OUTPOST: A comprehensive analysis software for whole‐metagenome shotgun sequencing incorporating group stratification by Yihang Zhou, Jihong Zheng, Wenqi Song, Xinyi Yan, Li Du, Zhonglin Ma, Yanbin Fu, Zhaohui Ouyang, Yuchen Xiao, Zhuoqun Liu, Feng Tian, Jason Wing Hon Wong, Jen Hao David Shih, Shikang Liang, Honglei Tian, Liu Liu, Ke Wei, Chao Zhang, Jiangtao Li, Xiaozhu Wang

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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

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Evaluation of the Yield and Agronomic Traits of Tropical alfalfa Cultivars in Sistan\'s Warm and Dry Climate by Ahmad Ghasemi, Mohammad Reza Narouierad, Mahmoud Mohammad ghasemi, Behnam Bakhshi

“…Days to greening, days to flowering, plant height, leaf-to-stem percentage, stem diameter, stem number, dry matter percentage, and wet and dry fodder yields were the traits measured during the experiment. …”
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Aberrant neuronal connectivity and network activity of neurons derived from patients with idiopathic schizophrenia by Johanna Heider, Emilio Pardo González, Sophia-Marie Hartmann, Nirmal Kannaiyan, Sabrina Vogel, Richard Wüst, Andreas J. Fallgatter, Moritz J. Rossner, Udo Kraushaar, Hansjürgen Volkmer

“…In parallel, we observed decreased lengths of axon initial segments, concordant with data from postmortem brains from patients with SCZ. …”
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Selecting patients with sickle cell disease for gene addition or gene editing‐based therapeutic approaches: Report on behalf of a joint EHA Specialized Working Group and EBMT Hemog... by Lucia de Franceschi, Franco Locatelli, David Rees, Christian Chabannon, Jean‐Hugues Dalle, Stefano Rivella, Achille Iolascon, Stephan Lobitz, Miguel R. Abboud, Josu de la Fuente, Pagona Flevari, Emanuele Angelucci, Mariane de Montalembert

“…Allogeneic hematopoietic stem cell transplantation potentially provides a cure with a relatively low rate of complications, but few patients have an HLA‐identical sibling. …”
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Experimental and numerical evaluation of the two-dimensional dynamics of water and nitrogen within a vegetated filter strip in the Daihai Basin, China by Bokai Yang, Xianyue Li, Fanfan Song, Delong Tian, Jianwen Yan, Ning Chen

“…In this study, VFSMOD and HYDRUS-1D were coupled via runoff depth linkage and validated using experimental data from the Daihai Basin, Inner Mongolia, China. …”
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Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex by Sulov Saha, Clémence Debacq, Christophe Audouard, Thomas Jungas, Pierrick Dupré, Fawal Mohamad-Ali, Clément Chapat, Henri-Alexandre Michaud, Laurent Le Cam, Matthieu Lacroix, David Ohayon, Alice Davy

“…Summary: Methionine is indispensable for cell proliferation, stem cell maintenance, and epigenetic regulation, three processes that are central to embryonic development. …”
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Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study by Yasuyuki Arai, Ruta Brazauskas, Naya He, A. Samer Al‐Homsi, Saurabh Chhabra, Minoo Battiwalla, Masamitsu Yanada, Amir Steinberg, Miguel Angel Diaz Perez, Sanghee Hong, Junya Kanda, Asad Bashey, Haydar A. Frangoul, Sherif M. Badawy, Leo F. Verdonck, Hillard M. Lazarus, Jean A. Yared, Hasan Hashem, Akshay Sharma, Mahmoud Aljurf, Ajoy L. Dias, Muhammad Bilal Abid, Baldeep Wirk, César O. Freytes, Amer M. Zeidan, Usama Gergis, Amer Beitinjaneh, Medhat Askar, Jeffrey J. Pu, Leslie E. Lehmann, Hemalatha G. Rangarajan, William A. Wood, Shahrukh Hashmi, Shingo Yano, Shinichi Kako, Yukiyasu Ozawa, Noriko Doki, Yoshinobu Kanda, Takahiro Fukuda, Yuta Katayama, Tatsuo Ichinohe, Junji Tanaka, Takanori Teshima, Shinichiro Okamoto, Yoshiko Atsuta, Wael Saber

“…ABSTRACT Background In this study, we compared outcomes of intensified myeloablative conditioning regimens using large registry data from Japan (Japanese Society for Transplantation and Cellular Therapy) and the United States (Center for International Blood and Marrow Transplant Research). …”
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In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles by Yifan Zhang, Masaki Nomura, Koutarou Nishimura, Weijia Zang, Yui Koike, Muran Xiao, Hiromi Ito, Miki Fukumoto, Atsushi Tanaka, Yumi Aoyama, Wataru Saika, Chihiro Hasegawa, Hiromi Yamazaki, Akifumi Takaori-Kondo, Daichi Inoue

“…Summary: The hierarchical organization of hematopoietic stem cells (HSCs) governing adult hematopoiesis has been extensively investigated. …”
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Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…The MBI-S was validated on self-reported data from 175 individuals. In an item analysis, the discriminatory power and item difficulties were examined. …”
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Reduced TREM2 activation in microglia of patients with Alzheimer's disease by Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sato

“…We generated an anti‐human TREM2 agonistic antibody and defined TREM2 activation in terms of the downstream expression changes induced by this antibody in microglia developed from human induced pluripotent stem cells (iPSC). Differentially expressed genes (DEGs) following TREM2 activation were compared with the gene set extracted from microglial single nuclear RNA sequencing data of patients with AD, using gene set enrichment analysis. …”
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Structural Comparison of Raw Sodium Bicarbonate and Hydrated Lime for Dry SO₂ Removal by Robert Makomere, Lawrence Koech, Hilary Rutto, Alfayo Alugongo, Sammy Kiambi, Ngeleshi Kibambe

“…These findings offer critical information pertinent to the intricate dry flue gas desulphurisation process. The data generated will help us to design fixed bed experiments in a subsequent study.…”
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Pangolin scales as adaptations for innate immunity against pathogens by Xuechen Tian, Li Chen, Jinfeng Zhou, Enbo Wang, Mu Wang, Nicholas Jakubovics, Jing Li, Kunping Song, King Tong Lau, Klaus-Peter Koepfli, Siyuan Zhang, Geok Yuan Annie Tan, Yixin Yang, Siew Woh Choo

“…Using a multi-omics analysis approach, we report a novel functional explanation for how mammalian scales can provide host–pathogen defense. Results Our data suggest that pangolin scales have a sophisticated structure that could potentially trap pathogens. …”
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Characterization of the binding features between SARS-CoV-2 5’-proximal transcripts of genomic RNA and nucleocapsid proteins by Shih-Cheng Chen, Cui-Ting Xu, Chuan-Fu Chang, Chia-Shin Yang, Pin-Han Lin, Wei-Min Liu, Yeh Chen, Chien-Hung Yu

“…We also observed that the conformer comprising multiple stem-loops (SLs) is preferentially bound by N proteins. …”
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The impact of antimicrobial use regulations on antimicrobial resistance among Salmonella isolates from bovine samples submitted to a veterinary diagnostic laboratory in Central New... by Maya Craig, Kevin J. Cummings, Claudia Cobo-Angel, Casey L. Cazer, Melissa S. Aprea, Rebecca J. Franklin-Guild

“…To address this gap in knowledge, we analyzed veterinary diagnostic laboratory data on 2413 Salmonella isolates from submitted bovine samples. …”
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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

“…DiscussionOur findings suggest that the degree of cellular susceptibility to oxidative stress is not conferred by soluble FH protein and other complement sources, but intercellularly because of the corresponding genetic risk predisposition. Our data support the hypothesis that RPE cells carrying high genetic risk are less resilient to oxidative stress.…”
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TREATMENT OF MYELOFIBROSIS: PRESENT AND FUTURE by Birsen Sahip Yesiralioğlu

“…Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterised by stem cell-derived clonal myeloproliferation often, but not always, accompanied by JAK2, CALR or MPL mutations. …”
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Digital PCR-based quantification of miR-181a in the cerebrospinal fluid aids patient stratification in pediatric acute lymphoblastic leukemia by Borbála Péterffy, Tamás J. Nádasi, Szilvia Krizsán, Anna Horváth, Ágnes Márk, Gábor Barna, Botond Timár, Laura Almási, Judit Müller, Krisztina Csanádi, Anna Rakonczai, Zsolt Nagy, Krisztián Kállay, Gabriella Kertész, Gergely Kriván, Monika Csóka, Anna Sebestyén, Ágnes F. Semsei, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Bödör, Bálint Egyed, Donát Alpár

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Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity by Guangsong Su, Bohan Chen, Yingjie Song, Qingqing Yin, Wenbin Wang, Xueyuan Zhao, Sibo Fan, Jie Lian, Dongqing Li, Jinfang Bi, Peng Li, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Wange Lu

“…By integrating multi-omics data (H3K27ac, Hi-C, scRNA-seq) across ESC states, we identified SEs interacting with master TFs, exemplified by the Klf5-adjacent SE (K5aSE). …”
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Epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years by Jian Wan, Jiaming Zhou, Zhuo Wang, Dan Liu, Hao Zhang, Shengmao Xie, Kaichun Wu, Yuanyuan Ji

“…Precision medicine integrating multi-omics data, advanced combination therapy, and complementary approaches, including stem cell transplantation, psychological therapies, neuromodulation, and gut microbiome modulation therapy, may offer solutions to break through the therapeutic ceiling.…”
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