The GDF11 represses the Stat3 signaling pathway, conferring metabolic, inflammatory, and oncogenic restrictions in cells derived from human hepatocellular carcinoma. by Melissa Sánchez-Rodríguez, Monserrat Gerardo-Ramírez, Arturo Simoni-Nieves, María Concepción Gutiérrez-Ruiz, Roxana U Miranda-Labra, Verónica Souza, Leticia Bucio-Ortiz, Alejandro Escobedo-Calvario, Luis E. Gomez-Quiroz

“…Functional and enrichment analysis was done using the Ingenuity Pathway Analysis (IPA) program. Results: Our data show 1450 differentially expressed genes. It is observed that GDF11 has a profound impact on highly oncogenic pathways, highlighting the Stat3 pathway, beta-catenin, and HIF-1 alpha, among others. …”
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Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…In addition to altering the mitotic spindle formation, the present data unveil that PCDH19 dysfunction leads to altered cytoskeletal rearrangement, providing therapeutic targets and pharmacological options to treat this disorder.…”
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Regenerative medicine in Obstetrics & Gynecology: Current status under the Act on the Safety of Regenerative Medicine in Japan by Satoshi Hosoya, Sena Awano-Kim, Ryo Yokomizo, Yuichiro Ukon, Kazuki Morita, Yuta Kasahara, Hiroshi Kishi, Aikou Okamoto

“…This study aimed to determine the current status of therapy and clinical research in the obstetrics and gynecology (OBGYN) in Japan under the Act on the Safety of Regenerative Medicine (RM Act). Methods: Detailed data were extracted from publicly available websites provided by the Ministry of Health, Labour, and Welfare. …”
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Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis by Tingwei Zheng, Tingwei Zheng, Dandan Wang, Yuxin Miao, Yuxin Miao, Meng Dong, Qin Liu, Qin Liu, Qiuning Zhang, Huiling Bai, Huiling Bai, Hongtao Luo, Meixuan Li

“…Studies were selected and data were extracted by two independent reviewers based on pre-established inclusion and exclusion criteria. …”
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Machine learning-based integration develops a metabolism-derived consensus model for improving immunotherapy in pancreatic cancer by Yang Song, Cheng Yang, Jie Min, Lei Hua, Haichuan Su, Ting Zhao, Yongdong Guo, Ronglin Wang, Jingjie Shi, Peixiang Ma, Junqiang Li

“…However, the metabolic landscape of PAC and its association with the TME remains largely unexplored.Methods We characterized the metabolic landscape of PAC based on 112 metabolic pathways and constructed a novel metabolism-related signature (MBS) using data from 1,188 patients with PAC. We evaluated the predictive performance of MBS for immunotherapy outcomes in 11 immunotherapy cohorts from both bulk-RNA and single-cell perspectives. …”
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Investigating the zoonotic origin of the West African Ebola epidemic by Almudena Marí Saéz, Sabrina Weiss, Kathrin Nowak, Vincent Lapeyre, Fee Zimmermann, Ariane Düx, Hjalmar S Kühl, Moussa Kaba, Sebastien Regnaut, Kevin Merkel, Andreas Sachse, Ulla Thiesen, Lili Villányi, Christophe Boesch, Piotr W Dabrowski, Aleksandar Radonić, Andreas Nitsche, Siv Aina J Leendertz, Stefan Petterson, Stephan Becker, Verena Krähling, Emmanuel Couacy‐Hymann, Chantal Akoua‐Koffi, Natalie Weber, Lars Schaade, Jakob Fahr, Matthias Borchert, Jan F Gogarten, Sébastien Calvignac‐Spencer, Fabian H Leendertz

“…Abstract The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2‐year‐old boy in Meliandou, Guinea. …”
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Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis by Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong

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Quantifying the Carbon Stocks in Urban Trees: The Rio de Janeiro Botanical Garden as an Important Tropical Carbon Sink by Bruno Coutinho Kurtz, Thaís Moreira Hidalgo de Almeida, Marcus Alberto Nadruz Coelho, Lara Serpa Jaegge Deccache, Ricardo Maximo Tortorelli, Diego Rafael Gonzaga, Louise Klein Madureira, Ramon Guedes-Oliveira, Claudia Franca Barros, Marinez Ferreira de Siqueira

“…Our survey included 6793 stems with a diameter at breast height (DBH) ≥ 10 cm. …”
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Stereotactic radiosurgery for brain metastases in a child with extra-skeletal Ewing's sarcoma by T. S. Rogova, P. G. Sakun, V. I. Voshedskii, S. G. Vlasov, L. Y. Rozenko, E. A. Karnaukhova, O. G. Rodionova, M. A. Komandirov, E. A. Gorbunova, S. A. Kuznetsov, M. V. Strazhetskaya, G. A. Mkrtchyan, D. Y. Yurchenko, E. E. Pak, A. I. Bespalova

“…To date, insufficient data has been published on the use of stereotactic radiosurgery in pediatric oncology, but in the available literature, the authors demonstrate the effectiveness and safety of treatment. …”
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Agromorphological Evaluation of Elite Lines of Native Tomato (<i>Solanum lycopersicum</i> L.) from Central and Southern Mexico by María Concepción Valencia-Juárez, Enrique González-Pérez, Salvador Villalobos-Reyes, Carlos Alberto Núñez-Colín, Jaime Canul-Ku, José Luis Anaya-López, Elizabeth Chiquito-Almanza, Ricardo Yáñez-López

“…Sixty characters were evaluated in 16 advanced lines of native tomatoes from Central and Southern Mexico during the fall–winter cycles 2023–2024 at the Bajío Experimental Station, Celaya, Guanajuato, Mexico, based on the guidelines of the International Union for the Protection of New Varieties of Plants (UPOV) and the International Plant Genetic Resources Institute (IPGRI). The data were analyzed using descriptive statistics, analysis of variance and post hoc tests, canonical discriminant analysis, and the Eigenanalysis selection index method (ESIM). …”
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The Mechanism and Dynamic Regulation of Epithelial to Mesenchymal Transition in Ovarian Cancer by Pande Kadek Aditya Prayudi, I Gde Sastra Winata, I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, Kade Yudi Saspriyana, Ketut Suwiyoga

“…Mechanism: A literature review using evidences from several data bases (i.e., PubMed, EMBASE, Web of Science, Medline, Cochrane, Science Direct, and Google Scholar) were conducted to describe the basic mechanism and dynamic regulation of EMT in OC cells. …”
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COMBINATION OF INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS by O. V. Shadrivova, S. N. Khostelidi, Yu. V. Borzova, E. A. Desyatik, A. G. Volkova, M. O. Popova, O. S. Uspenskaya, O. S. Ruzhinskaya, T. V. Shneyder, T. S. Bogomolova, S. M. Ignatyeva, L. S. Zubarovskaya, B. V. Afanasyev, N. N. Klimko

“…Objective. Data analysis of the register of patients with invasive aspergillosis (IA), which was founded in Saint Petersburg (1998–2017), and clinical case description of successful treatment of IA and mucormycosis with lungs involvement in a patient with Hodgkin’s lymphoma.Materials and methods. …”
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Young Adults Journey with Digital Fitness Tools-A Qualitative Study on Use of Fitness Tracking Device [version 1; peer review: 2 approved] by Vishweshwara Bhat, Mukesh Kumar Sinha, Nihala N, Rachel Edna Lobo, Asees Kaur Gulati, Vaishali K, Neha Bora

“…However, users often exhibit poor long-term adherence to these devices, which may stem from a lack of understanding of the factors influencing their use, as well as changes in health behavior. …”
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Systematic evaluation of plant metals/metalloids accumulation efficiency: a global synthesis of bioaccumulation and translocation factors by Wenbin Huang, Wenbin Huang, Chengnian Zhang, Bowei Zhu, Xiaoying Liu, Huxuan Xiao, Huxuan Xiao, Shibin Liu, Shibin Liu, Shibin Liu, Huaiyong Shao

“…It remains unclear how these factors modulate the efficiency of phytoremediation. We synthesized 547 data pairs from 82 studies to comprehensively evaluate the ability of hyperaccumulating plants to accumulate and translocate metals/metalloids under varying environmental conditions. …”
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From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines by Fengyan Deng, Valentina Peña, Pedro Morales-Sosa, Andrea Bernal-Rivera, Bowen Yang, Shengping Huang, Sonia Ghosh, Maria Katt, Luciana Andrea Castellano, Lucinda Maddera, Zulin Yu, Nicolas Rohner, Chongbei Zhao, Jasmin Camacho

“…Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. …”
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Neuropathic Pain Following Breast-conserving Surgery: A Systematic Review and Meta-Analysis by Esmee Kwee, Lucas G. de Groot, Paula Rijs Alonso, Keghart Krikour, Liron S. Duraku, Caroline A. Hundepool, J. Michiel Zuidam

“…Although neuropathic pain prevalence is reported at 24%-36% post-mastectomy, the data following breast-conserving surgery remain limited. …”
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LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy by Yuyan Xu, Jing Hu, Yuhang Fan, Licheng Sun, Ning Shen, Qihuang Jin, Ling Zhang, Jin Zhang, Fang Zhang, Hui Chen

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Integrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study by Saskia Hussung, Maria E. Hess, Elham Bavafaye Haghighi, Uwe A. Wittel, Melanie Boerries, Ralph M. Fritsch

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Crescimento e produção de bagas da mamoneira irrigada com água residuária doméstica Growth and production of seeds of castor bean crop irrigated with domestic wastewater by Luis N. Rodrigues, Aparecida R. Nery, Pedro D. Fernandes, Napoleão E. de M. Beltrão, Hans R. Gheyi

“…A produção de sementes foi avaliada na última data. A mamoneira irrigada com 0,60 ETc, em relação a 1,05 da ETc, aos 174 DAS, teve a altura de planta, o diâmetro caulinar, o número de folhas, a área foliar e produção de sementes reduzidos em 23,45, 16,14, 26,23, 44,06 e 50,59%, respectivamente. …”
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Histone marks enable formation of immiscible phase-separated chromatin compartments by Wenjing Sun, Jiacheng Wang, Wenqian Liu, Baixue Tang, Hongyuan Qu, Huanxing Su, Jianwei Wang, Haitao Li, Wei Xie, Pilong Li

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