Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke by Ahmet Alptekin, Mohammad B. Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A. Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams, Emily Blumling, Roxan Ara, Asamoah Bosomtwi, Joseph A. Frank, Krishnan M. Dhandapani, Ali S. Arbab

“…IntroductionExosomes from different sources have been used for therapeutic purposes to target stroke and other disorders. …”
Get full text

Effects of high light exposure and heterologous expression of β-carotene ketolase on the metabolism of carotenoids in Chlamydomonas reinhardtii by Rui Mei, Haihong Yang, Chunli Guo, Zeyu Hong, Zhangli Hu, Zhangli Hu, Yan Wu, Danqiong Huang, Chaogang Wang, Chaogang Wang

“…After designation, including intron insertion and chloroplast transit peptide, expression vectors were constructed and used for nuclear transformation of C. reinhardtii CC849 by bead milling method. Subsequently, DNA-PCR and RT-PCR were used to identify positive transformants grown with antibiotic stress, LC-MS/MS and metabolic analysis were performed to evaluate the products of transformants.ResultsIn this study, carotenoid metabolism regulation in C. reinhardtii was investigated in a time-dependent manner through high light exposure and heterologous expression of β-carotene ketolase. …”
Get full text

Trends and distribution of malaria among children under five in Tamale Metropolis in Ghana, amidst interventions: Analysis of surveillance and program data, 2017 -2021 by Shahadu Shembla Sayibu, Basil Benduri Kaburi, Dora Dadzie, Delia Bandoh, Isaac Baffoe-Nyarko, Charles Lwanga Noora, Abdul Gafaru Mohammed, Francis Genye Salifu, Peter Apetorgbor, Paul Hilarius Asiwome Kosi Abiwu, Ernest Kenu

“…Methods: Data sources were District Health Information Management System II (DHIMS II) at Tamale Metropolis from 2017 – 2021, Ghana Malaria Control Program reports, Ghana Expanded Program on Immunization and the Ghana Statistical Services. …”
Get full text

Cost-effective medium optimization and functional enhancement of Lactiplantibacillus plantarum 22F for industrial-scale probiotic production in swine feed by Nay Zin Myo, Ratchnida Kamwa, Benjamas Khurajog, Pawiya Pupa, Wandee Sirichokchatchawan, David J. Hampson, Nuvee Prapasarakul

“…Materials and Methods: Carbon (glucose, sucrose, and dextrose) and nitrogen (yeast extract, soy protein isolate, and whey protein concentrate) sources were screened using one-variable-at-a-time and Plackett–Burman design, followed by Response Surface Methodology for optimization. …”
Get full text

Psychiatric drugs dispensing trends in the affected population following Brumadinho dam failure by Marcelo Farah Dell'Aringa, Gabriel Elias Correa-Oliveira, Francesco Della Corte, Luca Ragazzoni, Ives Hubloue, Virginia Murray, Thais Piazza, Claudia Garcia Serpa Osorio-de-Castro, Elaine Miranda, Francesco Barone-Adesi

“…This study aims to investigate the impact of this disaster in the dispensing of psychiatric drugs.MethodsWe evaluated monthly aggregated data from 12 months before to 12 months after the event from two data sources, one accounting for psychiatric drugs dispensed by private pharmacies and the other by public health services. …”
Get full text

Biological characterization and in vitro fungicide screening of a new pathogen of basal stem rot of Schisandra chinensis in Jilin Province, China by Taiping Tian, Mengqi Wang, Jingmeng Zhu, Yining Sun, Mingjie Ma, Guoliang Liu, Jinshuo Wang, Bing Zhao, Yiping Yan, Yue Wang, Yue Wang, Yanli Wang, Yanli Wang, Changyu Li, Changyu Li, Dongyin Wang, Fang Yang, Wenpeng Lu, Wenpeng Lu, Peilei Xu, Peilei Xu

“…Biological characteristics were evaluated under different media, temperatures, light conditions, pH levels, and carbon/nitrogen sources. …”
Get full text

Isolation and Comprehensive Analysis of Cochlear Tissue‐Derived Small Extracellular Vesicles by Pei Jiang, Xiangyu Ma, Xinlin Wang, Jingyuan Huang, Yintao Wang, Jingru Ai, Hairong Xiao, Mingchen Dai, Yanqin Lin, Buwei Shao, Xujun Tang, Wei Tong, Zixuan Ye, Renjie Chai, Shasha Zhang

“…Currently, studies on the role of sEVs in the cochlea have relied on studying sEVs from in vitro sources. This study evaluates three cochlear tissue digestion and cochlear tissue‐derived sEV (CDsEV) isolation methods, and first proposes that the optimal approach for isolating CDsEVs using collagenase D and DNase І combined with sucrose density gradient centrifugation. …”
Get full text

Predictive model for assessing the prognosis of rhabdomyolysis patients in the intensive care unit by Yaxin Xiong, Hongyu Shi, Jianpeng Wang, Quankuan Gu, Yu Song, Weilan Kong, Jun Lyu, Mingyan Zhao, Mingyan Zhao, Xianglin Meng, Xianglin Meng, Xianglin Meng

“…Consequently, there is a pressing need for early prediction of survival rates among RM patients, yet reliable and effective predictive models are currently scarce.MethodsAll data utilized in this study were sourced from the MIMIC-IV database. …”
Get full text

Effects of Exergaming on Morphological Variables, Biochemical Parameters, and Blood Pressure in Children and Adolescents with Overweight/Obesity: A Systematic Review with Meta-Anal... by Jordan Hernandez-Martinez, Joaquín Perez-Carcamo, Hassan Melki, Izham Cid-Calfucura, Edgar Vasquez-Carrasco, Pedro Delgado-Floody, Claudio Romero, Tomás Herrera-Valenzuela, Braulio Henrique Magnani Branco, Pablo Valdés-Badilla

“…Methods: A systematic literature search was conducted until September 2024 using five databases: PubMed, Medline, CINAHL Complete, Scopus, and Web of Science. …”
Get full text

Competing risk nomogram for predicting cancer-specific survival in patients with primary bone diffuse large B-cell lymphoma: a SEER-based retrospective study by Rongbin Shen, Sichun Xiang, Jianyou Gu, Yu Zhang, Lili Qian, Jianping Shen, Qing Guo, Shana Chen, Chenyang Ma, Jingjing Xiang

“…Consequently, this study aims to identify prognostic factors in patients with primary bone diffuse large B-cell lymphoma (PB-DLBCL) using CVD as a competing risk and to develop a competing risk nomogram.MethodsData for patients diagnosed with PB-DLBCL from 2000 to 2015 were sourced from the Surveillance Epidemiology, and End Results (SEER) database and a total of 1,224 PB-DLBCL patients were eventually included in this study. …”
Get full text

Psychosocial and clinical characteristics in Takotsubo syndrome by Okezi Obrutu, Yujie Cui, Jenna Maughan, Paul Marano, Janet Wei, Martha Gulati, Marie Lauzon, Romana Herscovici, Chrisandra Shufelt, Natalie Rojas, Benita Tjoe, Thomas Rutledge, C. Noel Bairey Merz

“…Methods The Smidt Heart Institute Takotsubo registry enrolls individuals with a history of TTS sourced through physician referrals, medical records review, peer- and self-referrals. …”
Get full text

Productive and economic effects of adding Bacillus amyloliquefaciens CECT 5940 to bread waste-based diets in laying hens by Albertina Felizardo Manteiga, Abilio Paulo Changule, Nilza Jorge Manjate, Dercia Hilario Magaia, Florentina Domingos Chilala, Leonel Antonio Joaquim, Eunice Justino Chivale, Filomena dos Anjos, Manuel Garcia-Herreros, Custódio Gabriel Bila

“…Background and Aim: The high cost and limited availability of maize in poultry production necessitate the exploration of alternative feed sources. Bread waste (BW), a nutrient-rich by-product, offers a sustainable substitute. …”
Get full text

Effect of a Pleuran-Based Supplement on Salivary IgA Secretion in Children With Recurrent Respiratory Infections by Peter Kunc, MD, PhD, Jaroslav Fabry, MD, PhD, Michaela Matiscakova, MD, Katarina Istvankova, DVM, Zuzana Diamant, MD, PhD, Juraj Majtan, PhD, DSc, Milos Jesenak, MD, PhD

“…Background: ß-glucans isolated from natural sources have demonstrated pluripotent immunomodulatory potential, making them a promising supportive treatment for the management of recurrent respiratory infections (RRIs) in children. …”
Get full text

Disability-adjusted life years for colorectal cancer in China, 2017–2030: A prevalence-based analysis focusing on the impact of screening coverage and the application of local weig... by Yujie Wu, Yanjie Li, Xin Wang, Xinyi Zhou, Xinxin Yan, Hong Wang, Juan Zhu, Wanqing Chen, Jufang Shi, Jinjiao Li

“…This study aimed to apply local CRC-stage-specific DWs to estimate the burden of DALYs for CRC (CRC-DALYs) in populations in China and consider the influence of local screening coverage of CRC. Methods:. A prevalence-based model was constructed using data from various sources. …”
Get full text

Gut microbial metabolite trimethylamine N-oxide as a novel predictor for adverse cardiovascular events after PCI: a systematic review and dose-response meta-analysis by Chunyu Zhang, Jinyu He, Yujia Huo, Lin Liu, Yong Xie, Yufei Meng, Gang Wei, Li Deng, Yang Jiang, Jian Feng

“…This study aims to systematically evaluate TMAO’s predictive value for MACE post-PCI and explore its dose-response relationship. …”
Get full text

Assessing the latest advances in bone marrow stem cell therapy for Avascular Necrosis hip: A comprehensive systematic review, meta-analysis, and meta-regression of randomized contr... by Robin Novriansyah, Tanti Ajoe Kesoema, Kevin Christian Tjandra, I Nyoman Sebastian Sudiasa, Shakira Amirah, Imke Maria Del Rosario Puling, Prudence Lucianus, Revina Maharani, Danendra Rakha Putra Respati, Laksmana Adi Krista Nugraha, Ismail Hadisoebroto Dilogo

“…<h4>Method</h4>We performed this systematic review and meta-analysis from randomized controlled trials (RCTs) and sources published between 2013 and 2023 from six databases. …”
Get full text

Reducing US cardiovascular disease burden and disparities through national and targeted dietary policies: A modelling study. by Jonathan Pearson-Stuttard, Piotr Bandosz, Colin D Rehm, Jose Penalvo, Laurie Whitsel, Tom Gaziano, Zach Conrad, Parke Wilde, Renata Micha, Ffion Lloyd-Williams, Simon Capewell, Dariush Mozaffarian, Martin O'Flaherty

“…We also evaluated a combined policy approach, combining all of the above policies. …”
Get full text

Global Burden of Musculoskeletal Disorders in Adults Aged 50 and Over, 1990–2021: Risk Factors and Sociodemographic Inequalities by Shi‐Yang Guan, Jin‐Xin Zheng, Shun‐Xian Zhang, Shengqian Xu, Zongwen Shuai, Hong‐Yan Cai, Faming Pan

“…This study aims to comprehensively assess the global burden of MSK disorders among adults aged 50 and over from 1990 to 2021, as well as temporal trends, risk factors and sociodemographic inequalities. Methods Data were sourced from the Global Burden of Disease 2021 study. …”
Get full text

Incidence and predictors of mortality among low birth weight neonates in Africa: a systematic review and meta-analysis by Leweyehu Alemaw Mengstie, Wegayehu Zeneb Teklehaimanot, Mohammed Tesema Gebeyehu, Worku Abemie, Abatwoy Ayfokru, Yihenew Ayehu Dessie, Mitiku Tefera, Bekahegn Girma

“…Heterogeneity and publication bias were evaluated using the I2 statistic and Egger's test. …”
Get full text

Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case-control studies in 5 countries. by Matthew Cairns, Serign Jawo Ceesay, Issaka Sagara, Issaka Zongo, Hamit Kessely, Kadidja Gamougam, Abdoulaye Diallo, Johnbull Sonny Ogboi, Diego Moroso, Suzanne Van Hulle, Tony Eloike, Paul Snell, Susana Scott, Corinne Merle, Kalifa Bojang, Jean Bosco Ouedraogo, Alassane Dicko, Jean-Louis Ndiaye, Paul Milligan

“…<h4>Methods and findings</h4>Case-control studies were carried out in Mali and The Gambia in 2015, and in Burkina Faso, Chad, Mali, Nigeria, and The Gambia in 2016. …”
Get full text