The first experience of allogeneic bone marrow transplantation in a patient with Mycosis Fungoides (clinical report) by I. A. Kuklin, M. M. Kokhan, O. G. Rimar, T. S. Konstantinova, I. V. Anisimova, M. K. Kuklina

“…Taking into account the onset of the disease at a young age, the aggressive course and the late stage of the disease, the consultation decided to perform an allogeneic hematopoietic stem cell transplant for the patient. In the post-transplant period, simultaneously with standard systemic immunosuppressive therapy with cyclosporine A and mycophenolate mofetil, topical glucocorticosteroids and a dermatocosmetic agent with anti-inflammatory, antipruritic and regenerating effects were prescribed to the patient as external agents. …”
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Challenges and Advances in the Production of Transplantable Retinal Tissue from Retinal Organoids by Samir Malhotra, Magdalene J. Seiler, Andrew W. Browne

“…Recent innovations, including automated bioreactor systems and optimized surgical techniques, offer potential solutions. …”
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Parametric optimization of flow in a solar chimney power plant under variable semi elliptical constraints by Rajamurugu Natarajan, S. Yaknesh, K B Prakash, Mohammed Al Awadh, Qasem M. Al-Mdallal

“…Abstract In response to the ongoing quest for more efficient renewable energy sources, this research addresses a significant gap in understanding the performance variations of Solar Chimney Power Plant (SCPP) models, particularly focusing on the influence of flow parameters in full and half-inclined collector sections featuring semi-elliptical curvature. The motivation stems from the need to optimize SCPP designs for enhanced energy generation while minimizing resource utilization and environmental impact. …”
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A combined improved dung beetle optimization and extreme learning machine framework for precise SOC estimation by Kaihua Yao, Xinyu Yan, Xiling Mao, Mengwei Li, Xiao Li, Ziyu Lian, Yuxiang Han

“…The novelty of the model stems from the application of the IDBO algorithm, which incorporating Circle chaotic mapping, the Golden sine strategy, and the Levy flight strategy, for hyper-parameter optimization. …”
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Impact of Digestate-Derived Nitrogen on Nutrient Content Dynamics in Winter Oilseed Rape Before Flowering by Remigiusz Łukowiak, Witold Szczepaniak, Dominik Młodecki

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A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells by Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD van Veldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin

“…Here, we leveraged a series of isogenically matched, diseased and genetically engineered, human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) from patients to test a novel hERG allosteric modulator for treating congenital LQTS, drug‐induced LQTS or a combination of the two. …”
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Optimizing resazurin-based viability assays for P-MSC/TER308 cell line to enhance results reliability by Jessica Petiti, Laura Revel, Carla Divieto

“…This work describes the optimization of the resazurin-based viability assay on the P-MSC/TERT308 cell line, a placenta-derived mesenchymal stem cell used within the LifeSaver project. …”
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Optimizing Plasma Discharge Intensities and Spraying Intervals for Enhanced Growth, Mineral Uptake, and Yield in Aeroponically Grown Lettuce by Abdallah Harold Mosha, Pengfei Shen, Jianmin Gao, Osama Elsherbiny, Waqar Ahmed Qureshi

“…These results demonstrate the combined effect of plasma intensity and spraying frequency in optimizing plant development in aeroponic systems. As far as mineral uptake is concerned, T3 increased the nitrogen, potassium, phosphorus, calcium, and magnesium concentrations by 18.2%, 16.7%, 32.3%, 20.2%, and 11.2%, respectively, compared with T1. …”
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Deep Learning Network Selection and Optimized Information Fusion for Enhanced COVID-19 Detection: A Literature Review by Olga Adriana Caliman Sturdza, Florin Filip, Monica Terteliu Baitan, Mihai Dimian

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Enhancing Security for Resource-Constrained Smart Cities IoT Applications: Optimizing Cryptographic Techniques with Effective Field Multipliers by Atef Ibrahim, Fayez Gebali

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Multifaceted Optimization of MSC-Based Formulation upon Sodium Iodoacetate-Induced Osteoarthritis Models by Combining Advantageous HA/PG Hydrogel and Fluorescent Tracer by Ai-tong Wang, Meng Zhao, Ying Feng, Honghong Jia, Leisheng Zhang, Hao Yu, Zongjin Li, Zhibo Han, Zhongchao Han

“…Afterwards, we turned to a dual-luciferase reporter tracing system and evaluated the spatiotemporal distribution and metabolokinetics of bifluorescence expressing UC-MSCs (BF-MSCs) in OA rats. …”
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“Digital” generation in the educational system of the Russian region: problems and solutions by S. V. Butsyk

“…The second model, on the one hand, does not impose strict age restrictions, but, at the same time, requires an educational organization to implement the training system that would effectively motivate students to learning and cognitive activity (with or without gadgets) on school days.…”
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Recent advances in oral cryotherapy for the management of anticancer therapy-induced oral mucositis by Feng lin Hu, Ni Lou, Guo lin Wu

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Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers by Yilin Wang, Jingyuan Meng, Jiechao Zhang, Lichao Tian, Wenrui Wei, Xiaoye Tang, Qian Zhang, Daofang Ding, Xuepeng Wang, Zicheng Guo, Yong He

“…Quantitative data show that axial stretch preserves PI3K/Akt/mTOR activity, with phosphorylated Akt levels increasing by two‐ to three‐fold and fiber cross‐sectional area expanding by 10%–20%; low‐intensity compression activates AMPK and autophagy, with AMPK phosphorylation rising by 1.5‐fold without triggering excessive protein breakdown; and shear stress enhances VEGF and Nrf2‐mediated angiogenesis and antioxidant defenses, doubling VEGF expression and reducing ROS levels by 25% to mitigate neurogenic atrophy. Moreover, stem‐cell myogenic differentiation is optimized on 3D biomimetic substrates with stiffness from 11 to 17 kPa under physiological loading, and advances in biomaterials and tissue engineering enable more accurate muscle‐tissue models.Future Directions Translating these biomechanical insights into tailored clinical interventions—combining stretch, compression, and shear modalities with biomaterials, stem-cell technologies, and personalized exercise programs— holds promise for preventing and reversing muscle atrophy across diverse patient populations.…”
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Modeling and optimization of essential oils and extracts for meat quality evaluation during storage, with high-performance liquid chromatography analysis of aflatoxin levels by Sarah Alharthi, Sarah Alharthi, Rokayya Sami, Hilary Uguru, Ruqaiah I. Bedaiwi, Awatif M. Almehmadi, Suzan A. Abushal, Roqayah H. Kadi, Buthaina M. Aljehany, Eman A. Abduljawad, Abeer A. Aljehani, Sarah S. Aggad, Sarah A. Alasmari, Dalal A. Alkhudhayri, Fayez Alsulaimani, Fayez Alsulaimani, Ahmed M. Basri, Ahmed M. Basri

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The Optimization Path of VR Red Resource Reading Style under the Embodied Cognition: An Exploratory Study Based on Grounded Theory by Jia XU

“…The interaction of these three main categories forms a dynamic feedback loop, ensuring that the VR red resource reading system can be continuously optimized with the development of technology and changes in user needs, and promoting the continuous innovation and optimization of VR red resource reading methods. …”
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Targeted Drug Delivery System for Pulmonary Fibrosis: Design and Development of Biomaterials by Jinsha Liu, Zifeng Pan, Arshma Khan, Haoguang Li

“…Despite the promising potential of these systems, clinical translation is hindered by several challenges, including immune clearance, stability of delivery platforms, and optimization of drug retention within diseased tissues. …”
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Construction of genetic transformation system mediated by Agrobacterium rhizogenes in Vaccinium corymbosum by WU Tingting, LIU Liangqin, JIANG Yanqin, GE Chunfeng, TIAN Liangliang, LIU Mengxi, ZENG Qilong, YU Hong

“…The optimal conditions for the genetic transformation system are as follows: an Agrobacterium suspension with OD600=1.0 is used, supplemented with a combination of 200 μmol·L-1 AS and 0.05% S L-77 as additives, and the bud points and both ends of the green stem segments are infected via injection, followed by dark cultivation for 4 days. …”
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New Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review by Chiara Sassetti, Claudia Borrelli, Martha Mazuy, Cristina Guerriero, Donato Rigante, Susanna Esposito

“…<b>Conclusions:</b> While innovative systemic therapies show promise for juvenile scleroderma, their widespread clinical application remains limited by insufficient pediatric-specific evidence. …”
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Optimal Scheduling of Electric Vehicles for Peak Load Regulation: A Multi-Time Scale Approach with Comprehensive Evaluation and Feedback by Fei Xue, Wei Xiong, Jiahao Chen, Yonghai Yi, Zehui Liu, Jun Zeng, Junfeng Liu

“…Simulations on the IEEE 33-node system demonstrate that the proposed model effectively optimizes EV load profiles, reducing the peak-to-valley difference rate from 41.74% to 35.19%. …”
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