Phytochemical Screening and Biological Activities of <i>Lippia multiflora</i> Moldenke by Dorcas Tlhapi, Ntsoaki Malebo, Idah Tichaidza Manduna, Monizi Mawunu, Ramakwala Christinah Chokwe

“…The results show the stem bark, methanol leaf, and dichloromethane leaf extracts were well-tolerated by the Vero cell line at concentrations up to 50 µg/mL. …”
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Prognostic relevance of bone marrow immune cell fractions in newly diagnosed B-cell non-Hodgkin lymphoma patients by Luciana Valvano, Rocchina Vilella, Fiorella D’Auria, Giovanni D’Arena, Rossana Libonati, Michela Soda, Alessia Telesca, Giuseppe Pietrantuono, Giovanna Rosaria Mansueto, Oreste Villani, Simona D’Agostino, Giovanni Calice, Teodora Statuto

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PFS24 as a prognostic milestone in patients with newly diagnosed primary CNS lymphoma by Vanja Zeremski, Tobias R. Haage, Hanno M. Witte, Louisa Adolph, Sina A. Beer, Gerhard Behre, Benedikt Jacobs, Christoph Kahl, Chrysavgi Lalayanni, Jens Panse, Sotirios Papageorgiou, Marina P. Siakantaris, Jessica Schneider, Ulf Schnetzke, Alexander Schulz, Theodoros P. Vassilakopoulos, Jeanette Walter, Dimitrios Mougiakakos

“…Abstract High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation has significantly improved overall survival (OS) in primary central nervous system lymphoma (PCNSL). …”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…These triggers should be transparent to the public, validated, and updated over time with evolving data. These automatic triggers would prevent confusion, inconsistent guidelines, and inequitable contingency allocation at the hands of distressed providers when crisis standards are needed. …”
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Farmers’ willingness to adopt daylily forage technology in Northern Shanxi of China by Xiangjuan Hou, Qidong Li, Qidong Li, Qishen Jiang, Qishen Jiang, Minna Zheng, Chunyan Li, Chunyan Li, Yanting Yin, Yanting Yin, Changyu Gao, Changyu Gao, Cunzhen Liu, Cunzhen Liu, Xiangyang Hou, Xiangyang Hou

“…This study explores two aspects: first, the research on the impact of personal, family, planting, and other characteristics on farmers’ willingness to adopt the forage utilization technology of stems and leaves of Hemerocallis citrina Baroni (Hc-FUT); and second, the influence of behavioral attitudes, subjective norms, and perceived behavioral control on farmers’ willingness to adopt Hc-FUT, based on the Theory of Planned Behavior (TPB).MethodsData were obtained from 225 farmers in the Yunzhou District, Datong City, Shanxi Province, China. …”
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Synergistic effects of turmeric, banana peels, and onion extracts on broiler performance, mechanical properties, microbial quality, and chicken meat quality assessment by Ahmed M. Abdulfattah, Ahmed M. Abdulfattah, Fayez Alsulaimani, Fayez Alsulaimani, Ahmed M. Basri, Ahmed M. Basri, Nashi K. Alqahtani, Hilary Uguru, Okeoghene Eboibi, D. E. Edafiadhe, Rokayya Sami, Mahmoud Helal

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Cleaning methods for biosafety cabinet to eliminate residual mycoplasmas, viruses, and endotoxins after changeover by Mitsuru Mizuno, Saeri Kimbara, Hanae Ichise, Natsumi Ishikawa, Yuto Nishihara, Miwako Nishio, Ichiro Sekiya

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Persistent vegetation greening trends across China’s wetlands by Yongxing Ren, Dehua Mao, Tao Wang, Mohamed Abdalla, Pete Smith, Xiangming Xiao, Zicheng Yu, Xiuxue Chen, Yanbiao Xi, Ling Luo, Xiaoyan Li, Zongming Wang

“…This lack of understanding stems from insufficient in-situ observations, complex interactions between wetland vegetation growth and local hydrology, and challenges in estimating AGB using remote sensing data alone. …”
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Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces by Weihang Gao, Zineng Yan, Hong Zhou, Yi Xie, Honglin Wang, Jiaming Yang, Jingbo Yu, Changmao Ni, Pengran Liu, Mao Xie, Li Huang, Zhewei Ye

“…Neural interfacing electrodes are positioned between external electronic devices and the nervous system to capture complex neuronal activity data and promote the repair of damaged neural tissues. …”
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Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line stimulated with live probiotic bacteria by Akira Sen, Atsuki Imai, Eiji Miyauchi, Kota Yanagisawa, Tsukasa Oda, Fuki Sasaki, Shintaro Uchida, Takuhisa Okada, Takehiko Yokobori, Hiroshi Saeki, Toshitaka Odamaki, Nobuo Sasaki

“…B. longum-stimulated MHCO exhibited barrier-enhancing characteristics, as demonstrated in clinical trials. Our data represent a valuable resource for understanding gut microbe and host cell communication.…”
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E-CLIP: An Enhanced CLIP-Based Visual Language Model for Fruit Detection and Recognition by Yi Zhang, Yang Shao, Chen Tang, Zhenqing Liu, Zhengda Li, Ruifang Zhai, Hui Peng, Peng Song

“…While fruit detection and recognition are essential for robotic harvesting, existing methods suffer from limited generalizability, including adapting to complex environments and handling new fruit varieties. This problem stems from their reliance on unimodal visual data, which creates a semantic gap between image features and contextual understanding. …”
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Integrating Dilemma Stories into Chemistry Learning: Analyzing Students’ Critical Thinking Skills by Tritiyatma Hadinugrahaningsih, Yuli Rahmawati, Rika Siti Syaadah, Fitri Sumalia Dewi, Shakira Az-Zahra, Fitri Tamarani

“…A qualitative approach was used, with data collected through observations, reflective journals, interviews, and critical thinking tests. …”
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A novel molecular classification system based on the molecular feature score identifies patients sensitive to immune therapy and target therapy by Yang Li, Yang Li, Yinan Ding, Yinan Ding, Jinghao Wang, Xiaoxia Wu, Xiaoxia Wu, Dinghu Zhang, Dinghu Zhang, Han Zhou, Han Zhou, Pengfei Zhang, Pengfei Zhang, Guoliang Shao, Guoliang Shao

“…This study aims to investigate its molecular classifications based on multidimensional molecular features scores (FSs) and support classification-guided precision medicine.MethodsData of bulk RNA sequencing, single nucleotide variation, and single-cell RNA sequencing were collected. …”
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A Randomized Controlled ‘REAL‐FITNESS’ Trial to Evaluate Physical Activity in Patients With Newly Diagnosed Multiple Myeloma by Esther Dreyling, Jan Räder, Mandy‐Deborah Möller, Gabriele Ihorst, Sina Wenger, Antonia Pahl, Jann Arends, Georg Herget, Peter Deibert, Ralph Wäsch, Monika Engelhardt

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CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation by Edward Abadir, Robin E. Gasiorowski, Kaitao Lai, Fiona Kupresanin, Adelina Romano, Pablo A. Silveira, Tsun‐Ho Lo, Phillip D. Fromm, Marina L. Kennerson, Harry J. Iland, P. Joy Ho, P. Mark Hogarth, Kenneth Bradstock, Derek N.J. Hart, Georgina J. Clark

“…Detailed analysis of publicly available transcriptomic data indicated that CD34+ HSPC expressed fewer CD300f transcripts that lacked exon 4 compared to AML with monocytic differentiation. …”
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Successful termination of a multi-year wastewater-associated outbreak of NDM-5-carrying E. coli in a hemato-oncological center by Heidrun Kerschner, Linda Jernej, Adriana Cabal, Patrick Hyden, Sigrid Machherndl-Spandl, Lucia Berning, Anna Blaimschein, Werner Ruppitsch, Petra Apfalter, Rainer Hartl

“…This report details the outbreak investigation, control measures and the whole genome sequencing (WGS) data of the outbreak isolates. Methods A total of 15 isolates (seven clinical isolates from allogenic stem cell transplant (SCT) recipients and eight wastewater isolates recovered from patients’ toilets) were analyzed by whole genome sequencing. …”
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Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context by Junhao Wang, Xinyi Chen, Wenxuan Du, Cha Lin, Yu Liao, Jean-Christophe Corvol, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Michael A. Schwarzschild, Pille Taba, Sulev Kõks, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Baijayanta Maiti, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer, Ganqiang Liu, Ganqiang Liu, Rebecca R. Valentino, Zhixiang Liao, Joseph J. Locascio, Jean-Christophe Corvol, Xianjun Dong, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzchild, Michael T. Hayes, Anne-Marie Wills, Todd M. Herrington, Bernard Ravian, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Peter Heutink, Jacobus J. van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, Clemens R. Scherzer

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Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting by Valentina R. Minciacchi, Jimena Bravo, Christina Karantanou, Raquel S. Pereira, Costanza Zanetti, Rahul Kumar, Nathalie Thomasberger, Pablo Llavona, Theresa Krack, Katrin Bankov, Melanie Meister, Sylvia Hartmann, Véronique Maguer-Satta, Sylvain Lefort, Mateusz Putyrski, Andreas Ernst, Brian J. P. Huntly, Eshwar Meduri, Wolfram Ruf, Daniela S. Krause

“…Abstract Fibrinolysis influences the mobilization of hematopoietic stem cells from their bone marrow microenvironment (BMM). …”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

“…Consistent with CDK4 mediating CT-179 resistance, CT-179 combines effectively with the CDK4/6 inhibitor palbociclib, further prolonging survival in vivo. These data support therapeutic targeting of OLIG2+ tumor stem cells in regimens for SHH-driven MB, to improve response, delay recurrence and ultimately improve MB patient outcomes.…”
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Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes by Lisa Dietsche, Kristin Stirm, Veronika Lysenko, Corina Schneidawind, Alexandar Tzankov, Anne Müller, Alexandre P. A. Theocharides

“…Moreover, in MV4-11 cells SMAD1 presence sensitized cells for TGF-β mediated G1-arrest.ConclusionOverall, our data contributes to the understanding of the role of TGF-β signaling in acute myeloid leukemia with KMT2A::AFF1 by showing that SMAD1 loss can influence the growth dynamics and contribute to the pathogenic expression of disease driving factors.…”
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