Exosome-Loaded GelMA Hydrogel as a Cell-Free Therapeutic Strategy for Hypertrophic Scar Inhibition by Wang H, Gao X, Zhao Y, Sun S, Liu Y, Wang K

“…Exosomes (Exos) from adipose-derived stem cells (ASCs) are emerging as promising treatment for hypertrophic scar inhibition. …”
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On the Perspectives of Image-to-Lidar Constraints in Dynamic Network Optimisation by K. Mouzakidou, T. Stoltz, L. V. Jospin, D. A. Cucci, J. Skaloud

“…Yet, the common adjustment of both optical data streams is a non-trivial problem due to challenges associated with the different influences of errors affecting their mapping accuracy including those coming from navigation sensors. Stemming from a special form of graph-based optimization, the dynamic networks allow rigorous modeling of spatio-temporal constraints and thus provide the common framework for optimizing original observations from inertial systems with those coming from optical sensors. …”
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Targeting the hallmarks of aging: mechanisms and therapeutic opportunities by Fumihiro Sanada, Shinichiro Hayashi, Ryuichi Morishita

“…These processes act at molecular, cellular, and systemic levels, contributing to age-related disorders such as neurodegeneration, cardiovascular disease, and metabolic syndromes. …”
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Dynamic three-dimensional culture enhances tunneling nanotubes-mediated mitochondrial transfer in mesenchymal stromal cells to accelerate wound healing by Lin Ma, Xiaoxue Yang, Xiaoyao Huang, Hao Guo, Zihan Li, Siyuan Fan, Han Qin, Fanhui Meng, Peisheng Liu, Xinyu Wang, Meiling Wu, Kun Xuan, Anqi Liu

“…This study developed a dynamic 3D culture system for stem cells from human exfoliated deciduous teeth (SHED), a type of MSCs, utilizing gelatin microcryogel microcarriers and stirred tank bioreactor. …”
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ANFIS modelling of the strength properties of natural rubber latex modified concrete by Efiok Etim Nyah, David Ogbonna Onwuka, Joan Ijeoma Arimanwa, George Uwadiegwu Alaneme, G. Nakkeeran, Ulari Sylvia Onwuka, Chinenye Elizabeth Okere

“…This study investigates the optimization of Natural Rubber Latex Modified Concrete (NRLMC) using an Adaptive Neuro-Fuzzy Inference System (ANFIS), a hybrid AI model that integrates fuzzy logic and neural networks for precise property prediction. …”
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Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration by Ruizhe Zhao, Bing Liang, Yijie Shi, Jianfei Gao, Xuezhe Wang, Tianyi Shao, Kunyue Xing, Mingzhe Yan, Tianrui Wang, Yingze Zhang, Dongming Xing

“…Osteoarthritis (OA) is a prevalent joint disorder characterized by progressive cartilage degradation, impaired mesenchymal stem cell (MSC) function, and chronic inflammation, ultimately leading to irreversible structural damage and functional impairment. …”
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Overview of technical advances in the diagnosis and treatment of pulp and periapical diseases by LI Mengyuan, LIU Jie, ZHANG Yuerong, JIANG Fei, ZHANG Guangdong

“…The integration of dental microscopes with static/dynamic guided endodontics systems has enhanced root canal debridement efficiency. …”
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Early identification of functional high-risk multiple myeloma patients after transplant: the predictive power of fat fraction and Response Assessment Category score in diffusion-we... by Angelo Belotti, Barbara Frittoli, Sofia Terlizzi, Rossella Ribolla, Claudia Crippa, Chiara Saeli, Samantha Ferrari, Nicola Bianchetti, Chiara Bottelli, Chiara Cattaneo, Carmela Carbone, Alessandro Gullino, Marco Chiarini, Viviana Giustini, Aldo Roccaro, Luigi Grazioli, Alessandra Tucci

“…The Myeloma Response Assessment and Diagnosis System (MY-RADS) established the Response Assessment Category (RAC), a 5-point scale ranging from complete response (RAC 1) to progressive disease (RAC 5), which independently stratifies patients with different outcomes after autologous stem cell transplantation (ASCT). …”
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A supervised machine-learning analysis of doxorubicin-loaded electrospun nanofibers and their anticancer activity capabilities by Mohammadreza Rostami, Mohammadreza Rostami, Maliheh Gharibshahian, Maliheh Gharibshahian, Mehrnaz Mostafavi, Ali Sufali, Mahsa Golmohammadi, Mohammad Reza Barati, Reza Maleki, Nima Beheshtizadeh, Nima Beheshtizadeh

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A non-invasive method for screening mitochondrial diabetes by Hangyu Fang, Hangyu Fang, Xiaoe Li, Shuping Wang, Mei Zhang, Victor Wei Zhang, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu

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Intelligent diagnosis and prediction of pregnancy induced hypertension in obstetrics and gynecology teaching by integrating GA by Xiaolan Li, Xiaolan Li, Xiaolan Li, Fen Kang, Fen Kang, Fen Kang, Xiaojing Li, Xiaojing Li, Xiaojing Li

“…The potential for misdiagnosis, often stemming from the inexperience of healthcare professionals, underscores the necessity for an advanced diagnostic system.MethodsThis research introduces an innovative sampling and feature selection technique grounded in F-scores optimization, alongside the development of a comprehensive prediction model that integrates genetic algorithms with various heterogeneous learners. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…The decline in sleep quality of the elderly stems from the interplay between age-related physiological decline and multiple environmental factors. …”
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From community to science to community, enhancing remote sensing of water quality in Chesapeake Bay tributaries through participatory science by Min-Sun Lee, Maria Tzortziou, Ji-Eun Park, Tong Lin, Patrick Neale, Shelby Brown, Tara Sill, Alison Cawood

“…The optimized algorithms were applied to imagery from Landsat/OLI, Sentinel-2/MSI, and Sentinel-3/OLCI, and effectively captured the temporal and spatial distribution of turbidity, chlorophyll-a concentration, and dissolved organic matter dynamics in both optically complex tributaries and the main stem of the Bay. …”
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Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives by Kaihuan Zhou, Qianqian Qin, Junyu Lu

“…These mechanisms drive localized lung injury and contribute to systemic inflammatory response syndrome and multiple organ dysfunction syndrome. …”
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A Data-Driven Analysis of Engineering Contract Risk Characterization Based on Judicial Cases of Disputes by Yongcheng Zhang, Ziyi Wu, Chaohua Xiong, Jianwei Wang, Maxwell Fordjour Antwi-Afari

“…The study proposes stratified risk mitigation strategies, including governmental regulatory improvements and enterprise-level management optimizations. These findings offer valuable insights into advancing risk governance in construction contract administration, particularly through an enhanced understanding of dispute complexity and systemic vulnerabilities.…”
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The Impact of Student Loan Debt on Civic Engagement: Evidence from the College and Beyond II Dataset by Osasohan Agbonlahor

“…Drawing on data from the College and Beyond II dataset, this research analyzes how varying levels of debt burden impact political and community participation among 1673 graduates, including 1059 liberal arts majors and 614 graduates from professional, STEM, and other fields. Employing OLS regression models with multiple measures of debt burden and distinct dimensions of civic engagement, this study finds that both medium and high levels of student loan debt (USD 201–500 monthly and >USD 500 monthly) are associated with significantly higher political engagement—a pattern that aligns with relative deprivation theory’s proposition that financial strain may motivate political action aimed at systemic change. …”
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Distributions of agrobiont lady beetles (Coleoptera: Coccinellidae) among crop and non-crop habitats within an agricultural landscape in east-central South Dakota, USA by Louis Hesler, Eric Beckendorf

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Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing by Colin T. Konishi, Nancy Mulaiese, Tanvi Butola, Qinkun Zhang, Dana Kagan, Qiaoyan Yang, Mariel Pressler, Brooke G. Dirvin, Orrin Devinsky, Jayeeta Basu, Chengzu Long

“…We developed HEK293T and induced pluripotent stem cell (iPSC) models of FENIB, harboring a patient-specific pathogenic SERPINI1 variant or stably overexpressing mutant neuroserpin fused to GFP (MUT NS-GFP). …”
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Immune effector cell-associated hematotoxicity: mechanisms, clinical manifestations, and management strategies by Ofrat Beyar-Katz, Kai Rejeski, Roni Shouval

“…Standardized grading systems, based on the depth and duration of neutropenia, have improved ICAHT classification and enabled more consistent risk stratification. …”
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Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy by Mingyong Zha, Fei Huang, Songlin Li, Qi Wang, Qi Wang, Qi Wang, Yong Tang, Yong Tang, Yong Tang

“…In addition, we review the existing solutions to the problems of the immune clearance of virus, such as the use of inhibitors to prevent neutralizing antibodies from binding to the virus and the use of polymer encapsulation or mesenchymal stem cell loading. We also discussed Current directions include optimizing delivery systems, leveraging Artificial Intelligence for personalized designs of Oncolytic vaccinia virus inserted interleukins to guide the research in the future.…”
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