Reverse optimum safety factor approaches as effective tools for reliability-based topology optimization with application to cementless hollow stems used in total hip replacement by Ghais Kharmanda, Hasan Mulki

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Protocol for real-time measurement of mitochondrial bioenergetics in 3D-cultured brain tumor stem cells using the Resipher system by Cloé Tessier, Maxime Toujas, Antonio C. Pagano Zottola, Andreas Bikfalvi, Thomas Mathivet, Thomas Daubon, Lucie Brisson, Audrey Burban, Ahmad Sharanek

“…Here, we describe a cell-based protocol for measuring different mitochondrial respiratory parameters using the high-resolution real-time Resipher system. We optimized this protocol on brain tumor stem cells cultured in three-dimensional spheroids. …”
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Optimizing Nitrogen Input Increased Yield and Efficiency in Maize-Soybean Strip Intercropping System by Yuwen Liang, Qiannan Liu, Jinghan Zeng, Fei Xiong, Jian Guo, Guanghao Li, Dalei Lu

“…Optimizing nitrogen (N) fertilizer combination is a crucial measure to maximize yield and production efficiency in a maize-soybean strip intercropping system (MSSI). …”
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Advancing the pathway to allogeneic hematopoietic stem cell transplantation through a physician–nurse coordinator system in patients with acute leukemia by Chidapa Auepisit, Weerapat Owattanapanich, Smith Kungwankiattichai, Chutima Kunacheewa, Suparat Atakulreka, Kamolchanok Kulchutisin, Nawapotch Donsakul

“…The introduction of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has substantially improved patient outcomes, offering the potential for a cure. …”
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CD28 signaling domain boosts persistence and in vivo anti-tumor activity of stem cell-derived CD19-CAR-NK cells by Nina Kok, Didem Ozkazanc, Amanda A. van Vliet, Danielle Steenmans, Simar Pal Singh, Tolga Sutlu, Anna-Maria Georgoudaki, Monica Raimo, Jan Spanholtz, Adil Doganay Duru

“…In this study, we genetically engineered primary human hematopoietic stem cells using an optimized lentiviral backbone carrying CD19 CAR cassettes with varied hinge, transmembrane, and signaling domains to evaluate their role in CAR-NK development and function. …”
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Heat transfer and simulated coronary circulation system optimization algorithms for real power loss reduction by Kanagasabai L.

“…In this paper, the heat transfer optimization (HTO) algorithm and simulated coronary circulation system (SCCS) optimization algorithm has been designed for Real power loss reduction. …”
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A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications by Tianyang Lv, Yuzhu Chen, Ning Li, Xiaoyu Liao, Yumin Heng, Yayuan Guo, Kaijin Hu

“…Owing to their excellent biocompatibility, mild reaction conditions, and controllable gelation properties, these hydrogels represent a promising class of biomaterials suitable for minimally invasive treatment systems in diverse biomedical applications. This review systematically summarizes the gelation mechanisms of thermosensitive hydrogels and optimization strategies to enhance their performance for broader application requirements. …”
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Advancing Hematopoietic Stem Cell Transplantation Typing: Harnessing Hyperledger Fabric’s Blockchain Architecture by Meng Wu, Feng Xu, Geetha Subramaniam, Zeyu Li, Liyun Chen, Wenjuan Zhu

“…Hematopoietic stem cell transplantation (HSCT) is a crucial treatment option for hematological disorders. …”
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IoT plant watering system for integrating technology and sustainability in science practicum by Fatimatuz Zahro, Eko Hariyono, Beni Setiawan, Binar Kurnia Praharani

“…Results show the system maintains soil moisture within an optimal 40%–60% range, reduces water waste by up to 30%, and improves plant health. …”
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Comparative Evaluation and Optimization of Auxin Type and Concentration on Rooting Efficiency of <i>Photinia</i> × <i>fraseri</i> Dress: Stem Cuttings Using Response Surface Method... by Gülcay Ercan Oğuztürk, Müberra Pulatkan, Cem Alparslan, Türker Oğuztürk

“…This study aimed to evaluate and optimize the effects of three auxin types—indole-3-butyric acid (IBA), naphthaleneacetic acid (NAA), and indole-3-acetic acid (IAA)—applied at four concentrations (1000, 3000, 5000, and 8000 ppm) on the rooting performance of <i>Photinia × fraseri</i> Dress. stem cuttings. …”
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Statistical Foundations of Generative AI for Optimal Control Problems in Power Systems: Comprehensive Review and Future Directions by Elinor Ginzburg-Ganz, Eden Dina Horodi, Omar Shadafny, Uri Savir, Ram Machlev, Yoash Levron

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Optimal Solar‐Biomass‐Diesel‐Generator Hybrid Energy for Water Pumping System Considering Demand Response by Olumuyiwa Taiwo Amusan, Nnamdi Ikechi Nwulu, Saheed Lekan Gbadamosi

“…This study employs a generalized reduced gradient (GRG) optimization method to ascertain the most effective energy mix for water pumping system (WPS) application by integrating time of use demand response. …”
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CRISPR/Cas9 Edition of the <i>F9</i> Gene in Human Mesenchymal Stem Cells for Hemophilia B Therapy by Irving Jair Lara-Navarro, Luis Felipe Jave-Suárez, Juan Antonio Marchal, Ana Rebeca Jaloma-Cruz

“…This study aimed to develop an in vitro gene therapy model using the CRISPR/Cas9 system to incorporate the <i>F9</i> cDNA in human mesenchymal stem cells (hMSCs) to produce clotting factor IX. …”
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Stem cell transplantation cost in Iran by Fereshte Karimi, Ali Mohammad Mosadeghrad, Mohammad Vaezi, Ghasem Janbabaei, Hoda Ghobeishipour, Mohammad Hussein Nozarian, Seyed Asadollah Mousavi, Hossein Kamranzadeh Fumani, Soroush Rad, Maryam Barkhordar, Sahar Tavakoli Shiraji, Ardeshir Ghavamzadeh, Marjan Yaghmaie

“…Government subsidies covered 54.1% of direct costs, followed by out-of-pocket payments (13.9%) and basic insurance (12.8%). Conclusion Stem cell transplantation imposes a substantial financial burden on the healthcare system in Iran. …”
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Strategic participation of electric vehicles in vehicle-to-grid within a microgrid system: A decentralized optimization approach by Ayoub Zerka, Mohammed Ouassaid, Mohamed Maaroufi

“…In this perspective, motivation for the present work mainly stems from the rising need for intelligent and innovative grid management strategies that are capable of balancing energy demand and supply, sustaining economic viability, securing system stability as well as accommodating the growing penetration of Electric Vehicles (EVs). …”
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Multipotent mesenchymal stem cells in renal transplantation by N. V. Borovkova, M. Sh. Khubutiya, O. N. Rzhevskaya, A. V. Pinchuk, D. A. Vasil’chenkov

“…MMSCs realize their properties through interactions both with the innate and adoptive immune system. Meanwhile, actual questions such as an optimal dosage and injection timing are still need answers. …”
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Optimizing nutrient management protocol for Ophiopogon japonicus-corn intercropping: impacts on growth, yield, and medicinal quality by Xiaoyang Cai, Heling Fan, Hongmei Deng, Wenjing Li, Haohan Wang, Jiaming Zhang, Min Li

“…The optimal strategy for maximizing yield in the intercropping system includes ammonium nitrate (150 kg N/ha), magnesium sulfate (45 kg/ha), manganese sulfate (15 kg/ha), superphosphate (75 kg P2O5/ha), and potassium sulfate (450 kg K2O/ha). …”
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Enhancing the growth, yield and physiological response of two lettuce (Lactuca sativa L.) cultivars through NFT system optimization by Paulo Pastor-Arbulú, Alfredo Rodríguez-Delfín

“…IntroductionIn the context of increasing pressure on agricultural resources, hydroponic systems such as the nutrient film technique (NFT) are gaining prominence for their ability to optimize water use and space efficiency, and crop productivity in controlled environments. …”
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Wharton's jelly stem cells delivered via a curcumin-loaded nanofibrous wound dressings improved diabetic wound healing via upregulating VEGF and IGF genes: An in vitro and in vivo... by Chengjin Chen, Hui Zhao, Wenlu Zhang, Xuelan Hong, Shengjie Li, Saeed Rohani

“…In vitro experiments including scanning electron microscopy, cell viability assay, release assay, hemocompatibility assay, cell proliferation assay, and antibacterial assay were utilized to characterize the delivery system. Then, curcumin-loaded scaffolds were seeded with 30,000 Wharton's jelly stem cells and implanted into a rat model of diabetic wounds. …”
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Electroporation of mouse embryonic stem cells with Neon device by I. P. Savchenkova, A. A. Savchenkova

“…Therefore, the main goal was to optimize conditions of electroporation with Neon® Transfection System, a new-generation device, by selecting and changing of various parameters (voltage, impulse width and number of impulses) to maximize efficiency of D3 embryonic stem cell line transfection and to maintain cell viability. …”
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