Prevalence and clinical relavance of germline mutations in Chinese patients with pancreatic cancer by Yu Jiang, Dan Li, Yang Liu, Jiejie Qin, Hao Chen, Jun Zhang, Yijin Gu, Baiyong Shen, Jiabin Jin

“…Comparative data were sourced from The Genome Aggregation Database (gnomAD) and the China Metabolic Analytics Project (ChinaMAP) database. …”
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Predicting 30-day survival after in-hospital cardiac arrest: a nationwide cohort study using machine learning and SHAP analysis by Truls Råmunddal, Mats Borjesson, Erik Andersson, Per Nordberg, Kristofer Skoglund, Johan Herlitz, Araz Rawshani, Therese Djärv, Aidin Rawshani, Peter Lundgren, Antros Louca, Vibha Gupta, Joakim Sundström, Carl Magnusson

“…Despite advances in resuscitation, predicting 30-day survival remains difficult, and current methods lack interpretability for timely decision-making. …”
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Association of serum copeptin levels with pulmonary complications and heart right ventricular functions in common variable immunodeficiency by Mehmet Kılınç, Fatih Çölkesen, Filiz Sadi Aykan, Recep Evcen, Eray Yıldız, Bahadır Feyzioğlu, Metin Doğan, Yakup Alsancak, Sefa Tatar, Şevket Arslan

“…Clinical and biochemical parameters were sourced from existing hospital records.CVID patients were categorized into two subgroups: those with and without pulmonary complications. …”
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Fibrinogen and D-dimer protein levels in patients with preeclampsia: a systematic review and meta-analysis by Ermiyas Alemayehu, Alemu Gedefie, Fasil Getu, Zewudu Mulatie, Muluken Walle, Ousman Mohammed, Getachew Mesfin Bambo, Habtu Debash, Yenealem Solomon, Abdurehman Eshete Mohammed, Hussen Ebrahim, Melaku Ashagrie Belete

“…Furthermore, Egger’s regression test and funnel plot were utilized to evaluate publication bias among the included studies. …”
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OpenAI o1 Large Language Model Outperforms GPT-4o, Gemini 1.5 Flash, and Human Test Takers on Ophthalmology Board–Style Questions by Ryan Shean, BA, Tathya Shah, BS, Sina Sobhani, BS, Alan Tang, BS, Ali Setayesh, BA, Kyle Bolo, MD, Van Nguyen, MD, Benjamin Xu, MD, PhD

“…Methods: Three large language models interpreted the questions using standardized prompting procedures. …”
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IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling by Mengmeng Zhang, Bingnan Guo, Xiaowei Zhang, Dong Han, Lanxin Lv, Xiaoqing Yan, Chenglei Su, Dafei Chai, Ningjun Zhao, Xianliang Yan, Shuqun Hu

“…TUNEL assays were used to evaluate neuronal damage. TTC staining was performed to assess infarction volumes. …”
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Association between polychlorinated biphenyls and hypertension risk: a systematic review and meta-analysis by Seyedeh Fatemeh Hamzavi, Iman Elahi Vahed, Ali Samadi Shams, Fateme Nozari, Baroukh Gamzeh Latava, Saman Mardukhi, Behnoosh Sabaghi, Zakieh Sadat Hosseini, Zohre Masoumi Shahr-e Babak, Sahar Ahrari, Ali Keshavarzian, Mohammad Rahmanian

“…This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension.MethodsAdhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. …”
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TET3-facilitated differentiation of human umbilical cord mesenchymal stem cells into oligodendrocyte precursor cells for spinal cord injury recovery by Yubo Zhang, Zhibin Peng, Man Guo, Yangyang Wang, Jingsong Liu, Yishu Liu, Mi Li, Tianli Wei, Pengfei Li, Yingwei Zhao, Yansong Wang

“…This study aimed to explore the TET3-mediated one-step induction of HUCMSCs into OPCs. Methods In vitro, HUCMSCs were induced into OPCs following TET3 overexpression. …”
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Isolation and identification of Fusarium species from the water systems of ICUs and transplant wards of hospitals and determination of the in vitro susceptibilities of isolates to... by Fatemeh Mirhasani, Roshanak Daie-Ghazvini, Seyed Jamal Hashemi, Sadegh Khodavaisy, Pegah Ardi, Zahra Rafat, Davoud Roostaei, Heidar Bakhshi, Fatemeh Amirzadeh-Ghasemi

“…This study aimed to isolate and identify Fusarium species from the water systems of the ICUs and transplant units at Imam Khomeini Hospital Complex and Shariati Hospital in Tehran, Iran, as potential sources of future outbreaks. Additionally, the study sought to determine the in vitro susceptibilities of the isolates to conventional antifungal agents.MethodsSterile swabs and open plates containing Sabouraud dextrose agar (SDA) with chloramphenicol were used to collect water samples from sink surfaces, shower trays, faucets, and around the drains of sinks, as well as from bathroom areas. …”
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Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study by Jiaqi Chen, Haiqing Li, Xinrui Long, Hao Tong, Xin Xin, Han Zhang, Yeyao Li, Ping Liu, Xiaolin He, Zhuoyuan Chen

“…The inverse variance-weighted(IVW) method was applied to evaluate the association between gut microbiota composition and EC risk. …”
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Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…Neurotransmitter maps were sourced from JuSpace. We performed volumetric and whole-brain correlation analyses to evaluate relationships between brain regional volumes (BRVs) and neurotransmitter pathways. …”
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Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model by Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel

“…A suitable animal model will help delineate comparative aspects of HIV-1C and HIV-1B infections.MethodsHere, we used a humanized mouse model to evaluate HIV-1C infection, disease progression, response to anti-retroviral therapy (ART) and viral rebound following therapy interruption. …”
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An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits by Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta

“…Methods We conducted an epigenome-wide association study of SRS in child blood at approximately age 5 in the Study to Explore Early Development, a case-control study of ASD in the United States. …”
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Cost of integrated chronic care for severe non-communicable diseases at district hospitals in rural Rwanda by Joseph Mucumbitsi, Lauren Anne Eberly, Christian Rusangwa, Loise Ng'ang'a, Claire C Neal, Jean Paul Mukundiyukuri, Egide Mpanusingo, Jean Claude Mungunga, Hamissy Habineza, Todd Anderson, Gedeon Ngoga, Symaque Dusabeyezu, Gene Kwan, Charlotte Bavuma, Emmanual Rusingiza, Francis Mutabazi, Cyprien Gahamanyi, Cadet Mutumbira, Paul H Park, Tharcisse Mpunga, Gene Bukhman

“…Conditions addressed included type 1 and type 2 diabetes, chronic respiratory disease, heart failure and rheumatic heart disease.Methods A retrospective costing analysis was conducted from the facility perspective using data from administrative sources and the electronic medical record systems of Butaro District Hospital in rural Rwanda. …”
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Sentiment Dynamics Among Informal Caregivers in Web-Based Alzheimer Communities: Systematic Analysis of Emotional Support and Interaction Patterns by Congning Ni, Qingyuan Song, Qingxia Chen, Lijun Song, Patricia Commiskey, Lauren Stratton, Bradley Malin, Zhijun Yin

“…Web-based social media platforms have emerged as valuable sources of peer support for these caregivers. However, there has been limited investigation into how web-based peer support might influence their mental well-being. …”
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Cardiometabolic Risk Factor Changes Observed in Diabetes Prevention Programs in US Settings: A Systematic Review and Meta-analysis. by Uma Mudaliar, Azadeh Zabetian, Michael Goodman, Justin B Echouffo-Tcheugui, Ann L Albright, Edward W Gregg, Mohammed K Ali

“…Two reviewers independently evaluated article eligibility and extracted data on study designs, populations enrolled, intervention program characteristics (duration, number of core and maintenance sessions), and outcomes. …”
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Association of a Sulfur-Containing Diet and a CTH Polymorphism with Bone Density in the Uyghur Population of China: A Preliminary Study by Fang L, Zhang Z, He D, Hao Y, Gao Y, Lu R, Li C

“…Dietary sulfur intake was assessed using a food frequency questionnaire and categorized into animal protein-derived and non-animal protein-derived sources. Skeletal health of the calcaneus was evaluated using quantitative ultrasound scanning.Results: The study included a total of 200 participants, comprising 81 males and 119 females. …”
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Risk of bleeding with dentoalveolar surgery in patients taking direct oral anticoagulants or vitamin K antagonists: A systematic review and meta-analysis by Ke Dou, Yue Shi, Baoyi Yang, Zhiguo Zhao

“…Subgroup analyses were conducted according to study characteristics, while sensitivity analyses were used to pinpoint potential sources of heterogeneity and evaluate the reliability of the results. …”
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The mushrooms on the menu (MOM) study: vitamin D mushrooms (UV-exposed) are a feasible and acceptable way to increase vitamin D intake in a residential aged care facility by Celeste Ferraris, Michelle Blumfield, Emily Duve, Lucy Downey, Jutta Wright, Saamia Khan, Emma L. Beckett, Flávia Fayet-Moore, Flávia Fayet-Moore

“…Supplementation implementation is variable and dosages are often suboptimal. Due to limited food sources, diet is frequently overlooked, yet mushrooms can raise vitamin D levels in deficient individuals similar to a supplement.ObjectivesMushrooms on the Menu (MOM) was a 10-week prospective pre-post mixed method study that evaluated the feasibility of adding vitamin D mushrooms to the menu of a residential aged care facility.MethodsDuring the 4-week baseline phase, residential care (RC) participants ordered meals from the standard food service menu, while independent living (IL) followed their usual diet. …”
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The cost-effectiveness analysis of single-tablet efavirenz-based regimen among HIV-1 infected adults in China by Haijun Zhang, Haijun Zhang, Yuhao Kong, Haotian Chen, Sitong Luo, Sitong Luo, Pengyang Fan, Zhihui Li, Zhihui Li

“…This study aimed to evaluate the cost-effectiveness of various TLE treatment strategies for ART-naive HIV-1 infected adults in China.MethodsA decision-tree Markov state transition model was employed to assess the cost-effectiveness of various TLE treatment strategies over a 10-year timeframe, from a societal perspective. …”
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