Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches by Qi Sun, Longchuan Xie, He An, Wei Chen, Qirong Yang, Peng Wang, Yijun Tang, Chunyan Peng, Chunyan Peng

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VEGF-R1/Flt-1 Receptor as a Characteristic of the Angiogenic Phenotype of Uveal Melanoma by V. G. Likhvantseva, O. A. Anurova, S. E. Astakhova, M. V. Vereshchagina, V. E. Ovanesyan, E. V. Stepanova

“…Thanks to new fundamental data, our understanding of the angiogenesis’ role and its molecular participants has changed. …”
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The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects by Haiwei Tang, Tingxian Ling, Enze Zhao, Mingke You, Xi Chen, Gang Chen, Kai Zhou, Zongke Zhou

“…In the reported data, the regenerative group demonstrated significantly higher rates of subjective improvement in pain and functional outcomes compared to those in the CD group (71.74% (66/92) vs. 56.38% (53/94). …”
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Exploring the role of social media in mathematics learning: effects on self-efficacy, interest, and self-regulation by Ling Dai, Wu Jin, Biao Zhu, Rundong Liao, Guoxing Xu, Haozhe Jiang, Jia Guan

“…Data were collected through validated survey instruments that measured mathematics self-efficacy (MathSE), mathematics interest (MathI), and self-regulation in mathematics learning (SR). …”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…For instance, the absence of historical data on incidents involving unmanned ships complicates risk assessment. …”
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Remotely sensed estimation and mapping of soil moisture by eliminating the effect of vegetation cover by Cheng-yong WU, Guang-chao CAO, Ke-long CHEN, Chong-yi E, Ya-hui MAO, Shuang-kai ZHAO, Qi WANG, Xiao-yi SU, Ya-lan WEI

“…However, remotely sensed SM is constrained by its estimation accuracy, which mainly stems from the influence of vegetation cover on soil spectra information in mixed pixels. …”
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A Randomized, Double-Blind, Multicenter Clinical Study Comparing the Efficacy and Safety of a Drug Combination of Lopinavir/Ritonavir-Azithromycin, Lopinavir/Ritonavir-Doxycycline,... by Purwati, Budiono, Brian Eka Rachman, Yulistiani, Andang Miatmoko, Nasronudin, Soroy Lardo, Yongki Iswandi Purnama, Mafidhatul Laely, Ike Rochmad, Taufik Ismail, Sri Wulandari, Dwi Setyawan, Alfian Nur Rosyid, Herley Windo Setiawan, Prastuti Asta Wulaningrum, Tri Pudy Asmarawati, Erika Marfiani, Shinta Karina Yuniati, Muhammad Rabiul Fuadi, Pepy Dwi Endraswari, Purwaningsih, Eryk Hendrianto, Deya Karsari, Aristika Dinaryanti, Nora Ertanti, Igo Syaiful Ihsan, Disca Sandyakala Purnama, Yuni Indrayani

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Outcomes and factors influencing survival in patients with diffuse large B-cell lymphoma: a population-based analysis by Inna Y. Gong, Michael Crump, Anca Prica, Andrew Calzavara, Ning Liu, Tiana Kordbacheh, Danielle Rodin, David Hodgson, Lee Mozessohn, Matthew C. Cheung, John Kuruvilla

“…Univariate analysis demonstrated that curative-intent therapy (autologous stem cell transplantation [ASCT]) (58% of patients) was associated with better OS than palliative radiotherapy (hazard ratio [HR], 0.56; P < .0001). …”
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Biophysical warming patterns of an open-top chamber and its short-term influence on a Phragmites wetland ecosystem in China by Xue-yang Yu, Si-yuan Ye, Li-xin Pei, Liu-juan Xie, Ken W. Krauss, Samantha K. Chapman, Hans Brix

“…In this study, a set of six OTCs were established at a Phragmites wetland located in the Yellow River Delta of Dongying City, China. With data collected through online transmission and in-situ sensors, the attributes and patterns of realized OTCs warming are demonstrated. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

“…A neuronal eTau uptake and accumulation assay was developed for human induced pluripotent stem cell-derived neurons (iPSCNs) and Lund human mesencephalic cells (LUHMES)-derived neurons. …”
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Neither Bone Marrow Aspirate Concentrate nor Platelet-Rich Plasma Improves Patient-Reported Outcomes After Surgical Management of Acetabular Labral Tears; However, Bone Marrow Aspi... by Bilal S. Siddiq, B.S., Riccardo Giorgino, M.D., Stephen M. Gillinov, A.B., Jonathan S. Lee, B.A., Kieran S. Dowley, B.A., Nathan J. Cherian, M.D., Scott D. Martin, M.D.

“…Each study was queried for demographic data, orthobiologic agent used, volume of agent used, imaging modality used to guide administration, follow-up period, and all reported outcomes. …”
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Traditional uses and importance of Strychnos L. (Loganiaceae): A cross-cultural and spatial variation study in Benin by Donald Djidohokpin, Gbèwonmèdéa Hospice Dassou, Gnimansou Abraham Favi, Octave Mathieu Zountangni, Jéronime Marie-Ange Sènami Ouachinou, Judicael Makponsè, Ghyslain Kpetikou, Gbèkponhami Monique Tossou, Hounnankpon Yédomonhan, Aristide Cossi Adomou

“…Their fruits, seeds, and stems are the most exploited parts, which exposes them to local extinction risk. …”
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mTORC1-selective inhibitors rescue cellular phenotypes in TSC iPSC-derived neurons by Elizabeth D. Buttermore, Elizabeth D. Buttermore, Gayathri Rajaram Srinivasan, Gayathri Rajaram Srinivasan, Hellen Jumo, Hellen Jumo, Amanda C. Swanson, Amanda C. Swanson, Benjamin O’Kelly, Benjamin O’Kelly, Nina R. Makhortova, Nina R. Makhortova, Nina R. Makhortova, Mustafa Sahin, Mustafa Sahin, Mustafa Sahin, Stelios T. Tzannis

“…We previously reported cellular and functional deficits in induced pluripotent stem cell (iPSC)-derived neurons from TSC patients. …”
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Study of the Antioxidant and Antibacterial Effects of <i>Genipa americana</i> L. Against Food Pathogens by Lariza Leisla Leandro Nascimento, Geane Gabriele de Oliveira Souza, Ana Cecília Calixto Donelardy, Maria Inácio da Silva, Cícera Alane Coelho Gonçalves, Ana Maria Duarte Fernandes, José Walber Gonçalves Castro, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues

“…This study presents the chemical profile of the ethanolic extract of <i>Genipa americana</i> L. stem bark and the evaluation of its antibacterial and antioxidant activities. …”
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Updates from a single-center phase 2 study of PD-1 inhibitor combined with hypomethylating agent plus CAG regimen in patients with relapsed/refractory acute myeloid leukemia by Hui-Sheng Zhou, Hui-Sheng Zhou, Yong-Feng Su, Jun Wang, Ya-Lei Hu, Ya-Lei Hu, An Wang, Lei Xu, Yi-Zhi Wang, Xuan Zheng, Yu-Qing Li, Yu-Qing Li, Kai-Li Min, Kai-Li Min, Chun-Ji Gao, Dai-Hong Liu, Dai-Hong Liu, Xiao-Ning Gao, Xiao-Ning Gao

“…Additionally, bridging allogeneic hematopoietic stem cell transplantation was associated with extended event-free survival. …”
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Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis by Malek Shatila, Kian Abdul‐Baki, Andres Urias Rivera, Kei Takigawa, Irene Jeong‐Ah Lee, Andrew Sullivan, Tanvi Gupta, Linfeng Lu, Raakhi Menon, Ayesha Khan, Hamza Salim, Elliot Baerman, Carolina Colli Cruz, Cristina Natha, Varun Vemulapalli, Garrett Coleman, Krishnavathana Varatharajalu, Christopher Fan, Pablo Okhuysen, Anthony J. Olszanski, Yan Zhou, Hao Chi Zhang, Mehnaz Shafi, Yinghong Wang

“…ABSTRACT Background Gastrointestinal (GI) infections, which often result in or stem from intestinal dysbiosis, can affect the efficacy of immune checkpoint inhibitors (ICIs) and increase the risk of adverse effects, such as colitis. …”
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RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway by Han Wang, Xiwen Yuan, Jie Han, Zuoxing Wu, Zheru Ma, Fan Shi, Zhengqiong Luo, Zihan Chen, Chenyang Guo, Guixin Yuan, Xuemei He, Zemin Ling, Lin Meng, Rong Shen, Jianming Huang, Ren Xu

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Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation by Esther Rodríguez-Gallego, Marta Riera-Borrull, Anna Hernández-Aguilera, Roger Mariné-Casadó, Anna Rull, Raúl Beltrán-Debón, Fedra Luciano-Mateo, Javier A. Menendez, Alejandro Vazquez-Martin, Juan J. Sirvent, Vicente Martín-Paredero, Angel L. Corbí, Elena Sierra-Filardi, Gerard Aragonès, Anabel García-Heredia, Jordi Camps, Carlos Alonso-Villaverde, Jorge Joven

“…Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the CCl2 gene in the Gt(ROSA)26Sor locus of the mouse genome via homologous recombination in embryonic stem cells. …”
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Genetic Variants in Early-Onset Inflammatory Bowel Disease: Monogenic Causes and Clinical Implications by Duygu Demirtas Guner, Hacer Neslihan Bildik, Hulya Demir, Deniz Cagdas, Inci Nur Saltik Temizel, Riza Koksal Ozgul, Hayriye Hizarcioglu Gulsen, Cagman Tan, Begum Cicek, Hasan Ozen, Aysel Yuce, Ilhan Tezcan

“…Whole-exome sequencing (WES) was performed prospectively in patients without a prior diagnosis of monogenic disease, while clinical and laboratory data were reviewed retrospectively. Identified variants were evaluated for pathogenicity using standard bioinformatics tools. …”
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Agronomic Effects of Different Rock Powder Rates Associated with Irrigation Water Depths: Potential for Lettuce (<i>Lactuca sativa</i> L.) Production by Patrícia Costa Silva, Matheus Batista Sabino, Maria Beatriz Ferreira, Narla Costa Oliveira Sabino, Larissa Silva Sousa, Mariana Batista Elias, Amanda de Brito Silva, Ana Flávia Alves Ferreira, Adriana Rodolfo da Costa, Josué Gomes Delmond, Jhon Lennon Bezerra da Silva, Henrique Fonseca Elias de Oliveira, Thieres George Freire da Silva, Marcos Vinícius da Silva

“…The data were subjected to regression analysis and principal component analysis. …”
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