OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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Vancomycin Therapeutic Drug Monitoring by Bhaskar Shenoy, Devesh N Joshi, Pooja Doddikoppad

“…Children above the age of 3 months with suspected MRSA sepsis should receive vancomycin 60–80 mg/kg/day (should not increase >3600 mg/day) in three to four divided doses, considering they have normal renal function. …”
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Impact of seasons on industrial grounding resistance by Roman Sikora, Adrian Wilk, Przemysław Markiewicz, Ewa Korzeniewska

“…Abstract A properly designed and constructed ground electrode should perform well for many years. It must be periodically inspected to know its current technical condition. …”
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A Hybrid Algorithm Based Static Model Updating Method and Its Application to Spacecraft by Jutao Wang, Zhenzhong Liu, Xiaofei Wang

“…The corresponding optimization algorithm not only should have a stronger capability to find the global optimum, but also should achieve an optimal result with high accuracy. …”
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Fetal bradycardia associated with left ventricle noncompaction diagnosed as HCN4 mutations by Kosuke Yonehara

“…In addition, inherited arrhythmia syndrome should be considered.…”
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Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Renal Dysfunction by Z. D. Kobalava, A. A. Shavarov, M. V. Vatsik-Gorodetskaya

“…Oral anticoagulation for stroke prevention is therefore recommended in patients with atrial fibrillation and decreased renal function. Each direct oral anticoagulant has unique pharmacologic properties of which clinician should be aware to optimally manage patients. …”
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Energy-Momentum tensor correlators in ϕ4 theory I: The spin-zero sector by Nikos Irges, Leonidas Karageorgos

“…Then, using the 3-point function 〈Θϕϕ〉, we construct the operator Θ as a certain linear combination of the basis operators, using the requirements that Θ should vanish on the fixed point and that it should have zero anomalous dimension. …”
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Related factors of acute pancreatitis complicated by uremia by WANG Zhen, XU Zhe

“…Objective To investigate the related factors and prevention of acute pancreatitis(AP) complicated by uremia.Methods We retrospectively reviewed the medical records of all patients with AP complicated by uremia who were hospitalized between January 2009 and June 2014.According to whether or not suffering AP,they were divided into AP group and control group.For two groups,the baseline characteristics and laboratory measurements were collected and analyzed.Results During the study period,1 665 eligible patients were enrolled,30 patients had AP,the overall prevalence rate was 1.80%,and incidence of AP was 3.28 per 1 000 person-years.The prevalence rate was0.92%,and incidence of AP was 1.67 per 1 000 person-years in the hemodialysis group.The prevalence rate was 1.20%,and incidence of AP was 2.19 per 1 000 person-years in the peritoneal dialysis group.The prevalence rate was 3.17%,and incidence of AP was 5.77 per 1 000 person-years in the non-dialysis group.The AP group had marked differences in leukocyte count,renal function,carbon dioxide-combining power,calcemia,phosphorus,intact parathyroid hormone(iPTH),liver function,high sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT) and glomerular filtration rate(GFR) as compared with the control group(P<0.05).Multivariable logistic regression analysis showed that calcemia and GFR were related with AP in uremia patients.Conclusions The hypocalcemia and decline of residual renal function are the related factors for the occurrence of AP in patients with uremia.Clinically calcium and phosphorus imbalance should be prevented,and rGFR should be protected actively to prevent AP.…”
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Prescribing Medications in Patients with Decompensated Liver Cirrhosis by Deepak N. Amarapurkar

“…Caveat for the prescribing medications in patients with cirrhosis the drug dosing should be individualized depending on a number of factors like nutritional status, renal function, adherence, and drug interaction. …”
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Advances in Our Understanding of “Resistance” to Antiplatelet Agents for Prevention of Ischemic Stroke by Philip B. Gorelick, Muhammad U. Farooq

“…Debates have raged over the years about the application of platelet function tests in clinical practice. We conclude that platelet function testing is not indicated in routine clinical practice. …”
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Duszpasterstwo w dobie hiperkonsumpcji by Mateusz Mazurek

“…The first type assumes that the Church should conform to the modern world both in terms of values and working methods. …”
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Global Longitudinal Strain and Myocardial Work Index in Post-COVID-19 Syndrome with Mild Symptoms: A Case Series by Prima Almazini, Amiliana Mardiani Soesanto

“…Considering the high prevalence of cardiac abnormalities after COVID-19, clinicians should continue to monitor cardiac function in COVID-19 patients after hospital discharge. …”
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Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions by Alessia Mahoney, Arianna D’Angelo

“…It was found that co-prescribing Letrozole or Clomiphene Citrate alongside Metformin should be considered, Inositol should be examined as an alternative insulin sensitiser to Metformin and studies should be undertaken to identify the ideal dose and duration of Inositol therapy. …”
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Diagnostics and treatment of pancreatic exocrine insufficiency: clinical guidelines of the Russian gastroenterological association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Daily ration should be divided into six or more meals. Patients should be motivated to stop both alcohol intake and smoking as they can cause progression of PEI alone and/or persistence of symptoms, like pancreatic pain.…”
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prioriactions: Multi‐action management planning in R by José Salgado‐Rojas, Virgilio Hermoso, Eduardo Álvarez‐Miranda

“…Abstract Designing effective conservation strategies requires deciding not only where to locate conservation actions (i.e. which territorial units should be priortized), but also which type actions should be deployed. …”
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Size of the ulna and taxonomic order affect vane dimensions of secondary remiges in birds by D.C. Deeming, E.P. Bayliss, E. Ketley

“…Where feather count increases with increasing ulna length then vane width should exhibit negative allometry. Vane length should also correlate with ulna length, irrespective of the number of feathers. …”
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Primary hyperthyroidism complicated by primary hyperparathyroidism: a case report and literature review by Hongpeng Guo, Jie Lv, He Zhang, You Li, Xinghe Pan, Junjie Zhang, Chenglin Sun

“…There remains considerable debate regarding the necessity of iodine use prior to surgery for hyperthyroidism and whether thyroid function should be normalized before proceeding with the operation. …”
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Quality Control in Survey Design: Evaluating a Survey of Educators’ Attitudes Concerning Differentiated Compensation by Kelly D. Bradley, Michael Peabody, Shannon O. Sampson

“…Researchers addressing potentially contentious issues should ensure their methods stand up to rigorous criticism. …”
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Quality Control in Survey Design: Evaluating a Survey of Educators’ Attitudes Concerning Differentiated Compensation by Kelly D. Bradley, Michael Peabody, Shannon O. Sampson

“…Researchers addressing potentially contentious issues should ensure their methods stand up to rigorous criticism. …”
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An Empirical Study on Intelligent Rural Tourism Service by Neural Network Algorithm Models by Jingzhi Chen, Hongbo Xue, Sang-Bing Tsa

“…With the continuous development of social economy, tourism has become one of the many choices and is becoming more and more popular. However, it should be noted that how to provide high-quality and efficient tourism services is extremely important. …”
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