Probiotic Characterization of <i>Lactiplantibacillus paraplantarum</i> SDN1.2 and Its Anti-Inflammatory Effect on <i>Klebsiella pneumoniae</i>-Infected Mammary Glands by Jia Cheng, Jingdi Tong, Can Li, Ziyan Wang, Hao Li, Meiyi Ren, Jinshang Song, Deyuan Song, Qinna Xie, Mingchao Liu

“…In this study, the probiotic potential and safety of <i>L. paraplantarum</i> SDN1.2, as well as its ex vivo and in vivo anti-inflammatory effects against <i>K. pneumoniae</i>-induced mastitis, were comprehensively investigated using bioinformatics analyses and experimental validation methods. The results revealed that <i>L. paraplantarum</i> SDN1.2 exhibits non-hemolytic activity, is not cytotoxic, lacks virulence genes (e.g., adhesion factors, toxins, and invasion factors) and antibiotic resistance genes (e.g., beta-lactamases and tetracycline resistance genes), as supported by whole-genome sequencing, and significantly inhibits the growth of <i>K. pneumoniae</i>, as evaluated by antimicrobial tests. …”
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Stable water isotope analysis of plant-soil interspecific interactions in wheat-maize intercropping by Duo-Peng Shi, Ying-Bo Liu, Yun-Ling Cui, An-Yu Zhao, He-Zhe Sun, Liang Xue, Wen-Feng Cong, Muhammad Ali Raza, Li-Qin Zhang

“…Stable water isotope tracing is an effective tool for quantifying plant water sources; however, interspecific competition and root stratification mechanisms in intercropping systems remain insufficiently validated through isotopic methods. …”
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Dishwashing practice and its determinants among food handlers in food and drinking service establishments in Dessie City and Kombolcha Town, Northeastern Ethiopia by Mekonnen Moges, Metadel Adane, Balew Adane, Genanew Mulugeta Kassaw, Abraham Teym, Getasew Yirdaw, Lake Kumlachew, Agernesh Ayele, Yenewa Bewket, Mesfin Gebrehiwot

“…To bridge this gap, this study proposes to evaluate the dishwashing practice employed by food handlers in food and drinking establishments and its determinants in Dessie City and Kombolcha Town, Northeastern Ethiopia.Methods and MaterialsAn institution-based cross-sectional study was done on 405 food handlers from 405 food and drinking establishments from 25 June 2022 to 25 August 2022 in Dessie City and Kombolcha Town. …”
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Enhancing crop resilience to water stress through iron nanoparticles: A critical review of applications and implications by Tajwar Alam, Sanaullah Jalil, Ghulam Jilani, Arshad Nawaz Chaudhry, Zia Ul-Haq, Iram Naz, Muhammad Abbas Khan, Xinghong Yang, Marian Brestic, Milan Skalicky, Ayman El Sabagh

“…However, Fe-NP use in agriculture poses potential health and environmental risks, including water and soil contamination, soil microbial alteration, and residues in edible crop plants, which require careful consideration.Furthermore, Fe-NP effectiveness may vary depending on factors, viz., size of nanoparticles (NPs), concentration, method of application, and crop type. The paper concludes by discussing potential research avenues, highlighting the necessity of sustainable application methods, optimal Fe-NP formulations, and thorough environmental effect evaluations. …”
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The Efficacy of Hyaluronic Acid in Reducing Pelvic Adhesions in Patients Undergoing Gynecologic Laparoscopic Surgery: A Meta‐Analysis of Randomized Clinical Trials by Maryam Mazloomi, Arash Mohazzab, Kobra Tahermanesh, Maliheh Fakehi, Maryam Saeedzarandi, Zahra Kooshari, Paria Dehesh, Seyede Razieh Ghaffari

“…Two reviewers independently screened the studies, extracted the relevant data, and evaluated methodological quality using the Jadad scoring system. …”
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Novel biosynthesis of silver nanoparticles using Ulva lactuca and their potential toward environment and agricultural purposes by Mariame Taibi, Marouane Aouji, Hamada Imtara, Feras Abujaber, Asmaa Oubihi, Abdelmalek Ouannou, Lhoussain Hajji, Abdelaaty A. Shahat, Omar M. Noman, Mahmoud Tarayrah, Rachid Bengueddour, Oussama Hassani

“…To prevent the diseases caused by many commonly used pesticides, it is essential to synthesize safe alternatives from low-cost sources.Material and methodsThis study focuses on the eco-friendly extracellular production of AgNPs using an aqueous extract of Ulva lactuca as a reducing agent in a silver nitrate solution. …”
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Association of CALLY index and CLR with COPD risk in middle-aged and older Americans: evidence from NHANES 2017–2020 by Jiaji Zhou, Jiaji Zhou, Wenyi Du, Hanzhou Huang, Hanzhou Huang, Yongqi Chen, Yongqi Chen, Leyan Chen, Leyan Chen, Mingfeng Zheng, Mingfeng Zheng

“…This study assessed the predictive value of hematological inflammatory biomarkers, specifically the C-reactive protein-albumin-lymphocyte (CALLY) index and the C-reactive protein to lymphocyte ratio (CLR), for determining COPD risk in United States adults aged 40 and above.MethodsData were sourced from the National Health and Nutrition Examination Survey (NHANES) covering the period from 2017 to March 2020. …”
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Factors associated with clinical antimicrobial resistance in China: a nationwide analysis by Wenyong Zhou, Zexuan Wen, Wenlong Zhu, Jiali Gu, Jing Wei, Haiyan Xiong, Weibing Wang

“…Methods We analyzed data from 31 provincial-level administrative divisions in China, encompassing 20,762,383 bacterial isolates sourced from the China Antimicrobial Resistance Surveillance System dataset between 2014 and 2022. …”
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Providing TB and HIV outreach services to internally displaced populations in Northeast Nigeria: Results of a controlled intervention study. by Suraj A Abdullahi, Marina Smelyanskaya, Stephen John, Haruna I Adamu, Emperor Ubochioma, Ishaya Kennedy, Fatima A Abubakar, Haruna A Ago, Robert Stevens, Jacob Creswell

“…Although international investment supports some health interventions among IDPs, locally sourced solutions are lacking.<h4>Methods and findings</h4>We evaluated the impact of an active case finding (ACF) intervention for TB and testing for HIV in IDP communities and provided linkages to treatment in 3 states in Northeast Nigeria: Adamawa, Gombe, and Yobe. …”
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Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…We assessed the consistency of the results, performed sensitivity analyses, and examined publication bias to evaluate the influence of individual studies. Furthermore, subgroup analysis and network meta-regression analysis were conducted to explore potential sources of heterogeneity. …”
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Feasibility of implementing current best clinical practice for people who are using anabolic androgenic steroids within a Swiss primary care practice: a quality assurance study by Raphael Magnolini, Kuvinda Kossinna, Daniel Bjasch, Muriel Kruijver, Philip Bruggmann, Oliver Senn

“…The reporting and methodology to evaluate feasibility of this quality assurance study follow a checklist for pilot studies. …”
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Digital Health Literacy and Attitudes Toward eHealth Technologies Among Patients With Cardiovascular Disease and Their Implications for Secondary Prevention: Survey Study by Greta Ullrich, Alexander Bäuerle, Hannah Vogt, Amir Abbas Mahabadi, Katrin Paldán, Daniel Messiha, Lisa Maria Jahre, Christos Rammos, Tienush Rassaf, Julia Lortz

“…It involved 240 participants with known coronary artery disease. The assessment evaluated their current understanding of the general use of digital devices. …”
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One Health: governance and regulatory framework for antimicrobial use in Malawi by Amos Lucky Mhone, Dishon M. Muloi, Arshnee Moodley

“…Relevant policies and laws were sourced from government databases, the Food and Agricultural Organisation of the United Nations' (FAO) FAOLEX and AMR-LEX databases, and other publicly available resources. …”
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Effectiveness of shared decision-making for glycaemic control among type 2 diabetes mellitus adult patients: A systematic review and meta-analysis. by Edosa Tesfaye Geta, Dufera Rikitu Terefa, Wase Benti Hailu, Wolkite Olani, Emiru Merdassa, Markos Dessalegn, Miesa Gelchu, Dereje Chala Diriba

“…<h4>Methods</h4>Literature sources were searched in MEDLINE, PubMed, Cochrane library and HINARI bibliographic databases and Google Scholar. …”
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Snake Venom Peptide Fractions from <i>Bothrops jararaca</i> and <i>Daboia siamensis</i> Exhibit Differential Neuroprotective Effects in Oxidative Stress-Induced Zebrafish Models by Felipe Assumpção da Cunha e Silva, Brenda Rufino da Silva, Leticia Ribeiro de Barros, Emidio Beraldo-Neto, Adolfo Luis Almeida Maleski, Carlos Alberto-Silva

“…While the peptide fraction (<10 kDa) from <i>Bothrops jararaca</i> venom has shown in vitro neuroprotection, analogous fractions from related species remain unexplored in vivo. <b>Methods:</b> This study comparatively evaluated the neuroprotective effects of two peptide fractions (pf) from <i>Daboia siamensis</i> (pf-<i>Ds</i>) and <i>B. jararaca</i> (pf-<i>Bj</i>) against H₂O₂-induced oxidative stress using in vitro (PC12 cells) and in vivo (zebrafish, <i>Danio rerio</i>) models. …”
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Development and Optimization of a Novel Deep Learning Model for Diagnosis of Quince Leaf Diseases by A. Naderi Beni, H. Bagherpour, J. Amiri Parian

“…The majority of these images were sourced from the Agricultural Research Center of Isfahan Province in Iran, supplemented by contributions from researchers who had previously studied in this field. …”
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Trends in diet structural composition and quality among adults in Beijing, China (2010–2022) by Ningsu Chen, Liyu Huang, Kai Zhao, Yimei Sha, Mengnan Zhao, Yihong Yao, Yana Qi, Yan Zhang, Bo Yu, Hairong He, Jiajie Yu, Jiali Duan

“…Dietary structural composition was comprehensively analyzed, including the energy contribution of macronutrients and food sources of energy, protein, and fat intake. Population-level dietary quality was evaluated using the Chinese Diet Balance Index (DBI-22). …”
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Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China by Junting Yang, Junting Yang, Yunxiao Wu, Yunxiao Wu, Jinxin Guo, Jinxin Guo, Xiaoxuan Wang, Xiaoxuan Wang, Xin Gao, Xin Gao, Xin Chen, Xin Chen, Mengdi Zhang, Mengdi Zhang, Jin Yang, Zuojing Liu, Yan Liu, Zhike Liu, Zhike Liu, Siyan Zhan, Siyan Zhan, Siyan Zhan, Siyan Zhan

“…Algorithms for IBD and ITP required synthesis of multiple data sources to achieve acceptable performance (IBD: sensitivity 79.66%, PPV 70.15%; ITP: sensitivity 62.50%, PPV 70.00%). …”
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ChatGPT-o1 Preview Outperforms ChatGPT-4 as a Diagnostic Support Tool for Ankle Pain Triage in Emergency Settings by Pooya Hosseini-Monfared, Shayan Amiri, Alireza Mirahmadi, Amirhossein Shahbazi, Aliasghar Alamian, Mohammad Azizi, Seyed Morteza Kazemi

“…This study aimed to assess the performance of ChatGPT-4 and o1-preview in generating differential diagnoses for common cases of ankle pain in emergency settings. Methods: Common presentations of ankle pain were identified through consultations with an experienced orthopedic surgeon and a review of relevant hospital and social media sources. …”
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The efficacy and safety of qiwei baizhu san in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis by Quan Zhang, Hongyan Liu, Jiahong Zhang, Yujie Ouyang, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu, Chunguang Xie, Chunguang Xie, Chunguang Xie

“…As of August 2024, we searched eight databases to screen and include randomized controlled trials of QWBZS for T2DM. Heterogeneity sources were examined via subgroup analyses, the robustness of the results was determined by sensitivity analyses, publication bias was evaluated using funnel plots and Egger’s test, evidence quality was appraised with GRADEpro, and possible mechanisms of QWBZS for T2DM were categorized and summarized.ResultsThis analysis encompassed 14 qualifying trials with a total of 1,169 subjects. …”
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