu. Vlasova, E. A. Kuzmina, O. V. Kulemina, I. S. Nemchenko, A. V. Bykova, A. B. Sudarikov, A. V. Kokhno, A. G. Turkina

“…In a phase I clinical trial, asciminib at a dose of 200 mg twice daily showed efficacy in the treatment of chronic phase (Cp) CML patients with T315I mutation. There are no data on the efficacy of asciminib therapy in patients with T315I mutation and additional chromosomal abnormalities (ACA) or advanced disease. …”
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Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults by Ting Ge, Ting Ge, Ting Ge, Guixin He, Guixin He, Guixin He, Qian Cui, Qian Cui, Qian Cui, Shuangcui Wang, Shuangcui Wang, Shuangcui Wang, Zekun Wang, Yingying Xie, Yingying Xie, Yingying Xie, Yuanyuan Tian, Yuanyuan Tian, Yuanyuan Tian, Juyue Zhou, Juyue Zhou, Juyue Zhou, Wentao Li, Wentao Li, Baohui Wang, Keming Zhang, Jianchun Yu, Jianchun Yu

“…However, we are unable to specifically analyze the underlying causes owing to a lack of data on lymphocyte absolute counts and functional markers from two extremes of age.MethodsA total of 111 infants (≤ 6 months) and 111 older adults (≥ 65 years) were enrolled to assess the percentages and absolute counts of peripheral blood lymphocyte (PBL) subsets. …”
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Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALLResearch in context by Berta González-Martínez, Víctor Galán-Gómez, Alfonso Navarro-Zapata, Isabel Mirones-Aguilar, Marta Cobo, Alicia Pernas-Sánchez, Susana Vallejo, Elena Sánchez-Zapardiel, Odelaisy León-Triana, Carlos Echecopar, Isabel Martínez-Romera, Pilar Guerra-García, Sonsoles San Román-Pacheco, Adela Escudero, Elisa Izquierdo, Manuel Izquierdo, Sara Naharro, Alicia Martín-Ayuso, Halin Bareke, Andrés París-Muñoz, Peirong Hu, Dina Schneider, Rimas J. Orentas, Jordi Minguillón, Antonio Pérez-Martínez

“…Methods: We report Spanish clinical data on the safety and efficacy of tandem anti-CD19/CD22 CAR T-cells administered on a compassionate use basis in a cohort of 10 heavily pretreated paediatric, adolescent, and young adult (AYA) patients with r/r B-ALL. …”
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Carbon Footprint Assessment in Shrimp Pond Farming of Penaeus vannamei Based on Life Cycle Assessment Methods by Yunfei WANG, Xinmeng WANG, Ying LI, Jinzhen YU, Jie KONG, Jihong ZHANG

“…Here, the carbon footprint of P. vannamei pond culture was assessed using the "gate-to-gate" LCA methodology, based on primary data from on-site monitoring of culture ponds and aquaculture enterprises in Shandong Province. …”
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Behavioral Biases in Investor Decision-Making: A Comparative Meta-Analysis of Behavioral Finance Research by Seyed Amir Sabet, Saeed Aibaghi esfahani, Abdolmajid Abdolbaghi Ataabadi

“…These biases stem from bounded rationality, time constraints, emotions, social pressures, and information asymmetry, with Prospect Theory further explaining irrationalities by showing how investors assess gains and losses asymmetrically, particularly when facing losses. …”
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Safety and efficacy of glofitamab for relapsed/refractory large B-cell lymphoma in a multinational real-world study by Evgenii Shumilov, Rebecca Wurm-Kuczera, Andrea Kerkhoff, Meng Wang, Thomas Melchardt, Udo Holtick, Ulrike Bacher, Philipp Staber, Paolo Mazzeo, Corinna Leng, David Böckle, Alexander Hölscher, Joseph Kauer, Natalia Rotter, Vladan Vucinic, Jakob Rudzki, David Nachbaur, Veit Bücklein, Ulf Schnetzke, Isabelle Krämer, Kai Wille, Alexander Hasse, Bastian von Tresckow, Mathias Hänel, Christian Koenecke, Giuliano Filippini Velazquez, Andreas Viardot, Christoph Schmid, Lorenz Thurner, Dominik Wolf, Marion Subklewe, Martin Dreyling, Peter Dreger, Sascha Dietrich, Ulrich Keller, Ulrich Jäger, Richard Greil, Thomas Pabst, Georg Lenz, Björn Chapuy

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Anti-leishmanial activity of Carthamus tinctorius and Matricaria chamomilla extracts on the survival of promastigotes of Leishmania major by S Hamoonnavard, H Rezvan, M Maleki, H Heydarianpour, B Bazargani-Gilani, F Behdarvand

“…Therapeutic effects of mesenchymal stem cells on cutaneous leishmaniasis lesions caused by Leishmania major. …”
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Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)Research in context by Paul Coppo, Michael Bubenheim, Ygal Benhamou, Linus Völker, Paul Brinkkötter, Lucas Kühne, Paul Knöbl, Maria Eva Mingot-Castellano, Cristina Pascual-Izquierdo, Javier de la Rubia, Julio del Rio Garma, Shruti Chaturvedi, Camila Masias, Marshall Mazepa, X. Long Zheng, György Sinkovits, Marienn Réti, Christopher J. Patriquin, Katerina Pavenski, Tiago Boechat, João Farias, Eduardo Flavio Oliveira Ribeiro, Michaela Larissa Lobo de Andrade, Agnès Veyradier, Bérangère Joly, Raïda Bouzid, Kazuya Sakai, Masanori Matsumoto, Pasquale Agosti, Ilaria Mancini, Flora Peyvandi, Eleni Gavriilaki, Matthew Stubbs, Amjad Hmaid, Spero Cataland, Bernhard Lämmle, Marie Scully

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