Mechanistic insights curcumin’s anti-inflammatory in pancreatic cancer: experimental and computational evidence implicating IL1B interference via IL10RA upregulation and NLRP3/TLR3... by Jun-Feng Cao, Jun-Feng Cao, Kuan Hang, Hao Zhang, Qingjie Xia, Xiao Zhang, Jie Men, Jin Tian, Zengliang Xia, Dunshui Liao, Kezhou Li, Kezhou Li

“…We validated the differential gene targets by machine learning analysis of GSE28735 data, and performed survival analysis, pan-tumor analysis, immune infiltration analysis and single-cell transcriptional analysis on the differentially expressed targets. Computer simulations were utilized to verify the stability of curcumin binding to key proteins.ResultsResults of cellular experiments suggested 30 μg/mL curcumin and 50 μg/mL curcumin significantly inhibited the proliferation and growth of PL45 and SUIT-2, respectively. …”
Get full text

Application and Validation of AIRNET in Simulating Building Drainage Systems for Tall Buildings by Michael Gormley, Sarwar Mohammed, David A. Kelly, David P. Campbell

Get full text

Three-Dimensional Printing Experiments and Particle-Based Meshless Numerical Investigations on the Failure Modes of Tunnel-Lining Structures Containing Fissures by Shuyang Yu, Zhongqing Chen, Yifei Li, Wei Li, Bufan Zhang

“…This study investigated the failure modes of tunnel-lining structures with prefabricated fissures via 3D-printed samples, uniaxial compression experiments using DIC technology for full-field strain monitoring, and a particle-based meshless (SPH) numerical method to simulate tunnel–fissure interactions. …”
Get full text

<i>TP53</i> Is a Potential Target of Juglone Against Colorectal Cancer: Based on a Combination of Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments by Yunting Deng, Yanan Zhang, Xinghai Chen, Weiming Wang, Jinhai Huo

“…Molecular docking and molecular dynamics simulations showed that the p53 has strong affinity and stability with Juglone. …”
Get full text

Investigating the impact of abrasive tool wear on surface topography and microstructure evolution in polished GH4169G alloy through experiments and multi-scale simulations by Rui Yang, Xiaojun Lin, Youwei Chen, Tao Zhao

“…This study investigates the influence of abrasive tool wear on the surface topography and microstructure evolution of GH4169G during polishing, combining experiments and simulations to assess surface functionality. …”
Get full text

How does turbulence affect wake development in floating wind turbines? Some insights from comparative large-eddy simulations and wind tunnel experiments by L. Pagamonci, F. Papi, G. Cojocaru, M. Belloli, A. Bianchini

Get full text

Simulation of film transmission path based on ant colony optimization algorithm by Yiyuan Wang

“…Based on this, this paper proposes an ant colony optimization algorithm (ACA) to conduct simulation experiments on film and television transmission paths, and on this basis, optimize and upgrade the path to improve the speed and scope of network film and television transmission. …”
Get full text

Investigation of the constitutive relationship between energy damage and CFRP layers in axially compressed small coal cylinders: Experiment and simulation by Qingwen Li, Chuangchuang Pan, Yuqi Zhong, Wenxia Li, Mengjiao Xu, Lei Zhang, Shuaishuai Zhang

Get full text

An Integrated Approach via Design, Experiment, and Simulation for the Development of a Pot‐Type Stove for Energy‐Intensive Cooking Tasks by Delmer Gómez‐Heleria, José Núñez, Alberto Beltrán, Víctor M. Berrueta, Carlos A. García, Omar R. Masera

Get full text

Research on temperature field and heat dissipation development regularity of surrounding rock in adjacent parallel roadway: Simulation and similar experiment by Fei Tang, Yueping Qin, Mingyan Guo, Shibin Wang, Peng Wang, Yanjie Yang

“…An independently developed numerical solver was validated against simulation experiments, showing high accuracy with a maximum relative error of 1.92 %. …”
Get full text

Numerical Simulation and Experimental Study of a Small-Scale Vacuum Fish Pump by Changfeng Tian, Zhi Qu, Xuan Che, Mengxia Han, Yin Zhou, Fan Wu

“…However, the development of a small vacuum fish pump is not a single scaling of the existing vacuum fish pump but requires the support of relevant experiments and simulation theories. In this study, a vacuum fish pump suitable for small fishing vessels was developed. …”
Get full text

Effect of the Atlantic Multidecadal Variability on the Global Monsoon by Paul‐Arthur Monerie, Jon Robson, Buwen Dong, Dan L. R. Hodson, Nicholas P. Klingaman

“…In contrast, the thermodynamic changes are less important. Further experiments show that the impact of AMV is largely due to the tropical component of the sea surface temperature anomalies. …”
Get full text

NUMERICAL SIMULATION OF THE FORMATION OF HAILSTONES IN THE CLOUDS AT THE NATURAL DEVELOPMENT AND AT THE ACTIVE INFLUENCE WITH THE HELP OF CRYSTALLIZING REAGENT by Vitaly Alexandrovich Shapovalov

Get full text

Thermal Management in 500 kV Oil-Immersed Converter Transformers: Synergistic Investigation of Critical Parameters Through Simulation and Experiment by Zhengqin Zhou, Chuanxian Luo, Fengda Zhang, Jing Zhang, Xu Yang, Peng Yu, Minfu Liao

Get full text

Structure Design and Simulation Analysis of the Lower Limb Wearable Walking Aid by Wang Xin, Yan Peifeng

“…Taking the gait data collected from the motion capture experiment as the simulation driving force, the kinematics simulation verification of the walker is carried out. …”
Get full text

Mechanical properties of human spinal dura mater show rate dependency by Tomasz Wiczenbach, Radosław Wolny, Dawid Bruski, Karol Daszkiewicz, Wiktoria Kolczyk, Jan Henryk Spodnik, Ilya Krypets, Lukasz Pachocki

Get full text

Design and experiment of air-suction drum-type seedling seeder for irregular-shaped vegetable seeds by Yanjun Li, Yunqiang Liu, Yichao Ning, Hongxin Wu, Yaqian Zhao

“…The basic structure and working principle of the seeder were elaborated, the key components were designed, and the distribution of the airflow field in the flow paths of the suction nozzles of three different hole types was simulated and analyzed by Fluent software; the relationship between the main influencing factors of the seeder’s operational performance (suction air pressure, clearing air pressure, and vibration frequency of the seed cassette) and the sowing indexes (replanting rate, cavity rate, and qualification rate) was investigated and the relationship between the factors and the sowing indexes (reseeding rate, cavity rate, and qualification rate) was analyzed by the quadratic orthogonal combination experiment method. …”
Get full text

Influence of virtual reality simulation (excluding augmented reality) on endodontic learning experiences of undergraduate dental students: a systematic review by Muhammad Qasim Javed, Bilal Arjumand, Shaul Hameed Klarkodi, Sundus Atique, Ayman M. Abulhamael, Muhammad Sohail Zafar

Get full text

EXPERIMENT AND SIMULATION STUDY ON THE EFFECT OF Z-PIN REINFORCED ON THE PULL-OFF AND SHEAR CARRYING CAPACITY OF FIBER PLACEMENT COMPOSITE T-JOINTS by LIU Ji, XU XiWu

“…This article presents an experiment and simulation study on the effect of Z-pin reinforced on the pull-off and sheat carrying capacity of fiber placement composite T-joints,we used CMT5504 to conduct the pull-off test meanwhile we used MTS to conduct the shear test. we studied Z-pin reinforced And non-reinforced test-pieces,drawing Load-displacement curves.The pull-off test results donate that Z-pin can effectively improved the pull-off carrying capacity of T-joints and slow the decrease of the load significantly after pick loading compared to the non-reinforced T-joints. …”
Get full text

Numerical Simulation of Seepage in Shale Oil Reservoirs Under Hydraulic Fracturing: From Core-Scale Experiment to Reservoir-Scale Modeling by Yanfang Gao, Di Wang, Zupeng Chen, Yanchao Li, Shijie Shen, Dengke Li, Xuelin Liang, Zhi Huang

Get full text