Historical trends and controlling factors of isoprene emissions in CMIP6 Earth system models by N. T. N. Do, K. Sudo, K. Sudo, A. Ito, A. Ito, A. Ito, L. K. Emmons, V. Naik, K. Tsigaridis, K. Tsigaridis, Ø. Seland, G. A. Folberth, D. I. Kelley

“…</p> <p>To investigate isoprene emission trends, controlling factors, and discrepancies among models, we analysed long-term (1850–2014) global isoprene emissions from online simulations of CMIP6 Earth system models and offline simulations using the Vegetation Integrative SImulator for Trace gases (VISIT) dynamic vegetation model driven by climate reanalysis data.…”
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Development of Modified Drug Delivery Systems with Metformin Loaded in Mesoporous Silica Matrices: Experimental and Theoretical Designs by Mousa Sha’at, Maria Ignat, Florica Doroftei, Vlad Ghizdovat, Maricel Agop, Alexandra Barsan (Bujor), Monica Stamate Cretan, Fawzia Sha’at, Ramona-Daniela Pavaloiu, Adrian Florin Spac, Lacramioara Ochiuz, Carmen Nicoleta Filip, Ovidiu Popa

“…In vitro drug release profiles were recorded in simulated gastric and intestinal fluids over 12 h. …”
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Quantifying the contributions of cardiovascular risk factors to cardiovascular disease trends in 21st century Japan: a microsimulation studyResearch in context by Soshiro Ogata, Eri Kiyoshige, Yusuke Yoshikawa, Koji Iihara, Hitoshi Fukuda, Masanobu Ishii, Kenichi Tsujita, Anna Head, Brendan Collins, Martin O'Flaherty, Kunihiro Nishimura, Chris Kypridemos

“…Interpretation: SBP and smoking reductions drove most CVD burden declines in Japan (2001–2019). …”
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Identification of Priority Areas for Ecological Restoration at a Small Watershed Scale: A Case Study in Dali Prefecture of Yunnan Province in China by Qiyuan Zhou, Qiuping Zhu, Yu Feng, Jinman Wang

“…Conversely, water conservation declined significantly by 10.00%, with carbon sequestration and biodiversity protection experiencing slight reductions of 1.74% and 1.92%, all within a 2% variation margin. …”
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Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods by Mehmet Cengiz Baloglu, Lutfiye Yildiz Ozer, Buket Pirci, Yasemin Celik Altunoglu, Sanam Iram Soomro, Gokhan Zengin, Mehmet Veysi Cetiz, Simone Carradori, Zoltán Cziáky, József Jekő

“…The methanolic extract exhibited potent anticancer effects against lung cancer (A549) cells, with significant reductions in cell viability and induction of autophagy. …”
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Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammat... by Elsayed A. Elmorsy, Elsayed A. Elmorsy, Sameh Saber, Zubida M. Al-Majdoub, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Asmaa Ramadan, Norah Suliman Alsoqih, Mariam S. Alharbi, Hamad Alsaykhan, Alshaimaa A. Farrag, Hanan Eissa, Rasha Abdelhady, Rasha Abdelhady, Abousree T. Ellethy, Mostafa M. Khodeir, Mostafa M. Khodeir, Hossam A. Elsisi, Hossam A. Elsisi, Syed Suhail Ahmed, Ahmed Y. Kira

“…Treatment resulted in substantial reductions in key inflammatory markers, including HMGB1, RAGE, TLR4 expression, NFκB activity, pro-inflammatory cytokines (TNF-α and IL-6), and apoptosis marker caspase-3. …”
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Integrative review of artificial intelligence applications in nursing: education, clinical practice, workload management, and professional perceptions by Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken, Ahmed Ghannam, Fuad H. Abuadas, Joel Somerville, Joel Somerville, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair, Abbas Al Mutair

“…Study quality was assessed using the Mixed Methods Appraisal Tool (MMAT), and the risk of bias evaluated through ROBINS-I.ResultsThis review encompassed 25 studies, from which six overarching themes emerged.Education and trainingAI-powered simulations and content-creation platforms enriched nursing curricula by presenting realistic clinical scenarios, which consistently yielded deeper student engagement, enhanced case-management performance, and higher satisfaction scores. …”
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