CoREST3 exhibits isoform specific expression in Alzheimer’s disease and regulation of HDAC2 by Simon Maksour, Helena Targa Dias Anastacio, Jeremy S. Lum, Samara Walpole, Kelly A. Newell, Calista Turner, Adile Kaban, Rachelle Balez, Julia Lim, Greg T. Sutherland, Lezanne Ooi, Mirella Dottori

“…Conclusions Together these data suggest that CoREST3 plays an isoform specific and direct role in repressing HDAC2, with dysregulated CoREST3 expression in AD possibly contributing to altered HDAC2 levels involved in AD pathogenesis.  …”
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Psychological assessment and the role of the psychologist in early palliative care by Pamela Iannizzi, Alessandra Feltrin, Rosalba Martino, Chiara De Toni, Antonella Galiano, Ardi Pambuku, Mariateresa Nardi, Nicla Meraviglia, Antonella Brunello, Vittorina Zagonel

“…This study aims to assess the psychological needs of these patients, investigate any correlations between psychological symptoms (PSs) and factors such as awareness of diagnosis and prognosis, symptoms detected using the Edmonton Symptom Assessment System (ESAS), as well as the patient’s gender, age, social issues, and survival and to clarify the psychologist’s role within the interdisciplinary team.MethodsData were retrieved from a prospectively maintained database. …”
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The OsZHD1 and OsZHD2, Two Zinc Finger Homeobox Transcription Factor, Redundantly Control Grain Size by Influencing Cell Proliferation in Rice by Mingliang Guo, Chun Zheng, Chao Shi, Xiaozhuan Lu, Zeyuan She, Shuyu Jiang, Dagang Tian, Yuan Qin

“…Moreover, it is reliable that the altered expression of cell cycle and expansion-related and grain size-related genes were observed in RNA-seq data, highly consistent with the qRT-PCR results. …”
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snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Specifically, we observed altered differentiation trajectories in both adipose stem and progenitor cells (ASPCs) and adipocytes, suggesting dedifferentiation and reprogramming tendencies. …”
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A presentation of posterior reversible encephalopathy syndrome after heart transplantation: a case report and review of literature by Daniel Grandmougin, Tristan Ehrlich, Yihua Liu, Juliette Piccoli, Pan Dan, Elodie Phamisith, Francesco Ferraro, Cristina Sirbu, Irina Klemina, Emmanuelle Schmitt, Ismaël Yahia, Michael Massin, Benjamin Lefèvre, Carine Thivilier, Fabrice Vanhuyse, Stéphane Zuily, Juan-Pablo Maureira

“…Clinical symptomatology, imaging features, and evolution of posterior reversible encephalopathy syndrome as well therapeutic strategy and identification of contributing factors will be discussed on the basis of our experience and data from literature review. Case presentation We report the case of a 59-year-old white male patient who was diagnosed with posterior reversible encephalopathy syndrome 3 months after cardiac transplantation. …”
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Transcriptome Sequencing and Bioinformatic Analysis of Astragalus sinicus ‘Yuelvfei No. 1’ by Jingyu LI, Yan GU, Liping GONG, Zijian FU, Jiahao ZHONG, Jihua WANG

“…【Conclusion】The transcriptomic information of A.sinicus cultivar 'Yuelvfei No. 1, provides valuable data support for further exploration of resource identification and genetic improvement in A.sinicus.…”
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Fatty acid metabolism prognostic signature predicts tumor immune microenvironment and immunotherapy, and identifies tumorigenic role of MOGAT2 in lung adenocarcinoma by Denggang Fu, Biyu Zhang, Wenyan Fan, Fanfan Zeng, Fanfan Zeng, Jueping Feng, Xin Wang

“…However, studies on its impact in lung adenocarcinoma (LUAD) are limited.MethodsWe developed a prognostic signature comprising 10 FAM-related genes (GPR115, SOAT2, CDH17, MOGAT2, COL11A1, TCN1, LGR5, SLC34A2, RHOV, and DKK1) using data from LUAD patients in The Cancer Genome Atlas (TCGA). …”
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Trends and determinants of female genital mutilation prevalence among women of reproductive age in Tanzania and Kenya: a demographic and health survey analysis (2008–2022) by Dotto Daniel Kisendi, D. Lyakurwa, Heavenlight A. Paulo, Elizabeth Malingumu, Virna Vong, E. Matthews, Ebrima Huma, Mgole Eliud Mkama, kang Wu, Yili Zhang, Bei Li

“…Methods A retrospective analysis of Demographic and Health Survey (DHS) data from 6,517 women aged 15–49 in Kenya and Tanzania (2008–2022) was conducted. …”
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Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

“…Such inconsistencies might stem from different FFQs across cohorts and consumption ranges. …”
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Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells by Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang

“…Abstract Background Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the decline in muscle health. …”
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Efficacy and safety of micro-fragmented adipose tissue combined with knee arthroscopy in the treatment of knee osteoarthritis: a systematic review by Xinyu Hu, Zhongyi Zhang, Wen Zhang, Ning Wang, Shuaijie Lv, Chentong Pan, Peijian Tong

“…Micro-fragmented adipose tissue (MFAT), rich in mesenchymal stem cells and growth factors, has emerged as a promising biological material for cartilage repair and inflammation suppression. …”
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YPEL2 regulates the efficacy of BRD4-EZH2 dual targeting in EZH2Y641mut germinal center-derived lymphoma by Aránzazu Chamorro-Jorganes, Núria Profitós-Pelejà, Clara Recasens-Zorzo, Juan G Valero, Diana Reyes-Garau, Laura Magnano, Ray Butler, Antonio Postigo, Patricia Pérez-Galán, Marcelo Lima Ribeiro, Gaël Roué

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CCL4L2 participates in tendinopathy progression by promoting macrophage inflammatory responses: a single-cell analysis by Junxiang Xu, Minzhe Zheng, Zongxian Feng, Qiji Lin

“…The cellular communication mechanism between different cellular subsets such as Macs and tendon stem/progenitor cells (TSPCs) was demonstrated by cellular communication analysis. …”
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Patient-Specific Instrumentation Benefits for INBONE II Total Ankle Arthroplasty by Charlotte Jones BS, Allison Boden MD, Patricia Friedmann MS, Suzy Wang MS, Ricardo Villar MD, Constantine Demetracopoulos MD, Jonathan Deland MD, Elizabeth Cody MD, Matthew Conti MD, Jensen Henry MD, Scott Ellis MD

“…Chart review was performed to collect demographic data including primary surgeon, concomitant procedures, body mass index (BMI), age, tibial and talus implant sizes, total procedure time and total inflated tourniquet time. …”
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Survival outcomes of hybrid total hip replacement following failed proximal femoral nail antirotation: a retrospective study with a median 10-year follow-up by Yannan Chen, Zhifen Lai, Weiguang Yu, Xianshang Zeng, Mingdong Zhao, Guangquan Zhu

“…Non-infected individuals aged 50–60 achieved optimal 10-year survival. Complications like stem loosening were reduced, but cement degradation and infection risks remain challenges. …”
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Histone H4 lysine 20 methylation marks genes dynamically regulated during erythroid maturation by Kristin Murphy, Michael Getman, Xiurui Lv, Zachary Murphy, Deanna Abid, Nabil Rahman, Michael Bulger, Laurie Steiner

“…These changes occurred in genic regions, with H4K20me3 at the transcription start site correlated with Pol II pausing, and H4K20me1 gene body levels tightly linked with transcriptional changes. Together, these data provide important insights into the role of H4K20 methylation in the regulation of gene expression during cellular differentiation.…”
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In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review by Ramirez-Miranda A, Guerrero-Becerril J, Ramirez M, Vera-Duarte GR, Mangwani-Mordani S, Ortiz-Morales G, Navas A, Graue-Hernandez EO, Alio JL

“…Innovative applications include its use in regenerative therapies, such as adipose-derived stem cell implantation, demonstrating increases in keratocyte density and stromal integrity. …”
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Hope is Not a Strategy: Key Lessons from COVID-19 for Future Health Crises by Knudsen SV, Kristensen I, Kure-Biegel N, Bech M, Agerbak H, Hansen CP, Mohr-Jensen C, Valentin JB, Petersen MB, Mainz J

“…This paper builds on these collected experiences, covering crucial areas such as strategies to reduce transmission, digitalization, management of non-COVID diseases, tracking adverse events, workplace well-being, development and use of predictive models, and maintaining public trust. Patient-level data on contacts, contact types, and clinical procedures were obtained from health administrative systems and clinical quality registries. …”
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Emotional Eating, Impulsivity, and Affective Temperaments in a Sample of Obese Candidates for Bariatric Surgery: Which Linkage? by Davide Gravina, Miriam Violi, Andrea Bordacchini, Elisa Diadema, Sara Fantasia, Marly Simoncini, Claudia Carmassi

“…Sociodemographic and clinical data were collected by psychiatrists during a single consultation. …”
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PO09 | Comparison of different aggregometry methods for evaluation of platelet function in patients with myeloproliferative neoplasms

“… Background and Aims: Myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells characterized by increased thrombotic and hemorrhagic complications. …”
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