Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research by Jingjing Wang, Bingqian Qu, Fang Zhang, Cindy Zhang, Wanyan Deng, Viet Loan Dao Thi, Yuchen Xia

“…Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. …”
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Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells by Md Sharifur Rahman, Guangyan Qi, Quan Li, Xuming Liu, Jianfa Bai, Mingshun Chen, Anthony Atala, Xiuzhi Susan Sun

“…However, optimizing their differentiation into specific lineages within three-dimensional (3D) scaffold-based culture systems that mimic in vivo environments remains challenging. …”
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Potential Therapeutic Mechanisms and Tracking of Transplanted Stem Cells: Implications for Stroke Treatment by Yanhong Zhang, Honghong Yao

“…Methods to label transplanted cells and existing imaging systems for stem cell labeling and in vivo tracking will also be discussed.…”
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The Opportunities and Challenges regarding Induced Platelets from Human Pluripotent Stem Cells by Meng-Xue Xu, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…Furthermore, many novel culture systems have been developed to scale up the production of iPlatelets, including 2D flow systems, 3D rotary systems, and vertical reciprocal motion liquid culture bioreactors. …”
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Exosomes in neurodegenerative diseases: Therapeutic potential and modification methods by Hongli Chen, Na Li, Yuanhao Cai, Chunyan Ma, Yutong Ye, Xinyu Shi, Jun Guo, Zhibo Han, Yi Liu, Xunbin Wei

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A Model for Detecting <i>Xanthomonas campestris</i> Using Machine Learning Techniques Enhanced by Optimization Algorithms by Daniel-David Leal-Lara, Julio Barón-Velandia, Lina-María Molina-Parra, Ana-Carolina Cabrera-Blandón

“…The bacterium <i>Xanthomonas campestris</i> poses a significant threat to global agriculture due to its ability to infect leaves, fruits, and stems under various climatic conditions. Its rapid spread across large crop areas results in economic losses, compromises agricultural productivity, increases management costs, and threatens food security, especially in small-scale agricultural systems. …”
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Delivery of Prime editing in human stem cells using pseudoviral NanoScribes particles by Thibaut Halegua, Valérie Risson, Julien Carras, Martin Rouyer, Laurent Coudert, Arnaud Jacquier, Laurent Schaeffer, Théophile Ohlmann, Philippe Emmanuel Mangeot

“…However, its safe and efficient delivery into human stem cells remains a technical challenge. In this report, we engineer Nanoscribes, virus-like particles that encapsidate ribonucleoprotein complexes of the Prime Editing system and allow their delivery into recipient cells. …”
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Advances in stem cell-based therapeutics for acute high-altitude illness: research progress and prospects by Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Bai-Tao Dou, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Meng-Jiao Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Yan-Ling Li, Dan Chen, Dan Chen, Dan Chen, Cheng-Wei Yang, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Fang-Yi Fan, Hao Yao, Hao Yao, Hao Yao, Hao Yao, Hao Yao

“…Future research should prioritize elucidation of stem cell behavior in hypobaric hypoxia, optimization of delivery systems, and establishment of standardized therapeutic protocols. …”
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Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing by Dong Han, Weiwei Liu, Jinpeng Gong, Yupeng Ma, Zhengwen Sun

“…Mesenchymal stem cells (MSCs) demonstrate considerable potential for enhancing bone fracture healing due to their multipotency and immunomodulatory properties. …”
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Genetic features of the killer cell immunoglobulin-like receptors in the haematopoietic stem cell donors by Iu. V. Sokolova, L. N. Bubnova, I. E. Pavlova, S. S. Bessmeltsev

“…The results of the present study can be used to selection of donors with the favorable KIR types in order to improve therapeutic effect of transplantation, as well as to optimize database of the Republican Register of hematopoietic stem cells donors.…”
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Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells by Ghazaleh M. Shahriary, Hardeep Kataria, Soheila Karimi-Abdolrezaee

“…In the present study, we sought to elucidate the specific role of Nrg-1 in regulating microglial activity and more importantly their influence on the behavior of neural stem/progenitor cells (NPCs). Using injury-relevant in vitro systems, we demonstrate that Nrg-1 attenuates the expression of proinflammatory mediators in activated microglia. …”
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Modeling human early otic sensory cell development with induced pluripotent stem cells. by Hanae Lahlou, Alejandra Lopez-Juarez, Arnaud Fontbonne, Emmanuel Nivet, Azel Zine

“…The inner ear represents a promising system to develop cell-based therapies from human induced pluripotent stem cells (hiPSCs). …”
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Clinical application of mesenchymal stem cells in immunosenescence: a qualitative review of their potential and challenges by Xu Wang, Dan Guo, Chengmei He, Xiaoxi Wang, Yi Wei, Fengchun Zhang, Li Wang, Yanlei Yang

“…Although preclinical and clinical studies highlight the potential of MSC-based strategies for delaying immunosenescence, critical issues remain unresolved, including long-term safety and efficacy, optimizing cell delivery systems, and elucidating context-specific mechanisms. …”
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The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration by L. Dalle Carbonare, M. Cominacini, E. Trabetti, C. Bombieri, J. Pessoa, M. G. Romanelli, M. T. Valenti

“…Abstract Mesenchymal stem cells (MSCs) play a crucial role in bone formation and remodeling. …”
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Combination of dasatinib and quercetin promotes osteogenic differentiation and stemness maintenance of hPDLSCs via YAP/TAZ by Yunge Qiu, Yajun Zhao, Linglu Jia, Han Xiao, Shaoqing Sun, Weiting Gu, Yong Wen

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Research advances in mesenchymal stem cells and related therapies for rotator cuff tendon-to-bone healing by Laimeng Song, Na Li, Jiwu Chen

“…While preclinical results are encouraging, clinical translation requires standardization of protocols, optimization of delivery systems, and long-term safety evaluations.…”
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The influence of high-fat diet and energy-restricted diet on hematopoietic stem cells: mechanisms and implications by Zhi’an Chen, Haoyuan Ang, Jie Li, Meiling Yu, Xiaoling Chen, Li Wang

“…Increasing evidence demonstrates a close relationship between daily diet and homeostasis of the body’s internal environment, particularly hematopoietic system homeostasis. Hematopoietic stem cells (HSCs) are located at the top of the hematopoietic system and have the ability to self-renew and differentiate into various types of immune cells. …”
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Improved Method for Ex Ovo-Cultivation of Developing Chicken Embryos for Human Stem Cell Xenografts by Timo Schomann, Firas Qunneis, Darius Widera, Christian Kaltschmidt, Barbara Kaltschmidt

“…The characterization of human stem cells for the usability in regenerative medicine is particularly based on investigations regarding their differentiation potential in vivo. …”
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Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation by Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber

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Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models by Cheng Wang, Leah E. Latham, Shuliang Liu, John Talpos, Tucker A. Patterson, Joseph P. Hanig, Fang Liu

“…Safety concerns about general anesthetics (GA), such as desflurane (a commonly used gaseous anesthetic agent), arose from studies documenting neural cell death and behavioral changes after early-life exposure to anesthetics and compounds with related modes of action. Neural stem cells (NSCs) can recapitulate most critical events during central nervous system (CNS) development in vivo and, therefore, represent a valuable in vitro model for evaluating potential desflurane-induced developmental neurotoxicity. …”
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