Late-onset telomere biology disorders in adults: clinical insights and treatment outcomes from a retrospective registry cohort by Mareike Tometten, Fabian Beier, Martin Kirschner, Yannic Schumacher, Jeanette Walter, Margherita Vieri, Kim Kricheldorf, Alexander Röth, Uwe Platzbecker, Markus Radsak, Philippe Schafhausen, Selim Corbacioglu, Britta Höchsmann, Stefan Balabanov, Claas Hinze, Jörg Chromik, Michael Heuser, Michael Kreuter, Marcin W. Wlodarski, Miriam Elbracht, Ingo Kurth, Steffen Koschmieder, Jens Panse, Susanne Isfort, Robert Meyer, Tim H. Brümmendorf

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Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…Although preclinical trials in HD models have shown promise in improving cognitive and motor functions, stem cell therapy still faces many challenges and disadvantages including immunosuppression and immunorejection as well as ethical, technical, and safety concerns. …”
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Immunogenetic profile of MIC (A, B) HLA loci linked to MHC antigenic complex in Russians of the Chelyabinsk Region by A. L. Burmistrova, M. N. Vavilov, D. S. Stashkevich, T. A. Suslova

“…The smallest genetic distances between the population of Russians from Chelyabinsk Region and other world populations were found between the population of Slovenia, as well as the USA population of European origin. As based on scatterplot obtained by the MDS approach for MICA gene frequencies, using the data of cluster analysis, we have found that the population of Russians from Chelyabinsk Region belongs to a cluster of typical European populations.The obtained patterns could be used for practical purposes to create a registry of stem cell donors in Russia. …”
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Intrauterine infusion of autologous endometrial stem cells for the treatment of moderate and severe intrauterine adhesions: a before-and-after study by Enuo Peng, Yayue Zeng, Da He, Xiaojun Tan, Dabao Xu, Xingping Zhao

“…To explore the underlying mechanism, primary endometrial stem cells from healthy individuals and IUA patients, as well as fifth-generation endometrial stem cells from IUA patients, were further conducted with RNA sequencing to screen for differentially expressed genes, which were subsequently used for functional enrichment analysis. …”
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A comparison of relative survival and cause‐specific survival methods to measure net survival in cancer populations by Nupur Makkar, Quinn T. Ostrom, Carol Kruchko, Jill S. Barnholtz‐Sloan

“…Methods Using data from 18 SEER registries between 2000 and 2014, five‐year RS and CSS estimates were generated overall as well as by age groups and by sex. …”
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Safety and therapeutic potential of allogeneic adipose-derived stem cell spray transplantation in ischemic cardiomyopathy: a phase I clinical trial by Takuji Kawamura, Daisuke Yoshioka, Ai Kawamura, Yusuke Misumi, Takura Taguchi, Daisuke Mori, Shunsuke Saito, Takashi Yamauchi, Hiroki Hata, Shigeru Miyagawa

“…The participants were randomized to receive CABG as well as ADSC spray therapy or placebo. The primary endpoints were safety, changes in late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) volumes, and feasibility. …”
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Prognostic effect of body mass index in patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation: A retrospective cohort study by Jing Yu, Zhuoyue Shi, Hengwei Wu, Yi Luo, Jian Yu, Yamin Tan, Xiaoyu Lai, Lizhen Liu, Huarui Fu, Yishan Ye, Luxin Yang, Congxiao Zhang, He Huang, Jimin Shi, Yanmin Zhao

“…Obesity is a well-known risk factor for many diseases, but the impact of baseline body mass index (BMI) on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial. …”
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Incidence and risk factors of graft failure in allogeneic hematopoietic stem cell transplantation for mucopolysaccharidosis in a nationwide pediatric cohort. A study on behalf of t... by Laura Danhardt, Arnaud Wiedemann, Gerard Michel, Jean‐Hugues Dalle, Fanny Rialland, Cécile Renard, Charlotte Jubert, Johan Maertens, Anne Sirvent, Nimrod Buchbinder, Christine Devalck, Bénédicte Brichard, Catherine Paillard, Stephanie Nguyen, Angelo Paci, David Combarel, Martin Castelle, Simona Pagliuca, Cecile Pochon

“…Consequently, advancing allogeneic hematopoietic stem cell transplantation (HSCT) for young children is crucial. …”
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Clinical case of acquired idiopatic aplastic anemia by A. V. Serezhkina, G. I. Khmelevskaya, N. S. Razinkova, T. A. Minenkova, A. A. Bezykina, E. A. Sentishcheva, R. E. Gromov

“…Acquired idiopathic aplastic anemia is an extremely rare severe blood disease in which proliferation stops and blood stem cells die in the bone marrow, which is morphologically expressed in the replacement of functional BM cells with fat cells, as well as absolute pancytopenia. …”
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Utilization of novel systemic therapies for multiple myeloma: A retrospective study of front‐line regimens using the SEER‐Medicare data by Daisuke Goto, Rahul Khairnar, Jean A. Yared, Candice Yong, Dorothy Romanus, Eberechukwu Onukwugha, Julia F. Slejko

“…However, the real‐world utilization of these new agents has not been studied well. This study evaluated year‐to‐year changes in treatment choices in a cohort of patients aged 66 or older in the Surveillance, Epidemiology, and End Results (SEER) registry linked with Medicare claims (SEER‐Medicare) data who were diagnosed with MM between 2007 and 2011. …”
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Mapping changes in the utilization of childhood immunization over 5 years in a south Indian tertiary care hospital by Merrin Mathew, Savitha Rajapur Sanathan, Juny Sebastian, Mandyam Dhati Ravi, Taniya Joy, Rovin Mathew Theempalangad, Panchaksharappa Gowda

“…These variabilities may stem from a range of internal and external factors influencing parental preferences. …”
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Effect of long and short half-life PDE5 inhibitors on HbA1c levels: a systematic review and meta-analysisResearch in context by Joseph Kim, Rui Zhao, Lawrence Richard Kleinberg, Kitai Kim

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Cement-within-cement technique in revision reverse total shoulder arthroplasty: complications, reoperations, and revision rates at 5-year mean follow-up by Rodrigo de Marinis, MD, John W. Sperling, Jr., Erick M. Marigi, MD, Ausberto Velasquez Garcia, MD, Eric R. Wagner, MD, Joaquin Sanchez-Sotelo, MD, PhD

“…In hip arthroplasty, the cement-within-cement (CwC) technique has been well described as an effective option. However, for shoulder arthroplasty there remains a paucity of data investigating this technique. …”
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Studying and understanding the architectural ornamentations of residential buildings in the historical city of Masouleh by Saeid Hasanpour Loumer, Ahad Nejad Ebrahimi, Hassan Sattari Sarbangholi, Ali Vandshoari

“…The present research, based on field surveys, library studies, and utilizing descriptive-analytical methods, indicates that the decorations on residential buildings in Masouleh are categorized into elements such as doors, domes, windows, railings, bell covers, and electrical meter boxes, as well as floral and mirror motifs. The results also show that the main factors influencing the formation of decorations on residential buildings in Masouleh are for enhancing security (doors), reducing structural pressures against wind and earthquake (domes), meeting spatial lighting needs (windows), increasing safety, creating green spaces and seasonal employment spaces (railings), meeting user needs for facilitating and enhancing user well-being in contemporary times, and eliminating the undesirable appearance of electronic equipment (bell covers and electrical meter boxes) derived from religious and cultural beliefs (floral motifs) stemming from people's interest in flowers and plants and being influenced by the geography of Gilan Province (floral decorations), as well as rooted in the religious and ritual beliefs of the people of Masouleh.…”
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Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower‐risk myelodysplastic syndromes by David Rombaut, Sarah Sandmann, Tobias Tekath, Simon Crouch, Aniek O. deGraaf, Alexandra Smith, Daniel Painter, Olivier Kosmider, Magnus Tobiasson, Andreas Lennartsson, Bert A. van derReijden, Sophie Park, Maud D'Aveni, Borhane Slama, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Arjan van deLoosdrecht, Saskia Langemeijer, Argiris Symeonidis, Jaroslav Čermák, Claude Preudhomme, Aleksandar Savic, Ulrich Germing, Reinhard Stauder, David Bowen, Corine vanMarrewijk, Elsa Bernard, Theo deWitte, Julian Varghese, Eva Hellström‐Lindberg, Martin Dugas, Joost Martens, Luca Malcovati, Joop H. Jansen, Michaela Fontenay, MDS‐RIGHT consortium

“…We performed a comprehensive study of somatic mutations and DNA methylation in a large and clinically well‐annotated cohort of treatment‐naive patients with LR‐MDS at diagnosis from the EUMDS registry (ClinicalTrials.gov.NCT00600860). …”
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Enhancing programmatic scale-up: Applying the consolidated framework for implementation research to evaluate decentralized drug-resistant tuberculosis services in Southern Nigeria. by Ngozi Murphy-Okpala, Chinwe Eze, Edmund Ndudi Ossai, Chibuike Innocent Agu, Ifeyinwa Ezenwosu, Charles Nwafor, Ngozi Ekeke, Anthony Meka, Sode Matiku, Beatrice Kirubi, Okechukwu Ezeakile, Martin Njoku, Francis S Iyama, Jacob Creswell, Victor Babawale, Chukwuma Anyaike, Joseph Chukwu

“…<h4>Trial registration</h4>Pan African Clinical Trial Registry PACTR202309676675265.…”
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Hope is Not a Strategy: Key Lessons from COVID-19 for Future Health Crises by Knudsen SV, Kristensen I, Kure-Biegel N, Bech M, Agerbak H, Hansen CP, Mohr-Jensen C, Valentin JB, Petersen MB, Mainz J

“…This paper builds on these collected experiences, covering crucial areas such as strategies to reduce transmission, digitalization, management of non-COVID diseases, tracking adverse events, workplace well-being, development and use of predictive models, and maintaining public trust. …”
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