Harmonizing the Gut Microbiome and Cellular Immunotherapies: The Next Leap in Cancer Treatment by Kendall Harrington, Khalid Shah

“…The gut microbiome, a diverse community of microorganisms, plays a key role in shaping the host’s immune system and modulating cancer therapies. Emerging evidence highlights its critical influence on the efficacy and toxicity of cell-based immunotherapies, including chimeric antigen receptor T cell, natural killer cell, and stem cell therapies. …”
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Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…Abstract Polymorphonuclear neutrophils (PMNs), the most abundant leukocytes circulating in human blood, are pivotal players in the innate immune system. In recent years, PMNs have gained increasing recognition for their significant involvement in the pathogenesis of a wide array of human diseases, including sepsis, pulmonary conditions, autoimmune disorders, and various cancers. …”
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Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols by Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu

“…Interestingly, we found that while GPR161 signal almost completely disappeared from cilia upon Sonic hedgehog (SHH) stimulation in NSCs and immature neurons, this was not the case in more mature neurons, suggesting a possible developmental time window for cilia-dependent SHH signaling.ConclusionTaken together, our results provide a systematic description of cilia in hiPSC-derived neuronal cells generated with different protocols, underscoring the importance of selecting the optimal model system and controls for investigating primary cilia in hiPSC-derived neuronal cells.…”
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Extrinsic electric field modulates neuronal development and increases photoreceptor population in retinal organoids by Deepthi S. Rajendran Nair, Anika Gupta, Ege Iseri, Tianyuan Wei, Le Tam Phuong Quach, Magdalene J. Seiler, Magdalene J. Seiler, Gianluca Lazzi, Gianluca Lazzi, Biju B. Thomas, Biju B. Thomas

“…IntroductionConsidering the significant role played by both intrinsic and extrinsic electric fields in the growth and maturation of the central nervous system, the impact of short exposure to external electric fields on the development and differentiation of retinal organoids was investigated.MethodsRetinal organoids derived from human embryonic stem cells were used at day 80, a key stage in their differentiation. …”
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Diethyl aminoethyl hexanoate (DA-6) and planting density optimize soybean growth and yield formation in maize–soybean strip intercropping by Kai Luo, Xiaoting Yuan, Kejing Zhang, Yuanyuan Xue, Zhidan Fu, Ping Lin, Yiling Li, Yuze Li, Tian Pu, Xintong Qi, Yang Li, Xiaochun Wang, Wenyu Yang, Jaume Flexas, Taiwen Yong

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AI-Powered System to Facilitate Personalized Adaptive Learning in Digital Transformation by Yao Yao, Horacio González-Vélez

“…However, in addition to their current capabilities, LLMs occasionally generate responses that contain factual inaccuracies, stemming from their dependence on the parametric knowledge they encapsulate. …”
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Parenteral Nanoemulsion for Optimized Delivery of GL-II-73 to the Brain—Comparative In Vitro Blood–Brain Barrier and In Vivo Neuropharmacokinetic Evaluation by Kristina Jezdić, Jelena Đoković, Ivan Jančić, Tanja Ilić, Biljana Bufan, Bojan Marković, Jana Ivanović, Tijana Stanković, Nebojša D. Cekić, Vassiliki Papadimitriou, Dishary Sharmin, Prithu Mondal, James M. Cook, Snežana D. Savić, Miroslav M. Savić

“…<b>Background/Objectives</b>: GL-II-73 is a positive allosteric modulator that is selective for α5GABA_A receptors and has physicochemical properties that favor nanocarrier formulations when parenteral delivery to the central nervous system is desired. Our aim was to develop an optimized nanoemulsion containing GL-II-73 and subsequently test whether this would improve permeation across the blood–brain barrier (BBB) and availability in the brain. …”
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22 Advancing clinical trial reporting and AI integration: Optimizing protocol data extraction using LLMs and regulatory best practices by Ramya Sri Baluguri, Nicholas Anderson

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BASIL PERFORMANCE EVALUATION AND WATER QUALITY MONITORING IN A RECIRCULATING AQUAPONICS SYSTEM by Constanța MIHAI, Veronica IVANESCU, Mirela Alina SANDU

“…The study provides valuable insights into optimizing aquaponic systems for improved food security and environmental sustainability.…”
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Effect of Fertilization in Companion Cropping Systems of Andean Fruit Trees in the Municipality of Ipiales by Ovidio Javier Moran-Chamorro, Danita Andrade-Díaz, Juan Sebastian Chirivi-Salomon, Pedro Alexander Velasquez-Vasconez

“…The results indicated that the UF system (<i>P. peruviana</i> and <i>P. vulgaris</i>) had the highest plant height, while TF (tree tomato and bean) showed the best stem perimeter development. …”
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Mitigating Selection Bias in Recommendation Systems Through Sentiment Analysis and Dynamic Debiasing by Fan Zhang, Wenjie Luo, Xiudan Yang

“…Selection bias can cause recommendation systems to over-rely on users’ historical behavior and ignore potential interests, thus reducing the diversity and accuracy of recommendations. …”
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Chemical reprogramming culture for the expansion of salivary gland epithelial basal progenitor cells by Ye Jin Jeong, Yongpyo Hong, Yeo-Jun Yoon, Nam Suk Sim, Seung-Min Hong, Jae-Yol Lim

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Therapeutic Potential of Rho Kinase Inhibitors in Corneal Disease: A Systematic Review of Preclinical and Clinical Studies by Laura Andreea Ghenciu, Diana Andrei, Claudia Borza, Roxana Iacob, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Daniela Iacob, Ovidiu Alin Haţegan

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UNVEILING FAKE NEWS DETECTION MODELS AND THEIR INTEGRATION INTO WEB SYSTEMS: AN EXTENSIVE INVESTIGATION by Vimal Gaur, Naman Veerwal, Ujjwal Chaudhary, Sparsh Kadian

“…Through meticulous preprocessing, including stemming and TF-IDF vectorization, the system optimizes textual data for analysis. …”
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Role, Methodology, and Measurement of Cognitive Load in Computer Science and Information Systems Research by Mira Suryani, Harry Budi Santoso, Martin Schrepp, Rizal Fathoni Aji, Setiawan Hadi, Dana Indra Sensuse, Ryan Randy Suryono, Kautsarina

“…The motivation behind this research stems from the growing need to optimize user experiences and system efficiency through better CL management. …”
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BIOPHARMACEUTICAL RESEARCHES IN VITRO ON THE CHOICE OF OPTIMAL COMPOSITION OF PHARMACEUTICAL AID FOR OINTMENT PRODUCTION BASED ON СО2 EXTRACT OF SCHISANDRA CHINENSIS SEEDS by Y. A. Morozov, M. S. Makieva

“…Schisandra chinensis is valuable species of herbal medicines raw materials (fruits, seeds, caruncles, leaves, stem cortex, and roots with root systems) which are used for medicines and biologically active supplements production in food and cosmetic industry. …”
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Promising cell systems for targeted delivery of nano- and microcarriers loaded with drugs or biomolecules (review) by L. A. Miroshnichenko, T. Yu. Polyakova, I. A. Khlusov, E. Yu. Avdeeva, V. G. Luzhanin, E. I. Molokhova, A. L. Golovanenko, M. Yu. Khlusova, M. V. Belousov

“…Introduction. Cellular systems for targeted delivery of drug and biological molecules (drug delivery systems, DDSs) are currently considered as a promising solution to the problems of nano- and micro-sized drug carriers.Text. …”
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Optimizing GBM organoid construction with hydrogel-based models: GelMA-HAMA scaffold supports GBM organoids with clonal growth for drug screening by Min Zhou, Ke Yue, Jingjing Zhao, Shuhua Gong, Yutong Xie, Wenyu Wu, Zhenzhou Li, Shuo Wu, Zhengliang Gao, Huan Wang, Jianrong Guo

“…As versatile 3D culture systems in vitro , organoid models are emerging as a promising new tool for GBM research and combat. …”
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Establishment of regeneration system of Peucedanum praeruptorum and molecular association analysis of coumarin secondary metabolism by Liu Tianliang, Liu Tianliang, Wang Liang, Zhang Yudan, Zheng Yujiao, Zhou Tao, Huang Luqi

“…IntroductionPeucedanum praeruptorum is a medicinally critical species whose sustainable utilization is hindered by declining wild populations and insufficient cultivation systems. This study aimed to establish an optimized regeneration system for P. praeruptorum and elucidate the molecular mechanisms underlying coumarin biosynthesis, focusing on the roles of key phenylpropanoid pathway genes.MethodsLeaf, stem, and root explants were cultured on MS media supplemented with varying concentrations of 2,4-D, 6-BA, and IBA to induce callus, proliferation, differentiation, and rooting. …”
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Foliar Application of Silicon: An Innovative and Effective Strategy for Enhancing Tomato Yield in Hydroponic Systems by Raoudha Baioui, Rabaa Hidri, Slim Zouari, Mounir Hajji, Mohamed Falouti, Farah Bounaouara, Moufida Borni, Ahmed Hichem Hamzaoui, Chedly Abdelly, Walid Zorrig, Inès Slama

“…Although the integration of silicon (Si) in hydroponic systems is still limited, its foliar application is crucial for optimizing plant growth, enhancing resilience, and improving productivity. …”
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