Mesenchymal stem cell-derived exosomes for the treatment of knee osteoarthritis: a systematic review and meta-analysis based on rat model by Zhe Wang, Zihao Hu, Lin Niu, Yongsheng Xu, Yansong Qi

“…Subgroup analysis of MSC types may suggest that exosomes derived from synovial fluid mesenchymal stem cells (SF-MSC-exos) and umbilical cord mesenchymal stem cells (UMSC-exos) have better effects on cartilage repair. …”
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A three-tiered mentorship approach for supporting high school students interested in science, technology, engineering, and mathematics (STEM) careers by Brittney D. Browning, Janiece S. Glover, Lindsay R. Meredith, Anna E. Kirkland, Kathryn S. Gex, Rachel L. Tomko, Felicity Duong, Lindsay M. Squeglia

“…Racially and ethnically minoritized individuals, first-generation college students, and women are significantly underrepresented in science, technology, engineering, and mathematics (STEM) careers. This lack of equal representation limits creativity and progress in these fields and perpetuates systemic barriers that discourage students from pursuing STEM pathways. …”
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A Survey on Hyperparameters Optimization of Deep Learning for Time Series Classification by Ayuningtyas Hari Fristiana, Syukron Abu Ishaq Alfarozi, Adhistya Erna Permanasari, Mahardhika Pratama, Sunu Wibirama

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Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeutics by Jiaqian Si, Jie Wang, Hao Dai, Tuochen Lv, Songyun Zhao, Wanying Chen, Liqun Li, Siqi Ding, Yucang He

“…It also reviews the translational potential of combined therapeutic strategies based on engineered exosomes delivery systems and biomaterials, emphasizing the optimization of delivery efficiency and functional enhancement to address the bottleneck of clinical applications. …”
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Physical–Mechanical Properties of Tomato Seedlings for the Design and Optimization of Automatic Transplanters by Gaudencio Grande, Martín Hidalgo-Reyes, Pedro Cruz, Noé Velázquez-López

“…This study was based on the hypothesis that the hybrid type and its physical–mechanical properties significantly influence the operational efficiency of transplanting systems. Understanding these properties is essential for optimizing the performance of semi-automatic and automatic transplanters. …”
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Successful Reimplantation of a Femoral Stem Fracture After Cementless Total Hip Replacement Using the Femoral Window Technique in a Small Dog by Yoshiyuki Inoue, Kohei Kuroda

“…This case highlights the effectiveness of the window technique for stem replacement in small dogs and emphasizes the importance of optimal stem selection and positioning during the initial THR.…”
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Engineering 3D Scaffold‐Free Nanoparticle‐Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function by Emma Claire James, Eva Tomaskovic‐Crook, Jeremy Micah Crook

“…Abstract Electrical stimulation (ES) of cellular systems can be utilized for biotechnological applications and electroceuticals (bioelectric medicine). …”
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Sinh-Cosh Optimization-Based Efficient Clustering for Big Data Applications by Lahbib Khrissi, Mohammed Es-Sabry, Nabil El Akkad, Hassan Satori, Saad Aldosary, Walid El-Shafai

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Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy by Anna Ochalek, Karolina Szczesna, Paolo Petazzi, Julianna Kobolak, Andras Dinnyes

“…Despite the availability of various genetically engineered animal models, these systems are still not adequate enough due to species variation and differences in genetic background. …”
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Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

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Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model by Lina Zhang, Jing Jin, Jing Jin, Liguang Sun, Gang Hou, Mingming Deng, Yiding Bian, Jianming Liu, Wei Cheng, Shaoliang Xing, Shaoliang Xing, Wenjia Wang, Xin Dong, Qingjie Fan, Lei Gao, Xinhua Lei, Xinhua Lei, Yongli Bao, Yongguang Yang

“…IntroductionThe clinical translation of mesenchymal stem cell-derived exosome faces critical challenges in scalable production, subpopulation stability, and therapeutic route optimization. …”
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Effect of treadmill exercise timing on repair of full-thickness defects of articular cartilage by bone-derived mesenchymal stem cells: an experimental investigation in rats. by Jin-qi Song, Fu Dong, Xue Li, Chang-peng Xu, Zhuang Cui, Nan Jiang, Jun-jie Jia, Bin Yu

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Sustainable valorization of Eclipta alba (L.) Hassk. Stem using eco-friendly extraction: Bioactive compound profiling and in vitro wound-healing assessment by Hla Myo, Nuntawat Khat-udomkiri, Anuchit Phanumartwiwath

“…Hassk. stems by optimizing ultrasound-assisted extraction with an aqueous propylene glycol (PG) system using Box-Behnken Design. …”
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Exploring two tumor treatment strategies: effectiveness of ribosome inactivating proteins and mesenchymal stem cells/MSC derived extracellular vesicles in cancer treatment by Maryamosadat Mavaei, Maryamosadat Mavaei, Simin Farokhi, Mohammad Hasan Yousefi, Mohammad Hasan Yousefi, Mohammad Hasan Yousefi, Arshia Fakouri, Alireza Shadab, Alireza Shadab, Mohammad Hossein Abdolmohammadi, Faranak Fallahian, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami

“…This article presents a novel hypothesis: the simultaneous use of ribosome-inactivating proteins (RIPs) and mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (EVs) in cancer treatment. …”
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Risk Factors of Aseptic Loosening After Total Hip Arthroplasty With Collum Femoris Preserving Stem: A Long‐Term Follow‐Up Study by Yongbo Ma, Yansong Liu, Zeming Liu, Jiangqi Chang, Mengnan Li, Tao Wu

“…ABSTRACT Objective The Collum Femoris Preserving (CFP) stem offers biomechanical advantages in total hip arthroplasty (THA). …”
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Advances and Challenges in Modeling Autosomal Dominant Polycystic Kidney Disease: A Focus on Kidney Organoids by Jinglan Gu, Fei Liu, Lu Li, Jianhua Mao

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Canine Adipose-Derived Mesenchymal Stromal Cells Reduce Cell Viability and Migration of Metastatic Canine Oral Melanoma Cell Lines In Vitro by Fwu Shing Teng, Patricia de Faria Lainetti, Mayara Simão Franzoni, Antonio Fernando Leis Filho, Cristina de Oliveira Massoco Salles Gomes, Renée Laufer-Amorim, Rogério Martins Amorim, Carlos Eduardo Fonseca-Alves

“…Canine oral melanoma (COM) is a promising target for immunomodulatory therapies aimed at enhancing the immune system’s antitumor response. Given that adipose-derived mesenchymal stem cells (Ad-MSCs) possess immunomodulatory properties through cytokine release, we hypothesized that co-culturing Ad-MSCs and canine peripheral blood mononuclear cells (PBMCs) could stimulate interleukin (IL) production against melanoma cell lines (MCCLs) and help identify therapeutic targets. …”
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Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…These findings offer vital guidance for optimizing personalized treatment of IBD, emphasizing the importance of carefully managing the timing and dosage of α-MSH for its effective clinical application.Keywords: IBD, α-MSH, hematopoietic stem cells, neutrophils, inflammation…”
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Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration by Yeo Gyun Yun, Soon Chul Heo, Ji-Won Jung, Donghyeon Yeo, Seong-Jin Shin, Khaliunsarnai Tsogtbaatar, Yongsung Hwang, Jung-Hwan Lee, Jun Hee Lee, Hae-Won Kim

“…Activating angiogenic and immunomodulatory potential of stem cells through optimized cultivation strategies presents significant opportunities for cell-based tissue therapeutics. …”
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A framework of artificial light management for optimal plant development for smart greenhouse application. by João Pereira, Abdul Mounem Mouazen, Mathias Foo, Hafiz Ahmed

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